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Artikain Difüzyon Hacminin Manyetik Rezonans Görüntüleme Yöntemi İle İn Vivo Olarak Değerlendirilmesi

Year 2010, Volume: 13 Issue: 2, 58 - 62, 05.01.2011

İlker Ozeç , Ufuk Tasdemir Cesur Gumus Orhan Solak

Abstract

Amaç: İn vivo olarak artikain solüsyonunun difüzyon hacminin manyetik rezonans görüntüleme yöntemi ile değerlendirilmesi ve adrenalin miktarının ve enjeksiyon bölgesinin artikainin difüzyon hacmi üzerine etkisinin belirlenmesidir.

Gereç ve Yöntem: Otuz gönüllüye birinci premolar (15 gönüllü) veya birinci molar (15 gönüllü) diş bölgesine bilateral olarak maksiller bukkal supraperiostal enjeksiyon 1:100.000 oranında (1.7 ml) ve 1:200.000 oranında (1.7 ml) adrenalin içeren % 4’lük artikain solüsyonu kullanılarak uygulanmıştır. Manyetik rezonans görüntüleri enjeksiyondan önce ve enjeksiyondan 5 dakika sonra elde edilmiştir. Lokal anestezik solüsyonun difüzyon hacmi planimetri metodu ve Cavalieri prensibi kullanılarak hesaplanmıştır. İstatistiksel analiz Student t testi kullanılarak yapılmıştır.

Bulgular: Artikain solüsyonun ortalama difüzyon hacmi 3.23 cm3 olarak hesaplanmıştır. Adrenalin miktarının ve enjeksiyon lokalizasyonunun difüzyon hacmi üzerindeki etkisinin istatistiksel olarak önemli olmadığı görülmüştür (P>0.05).

Sonuç: Artikainin 5 dakikalık bekleme süresi sonunda enjekte edilen solüsyon hacminin yaklaşık iki katı büyüklükteki dokuya difüze olabildiği görülmüştür

