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Evaluation of serum adipocytokine and interleukin-18 levels in patients with epilepsy

Yıl 2023, Cilt: 14 Sayı: 48, 18 - 24, 30.04.2023

Ahmet Dündar Derya Kılınç Ahmet Yılmaz Vugar Jafar Orhan Ayan Mehmet Uğur Çevik Hamza Aslanhan

https://doi.org/10.17944/interdiscip.1285784

Öz

Objective: Epilepsy is a neurological disease characterized by recurrent seizures. The underlying pathophysiological mechanisms in epilepsy are not fully known. Our aim is to investigate the relationship between serum adipocytokine and interleukin (IL)-18 levels in epilepsy patients receiving and not receiving antiepileptic therapy.

Method: Our study was established as three groups. I: Epilepsy patients receiving antiepileptic therapy (n=30), II: Newly diagnosed epilepsy patients (n=30) and III: Control group (n=30). Serum adipocytokine and IL-18 levels were measured by enzyme-linked immunoassorbent assay method.

Results: It was determined that serum adipocytokine and IL-18 levels were increased in epilepsy patients who received topiramate treatment and did not receive antiepileptic therapy compared to the control group. Serum glucose, total protein, cholesterol and albumin concentrations of patients who received antiepileptic treatment were decreased compared to the control group (p<0.001). It was found that serum adipocytokine and IL-18 concentration in epilepsy patients who received topiramate treatment decreased compared to patients who did not receive treatment, but it was not significant (p>0.05). It was found that the body mass index (BMI) ratio of epilepsy patients who received antiepileptic treatment decreased and was significant compared to the control group and the group that did not receive treatment (p<0.01).

Conclusion: In our study, it was shown that serum adipocytokine and IL-18 levels were increased in epilepsy patients who received and did not receive antiepileptic therapy. Findings from this study suggest that adipocytokine and IL-18 may be useful markers for the inflammatory process of epileptogenesis.

