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INVESTIGATION OF THE RELATIONSHIP BETWEEN NEUTROPHIL/LYMPHOCYTE RATIO AND ANALGESIC CONSUMPTION IN BIMAXILLARY ORTHOGNATHIC SURGERY PATIENTS

Yıl 2022, Cilt 25, Sayı Supplement, 34 - 36, 25.03.2022
https://doi.org/10.7126/cumudj.1031144

Öz

Objectives Neutrophil to lymphocyte ratio; as an inexpensive, easily measurable, and repeatable laboratory parameter is an indicator of subclinical inflammation, and is also a parameter that gives an idea about the systemic inflammatory response and cellular immune response. In general, lymphopenia reflects the weakness of cellular immunity, while neutrophilia is indicative of the response to systemic inflammation. The ratio of these two values to each other seems to be a marker showing the adequacy of the cellular immune response against this situation, despite the magnitude of systemic inflammation. In this study, we aimed to investigate the relationship between preoperative neutrophil-lymphocyte ratio (NLR) and postoperative analgesic drug consumption. Materials and Method Within the scope of the study, the files of 50 patients who underwent bimaxillary orthognathic surgery were retrospectively analyzed. The preoperative NLR values of the patients and the need for the analgesic drugs in the first 24 hours and after 24 hours were recorded and correlated. Results 24% of the patients were girls and 76% were boys. The average age was 20.54, and the average weight was 65.28 kg. There was a positive, strong, and significant correlation between the preoperative neutrophil count and preoperative NLR value and variables of analgesic drug consumption in the first 24 hours (r = 0.6814, p <0.001, and r = 0.6148, p <0.001, respectively). There was a negative, strong and significant correlation between the preoperative lymphocyte count and the first 24-hour analgesic drug consumption variables (r = -0.6773, p <0.001). Conclusion It was concluded that patients with a preoperative NLR value of 2.11 and above may require 4 or more analgesics in the first 24 hours, therefore, NLR value can give preliminary information about the need for postoperative analgesia, and these values could be taken into account when developing a strategy for postoperative analgesia.

