Öz
Amaç: Bifosfonatlar, metastatik kemik kanserlerin önlenmesinde ve osteopörözün tedavisinde kullanılmaktadır. İntravenöz (i.v) bifosfonat (pamidronat, zoledronat) tedavisine bağlı olarak çene kemiklerinde osteonekroz gelişmektedir. Bu vaka raporu ile kliniğimize başvuran hastanın tedavisi sunulmuştur.
Vaka Raporu: Kliniğimize başvuran 51 yaşındaki kadın hastada, uzun süreli intravenöz bifosfonat kullanımına bağlı sol maksilla molar bölgesinde asemptomatik osteonekroz görülmüştür. Hastaya gerekli debridman, sekestrasyon ve hiperbarik oksijen tedavisi uygulanmıştır. Hasta belirli aralıklarla takip edilmektedir.
Sonuç: Bifosfonat kullanımına bağlı oluşan osteonekroz, i.v. bifosfonat kullanımının artmasına bağlı olarak daha sık görülmektedir. Bu nedenle bifosfonat tedavisi görecek olan hastaların oluşabilecek komplikasyonların engellenmesi amacıyla, tedavi öncesinde diş hekimine yönlendirilip, tüm dental tedavilerinin yapılması önerilmektedir.
Anahtar Kelimeler
Kaynakça
- Hortobayi GN, Theriualt RL, Lipton A; et al: Long-term prevention of skeletal complications of metastatic breast cancer with pamidronate. J Clin Oncol ;16:2038.
- Wutzl A, Seeman R, Waltzinger F, Millesi G. Treatment Results of Bisphosphonate- Osteonecrosis of The Jaws. Head&Neck- DOI 2008; :1002. Related
- Junquera L, Gallego L. Related Osteonecrosis of the Jaws. Another Clinical Variant? J Oral Maxillofac Surg 2008;66:1516-1517.
- Woo SB, Hellstein JW, Kamlar JR. Narrative corrective] review: bisphosphonates and osteonecrosis of the jaws. Ann Intern Med 2006; 144:753-761.
- Khan A. Bisphosphonate-associated osteonecrosis of the jaw. Canadian Family Physician 2008;54:1019
- Migliorati C.A, Schubert MM, Peterson DE, Seneda LM. Bisphosphonate- Associated Osteonecrosis of Mandibular and Maxillary Bone: An emerging oral complication of supportive cancer therapy. Cancer ;104:83. Fleisch H, Reszka A, Rodan G, et al. Bisphoshonates:mechanism of action. In:Bilezikian JP, Raisz LG, Rodan GA. editors. Principles of bone biology. San Diego, California: Academic Pres ;1361-1385.
- Santini D, Vespasiani Gentilucci U, Vincenzi B, et al. The antineoplastic role of bisphosphonates: from basic research to clinical evidence. Ann Oncol 2003; :1468-1476.
- Gevorgyan A, Enepekides DJ. Bisphosphonate- induced necrosis of the jaws: a reconstructive nightmare. Current Opinion in Otolaryngolojy & Head and Neck Surgery 2008;16:325-330. Marx
- Bisphosphonate-Induced (Osteonecrosis/Osteopetrosis) of the Jaws: Risk Factors, Recognition, Prevention, and Treatment. J Oral Maxillofac Surg 2005;63:1567-1575.
- Marx RE, Uncovering the Cause of ‘ Phossy Jaw’ Circa 1858 to 1906: Oral and Maxillofasial Surgery
- Closed Case Files- Case Closed. J Oral Maxillofac Surg 2008;66:2356-2363.
- Marx RE, Pamidronate (Aredia) and Zoledronate (Zometa) Induced Avascular Necrosis of The Jaws: A Growing Epidemic. J Oral Maxillofac Surg 2003;61: 1118.
- Ruggerio SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the Jaws Associated With the Use of Bisphosphonates: A Review of 63 Cases. J Oral Maxillofac Surg 2004;62:527–534.
- Migliorati CA, Casiglia J, Epstein J, Jacobsen PL, Siegel MA, Woo S. Managing the care of patients with bisphosphonate- associated osteonecrosis. J Am Dent Assoc 2005;136;1658–1668.
- Silverman SL, Landesberg R. Osteonecrosis of the jaw and the role of bisphosphonates: a critical review. Am J Med. 2009 ;122(2 Suppl):S33-45.
Öz
Amaç: Bifosfonatlar, metastatik kemik kanserlerin
önlenmesinde ve osteopörözün tedavisinde kullanılmaktadır.