Keywords

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References

  • Richardson JC, Bowtell RW, Mäder K, Melia CD. Pharmaceutical applications of magnetic resonance imaging (MRI). Adv Drug Deliv Rev 2005; 57: 1191
  • Rodríguez I, Pérez-Rial S, González-Jimenez J, Pérez-Sánchez J, Herranz F, Beckmann N, Ruiz- Cabello J. Magnetic resonance methods and applications in pharmaceutical research. J Pharm Sci ; 97: 3637-65.
  • Metz H, Mäder K. Benchtop-NMR and MRI--a new analytical tool in drug delivery research. Int J Pharm ; 364: 170-75. Steingftter A, Weishaupt D, Kunz P, Mäder K, Lengsfeld H, Thumshirn M, Boesiger P, Fried M, Schwizer W. Magnetic resonance imaging for the in vivo evaluation of gastric-retentive tablets. Pharm Res ; 20: 2001-7.
  • Barnhart K, Pretorius ES, Stolpen A, Malamud D. Distribution of topical medication in the human vagina as imaged by magnetic resonance imaging. Fertil Steril ; 76: 189-195. Madhu B, Elmroth I, Lundgren A, Abrahamsson B, Soussi B. A novel evaluation of subcutaneous formulations by in vivo magnetic resonance imaging (MRI). Pharmacol Res 2002; 45: 207-12.
  • Li SK, Lizak MJ, Jeong EK. MRI in ocular drug delivery. NMR Biomed 2008; 21: 941-56.
  • Malamed SF, Gagnon S, Leblanc D. Efficacy of articaine: a new amide local anesthetic. J Am Dent Assoc 2000; 131: 635-42.
  • Malamed SF. Handbook of local anesthesia. 4 th ed. St. Louis: Mosby; 2004, p. 161-164.
  • Mazonakis M, Damilakis J, Maris T, Prassopoulos P, Gourtsoyiannis N. Comparison of two volumetric techniques for estimating liver volume sing magnetic resonance imaging. J Magn Reson Imaging 2002; 15: 63.
  • Howard JR, Hadgraft J. The clearance of oily vehicles following intramuscular and subcutaneous injections in rabbits. Int J Pharm 1983; 16: 31–9.
  • Davis SS, Illum L, Walker IM. The in vivo evaluation of emulsion formulations administered intramuscularly. Int J Pharm 1987; 38: 133–37.
  • Kremser C, Albrecht K, Greindl M, Wolf C, Debbage determination of the time and location of mucoadhesive drug delivery systems disintegration in the gastrointestinal tract. Magn Reson Imaging 2008; 26: 43.
  • Viglianti BL, Abraham SA, Michelich CR, Yarmolenko PS, MacFall JR, Bally MB, Dewhirst MW. In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: illustration of targeted delivery. Magn Reson Med 2004; 51: 1153-62.
  • Pretorius ES, Timbers K, Malamud D, Barnhart K. Magnetic resonance imaging to determine the distribution of a vaginal gel: before, during, and after both simulated and real intercourse. Contraception ; 66: 443-51. Uckan S, Dayangac E, Araz K. Is permanent maxillary tooth removal without palatal injection possible? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 102: 733-35.
  • Badcock ME, Gordon I, McCullough MJ. A blinded randomized controlled trial comparing lignocaine and placebo administration to the palate for removal of maxillary third molars. Int J Oral Maxillofac Surg 2007; 36: 1177-82.
  • Fan S, Chen WL, Yang ZH, Huang ZQ. Comparison of the efficiencies of permanent maxillary tooth removal performed with single buccal infiltration versus routine buccal and palatal injection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107: 63.
  • Robertson D, Nusstein J, Reader A, Beck M, McCartney M. The anesthetic efficacy of articaine in buccal infiltration of mandibular posterior teeth. J Am Dent Assoc 2007; 138: 1104-12.
  • Kanaa MD, Whitworth JM, Corbett IP, Meechan JG. Articaine buccal infiltration enhances the effectiveness of lidocaine inferior alveolar nerve block. Int Endod J 2009; 42: 238-46.
  • Moore PA, Doll B, Delie RA, Hersh EV, Korostoff J, Johnson S, Goodson JM, Halem S, Palys M, Leonel JS, Kozlowski VA, Peterson C, Hutcheson M. Hemostatic and anesthetic efficacy of 4% articaine HCl with 1:200,000 epinephrine and 4% articaine HCl with :100,000 epinephrine when administered intraorally for periodontal surgery. J Periodontol 2007; 78: 247
  • Hersh EV, Giannakopoulos H, Levin LM, Secreto S, Moore PA, Peterson C, Hutcheson M, Bouhajib M, Mosenkis A, Townsend RR. The pharmacokinetics and cardiovascular effects of high-dose articaine with :100,000 and 1:200,000 epinephrine. J Am Dent Assoc 2006; 137: 1562-71.
  • Tateno K, Inoue K, Sato T, Fukayama H. Differences in the degree of infiltration of local anesthesia according to the site of injection in rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; : 6-10.
  • Roberts N, Cruz-Orive LM, Reid NM, Brodie DA, Bourne M, Edwards RH. Unbiased estimation of human body composition by the Cavalieri method using magnetic resonance imaging. J Microsc 1992; : 239-53.
  • Sahin B, Ergur H. Assessment of the optimum section thickness for the estimation of liver volume using magnetic resonance images: a stereological gold standard study. Eur J Radiol 2006; 57: 96-101.

