Öz
Discoid lupus erythematosus (DLE) is a chronic, autoimmune and a mucocutaneous disease of unknown etiology. In this case report we presented the intra oral findings and histopathological examination results of a patient who diagnosed and medically treated with DLE. A 59-year-old female patient referred to our clinic with complaint of burning sensation and redness in the gingiva. The patient was previously diagnosed with DLE and had been taken treatment because of the systemic symptoms. Intra oral examination showed gingival inflammation, macule in the palatal mucosa, telangiectatic areas in the buccal mucosa, erythematos and Nicolsky’s sign (+) areas especially in the free and attached gingiva of the vestibule surfaces of maxillary and mandibular teeth. Following the clinical and radiographic examination she was diagnosed with chronic periodontitis. Histopathologic examination was performed on biopsy taken from vestibular surface of mandibular anterior teeth.DLE is a risk factor for squamous cell carcinoma. Further it has been reported that oral mucosal lessions of DLE may occur before the skin lesions. For this reasons, intra oral lessions and systemic findings of DLE patients should be well examined and followed up after diagnosis.
Anahtar Kelimeler
Kaynakça
- Kaynaklar
- Schiödt M, Halberg P, Hentzer B. A clinical study of 32 patients with oral discoid lupus erythematosus. Int J Oral Surg 1978;7:85-94.
- Kranti K, Seshan H, Juliet J. Discoid lupus erythematosus involving gingiva. J Indian Soc Periodontol 2012;16:126-8.
- Yıldız M, Yazıcı B, Gülaydın F, Yalçınkaya U. Gozkapağı Diskoid Lupus Eritematozisi: Olgu Sunumu. T Oft Gaz 2006;36:512-5.
- Panjwani S. Early Diagnosis and Treatment of Discoid Lupus Erythematosus. JABFM 2009;22:2.
- Serpico R, Pannone G, Santoro A, Mezza E, Piccolo S, Esposito V, Busciolano M, Ciavarella D, Lo Muzio L, Bufo P. Report of a case of discoid lupus erythematosus localised to the oral cavity: immunofluorescence findings. Int J Immunopathol Pharmacol 2007;20: 651-3.
- Kramer IR, Lucas RB, Pindborg JJ, Sobin LH. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol 1978;46:518-39.
- Dereli T, Akın Yazkan F, Ceylan C, Ertan İ, Gerzile Y, Akalın T,Alper S. Peeling Sonrası İndüklenen Diskoid Lupus Eritematozus Olgusu. Ege Tıp Dergisi 2006;45:211-3.
- Derviş E, Derviş E. Oral Ülserler. Haseki Eğitim ve Araştırma Hastanesi, Dermatoloji Kliniği, İstanbul, İstanbul Üniversitesi, Diş Hekimliği Fakültesi, İstanbul. Klinik Gelişim: 24-28.
- Gündüz S, Mansur T, Öncel Çelikten Ç. Erçin S. Antifosfolipid Sendromu Olan Bir Hastada Diskoid Lupus Eritematozus Gelişimi. Türkderm 2006;40:69-71.
- Ranginwala AM, Chalishazar MM, Panja P, Buddhdev KP, Kale HM. Oral discoid lupus erythematosus: A study of twenty-one cases. J Oral Maxillofac Pathol 2012;16:368-73.
- Adışen E, Önder M, Öztaş P, Gürer MA. Succesful Treatment of Severe Diccoid Lupus Erythematosus with Azathioprine: A Case Report. Gazi Tıp Dergisi / Gazi Medical Journal 2005;16:150-152.
- Daldon PE, Macedo de Souza E, Cintra ML. Hypertrophic lupus erythematosus: A clinicopathological study of 14 cases. J Cutan Pathol 2003;30:443-8.
- Baz K, Corda Yazıcı A, Köktürk A, Kaya Tİ, Polat A, Demirseren DD, İkizoğlu G. Verrüköz Diskoid Lupus Eritematozus. Turkiye Klinikleri J Med Sci 2004;24:562-564.
- Schiödt M, Andersen L. Ultrastructural features of oral discoid lupus erythematosus. Acta Derm Venereol 1980;60:99–107.
- Varotti C, Patrizi A, Siverio GA, Masina M, Passarini B. The Lupus Band Test and serology of lupus erythematosus. Our experience. G Ital Dermatol Venereol 1990;125:243-6.
- O'Sullivan M, McLean-Tooke A, Loh RK. Antinuclear antibody test. Aust Fam Physician. 2013;42:718-21.
- Prystowsky SD, Gilliam JN. Antinuclear antibody studies in chronic cutaneous discoid lupus erythematosus. Arch Dermatol 1977;113:183-6.