İntravenöz (i.v) bifosfonat (pamidronat, zoledronat)
tedavisine bağlı olarak çene kemiklerinde osteonekroz
gelişmektedir. Bu vaka raporu ile kliniğimize başvuran
hastanın tedavisi sunulmuştur.
Vaka Raporu: Kliniğimize başvuran 51 yaşındaki
kadın hastada, uzun süreli intravenöz bifosfonat
kullanımına bağlı sol maksilla molar bölgesinde
asemptomatik osteonekroz görülmüştür. Hastaya
gerekli debridman, sekestrasyon ve hiperbarik oksijen
tedavisi uygulanmıştır. Hasta belirli aralıklarla takip
edilmektedir.
Sonuç: Bifosfonat kullanımına bağlı oluşan
osteonekroz, i.v. bifosfonat kullanımının artmasına bağlı
olarak daha sık görülmektedir. Bu nedenle bifosfonat
tedavisi görecek olan hastaların oluşabilecek
komplikasyonların engellenmesi amacıyla, tedavi
öncesinde diş hekimine yönlendirilip, tüm dental
tedavilerinin yapılması önerilmektedir.
Anahtar Kelimeler
Kaynakça
- Hortobayi GN, Theriualt RL, Lipton A; et al: Long-term prevention of skeletal complications of metastatic breast cancer with pamidronate. J Clin Oncol ;16:2038.
- Wutzl A, Seeman R, Waltzinger F, Millesi G. Treatment Results of Bisphosphonate- Osteonecrosis of The Jaws. Head&Neck- DOI 2008; :1002. Related
- Junquera L, Gallego L. Related Osteonecrosis of the Jaws. Another Clinical Variant? J Oral Maxillofac Surg 2008;66:1516-1517.
- Woo SB, Hellstein JW, Kamlar JR. Narrative corrective] review: bisphosphonates and osteonecrosis of the jaws. Ann Intern Med 2006; 144:753-761.
- Khan A. Bisphosphonate-associated osteonecrosis of the jaw. Canadian Family Physician 2008;54:1019
- Migliorati C.A, Schubert MM, Peterson DE, Seneda LM. Bisphosphonate- Associated Osteonecrosis of Mandibular and Maxillary Bone: An emerging oral complication of supportive cancer therapy. Cancer ;104:83. Fleisch H, Reszka A, Rodan G, et al. Bisphoshonates:mechanism of action. In:Bilezikian JP, Raisz LG, Rodan GA. editors. Principles of bone biology. San Diego, California: Academic Pres ;1361-1385.
- Santini D, Vespasiani Gentilucci U, Vincenzi B, et al. The antineoplastic role of bisphosphonates: from basic research to clinical evidence. Ann Oncol 2003; :1468-1476.
- Gevorgyan A, Enepekides DJ. Bisphosphonate- induced necrosis of the jaws: a reconstructive nightmare. Current Opinion in Otolaryngolojy & Head and Neck Surgery 2008;16:325-330. Marx
- Bisphosphonate-Induced (Osteonecrosis/Osteopetrosis) of the Jaws: Risk Factors, Recognition, Prevention, and Treatment. J Oral Maxillofac Surg 2005;63:1567-1575.
- Marx RE, Uncovering the Cause of ‘ Phossy Jaw’ Circa 1858 to 1906: Oral and Maxillofasial Surgery
- Closed Case Files- Case Closed. J Oral Maxillofac Surg 2008;66:2356-2363.
- Marx RE, Pamidronate (Aredia) and Zoledronate (Zometa) Induced Avascular Necrosis of The Jaws: A Growing Epidemic. J Oral Maxillofac Surg 2003;61: 1118.
- Ruggerio SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the Jaws Associated With the Use of Bisphosphonates: A Review of 63 Cases. J Oral Maxillofac Surg 2004;62:527–534.
- Migliorati CA, Casiglia J, Epstein J, Jacobsen PL, Siegel MA, Woo S. Managing the care of patients with bisphosphonate- associated osteonecrosis. J Am Dent Assoc 2005;136;1658–1668.
- Silverman SL, Landesberg R. Osteonecrosis of the jaw and the role of bisphosphonates: a critical review. Am J Med. 2009 ;122(2 Suppl):S33-45.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Original Research Articles |
| Yazarlar | |
| Yayımlanma Tarihi | 5 Ocak 2011 |
| Gönderilme Tarihi | 5 Ocak 2011 |
| Yayımlandığı Sayı | Yıl 2010Cilt: 13 Sayı: 1 |
Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.
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