Kaynakça

  • Referans1. Jilma B, Blann A, Pernerstorfer T, et al. Regulation of adhesion molecules during human endotoxemia. Am J Respir Crit Care Med1999; 159: 857-863
  • Referans2. Dionigi R, Dominioni L, Benevento A, et al. Effects of surgical trauma of laparoscopic vs. open cholecystectomy. Hepatogastroenterology 1994; 41: 471-476
  • Referans3. O’Mahony JB, Palder SB, Wood JJ, et al. Depression of cellular immunity after multiple trauma in the absence of sepsis. J Trauma 1984; 24: 869-875
  • Referans4. Zahorec R. Ratio of neutrophil to lymphocyte counts- Rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001; 102: 5-14
  • Referans5. Duffy BK, Gurm HS, Rajagopal V, et al. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. Am J Cardiol 2006; 97: 993-996
  • Referans6. Tsujimura A, Kawamura N, Ichimura T, et al. Telomerase activity in needle biopsied uterine myoma-like tumors: differential diagnosis between uterine sarcomas and leiomyomas. Int J Oncol 2002; 20: 361-365
  • Referans7. Lee UL, Lee EJ, Seo HY, Han SH, Choi WC, Choi YJ. Prevalence and risk factors of tooth discolouration after orthognathic surgery: a retrospective study of 1455 patients. Int J Oral Maxillofac Surg. 2016; 45:1464-1470
  • Referans8. Svedstrom-Oristo AL, Tuomisto MT. Patients’ perceptions of orthognathic treatment, well-being, and psychological or psychiatric status: a systematic review. Acta Odontol Scand 2010; 68:249–260
  • Referans9. Kalha A. Orthognathic treatment and temporomandibular disorders—part 1. Evid Based Dent 2010; 11:82–83
  • Referans10. Magalhaes IB, Pereira LJ, Marques LS, Gameiro GH. The influence of malocclusion on masticatory performance: a systematic review. Angle Orthod 2010; 80:981–987.
  • Referans11. Nagatsuka C, Ichinohe T, Kaneko Y. Preemptive effects of a combination of preoperative diclofenac, butorphanol, and lidocaine on postoperative pain management following orthognathic surgery. Anesth Prog 2000; 47:119–124
  • Referans12. Niederhagen B, Braumann B, Dierke-Dzierzon C, Albrecht S. Postoperative pain after interventions in the area of the mouth-jaw-face. Mund Kiefer Gesichtschir 1997; 1:229–234
  • Referans13. Jia D, Liu F, Zhang Q, Zeng GQ, Li XL, Hou G. Rapid on-site evaluation of routine biochemical parameters to predict right ventricular dysfunction in and the prognosis of patients with acute pulmonary embolism upon admission to the emergency room. J Clin Lab Anal. 2018;32:e22362
  • Referans14. Eryigit U, Altunayoglu C, Sahin A, et al. The diagnostic value of the neutrophil-lymphocyte ratio in distinguishing between subarachnoid hemorrhage and migraine. Am J Emerg Med. 2017;35:1276-1280.
  • Referans15. Öner K, Okutan AE, Ayas MS, Paksoy AE, Polat F. Predicting postoperative pain with neutrophil/ lymphocyte ratio after arthroscopic rotator cuff repair. Asia Pac J Sports Med Arthrosc Rehabil Technol. 2020;20:24-27
  • Referans16. Daoudia M, Decruynaere C, Le Polain de Waroux B, Thonnard JL, Plaghki L, Forget P. Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements. BMC Anesthesiol. 2015;15:183.
  • Referans17. Bozkurt H, Arac D, Cigdem B. Effect of Preoperative Uric Acid Level and Neutrophil / Lymphocyte Ratio on Preoperative and Postoperative Visual Analogue Pain Scores in Patients with Lumbar Disc Herniation: A Cross-Sectional Study. Turk Neurosurg. 2019;29:705-709
  • Referans18. Turgut HC, Alkan M, Ataç MS, Altundağ SK, Bozkaya S, Şimşek B, et al. Neutrophil lymphocyte ratio predicts postoperative pain after orthognathic surgery. Niger J Clin Pract 2017; 20:1242‑5.
  • Referans19. Alkan M, Erkent FD, Celik A, Gokce A, Arslan M, Unal Y. Effects of thoracic epidural or intravenous analgesia on the neutrophil-to-lymphocyte ratio in thoracotomy cases. Niger J Clin Pract. 2018;21:1337-1340.

Yıl 2022, Cilt 25, Sayı Supplement, 34 - 36, 25.03.2022
https://doi.org/10.7126/cumudj.1031144

