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Year 2014, Volume: 17 Issue: 4, 414 - 422, 09.07.2014

Neslihan Şimşek , Ülkü Özan , Kürşat Er

https://doi.org/10.7126/cdj.58140.5000045677

Abstract

Success of the endodontic treatment depends on the microbial elimination in the root canal and periradicular region. Mechanic instrumentation alone cannot achieve a sterile condition. For this reason, some researchers have tried to solve this problem with local administration of antibiotic mixtures. Triple antibiotic paste containing metronidazole, ciprofloxacin, and minocycline has been reported to be a successful protocol in controlling the root canal pathogens. The developed treatment method have been named lesion sterilization and tissue reapir. The purpose of this review is to make contribution to beter understanding of biocompatibility, efficiency, and the restricted properties of the triple antibiotic paste in endodontic therapy and pulp revascularization

Keywords

Lesion sterilizationTissue repairAntibiotic mixtureEndodontic treatmentA B S T R A C T

References

  • Love RM, Jenkinson HF. Invasion dentinal tubules by oral bacteria. Crit Rev Oral Biol Med 2002;13:171-83.
  • Moore WE, Moore LV. The bacteria of periodontal diseases. Periodontol 2000 1994;5:66-77.
  • Jung II-Y, Choi B-K, Lee S-J, Park D-S. Molecular epidemiology and association of putative pathogens in root canal infection. J Endod 2000;25:599-604.
  • Kantz WE, Henry CA. Isolation and classification of anaerobic bacteria from intact pulp chambers of non-vital teeth in man. Arch Oral Biol 1974;19:91-6.
  • Dahlén G, Bergenholtz G. Endodontic activity in teeth with necrotic pulps. J Dent Res 1980;59:1033-40.
  • Sundqvist G. Associations between microbial species in dental root canal infections. Oral Microbiol Immunol 1992;7:257-62.
  • Sundqvist G. Ecology of the root canal flora. J Endod 1992;18:427-30.
  • Sundqvist G. Taxonomy, ecology, and pathogenicity of the root canal flora. Oral Surg Oral Med Oral Pathol 1994;78:522-30.
  • Gomes B, Pinheiro ET, Gade-Neto CR, Sousa EL, Ferraz CC, Zaia AA, Teixeira FB, Sousa-Filho FJ. Microbiological examination of infected dental root canals. Oral Microbiol Immunol 2004;19:71-6.
  • Abbott PV. Selective and intelligent use of antibiotics in endodontics. Aust Endod J 2000;26:30-9.
  • Ando N, Hoshino E. Predominant obligate anaerobes invading the deep layers of root canal dentine. Int Endod J 1990;23:20-7.
  • Hoshino E. Sterilization of carious lesons by drugs. J Jpn Assoc Dent Sci 1990;9:32-7.
  • Iwaku M, Hoshino E, Kota K. Lesion sterilization and tissue repair (LSTR) therapy: new pulpal treatment. How to conserve infected pulps. Tokyo, Japan: Nihon-Shika-Hyoron, 1996.
  • Hoshino E, Takushige T. LSTR 3Mix-MP method-better and efficient clinical procedures of lesion sterilization and tissue repair (LSTR) therapy. Dent Rev 1998;666:57-106.
  • Hoshino E. Predominant obligate anaerobes in human carious dentine. J Dent Res 1985;64:1195-8.
  • Hoshino E, Kota K, Sato M, Iwaku M. Bactericidal efficacy of metronidazole against bacteria of human carious dentin in vitro. Caries Res 1988;22:280-2.
  • Hoshino E, Iwaku M, Sato M, Ando N, Kota K. Bactericidal efficacy of metronidazole against bacteria of human carious dentin in vivo. Caries Res 1989;23:78-80.
  • Hoshino E, Ando N, Sato M, Kota K. Bacterial invasion of non-exposed dental pulp. Int Endod J 1992;25:2-5.
  • Sato T, Hoshino E, Uematsu H, Noda T. Predominant obligate anaerobes in necrotic pulps of human decideus teeth. Microb Ecol Health Dis 1993b:6:269-75.
  • Kiryu T, Hoshino E, Iwaku M. Bacteria invading periapical cementum. J Endod 1994;20:169-72.
  • Hoshino E, Sato M, Sasano T, Kota K. Characterization of bacterial deposits formed in vivo on hydrogen-ion-sensitive field transistor electrodes and enamel surfaces. Jpn J Oral Biol 1989;31:102-6.
  • Hori R, Kohno S, Hoshino E. Tongue microflora in edentulous geriatric denture-wearers. Microb Ecol Health Dis 1999;11:89-95.
  • Hoshino E, Sato M. Composition of bacterial deposits on full denture. Jpn J Prosth Dent 1988;32:762-6.
  • Sato M, Hoshino E, Nomura S, Ishioka K. Salivary microflora of geriatric edentulous persons wearing dentures. Microb Ecol Health Dis 1993;6:293-9.
  • Uematsu H, Hoshino E. Predominant obligate anaerobes in human periodontal pockets. J Periodontal Res 1992;27:15-9.
  • Hoshino E, Echigo S, Yamada T, Teshima T. Isolation of Propionibacterium acnes from sclerosing osteomyelitis of mandibles. Jpn J Oral Biol 1984;26:48-51.
  • Edwardsson S. Bacteriological studies on deep areas of carious dentine. Odontol Rev 1974;25:1-143.
  • Wittgow WC, Sabiston CB. Microorganisms from pulpal chambers of intact teeth with necrotic pulps. J Endod 1975;1:168-71.