Anahtar Kelimeler

Topiramate Interleukin-18 Adipocytokine Epilepsy

Kaynakça

  • Hamed SA. The vascular risk associations with migraine: relation to migraine susceptibility and progression. Atherosclerosis 2009;205(1):15-22. https://doi.org/10.1016/j.atherosclerosis.2008.10.016
  • Sachdev A, Marmura MJ. Metabolic syndrome and migraine. Front Neurol 2012 19;3:161. https://doi.org/10.3389/fneur.2012.00161
  • Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, et al. Commonalities in epileptogenic processes from different acute brain insults: Do they translate?Epilepsia 2018;59(1):37-66. https://doi.org/10.1111/epi.13965
  • Liebner S, Dijkhuizen RM, Reiss Y, Plate KH, Agalliu D, Constantin G. Functional morphology of the blood-brain barrier in health and disease. Acta Neuropathol 2018;135(3):311-336. https://doi.org/10.1007/s00401-018-1815-1
  • Maroso M, Balosso S, Ravizza T, Liu J, Aronica E, Iyer AM, et al. Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med 2010;16(4):413-9. https://doi.org/10.1038/nm.2127
  • Klöting N, Berndt J, Kralisch S, Kovacs P, Fasshauer M, Schön MR, et al. Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes. Biochem Biophys Res Commun 2006;339(1):430-6. https://doi.org/10.1016/j.bbrc.2005.11.039
  • Wada J Vaspin. A novel serpin with insulin-sensitizing effects.Expert Opin Investig Drugs 2008;17(3):327-33. https://doi.org/10.1517/13543784.17.3.327
  • Luk T, Malam Z, Marshall JC.Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity.J Leukoc Biol 2008;83(4):804-16. https://doi.org/10.1189/jlb.0807581
  • Moschen AR, Kaser A, Enrich B, Mosheimer B, Theurl M, Niederegger H, et al. H.Visfatin, an adipocytokine with proinflammatory and immunomodulating properties.J Immunol 2007;178(3):1748-58. https://doi.org/10.4049/jimmunol.178.3.1748
  • Zabel BA, Allen SJ, Kulig P, Allen JA, Cichy J, Handel TM, et al. EC.Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. J Biol Chem 2005;280(41):34661-6. https://doi.org/10.1074/jbc.M504868200
  • Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R,et al. Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Lett 2008;582(5):573-8. https://doi.org/10.1016/j.febslet.2008.01.023
  • Leslie JA, Meldrum KK. The role of interleukin-18 in renal injury. J Surg Res 2008;145(1):170-5. https://doi.org/10.1016/j.jss.2007.03.037
  • Meral C, Cekmez F, Vurucu S, Tascılar E, Pirgon O, Canpolat FE, et al. New adipocytokines (vaspin, apelin, visfatin, adiponectin) levels in children treated with valproic acid. Eur Cytokine Netw 2011;22(2):118-22.: https://doi.org/10.1684/ecn.2011.0284
  • Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology.Epilepsia 2017;58(4):522-530. https://doi.org/10.1111/epi.13670
  • Si J, Wang S, Liu N, Yang X, Wang Y, Li L, et al. Anticonvulsant effect of exogenous β-hydroxybutyrate on kainic acid-induced epilepsy. Exp Ther Med. 2017 Jul;14(1):765-770. https://doi.org/10.3892/etm.2017.4552
  • Scorza CA, Marques MJG, Gomes da Silva S, Naffah-Mazzacoratti MDG, Scorza FA, Cavalheiro EA. Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis..Neurosci Lett. 2018 Mar 6;668:169-173. doi: 10.1016/j.neulet.2017.02.049. Epub 2017 Feb 22. https://doi.org/10.1016/j.neulet.2017.02.049
  • Alboni S, Cervia D, Sugama S, Conti B. Interleukin 18 in the CNS. JNeuroinflammation 2010;7:9. https://doi.org/10.1186/1742-2094-7-9
  • Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, et al. Cloningof a new cytokine that induces IFN-gamma production by T cells. Nature1995;378:88–91. https://doi.org/10.1038/378088a0
  • Dinarello CA. IL-18: a TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol 1999;103:11–24.). https://doi.org/10.1016/S0091-6749(99)70518-X
  • Liu R, Wu S, Guo C, Hu Z, Peng J, Guo K, et al. Li Ibuprofen Exerts Antiepileptic and Neuroprotective Effects in the Rat Model of Pentylenetetrazol-Induced Epilepsy via the COX-2/NLRP3/IL-18 Pathway.