Öz

Kaynakça

  • Referans1. Jilma B, Blann A, Pernerstorfer T, et al. Regulation of adhesion molecules during human endotoxemia. Am J Respir Crit Care Med1999; 159: 857-863
  • Referans2. Dionigi R, Dominioni L, Benevento A, et al. Effects of surgical trauma of laparoscopic vs. open cholecystectomy. Hepatogastroenterology 1994; 41: 471-476
  • Referans3. O’Mahony JB, Palder SB, Wood JJ, et al. Depression of cellular immunity after multiple trauma in the absence of sepsis. J Trauma 1984; 24: 869-875
  • Referans4. Zahorec R. Ratio of neutrophil to lymphocyte counts- Rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001; 102: 5-14
  • Referans5. Duffy BK, Gurm HS, Rajagopal V, et al. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. Am J Cardiol 2006; 97: 993-996
  • Referans6. Tsujimura A, Kawamura N, Ichimura T, et al. Telomerase activity in needle biopsied uterine myoma-like tumors: differential diagnosis between uterine sarcomas and leiomyomas. Int J Oncol 2002; 20: 361-365
  • Referans7. Lee UL, Lee EJ, Seo HY, Han SH, Choi WC, Choi YJ. Prevalence and risk factors of tooth discolouration after orthognathic surgery: a retrospective study of 1455 patients. Int J Oral Maxillofac Surg. 2016; 45:1464-1470
  • Referans8. Svedstrom-Oristo AL, Tuomisto MT. Patients’ perceptions of orthognathic treatment, well-being, and psychological or psychiatric status: a systematic review. Acta Odontol Scand 2010; 68:249–260
  • Referans9. Kalha A. Orthognathic treatment and temporomandibular disorders—part 1. Evid Based Dent 2010; 11:82–83
  • Referans10. Magalhaes IB, Pereira LJ, Marques LS, Gameiro GH. The influence of malocclusion on masticatory performance: a systematic review. Angle Orthod 2010; 80:981–987.
  • Referans11. Nagatsuka C, Ichinohe T, Kaneko Y. Preemptive effects of a combination of preoperative diclofenac, butorphanol, and lidocaine on postoperative pain management following orthognathic surgery. Anesth Prog 2000; 47:119–124
  • Referans12. Niederhagen B, Braumann B, Dierke-Dzierzon C, Albrecht S. Postoperative pain after interventions in the area of the mouth-jaw-face. Mund Kiefer Gesichtschir 1997; 1:229–234
  • Referans13. Jia D, Liu F, Zhang Q, Zeng GQ, Li XL, Hou G. Rapid on-site evaluation of routine biochemical parameters to predict right ventricular dysfunction in and the prognosis of patients with acute pulmonary embolism upon admission to the emergency room. J Clin Lab Anal. 2018;32:e22362
  • Referans14. Eryigit U, Altunayoglu C, Sahin A, et al. The diagnostic value of the neutrophil-lymphocyte ratio in distinguishing between subarachnoid hemorrhage and migraine. Am J Emerg Med. 2017;35:1276-1280.
  • Referans15. Öner K, Okutan AE, Ayas MS, Paksoy AE, Polat F. Predicting postoperative pain with neutrophil/ lymphocyte ratio after arthroscopic rotator cuff repair. Asia Pac J Sports Med Arthrosc Rehabil Technol. 2020;20:24-27
  • Referans16. Daoudia M, Decruynaere C, Le Polain de Waroux B, Thonnard JL, Plaghki L, Forget P. Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements. BMC Anesthesiol. 2015;15:183.
  • Referans17. Bozkurt H, Arac D, Cigdem B. Effect of Preoperative Uric Acid Level and Neutrophil / Lymphocyte Ratio on Preoperative and Postoperative Visual Analogue Pain Scores in Patients with Lumbar Disc Herniation: A Cross-Sectional Study. Turk Neurosurg. 2019;29:705-709
  • Referans18. Turgut HC, Alkan M, Ataç MS, Altundağ SK, Bozkaya S, Şimşek B, et al. Neutrophil lymphocyte ratio predicts postoperative pain after orthognathic surgery. Niger J Clin Pract 2017; 20:1242‑5.
  • Referans19. Alkan M, Erkent FD, Celik A, Gokce A, Arslan M, Unal Y. Effects of thoracic epidural or intravenous analgesia on the neutrophil-to-lymphocyte ratio in thoracotomy cases. Niger J Clin Pract. 2018;21:1337-1340.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Yayınlanma Tarihi Kış
Bölüm Original Research Articles
Yazarlar

Seher ORBAY YAŞLI (Sorumlu Yazar)
ERCIYES UNIVERSITY, FACULTY OF DENTISTRY
0000-0001-5163-3893
Türkiye


Dilek GÜNAY CANPOLAT
ERCİYES ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ
0000-0002-8985-6918
Türkiye

Yayımlanma Tarihi 25 Mart 2022
Başvuru Tarihi 1 Aralık 2021
Kabul Tarihi 16 Şubat 2022
Yayınlandığı Sayı Yıl 2022, Cilt 25, Sayı Supplement

Kaynak Göster

EndNote %0 Cumhuriyet Dental Journal INVESTIGATION OF THE RELATIONSHIP BETWEEN NEUTROPHIL/LYMPHOCYTE RATIO AND ANALGESIC CONSUMPTION IN BIMAXILLARY ORTHOGNATHIC SURGERY PATIENTS %A Seher Orbay Yaşlı , Dilek Günay Canpolat %T INVESTIGATION OF THE RELATIONSHIP BETWEEN NEUTROPHIL/LYMPHOCYTE RATIO AND ANALGESIC CONSUMPTION IN BIMAXILLARY ORTHOGNATHIC SURGERY PATIENTS %D 2022 %J Cumhuriyet Dental Journal %P 1302-5805-2146-2852 %V 25 %N Supplement %R doi: 10.7126/cumudj.1031144 %U 10.7126/cumudj.1031144

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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