  • Zavistoski J, Dzink J, Onderdonk A, Bartlett J. Quantitative bacteriology of endodontic infections. Oral Surg Oral Med Oral Pathol 1980;49:171-4.
  • Yoshida M, Fukushima H, Yamada K, Ogawa K, Toda T, Sagawa H. Correlation between clinical symptoms and microorganisms isolated from root canals of teeth with periapical pathosis. J Endod 1987;13:24-8.
  • Windley W, Teixeira F, Levin L, Sigurdsson A, Trope M. Disinfection of immature teeth with a triple antibiotic paste. J Endod 2005;31:439-43.
  • Roche Y, Yoshimori RN. In-vitro activity of spiramycin and metronidazole alone or combination against clinical isolates from odontogenic abscesses. J Antimicrob Chemother 1997;40:353-77.
  • Black A, Redmond AO, Steen HJ, Oborska IT. Tolerance and safety of ciprofloxacin in paediatric patients. J Antimicrob Chemother 1990;26:25-9.
  • Takushige T, Cruz EV, Asgor Moral A, Hoshino E. Endodontic treatment of primary teeth using a combination of antibacterial drugs. Int Endod J 2004;37:132-8.
  • Ayukawa Y. Pulpal response of human teeth to antibacterial biocompatible pulp-capping agent-improvement of mixed drugs. Jpn J Conservative Dent 1994;37:643-51.
  • Sato T, Hoshino E, Uematsu H, Noda T. In vitro antimicrobial susceptibility to combinations of drugs of bacteria from carious and endodontic lesions of human deciduous teeth. Oral Microbiol Immunol 1993;8:172 6.
  • Hoshino E, Kurihara-Ando N, Sato I, Uematsu H, Sato M, Kota K, Iwaku M. In vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. Int Endod J 1996;29:125-30.
  • Sato I, Kurihara-Ando N, Kota K, Iwaku M, Hoshino E. Sterilization of infected root-canal dentine by topical application of a mixture of ciprofloxacin, metronidazole and minocycline in situ. Int Endod J 1996;29:118-24.
  • Er K, Celik D, Taşdemir T, Yildirim T. Treatment of horizontal root fractures using a triple antibiotic paste and mineral trioxide aggregate: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:e63-6.
  • Kusgoz A, Yildirim T, Er K, Arslan I. Retreatment of a resected tooth associated with a large periradicular lesion by using a triple antibiotic paste and mineral trioxide aggregate: a case report with a thirty-month follow-up. J Endod 2009;35:1603-6.
  • Özan Ü, Er K. Endodontic treatment of a large cyst-like periradicular lesion using a combination of antibiotic drugs: a case report. J Endod 2005;31:898-900.
  • Iwaya SI, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with apical periodontitis and sinus tract. Dent Traumatol 2001;17:185-7.
  • Banchs F, Trope M. Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol?. J Endod 2004;30:196-200.
  • Thibodeau B, Teixeira F, Yamauchi M, Caplan DJ, Trope M. Pulp revascularization of immature dog teeth with apical periodontitis. J Endod 2007;33:680-9.
  • Sönmez IS, Akbay Oba A, Erkmen Almaz M. Revascularization/regeneration performed in immature molars: case reports. J Clin Pediatr Dent 2013;37:231-4.
  • Jeeruphan T, Jantarat J, Yanpiset K, Suwannapan L, Khewsawai P, Hargreaves KM. Mahidol Study 1: Comparison of radiographic and survival outcomes of immature teeth treated with either regenerative endodontic or apexification methods: a retrospective study. J Endod 2012;38:1330-6.
  • Martin G, Ricucci D, Gibbs JL, Lin LM. Histological findings of revascularized/revitalized immature permanent molar with apical periodontitis using platelet-rich plasma. J Endod 2013;39:138-44.
  • Becerra P, Ricucci D, Loghin S, Gibbs JL, Lin LM. Histologic study of a human immature permanent premolar with chronic apical abscess after revascularization/revitalization. J Endod 2014;40:133-9.
  • Cehreli ZC, Isbitiren B, Sara S, Erbas G. Regenerative endodontic treatment (revascularization) of immature necrotic molars medicated with calcium hydroxide: a case series. J Endod 2011;37:1327-30.
  • Soares Ade J, Lins FF, Nagata JY, Gomes BP, Zaia AA, Ferraz CC, de Almeida JF, de Souza-Filho FJ. Pulp revascularization after root canal decontamination with calcium hydroxide and 2% chlorhexidine gel. J Endod 2013;39:417-20.
  • Epstein JB, Chong S, Le ND. A survey of antibiotics use in dentistry. J Am Dent Assoc 2000;131:1600-9.
  • Pallasch TJ. Global antibiotics resistance and its impact on the dental community. J Calif Dent Assoc 2000;28:215-33.
  • Kim JH, Kim Y, Shin SJ, Park JW, Jung IY. Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report. J Endod 2010;36:1086-91.
  • Bezgin T, Yilmaz AD, Celik BN, Sönmez H. Concentrated platelet-rich plasma used in root canal revascularization: 2 case reports. Int Endod J 2014;47:41-9. Nagy MM, Tawfik HE, Hashem AA, Abu-Seida AM.
  • Regenerative potential of immature permanent teeth with necrotic pulps after different regenerative protocols. J Endod 2014;40:192-8.