  • J.Neurochem Res. 2020 Oct;45(10):2516-2526. doi: 10.1007/s11064-020-03109-9. Epub 2020 Aug 13. https://doi.org/10.1007/s11064-020-03109-9
  • Mochol M, Taubøll E, Sveberg L, Tennøe B, Berg Olsen K, Heuser K, et al. Seizure control after late introduction of anakinra in a patient with adult onset Rasmussen’s encephalitis.Epilepsy Behav Rep 2021;16:100462. https://doi.org/10.1016/j.ebr.2021.100462 Hung J, McQuillan BM, Chapman CM, Thompson PL, Beilby JP. Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesityand insulin resistance. Arterioscler Thromb Vasc Biol 2005;25:1268–73. https://doi.org/10.1161/01.ATV.0000163843.70369.12
  • Weigert J, Neumeier M, Wanninger J, Filarsky M, Bauer S, Wiest R, et al. Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes.Clin Endocrinol (Oxf) 2010;72(3):342-8. https://doi.org/10.1111/j.1365-2265.2009.03664.x
  • Rourke JL, Dranse HJ, Sinal CJ. Towards an integrative approach to understanding the role of chemerin in human health and disease.Obes Rev 2013;14(3):245-62. https://doi.org/10.1111/obr.12009
  • Elhady M, Youness ER, Gafar HS, Abdel Aziz A, Mostafa RSI. Circulating irisin and chemerin levels as predictors of seizure control in children with idiopathic epilepsy.Neurol Sci. 2018;39(8):1453-1458. https://doi.org/10.1007/s10072-018-3448-5
  • Adya R, Tan BK, Chen J, Randeva HS.Nuclear factor-kappaB induction by visfatin in human vascular endothelial cells: its role in MMP-2/9 production and activation.Diabetes Care 2008;31(4):758-60. https://doi.org/10.2337/dc07-1544
  • Lee WJ, Wu CS, Lin H, Lee IT, Wu CM, Tseng JJ, et al. Visfatin-induced expression of inflammatory mediators in human endothelial cells through the NF-kappaB pathway. I nt J Obes (Lond) 2009;33(4):465-72. https://doi.org/10.1038/ijo.2009.24
  • Meral C, Cekmez F, Vurucu S, Tascılar E, Pirgon O, Canpolat FE, et al. New adipocytokines (vaspin, apelin, visfatin, adiponectin) levels in children treated with valproic acid.Eur Cytokine Netw 2011;22(2):118-22. https://doi.org/10.1684/ecn.2011.0284
  • Sonmez FM, Zaman D, Aksoy A, Deger O, Aliyazicioglu R, Karaguzel G, et al. The effects of topiramate and valproate therapy on insulin, c-peptide, leptin, neuropeptide Y, adiponectin, visfatin, and resistin levels in children with epilepsy. Seizure 2013;22(10):856-61. https://doi.org/10.1016/j.seizure.2013.07.007
  • Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, et al. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci U S A 2005;102(30):10610-5. https://doi.org/10.1073/pnas.0504703102
  • Richard D, Ferland J, Lalonde J, Samson P, Deshaies Y. Influence of topiramate in the regulation of energy balance. Nutrition 2000;16(10):961-6. https://doi.org/10.1016/S0899-9007(00)00452-4
  • Li HF, Zou Y, Xia ZZ, Gao F, Feng JH, Yang CW. Effects of topiramate on weight and metabolism in children with epilepsy.Acta Paediatr 2009;98:1521-5.). https://doi.org/10.1111/j.1651-2227.2009.01349.x
  • Uludağ Fİ, Şener U, Zorlu Y, Köseoğlu MH, Kantaroğlu Aydın T. Serum Leptin Levels in Epileptic Patients Treated with Topiramate and Valproic Acid. Turk J Neurol. 2011; 17(1): 17-3.
  • Lalonde J, Samson P, Poulin S, Deshaies Y, Richard D Additive effects of leptin and topiramate in reducing fat deposition in lean and obese ob/ob mice. Physiol Behav 2004;80(4):415-20. https://doi.org/10.1016/j.physbeh.2003.08.013
  • Picard F, Deshaies Y, Lalonde J, Samson P, Richard D. Topiramate reduces energy and fat gains in lean (Fa/?) and obese (fa/fa) Zucker rats. Obes Res 2000;8:656-63. https://doi.org/10.1038/oby.2000.84
  • Ben-Menachem E, Axelsen M, Johanson EH, Stagge A, Smith U. Predictors of weight loss in adults with topiramate-treated epilepsy. Obes Res 2003;11(4):556-62. https://doi.org/10.1038/oby.2003.78

