Araştırma Makalesi
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Atorvastatin induced rhabdomyolysis: A case report

Yıl 2022, Cilt: 8 Sayı: 1, 46 - 53, 01.01.2022

Alpaslan Mert Ömer Faruk Tekin

Öz

Background: Rhabdomyolysis is a clinical condition occurring due to direct or indirect injury to skeletal muscles. This condition is precipitated by a number factors like trauma, crush injury, strenuous exercise, etc. Some of the widely prescribed drugs like statins are known to induce rhabdomyolysis especially when coadministered with other drugs like fibrates, macrolide antibiotics, calcium channel blockers, aspirins, etc.
Case presentation: Here we present a case of rhabdomyolysis (creatinine phosphokinase 6250 IU/L) in a 58-year-old male following intake of atorvastatin, benidipine and aspirin. The patient was managed conservatively on outpatient basis with withdrawal of the offending drug and fluid therapy. He responded well with normalization of CPK (creatinine phosphokinase) level (125 IU/L) within one week. To conclude both family physicians and patients should be aware of this side-effect associated with statins.
Conclusion: As prompt identification of the symptoms and seeking medical attention on the patient’s part is very important for the final outcome, besides prompt diagnosis and management, the family physicians must give importance to patient education while prescribing the drugs

Anahtar Kelimeler

Creatinine phosphokinase (CPK) Rhabdomyolysis Statin

Kaynakça

  • Alavi-Moghaddam, M., Safari, S., Najafi, I., & Hosseini, M. (2012). Accuracy of urine dipstick in the detection of patients at risk for crush-induced rhabdomyolysis and acute kidney injury. European Journal of Emergency Medicine, 19(5), 329–332. https://doi.org/10.1097/MEJ.0b013e32834dd2ef
  • Dalugama, C., Pathirage, M., & Kularatne, S. A. M. (2018). Delayed presentation of severe rhabdomyolysis leading to acute kidney injury following atorvastatin-gemfibrozil combination therapy: a case report. Journal of Medical Case Reports, 12(1), 143. https://doi.org/10.1186/s13256-018-1685-0
  • Dybro, A. M., Damkier, P., Rasmussen, T. B., & Hellfritzsch, M. (2016). Statin-associated rhabdomyolysis triggered by drug–drug interaction with itraconazole. BMJ Case Reports, bcr2016216457. https://doi.org/10.1136/bcr-2016-216457
  • Ferri, F. F. (2016). Rhabdomyolysis. In Ferri’s Clinical Advisor (pp. 1080–1083). Philadelphia: Elsevier, Inc.
  • Grover, D. S., Atta, M. G., Eustace, J. A., Kickler, T. S., & Fine, D. M. (2004). Lack of clinical utility of urine myoglobin detection by microconcentrator ultrafiltration in the diagnosis of rhabdomyolysis. Nephrology Dialysis Transplantation, 19(10), 2634–2638. https://doi.org/10.1093/ndt/gfh422
  • Kahanov, L., Eberman, L. E., Wasik, M., & Alvey, T. (2012). Exertional Rhabdomyolysis in a Collegiate American Football Player After Preventive Cold-Water Immersion: A Case Report. Journal of Athletic Training, 47(2), 228–232. https://doi.org/10.4085/1062-6050-47.2.228
  • Maggini, M., Raschetti, R., Traversa, G., Bianchi, C., Caffari, B., Da Cas, R., & Panei, P. (2004). The cerivastatin withdrawal crisis: a “post-mortem” analysis. Health Policy, 69(2), 151–157. https://doi.org/10.1016/j.healthpol.2004.04.001
  • McPhee, S. J., Papadakis, M. A., & Rabow, M. W. (Eds.). (2010). Current medical diagnosis & treatment 2010. New York: McGraw-Hill Medical.
  • Mendes, P., Robles, P. G., & Mathur, S. (2014). Statin-Induced Rhabdomyolysis: A Comprehensive Review of Case Reports. Physiotherapy Canada, 66(2), 124–132. https://doi.org/10.3138/ptc.2012-65
  • Mohamed, M. F. H., Salameh, O. K., & Saeed, A. A. M. (2019). Statin-Induced Rhabdomyolysis, Acute Kidney Injury, and Hepatitis Leading to Death. American Journal of Case Reports, 20, 709–712. https://doi.org/10.12659/AJCR.914707
  • Mrsić, V., Rasić, Z., Smiljanić, A., & Turcić, I. (2008). Acute rhabdomyolysis: a case report and literature review. Acta Medica Croatica: Casopis Hravatske Akademije Medicinskih Znanosti, 62(3), 317–322. Peringat, J., Manappallil, R. G., & Karadan, U. (2018). Rhabdomyolysis: a rare complication of Hashimoto’s thyroiditis precipitated by statin therapy. BMJ Case Reports, bcr-2017-223229. https://doi.org/10.1136/bcr-2017-223229
  • Porter, R. S. (2011). The Merck Manuel of Patient Symptoms (2nd ed.). Merck and Co.,Inc.
  • Rodríguez-Capote, K., Balion, C. M., Hill, S. A., Cleve, R., Yang, L., & El Sharif, A. (2009). Utility of Urine Myoglobin for the Prediction of Acute Renal Failure in Patients with Suspected Rhabdomyolysis: A Systematic Review. Clinical Chemistry, 55(12), 2190–2197. https://doi.org/10.1373/clinchem.2009.128546
  • Thompson, P. D., Panza, G., Zaleski, A., & Taylor, B. (2016). Statin-Associated Side Effects. Journal of the American College of Cardiology, 67(20), 2395–2410. https://doi.org/10.1016/j.jacc.2016.02.071
  • Torres, P., Helmstetter, J., & Journal, A. K. (2015). Rhabdomyolysis: pathogenesis, diagnosis, and treatment. Ochsner Journal, 15(1), 58–69.
  • Vanholder, R., Sever, M. S., Erek, E., & Lameire, N. (2000). Rhabdomyolysis. Journal of the American Society of Nephrology, 11(8), 1553–1561. https://doi.org/10.1681/ASN.V1181553