Lezyon Sterilizasyonu ve Doku Tamiri

Year 2014, Volume: 17 Issue: 4, 414 - 422, 09.07.2014

Neslihan Şimşek , Ülkü Özan , Kürşat Er

https://doi.org/10.7126/cdj.58140.5000045677

Abstract

Özet

Endodontik tedavinin başarısı, kök kanalı ve periradiküler bölgedeki mikroorganizmaların yok edilmesine bağlıdır. Mekanik preparasyon tek başına steril bir ortam sağlanmasına yardımcı olamaz. Bu nedenle, bazı araştırmacılar antibiyotik karışımlarının lokal uygulaması ile bu problemi çözmeye çalışmıştır. Metronidazol, siprofloksasin ve minosiklinden oluşan üçlü antibiyotik patının kök kanal patojenlerinin kontrolünde başarılı bir protokol olduğu rapor edilmiştir. Geliştirilen bu tedavi yöntemine de lezyon sterilizasyonu ve doku tamiri tedavisi adı verilmiştir. Bu derlemenin amacı, endodontik tedavi ve pulpa revaskülarizasyonunda kullanılan üçlü antibiyotik patının; biyouyumluluğunu, etkinliğini ve sınırlı yanlarını ortaya koyarak daha iyi anlaşılmasına katkıda bulunmaktır.  