Yıl 2023, Cilt: 14 Sayı: 48, 18 - 24, 30.04.2023

Ahmet Dündar Derya Kılınç Ahmet Yılmaz Vugar Jafar Orhan Ayan Mehmet Uğur Çevik Hamza Aslanhan

https://doi.org/10.17944/interdiscip.1285784

Öz

Kaynakça

  • Hamed SA. The vascular risk associations with migraine: relation to migraine susceptibility and progression. Atherosclerosis 2009;205(1):15-22. https://doi.org/10.1016/j.atherosclerosis.2008.10.016
  • Sachdev A, Marmura MJ. Metabolic syndrome and migraine. Front Neurol 2012 19;3:161. https://doi.org/10.3389/fneur.2012.00161
  • Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, et al. Commonalities in epileptogenic processes from different acute brain insults: Do they translate?Epilepsia 2018;59(1):37-66. https://doi.org/10.1111/epi.13965
  • Liebner S, Dijkhuizen RM, Reiss Y, Plate KH, Agalliu D, Constantin G. Functional morphology of the blood-brain barrier in health and disease. Acta Neuropathol 2018;135(3):311-336. https://doi.org/10.1007/s00401-018-1815-1
  • Maroso M, Balosso S, Ravizza T, Liu J, Aronica E, Iyer AM, et al. Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med 2010;16(4):413-9. https://doi.org/10.1038/nm.2127
  • Klöting N, Berndt J, Kralisch S, Kovacs P, Fasshauer M, Schön MR, et al. Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes. Biochem Biophys Res Commun 2006;339(1):430-6. https://doi.org/10.1016/j.bbrc.2005.11.039
  • Wada J Vaspin. A novel serpin with insulin-sensitizing effects.Expert Opin Investig Drugs 2008;17(3):327-33. https://doi.org/10.1517/13543784.17.3.327
  • Luk T, Malam Z, Marshall JC.Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity.J Leukoc Biol 2008;83(4):804-16. https://doi.org/10.1189/jlb.0807581
  • Moschen AR, Kaser A, Enrich B, Mosheimer B, Theurl M, Niederegger H, et al. H.Visfatin, an adipocytokine with proinflammatory and immunomodulating properties.J Immunol 2007;178(3):1748-58. https://doi.org/10.4049/jimmunol.178.3.1748
  • Zabel BA, Allen SJ, Kulig P, Allen JA, Cichy J, Handel TM, et al. EC.Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. J Biol Chem 2005;280(41):34661-6. https://doi.org/10.1074/jbc.M504868200
  • Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R,et al. Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Lett 2008;582(5):573-8. https://doi.org/10.1016/j.febslet.2008.01.023
  • Leslie JA, Meldrum KK. The role of interleukin-18 in renal injury. J Surg Res 2008;145(1):170-5. https://doi.org/10.1016/j.jss.2007.03.037
  • Meral C, Cekmez F, Vurucu S, Tascılar E, Pirgon O, Canpolat FE, et al. New adipocytokines (vaspin, apelin, visfatin, adiponectin) levels in children treated with valproic acid. Eur Cytokine Netw 2011;22(2):118-22.: https://doi.org/10.1684/ecn.2011.0284
  • Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology.Epilepsia 2017;58(4):522-530. https://doi.org/10.1111/epi.13670
  • Si J, Wang S, Liu N, Yang X, Wang Y, Li L, et al. Anticonvulsant effect of exogenous β-hydroxybutyrate on kainic acid-induced epilepsy. Exp Ther Med. 2017 Jul;14(1):765-770. https://doi.org/10.3892/etm.2017.4552
  • Scorza CA, Marques MJG, Gomes da Silva S, Naffah-Mazzacoratti MDG, Scorza FA, Cavalheiro EA. Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis..Neurosci Lett. 2018 Mar 6;668:169-173. doi: 10.1016/j.neulet.2017.02.049. Epub 2017 Feb 22. https://doi.org/10.1016/j.neulet.2017.02.049
  • Alboni S, Cervia D, Sugama S, Conti B. Interleukin 18 in the CNS. JNeuroinflammation 2010;7:9. https://doi.org/10.1186/1742-2094-7-9
  • Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, et al. Cloningof a new cytokine that induces IFN-gamma production by T cells. Nature1995;378:88–91. https://doi.org/10.1038/378088a0
  • Dinarello CA. IL-18: a TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol 1999;103:11–24.). https://doi.org/10.1016/S0091-6749(99)70518-X
  • Liu R, Wu S, Guo C, Hu Z, Peng J, Guo K, et al. Li Ibuprofen Exerts Antiepileptic and Neuroprotective Effects in the Rat Model of Pentylenetetrazol-Induced Epilepsy via the COX-2/NLRP3/IL-18 Pathway.
  • J.Neurochem Res. 2020 Oct;45(10):2516-2526. doi: 10.1007/s11064-020-03109-9. Epub 2020 Aug 13. https://doi.org/10.1007/s11064-020-03109-9