Öz
Diskoid lupus eritamatozus (DLE) etyolojisi bilinmeyen, kronik, otoimmün ve mukokütanöz bir hastalıktır. Bu vaka raporunda DLE teşhisi ile tıbbi tedavi görmüş hastanın ağız içi bulguları ve histopatolojik muayene sonuçları sunulmaktadır. Elli dokuz yaşındaki bayan hasta kliniğimize dişetlerindeki kızarıklık ve yanma hissi şikayeti ile başvurdu. Sistemik belirtileri nedeniyle daha önce DLE tanısı konmuş ve tedavi görmüş hastada ağız içi muayenede dişeti enflamasyonu, palatal mukozada makül, bukkal mukozada telenjiektazik alanlar, özellikle maksiller ve mandibular anterior dişlerin vestibul yüzeylerinde serbest ve yapışık dişetinde eritematöz ve Nikolski belirtisi (+) alanlar izlendi. Klinik ve radyografik muayene sonucu kronik periodontitis teşhisi kondu. Alt çene anterior dişler vestibülunden alınan biyopsi ile histopatolojik inceleme yapıldı. DLE, skuamoz hücreli karsinom için bir risk faktörüdür. Ayrıca ağızdaki mukozal lezyonların vücuttaki lezyonlardan daha önce oluşabileceği bildirilmiştir. Bu nedenle DLE hastalarında ağız içi ve sistemik bulgular iyi değerlendirilmeli ve takip altında tutulmalıdır.
Anahtar Kelimeler
Kaynakça
- Kaynaklar
- Schiödt M, Halberg P, Hentzer B. A clinical study of 32 patients with oral discoid lupus erythematosus. Int J Oral Surg 1978;7:85-94.
- Kranti K, Seshan H, Juliet J. Discoid lupus erythematosus involving gingiva. J Indian Soc Periodontol 2012;16:126-8.
- Yıldız M, Yazıcı B, Gülaydın F, Yalçınkaya U. Gozkapağı Diskoid Lupus Eritematozisi: Olgu Sunumu. T Oft Gaz 2006;36:512-5.
- Panjwani S. Early Diagnosis and Treatment of Discoid Lupus Erythematosus. JABFM 2009;22:2.
- Serpico R, Pannone G, Santoro A, Mezza E, Piccolo S, Esposito V, Busciolano M, Ciavarella D, Lo Muzio L, Bufo P. Report of a case of discoid lupus erythematosus localised to the oral cavity: immunofluorescence findings. Int J Immunopathol Pharmacol 2007;20: 651-3.
- Kramer IR, Lucas RB, Pindborg JJ, Sobin LH. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol 1978;46:518-39.
- Dereli T, Akın Yazkan F, Ceylan C, Ertan İ, Gerzile Y, Akalın T,Alper S. Peeling Sonrası İndüklenen Diskoid Lupus Eritematozus Olgusu. Ege Tıp Dergisi 2006;45:211-3.
- Derviş E, Derviş E. Oral Ülserler. Haseki Eğitim ve Araştırma Hastanesi, Dermatoloji Kliniği, İstanbul, İstanbul Üniversitesi, Diş Hekimliği Fakültesi, İstanbul. Klinik Gelişim: 24-28.
- Gündüz S, Mansur T, Öncel Çelikten Ç. Erçin S. Antifosfolipid Sendromu Olan Bir Hastada Diskoid Lupus Eritematozus Gelişimi. Türkderm 2006;40:69-71.
- Ranginwala AM, Chalishazar MM, Panja P, Buddhdev KP, Kale HM. Oral discoid lupus erythematosus: A study of twenty-one cases. J Oral Maxillofac Pathol 2012;16:368-73.
- Adışen E, Önder M, Öztaş P, Gürer MA. Succesful Treatment of Severe Diccoid Lupus Erythematosus with Azathioprine: A Case Report. Gazi Tıp Dergisi / Gazi Medical Journal 2005;16:150-152.
- Daldon PE, Macedo de Souza E, Cintra ML. Hypertrophic lupus erythematosus: A clinicopathological study of 14 cases. J Cutan Pathol 2003;30:443-8.
- Baz K, Corda Yazıcı A, Köktürk A, Kaya Tİ, Polat A, Demirseren DD, İkizoğlu G. Verrüköz Diskoid Lupus Eritematozus. Turkiye Klinikleri J Med Sci 2004;24:562-564.
- Schiödt M, Andersen L. Ultrastructural features of oral discoid lupus erythematosus. Acta Derm Venereol 1980;60:99–107.
- Varotti C, Patrizi A, Siverio GA, Masina M, Passarini B. The Lupus Band Test and serology of lupus erythematosus. Our experience. G Ital Dermatol Venereol 1990;125:243-6.
- O'Sullivan M, McLean-Tooke A, Loh RK. Antinuclear antibody test. Aust Fam Physician. 2013;42:718-21.
- Prystowsky SD, Gilliam JN. Antinuclear antibody studies in chronic cutaneous discoid lupus erythematosus. Arch Dermatol 1977;113:183-6.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Case Reports |
| Yazarlar | |
| Yayımlanma Tarihi | 5 Kasım 2014 |
| Gönderilme Tarihi | 11 Kasım 2013 |
| Yayımlandığı Sayı | Yıl 2014Cilt: 17 Sayı: 4 |
Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.
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