Abstract

Success of the endodontic treatment depends on the microbial elimination in the root canal and periradicular region. Mechanic instrumentation alone cannot achieve a sterile condition. For this reason, some researchers have tried to solve this problem with local administration of antibiotic mixtures. Triple antibiotic paste containing metronidazole, ciprofloxacin, and minocycline has been reported to be a successful protocol in controlling the root canal pathogens. The developed treatment method have been named lesion sterilization and tissue reapir. The purpose of this review is to make contribution to beter understanding of biocompatibility, efficiency, and the restricted properties of the triple antibiotic paste in endodontic therapy and pulp revascularization.

Keywords

Lezyon sterilizasyonuDoku tamiriAntibiyotik karışımıEndodontik tedavi

References

  • Love RM, Jenkinson HF. Invasion dentinal tubules by oral bacteria. Crit Rev Oral Biol Med 2002;13:171-83.
  • Moore WE, Moore LV. The bacteria of periodontal diseases. Periodontol 2000 1994;5:66-77.
  • Jung II-Y, Choi B-K, Lee S-J, Park D-S. Molecular epidemiology and association of putative pathogens in root canal infection. J Endod 2000;25:599-604.
  • Kantz WE, Henry CA. Isolation and classification of anaerobic bacteria from intact pulp chambers of non-vital teeth in man. Arch Oral Biol 1974;19:91-6.
  • Dahlén G, Bergenholtz G. Endodontic activity in teeth with necrotic pulps. J Dent Res 1980;59:1033-40.
  • Sundqvist G. Associations between microbial species in dental root canal infections. Oral Microbiol Immunol 1992;7:257-62.
  • Sundqvist G. Ecology of the root canal flora. J Endod 1992;18:427-30.
  • Sundqvist G. Taxonomy, ecology, and pathogenicity of the root canal flora. Oral Surg Oral Med Oral Pathol 1994;78:522-30.
  • Gomes B, Pinheiro ET, Gade-Neto CR, Sousa EL, Ferraz CC, Zaia AA, Teixeira FB, Sousa-Filho FJ. Microbiological examination of infected dental root canals. Oral Microbiol Immunol 2004;19:71-6.
  • Abbott PV. Selective and intelligent use of antibiotics in endodontics. Aust Endod J 2000;26:30-9.
  • Ando N, Hoshino E. Predominant obligate anaerobes invading the deep layers of root canal dentine. Int Endod J 1990;23:20-7.
  • Hoshino E. Sterilization of carious lesons by drugs. J Jpn Assoc Dent Sci 1990;9:32-7.
  • Iwaku M, Hoshino E, Kota K. Lesion sterilization and tissue repair (LSTR) therapy: new pulpal treatment. How to conserve infected pulps. Tokyo, Japan: Nihon-Shika-Hyoron, 1996.
  • Hoshino E, Takushige T. LSTR 3Mix-MP method-better and efficient clinical procedures of lesion sterilization and tissue repair (LSTR) therapy. Dent Rev 1998;666:57-106.
  • Hoshino E. Predominant obligate anaerobes in human carious dentine. J Dent Res 1985;64:1195-8.
  • Hoshino E, Kota K, Sato M, Iwaku M. Bactericidal efficacy of metronidazole against bacteria of human carious dentin in vitro. Caries Res 1988;22:280-2.
  • Hoshino E, Iwaku M, Sato M, Ando N, Kota K. Bactericidal efficacy of metronidazole against bacteria of human carious dentin in vivo. Caries Res 1989;23:78-80.
  • Hoshino E, Ando N, Sato M, Kota K. Bacterial invasion of non-exposed dental pulp. Int Endod J 1992;25:2-5.