  • Mochol M, Taubøll E, Sveberg L, Tennøe B, Berg Olsen K, Heuser K, et al. Seizure control after late introduction of anakinra in a patient with adult onset Rasmussen’s encephalitis.Epilepsy Behav Rep 2021;16:100462. https://doi.org/10.1016/j.ebr.2021.100462 Hung J, McQuillan BM, Chapman CM, Thompson PL, Beilby JP. Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesityand insulin resistance. Arterioscler Thromb Vasc Biol 2005;25:1268–73. https://doi.org/10.1161/01.ATV.0000163843.70369.12
  • Weigert J, Neumeier M, Wanninger J, Filarsky M, Bauer S, Wiest R, et al. Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes.Clin Endocrinol (Oxf) 2010;72(3):342-8. https://doi.org/10.1111/j.1365-2265.2009.03664.x
  • Rourke JL, Dranse HJ, Sinal CJ. Towards an integrative approach to understanding the role of chemerin in human health and disease.Obes Rev 2013;14(3):245-62. https://doi.org/10.1111/obr.12009
  • Elhady M, Youness ER, Gafar HS, Abdel Aziz A, Mostafa RSI. Circulating irisin and chemerin levels as predictors of seizure control in children with idiopathic epilepsy.Neurol Sci. 2018;39(8):1453-1458. https://doi.org/10.1007/s10072-018-3448-5
  • Adya R, Tan BK, Chen J, Randeva HS.Nuclear factor-kappaB induction by visfatin in human vascular endothelial cells: its role in MMP-2/9 production and activation.Diabetes Care 2008;31(4):758-60. https://doi.org/10.2337/dc07-1544
  • Lee WJ, Wu CS, Lin H, Lee IT, Wu CM, Tseng JJ, et al. Visfatin-induced expression of inflammatory mediators in human endothelial cells through the NF-kappaB pathway. I nt J Obes (Lond) 2009;33(4):465-72. https://doi.org/10.1038/ijo.2009.24
  • Meral C, Cekmez F, Vurucu S, Tascılar E, Pirgon O, Canpolat FE, et al. New adipocytokines (vaspin, apelin, visfatin, adiponectin) levels in children treated with valproic acid.Eur Cytokine Netw 2011;22(2):118-22. https://doi.org/10.1684/ecn.2011.0284
  • Sonmez FM, Zaman D, Aksoy A, Deger O, Aliyazicioglu R, Karaguzel G, et al. The effects of topiramate and valproate therapy on insulin, c-peptide, leptin, neuropeptide Y, adiponectin, visfatin, and resistin levels in children with epilepsy. Seizure 2013;22(10):856-61. https://doi.org/10.1016/j.seizure.2013.07.007
  • Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, et al. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci U S A 2005;102(30):10610-5. https://doi.org/10.1073/pnas.0504703102
  • Richard D, Ferland J, Lalonde J, Samson P, Deshaies Y. Influence of topiramate in the regulation of energy balance. Nutrition 2000;16(10):961-6. https://doi.org/10.1016/S0899-9007(00)00452-4
  • Li HF, Zou Y, Xia ZZ, Gao F, Feng JH, Yang CW. Effects of topiramate on weight and metabolism in children with epilepsy.Acta Paediatr 2009;98:1521-5.). https://doi.org/10.1111/j.1651-2227.2009.01349.x
  • Uludağ Fİ, Şener U, Zorlu Y, Köseoğlu MH, Kantaroğlu Aydın T. Serum Leptin Levels in Epileptic Patients Treated with Topiramate and Valproic Acid. Turk J Neurol. 2011; 17(1): 17-3.
  • Lalonde J, Samson P, Poulin S, Deshaies Y, Richard D Additive effects of leptin and topiramate in reducing fat deposition in lean and obese ob/ob mice. Physiol Behav 2004;80(4):415-20. https://doi.org/10.1016/j.physbeh.2003.08.013
  • Picard F, Deshaies Y, Lalonde J, Samson P, Richard D. Topiramate reduces energy and fat gains in lean (Fa/?) and obese (fa/fa) Zucker rats. Obes Res 2000;8:656-63. https://doi.org/10.1038/oby.2000.84
  • Ben-Menachem E, Axelsen M, Johanson EH, Stagge A, Smith U. Predictors of weight loss in adults with topiramate-treated epilepsy. Obes Res 2003;11(4):556-62. https://doi.org/10.1038/oby.2003.78
Toplam 36 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Research Articles
Yazarlar

Ahmet Dündar Bu kişi benim 0000-0003-0527-189X

Derya Kılınç Bu kişi benim 0000-0002-2905-6636

Ahmet Yılmaz 0000-0002-2648-2824

Vugar Jafar Bu kişi benim 0000-0001-5384-3464

Orhan Ayan Bu kişi benim 0000-0003-4009-1157

Mehmet Uğur Çevik Bu kişi benim 0000-0003-0861-8588

Hamza Aslanhan Bu kişi benim 0000-0002-0904-3811

Erken Görünüm Tarihi 30 Nisan 2023
Yayımlanma Tarihi 30 Nisan 2023
Gönderilme Tarihi 30 Ocak 2022
Yayımlandığı Sayı Yıl 2023 Cilt: 14 Sayı: 48

Kaynak Göster

Vancouver Dündar A, Kılınç D, Yılmaz A, Jafar V, Ayan O, Çevik MU, Aslanhan H. Evaluation of serum adipocytokine and interleukin-18 levels in patients with epilepsy. Interdiscip Med J. 2023;14(48):18-24.
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