Abstract
References
- Chapple IL, Matthews JB. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000 2007;43:160-232. 11. C
- happle IL, Mason GI, Garner ZI, GH, Maxwell SR, Whitehead TP. Enhanced chemiluminescent assay for measuring the total antioxidant capacity of serum, saliva and crevicular fluid. Ann Clin Biochem 1997;34:412-421. Thorpe
- Halliwell B, Gutteridge JMC. Oxidative stress: adaptation, damage, repair and death. In: Halliwell B, Gutteridge JMC (eds). Free radicals in biology and medicine. Oxford, UK: Oxford University Press, 1999:284– 330.
- Luqman S, Rizvi SI. Protection of lipid peroxidation and carbonyl formation in proteins by capsaicin in human erythrocytes subjected to oxidative stress. Phytother Res 2006; 20:303- 306.
- Little RE, Gladen BC. Levels of lipid peroxides in uncomplicated pregnancy: a review of the literature. Reprod Toxicol 1999;13:347-352.
- Poston L, Raijmakers MT. Trophoblast oxidative stress, antioxidants and pregnancy outcome-a review. Placenta 2004;25:72-78.
- Akpinar A, Toker H, Ozdemir H, Bostanci V, Aydin H. The effects of non-surgical periodontal therapy on oxidant and anti-oxidant status in smokers with chronic periodontitis. Arch Oral Biol 2013;58:717-723.
- Canakci CF, Cicek Y, Yildirim A, Sezer U, Canakci V. Increased levels of 8-hydroxydeoxyguanosine and malondialdehyde and its relationship with antioxidant enzymes in saliva of periodontitis patients. Eur J Dent 2009;3:100-106.
- Ergun S, Troşala SC, Warnakulasuriya S, Özel S, Önal AE, Ofluoğlu D, Güven Y, Tanyeri H. Evaluation of oxidative stress and antioxidant profile in patients with oral lichen planus. J Oral Pathol Med 2011;40:286–293.
- Brock GR, Butterworth CJ, Matthews JB, Chapple IL. Local and systemic total antioxidant capacity in periodontitis and health. J Clin Periodontol 2004;31:515-521.
- Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
- Armstrong D, al-Awadi F. Lipid peroxidation and retinopathy in streptozotocin-induced diabetes. Free Radic Biol Med 1991;11:433-436.
- Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 2004;37:112-119.
- Romero FJ, Bosch-Morell F, Romero MJ, Jareño EJ, Romero B, Marín N, Romá J. Lipid peroxidation products and antioxidants in human disease. Environ Health Perspect 1998; 106:1229-1234.
- Del Rio D, Stewart AJ, Pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis 2005; 15:316-328.
- Tekin U, Kısa Ü, Güven O, Kurku H. Malondialdehyde levels in dental follicles of asymptomatic impacted third molars. J Oral Maxillofac Surg 2011;69:1291-1294.
- Ghiselli A, Serafini M, Natella F, Scaccini C. Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radic Biol Med 2000;29:1106- 1114.
- Serafini M, Del Rio D. Understanding the association between dietary antioxidants, redox status and disease: is the total antioxidant capacity the right tool? Redox Rep 2004;9:145–152.
- Kolanjiappan K, Ramachandran CR, Manoharan S. Biochemical changes in tumor tissues of oral cancer patients. Clin Biochem 2003;36:61-65.
- Panjamurthy K, Manoharan S, Ramachandran CR. Lipid peroxidation and antioxidant status in patients with periodontitis. Cell Mol Biol Lett 2005;10:255-264.
- How to cite this article: Umut Tekin, Ucler Kisa, Fethi Atil, Meltem Karsiyaka Hendek, Ozlem Dogan, Safa
- Gurcan. Malondialdehyde levels and total antioxidant capacity in the dental follicles of the asymptomatic
- impacted third molars. Cumhuriyet Dent J 2015;18(2):108-115.
- Periodontal disease is associated with
- lower antioxidant capacity in whole
- saliva and evidence of increased
- protein oxidation. Clin Sci (Lond) 2003;105:167-172.
Malondialdehyde levels and total antioxidant capacity in the dental follicles of the asymptomatic impacted third molars
Abstract
Objectives: Malondialdehyde (MDA), is one of many low molecular weight end products of lipid peroxidation (LPO), increases in oxidative stress. Antioxidants such as total antioxidant capacity (TAC) have a protective effect against reactive oxygen species. The aim of this study is to examine the development of the antioxidant defense mechanism in dental follicles (DF) of radiologically asymptomatic impacted third molars (ITM) by using MDA and TAC.
Materials and Methods: This study involved 40 DF of 40 patients referred for clinically and radiographically asymptomatic ITM. 40 healthy gingival tissues in the same patients obtained during surgical removal of teeth as a control group. This study involved DF widths on periapical radiographs narrower than 2.5 mm were included in the study. All of tissues samples were analyzed for MDA and TAC.