  • Sato T, Hoshino E, Uematsu H, Noda T. Predominant obligate anaerobes in necrotic pulps of human decideus teeth. Microb Ecol Health Dis 1993b:6:269-75.
  • Kiryu T, Hoshino E, Iwaku M. Bacteria invading periapical cementum. J Endod 1994;20:169-72.
  • Hoshino E, Sato M, Sasano T, Kota K. Characterization of bacterial deposits formed in vivo on hydrogen-ion-sensitive field transistor electrodes and enamel surfaces. Jpn J Oral Biol 1989;31:102-6.
  • Hori R, Kohno S, Hoshino E. Tongue microflora in edentulous geriatric denture-wearers. Microb Ecol Health Dis 1999;11:89-95.
  • Hoshino E, Sato M. Composition of bacterial deposits on full denture. Jpn J Prosth Dent 1988;32:762-6.
  • Sato M, Hoshino E, Nomura S, Ishioka K. Salivary microflora of geriatric edentulous persons wearing dentures. Microb Ecol Health Dis 1993;6:293-9.
  • Uematsu H, Hoshino E. Predominant obligate anaerobes in human periodontal pockets. J Periodontal Res 1992;27:15-9.
  • Hoshino E, Echigo S, Yamada T, Teshima T. Isolation of Propionibacterium acnes from sclerosing osteomyelitis of mandibles. Jpn J Oral Biol 1984;26:48-51.
  • Edwardsson S. Bacteriological studies on deep areas of carious dentine. Odontol Rev 1974;25:1-143.
  • Wittgow WC, Sabiston CB. Microorganisms from pulpal chambers of intact teeth with necrotic pulps. J Endod 1975;1:168-71.
  • Zavistoski J, Dzink J, Onderdonk A, Bartlett J. Quantitative bacteriology of endodontic infections. Oral Surg Oral Med Oral Pathol 1980;49:171-4.
  • Yoshida M, Fukushima H, Yamada K, Ogawa K, Toda T, Sagawa H. Correlation between clinical symptoms and microorganisms isolated from root canals of teeth with periapical pathosis. J Endod 1987;13:24-8.
  • Windley W, Teixeira F, Levin L, Sigurdsson A, Trope M. Disinfection of immature teeth with a triple antibiotic paste. J Endod 2005;31:439-43.
  • Roche Y, Yoshimori RN. In-vitro activity of spiramycin and metronidazole alone or combination against clinical isolates from odontogenic abscesses. J Antimicrob Chemother 1997;40:353-77.
  • Black A, Redmond AO, Steen HJ, Oborska IT. Tolerance and safety of ciprofloxacin in paediatric patients. J Antimicrob Chemother 1990;26:25-9.
  • Takushige T, Cruz EV, Asgor Moral A, Hoshino E. Endodontic treatment of primary teeth using a combination of antibacterial drugs. Int Endod J 2004;37:132-8.
  • Ayukawa Y. Pulpal response of human teeth to antibacterial biocompatible pulp-capping agent-improvement of mixed drugs. Jpn J Conservative Dent 1994;37:643-51.
  • Sato T, Hoshino E, Uematsu H, Noda T. In vitro antimicrobial susceptibility to combinations of drugs of bacteria from carious and endodontic lesions of human deciduous teeth. Oral Microbiol Immunol 1993;8:172 6.
  • Hoshino E, Kurihara-Ando N, Sato I, Uematsu H, Sato M, Kota K, Iwaku M. In vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. Int Endod J 1996;29:125-30.
  • Sato I, Kurihara-Ando N, Kota K, Iwaku M, Hoshino E. Sterilization of infected root-canal dentine by topical application of a mixture of ciprofloxacin, metronidazole and minocycline in situ. Int Endod J 1996;29:118-24.
  • Er K, Celik D, Taşdemir T, Yildirim T. Treatment of horizontal root fractures using a triple antibiotic paste and mineral trioxide aggregate: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:e63-6.
