Objective: Ozone accelerates wound healing and increases oxygen supply. The
purpose of this study was to investigate the effect of ozone therapy combined
with bone allograft on bone regeneration in rats with calvarial defects, histomorphometrically
and histopathologically.
Material-Method: Twenty four male Wistar rats were used in
this study. A 5 mm diameter critical-size defects were created in all rats
using a trephine bur. The rats were divided into 4 groups; empty defect
(control) (n=6), ozone application into the control defect (control+ ozone)
group (n=6), defect filled with allograft (Allograft) group (n=6), ozone
combined with allograft application (allograft + ozone) group (n=6). Gaseous
ozone administered at 80% density for 14 days. The animals were euthanized at
8-week.
Total bone area was measured
histomorphometrically and osteoclast and osteoblast number were analyzed
histopathologically.
Results: The
osteoblast numbers increased in allograft + ozone group compared to the
allograft group (p<0.05). The control defects showed significantly less new
bone formation than those of the allograft groups at 8 weeks (p<0.05). Total
bone area was significantly higher in allograft+ozone group than those of the
allograft group (p<0.05).
Conclusions: Within
the limitations of this study, we suggested that allograft+ozone combination
increased osteoblast number and new bone area. However, further studies are
needed to investigate the mechanisms of action of ozone on bone regeneration.
Konular | Sağlık Kurumları Yönetimi |
---|---|
Bölüm | Original Research Articles |
Yazarlar | |
Yayımlanma Tarihi | 24 Mart 2017 |
Gönderilme Tarihi | 15 Ocak 2015 |
Yayımlandığı Sayı | Yıl 2016Cilt: 19 Sayı: 3 |
Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.
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