Results: Levels of the MDA and TAC in DF were significantly higher than the levels of MDA and TAC provided from healthy gingival tissues of the same patients (p<0.05).
Conclusions: The results of our study showed that an important antioxidant defense mechanism may also occur in DFs of asymptomatic ITM. In the light of these preliminary findings of the presented study, supplementary studies should be undertaken to establish the differences between inflammation affecting the DF and clinical outcomes.
References
- Chapple IL, Matthews JB. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000 2007;43:160-232. 11. C
- happle IL, Mason GI, Garner ZI, GH, Maxwell SR, Whitehead TP. Enhanced chemiluminescent assay for measuring the total antioxidant capacity of serum, saliva and crevicular fluid. Ann Clin Biochem 1997;34:412-421. Thorpe
- Halliwell B, Gutteridge JMC. Oxidative stress: adaptation, damage, repair and death. In: Halliwell B, Gutteridge JMC (eds). Free radicals in biology and medicine. Oxford, UK: Oxford University Press, 1999:284– 330.
- Luqman S, Rizvi SI. Protection of lipid peroxidation and carbonyl formation in proteins by capsaicin in human erythrocytes subjected to oxidative stress. Phytother Res 2006; 20:303- 306.
- Little RE, Gladen BC. Levels of lipid peroxides in uncomplicated pregnancy: a review of the literature. Reprod Toxicol 1999;13:347-352.
- Poston L, Raijmakers MT. Trophoblast oxidative stress, antioxidants and pregnancy outcome-a review. Placenta 2004;25:72-78.
- Akpinar A, Toker H, Ozdemir H, Bostanci V, Aydin H. The effects of non-surgical periodontal therapy on oxidant and anti-oxidant status in smokers with chronic periodontitis. Arch Oral Biol 2013;58:717-723.
- Canakci CF, Cicek Y, Yildirim A, Sezer U, Canakci V. Increased levels of 8-hydroxydeoxyguanosine and malondialdehyde and its relationship with antioxidant enzymes in saliva of periodontitis patients. Eur J Dent 2009;3:100-106.
- Ergun S, Troşala SC, Warnakulasuriya S, Özel S, Önal AE, Ofluoğlu D, Güven Y, Tanyeri H. Evaluation of oxidative stress and antioxidant profile in patients with oral lichen planus. J Oral Pathol Med 2011;40:286–293.
- Brock GR, Butterworth CJ, Matthews JB, Chapple IL. Local and systemic total antioxidant capacity in periodontitis and health. J Clin Periodontol 2004;31:515-521.
- Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
- Armstrong D, al-Awadi F. Lipid peroxidation and retinopathy in streptozotocin-induced diabetes. Free Radic Biol Med 1991;11:433-436.
- Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 2004;37:112-119.
- Romero FJ, Bosch-Morell F, Romero MJ, Jareño EJ, Romero B, Marín N, Romá J. Lipid peroxidation products and antioxidants in human disease. Environ Health Perspect 1998; 106:1229-1234.
- Del Rio D, Stewart AJ, Pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis 2005; 15:316-328.
- Tekin U, Kısa Ü, Güven O, Kurku H. Malondialdehyde levels in dental follicles of asymptomatic impacted third molars. J Oral Maxillofac Surg 2011;69:1291-1294.
- Ghiselli A, Serafini M, Natella F, Scaccini C. Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radic Biol Med 2000;29:1106- 1114.
- Serafini M, Del Rio D. Understanding the association between dietary antioxidants, redox status and disease: is the total antioxidant capacity the right tool? Redox Rep 2004;9:145–152.
- Kolanjiappan K, Ramachandran CR, Manoharan S. Biochemical changes in tumor tissues of oral cancer patients. Clin Biochem 2003;36:61-65.
- Panjamurthy K, Manoharan S, Ramachandran CR. Lipid peroxidation and antioxidant status in patients with periodontitis. Cell Mol Biol Lett 2005;10:255-264.
- How to cite this article: Umut Tekin, Ucler Kisa, Fethi Atil, Meltem Karsiyaka Hendek, Ozlem Dogan, Safa
- Gurcan. Malondialdehyde levels and total antioxidant capacity in the dental follicles of the asymptomatic
- impacted third molars. Cumhuriyet Dent J 2015;18(2):108-115.
- Periodontal disease is associated with
- lower antioxidant capacity in whole
- saliva and evidence of increased
- protein oxidation. Clin Sci (Lond) 2003;105:167-172.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Research Articles |
| Authors | |
| Publication Date | April 24, 2015 |
| Submission Date | September 12, 2014 |
| Published in Issue | Year 2015 Volume: 18 Issue: 2 |
Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.
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