  • Kusgoz A, Yildirim T, Er K, Arslan I. Retreatment of a resected tooth associated with a large periradicular lesion by using a triple antibiotic paste and mineral trioxide aggregate: a case report with a thirty-month follow-up. J Endod 2009;35:1603-6.
  • Özan Ü, Er K. Endodontic treatment of a large cyst-like periradicular lesion using a combination of antibiotic drugs: a case report. J Endod 2005;31:898-900.
  • Iwaya SI, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with apical periodontitis and sinus tract. Dent Traumatol 2001;17:185-7.
  • Banchs F, Trope M. Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol?. J Endod 2004;30:196-200.
  • Thibodeau B, Teixeira F, Yamauchi M, Caplan DJ, Trope M. Pulp revascularization of immature dog teeth with apical periodontitis. J Endod 2007;33:680-9.
  • Sönmez IS, Akbay Oba A, Erkmen Almaz M. Revascularization/regeneration performed in immature molars: case reports. J Clin Pediatr Dent 2013;37:231-4.
  • Jeeruphan T, Jantarat J, Yanpiset K, Suwannapan L, Khewsawai P, Hargreaves KM. Mahidol Study 1: Comparison of radiographic and survival outcomes of immature teeth treated with either regenerative endodontic or apexification methods: a retrospective study. J Endod 2012;38:1330-6.
  • Martin G, Ricucci D, Gibbs JL, Lin LM. Histological findings of revascularized/revitalized immature permanent molar with apical periodontitis using platelet-rich plasma. J Endod 2013;39:138-44.
  • Becerra P, Ricucci D, Loghin S, Gibbs JL, Lin LM. Histologic study of a human immature permanent premolar with chronic apical abscess after revascularization/revitalization. J Endod 2014;40:133-9.
  • Cehreli ZC, Isbitiren B, Sara S, Erbas G. Regenerative endodontic treatment (revascularization) of immature necrotic molars medicated with calcium hydroxide: a case series. J Endod 2011;37:1327-30.
  • Soares Ade J, Lins FF, Nagata JY, Gomes BP, Zaia AA, Ferraz CC, de Almeida JF, de Souza-Filho FJ. Pulp revascularization after root canal decontamination with calcium hydroxide and 2% chlorhexidine gel. J Endod 2013;39:417-20.
  • Epstein JB, Chong S, Le ND. A survey of antibiotics use in dentistry. J Am Dent Assoc 2000;131:1600-9.
  • Pallasch TJ. Global antibiotics resistance and its impact on the dental community. J Calif Dent Assoc 2000;28:215-33.
  • Kim JH, Kim Y, Shin SJ, Park JW, Jung IY. Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report. J Endod 2010;36:1086-91.
  • Bezgin T, Yilmaz AD, Celik BN, Sönmez H. Concentrated platelet-rich plasma used in root canal revascularization: 2 case reports. Int Endod J 2014;47:41-9. Nagy MM, Tawfik HE, Hashem AA, Abu-Seida AM.
  • Regenerative potential of immature permanent teeth with necrotic pulps after different regenerative protocols. J Endod 2014;40:192-8.
There are 55 citations in total.

Details

Primary Language Turkish
Journal Section Review
Authors

Neslihan Şimşek

Ülkü Özan

Kürşat Er

Publication Date July 9, 2014
Submission Date July 9, 2014
Published in Issue Year 2014Volume: 17 Issue: 4

Cite

EndNote Şimşek N, Özan Ü, Er K (November 1, 2014) Lezyon Sterilizasyonu ve Doku Tamiri. Cumhuriyet Dental Journal 17 4 414–422.

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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