Recent recognition of the importance of periodontal disease and its impact on the perpetuation and management of systemic diseases calls for a global effort to control periodontal disease. With the advent of advanced molecular diagnostic techniques, a better understanding of the role of specific pathogens and the contributory role of the host immune response in the initiation and progression of periodontal disease has been possible. However, successful vaccine development that fully utilizes the current level of understanding has not yet occurred for human use. This article reviews the various trials undertaken to develop a vaccine against periodontal disease, so as to construct a more sophisticated design which may be relevant in the future. Periodontal disease as a multifactorial and polymicrobial disease requires a vaccine design targeting multiple pathogenic species. As an innovative strategy, vaccine trials to stimulate antigen-specific T-cells polarized towards helper T-cells with a regulatory phenotype have been introduced. Conjugate and recombinant vaccines, immune regulation with coinfecting microorganisms within the biofilm and vaccine regimens like commonly shared antigens by selected periodontopathogenic species are new avenues that are being explored. The role of RecA protein and osteoprotegerin-ligand cannot be overlooked. Targeting not only a single pathogen, but polymicrobial organisms, and targeting not only periodontal disease, but also periodontal disease-triggered systemic disease could be a feasible goal.
KEYWORDS: Vaccination, Periodontitis, Immune response, DNA vaccine.
Birincil Dil | İngilizce |
---|---|
Bölüm | Review |
Yazarlar | |
Yayımlanma Tarihi | 24 Nisan 2015 |
Gönderilme Tarihi | 13 Mart 2012 |
Yayımlandığı Sayı | Yıl 2015Cilt: 18 Sayı: 2 |
Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.
CDJ accepts articles in English. Submitting a paper to CDJ is free of charges. In addition, CDJ has not have article processing charges.
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