Artikain Difüzyon Hacminin Manyetik Rezonans Görüntüleme Yöntemi İle İn Vivo Olarak Değerlendirilmesi

Year 2010, Volume: 13 Issue: 2, 58 - 62, 05.01.2011

İlker Ozeç , Ufuk Tasdemir Cesur Gumus Orhan Solak

Abstract

Amaç: İn vivo olarak artikain solüsyonunun difüzyon hacminin manyetik rezonans görüntüleme yöntemi ile değerlendirilmesi ve adrenalin miktarının ve enjeksiyon bölgesinin artikainin difüzyon hacmiüzerine etkisinin belirlenmesidir. Gereç ve Yöntem: Otuz gönüllüye birinci premolar (15 gönüllü) veya birinci molar (15 gönüllü) diş bölgesine bilateral olarak maksiller bukkal supraperiostal enjeksiyon 1:100.000 oranında (1.7 ml) ve 1:200.000 oranında (1.7 ml) adrenalin içeren % 4’lük artikain solüsyonu kullanılarakuygulanmıştır. enjeksiyondan önce ve enjeksiyondan 5 dakika sonra elde edilmiştir. Lokal anestezik solüsyonun difüzyon hacmi planimetri metodu ve Cavalieri prensibi kullanılarak hesaplanmıştır. İstatistiksel analiz Student t testi kullanılarak yapılmıştır. Bulgular: Artikain solüsyonun ortalama difüzyon hacmi 3.23 cm3 olarak hesaplanmıştır. Adrenalin miktarının ve enjeksiyon lokalizasyonunun difüzyon hacmi üzerindeki etkisinin istatistiksel olarak önemli olmadığı görülmüştür (P0.05). Sonuç: Artikainin 5 dakikalık bekleme süresi sonunda enjekte edilen solüsyon hacminin yaklaşık iki katı büyüklükteki dokuya difüze olabildiği görülmüştür

Keywords

Artikain difüzyon manyetik rezonans görüntüleme

References

  • Richardson JC, Bowtell RW, Mäder K, Melia CD. Pharmaceutical applications of magnetic resonance imaging (MRI). Adv Drug Deliv Rev 2005; 57: 1191
  • Rodríguez I, Pérez-Rial S, González-Jimenez J, Pérez-Sánchez J, Herranz F, Beckmann N, Ruiz- Cabello J. Magnetic resonance methods and applications in pharmaceutical research. J Pharm Sci ; 97: 3637-65.
  • Metz H, Mäder K. Benchtop-NMR and MRI--a new analytical tool in drug delivery research. Int J Pharm ; 364: 170-75. Steingftter A, Weishaupt D, Kunz P, Mäder K, Lengsfeld H, Thumshirn M, Boesiger P, Fried M, Schwizer W. Magnetic resonance imaging for the in vivo evaluation of gastric-retentive tablets. Pharm Res ; 20: 2001-7.
  • Barnhart K, Pretorius ES, Stolpen A, Malamud D. Distribution of topical medication in the human vagina as imaged by magnetic resonance imaging. Fertil Steril ; 76: 189-195. Madhu B, Elmroth I, Lundgren A, Abrahamsson B, Soussi B. A novel evaluation of subcutaneous formulations by in vivo magnetic resonance imaging (MRI). Pharmacol Res 2002; 45: 207-12.
  • Li SK, Lizak MJ, Jeong EK. MRI in ocular drug delivery. NMR Biomed 2008; 21: 941-56.
  • Malamed SF, Gagnon S, Leblanc D. Efficacy of articaine: a new amide local anesthetic. J Am Dent Assoc 2000; 131: 635-42.
  • Malamed SF. Handbook of local anesthesia. 4 th ed. St. Louis: Mosby; 2004, p. 161-164.
  • Mazonakis M, Damilakis J, Maris T, Prassopoulos P, Gourtsoyiannis N. Comparison of two volumetric techniques for estimating liver volume sing magnetic resonance imaging. J Magn Reson Imaging 2002; 15: 63.
  • Howard JR, Hadgraft J. The clearance of oily vehicles following intramuscular and subcutaneous injections in rabbits. Int J Pharm 1983; 16: 31–9.
  • Davis SS, Illum L, Walker IM. The in vivo evaluation of emulsion formulations administered intramuscularly. Int J Pharm 1987; 38: 133–37.
  • Kremser C, Albrecht K, Greindl M, Wolf C, Debbage determination of the time and location of mucoadhesive drug delivery systems disintegration in the gastrointestinal tract. Magn Reson Imaging 2008; 26: 43.
  • Viglianti BL, Abraham SA, Michelich CR, Yarmolenko PS, MacFall JR, Bally MB, Dewhirst MW. In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: illustration of targeted delivery. Magn Reson Med 2004; 51: 1153-62.
  • Pretorius ES, Timbers K, Malamud D, Barnhart K. Magnetic resonance imaging to determine the distribution of a vaginal gel: before, during, and after both simulated and real intercourse. Contraception ; 66: 443-51. Uckan S, Dayangac E, Araz K. Is permanent maxillary tooth removal without palatal injection possible? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 102: 733-35.
  • Badcock ME, Gordon I, McCullough MJ. A blinded randomized controlled trial comparing lignocaine and placebo administration to the palate for removal of maxillary third molars. Int J Oral Maxillofac Surg 2007; 36: 1177-82.
  • Fan S, Chen WL, Yang ZH, Huang ZQ. Comparison of the efficiencies of permanent maxillary tooth removal performed with single buccal infiltration versus routine buccal and palatal injection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107: 63.
  • Robertson D, Nusstein J, Reader A, Beck M, McCartney M. The anesthetic efficacy of articaine in buccal infiltration of mandibular posterior teeth. J Am Dent Assoc 2007; 138: 1104-12.
  • Kanaa MD, Whitworth JM, Corbett IP, Meechan JG. Articaine buccal infiltration enhances the effectiveness of lidocaine inferior alveolar nerve block. Int Endod J 2009; 42: 238-46.
  • Moore PA, Doll B, Delie RA, Hersh EV, Korostoff J, Johnson S, Goodson JM, Halem S, Palys M, Leonel JS, Kozlowski VA, Peterson C, Hutcheson M. Hemostatic and anesthetic efficacy of 4% articaine HCl with 1:200,000 epinephrine and 4% articaine HCl with :100,000 epinephrine when administered intraorally for periodontal surgery. J Periodontol 2007; 78: 247
  • Hersh EV, Giannakopoulos H, Levin LM, Secreto S, Moore PA, Peterson C, Hutcheson M, Bouhajib M, Mosenkis A, Townsend RR. The pharmacokinetics and cardiovascular effects of high-dose articaine with :100,000 and 1:200,000 epinephrine. J Am Dent Assoc 2006; 137: 1562-71.
  • Tateno K, Inoue K, Sato T, Fukayama H. Differences in the degree of infiltration of local anesthesia according to the site of injection in rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; : 6-10.
  • Roberts N, Cruz-Orive LM, Reid NM, Brodie DA, Bourne M, Edwards RH. Unbiased estimation of human body composition by the Cavalieri method using magnetic resonance imaging. J Microsc 1992; : 239-53.
  • Sahin B, Ergur H. Assessment of the optimum section thickness for the estimation of liver volume using magnetic resonance images: a stereological gold standard study. Eur J Radiol 2006; 57: 96-101.
There are 22 citations in total.

Details

Primary Language English
Journal Section Original Research Articles
Authors

İlker Ozeç

Ufuk Tasdemir

Cesur Gumus

Orhan Solak

Publication Date January 5, 2011
Submission Date January 5, 2011
Published in Issue Year 2010Volume: 13 Issue: 2

Cite

EndNote Ozeç İ, Tasdemir U, Gumus C, Solak O (January 1, 2011) Artikain Difüzyon Hacminin Manyetik Rezonans Görüntüleme Yöntemi İle İn Vivo Olarak Değerlendirilmesi. Cumhuriyet Dental Journal 13 2 58–62.

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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