Yıl 2022, Cilt: 8 Sayı: 1, 46 - 53, 01.01.2022

Alpaslan Mert Ömer Faruk Tekin

Öz

Kaynakça

  • Alavi-Moghaddam, M., Safari, S., Najafi, I., & Hosseini, M. (2012). Accuracy of urine dipstick in the detection of patients at risk for crush-induced rhabdomyolysis and acute kidney injury. European Journal of Emergency Medicine, 19(5), 329–332. https://doi.org/10.1097/MEJ.0b013e32834dd2ef
  • Dalugama, C., Pathirage, M., & Kularatne, S. A. M. (2018). Delayed presentation of severe rhabdomyolysis leading to acute kidney injury following atorvastatin-gemfibrozil combination therapy: a case report. Journal of Medical Case Reports, 12(1), 143. https://doi.org/10.1186/s13256-018-1685-0
  • Dybro, A. M., Damkier, P., Rasmussen, T. B., & Hellfritzsch, M. (2016). Statin-associated rhabdomyolysis triggered by drug–drug interaction with itraconazole. BMJ Case Reports, bcr2016216457. https://doi.org/10.1136/bcr-2016-216457
  • Ferri, F. F. (2016). Rhabdomyolysis. In Ferri’s Clinical Advisor (pp. 1080–1083). Philadelphia: Elsevier, Inc.
  • Grover, D. S., Atta, M. G., Eustace, J. A., Kickler, T. S., & Fine, D. M. (2004). Lack of clinical utility of urine myoglobin detection by microconcentrator ultrafiltration in the diagnosis of rhabdomyolysis. Nephrology Dialysis Transplantation, 19(10), 2634–2638. https://doi.org/10.1093/ndt/gfh422
  • Kahanov, L., Eberman, L. E., Wasik, M., & Alvey, T. (2012). Exertional Rhabdomyolysis in a Collegiate American Football Player After Preventive Cold-Water Immersion: A Case Report. Journal of Athletic Training, 47(2), 228–232. https://doi.org/10.4085/1062-6050-47.2.228
  • Maggini, M., Raschetti, R., Traversa, G., Bianchi, C., Caffari, B., Da Cas, R., & Panei, P. (2004). The cerivastatin withdrawal crisis: a “post-mortem” analysis. Health Policy, 69(2), 151–157. https://doi.org/10.1016/j.healthpol.2004.04.001
  • McPhee, S. J., Papadakis, M. A., & Rabow, M. W. (Eds.). (2010). Current medical diagnosis & treatment 2010. New York: McGraw-Hill Medical.
  • Mendes, P., Robles, P. G., & Mathur, S. (2014). Statin-Induced Rhabdomyolysis: A Comprehensive Review of Case Reports. Physiotherapy Canada, 66(2), 124–132. https://doi.org/10.3138/ptc.2012-65
  • Mohamed, M. F. H., Salameh, O. K., & Saeed, A. A. M. (2019). Statin-Induced Rhabdomyolysis, Acute Kidney Injury, and Hepatitis Leading to Death. American Journal of Case Reports, 20, 709–712. https://doi.org/10.12659/AJCR.914707
  • Mrsić, V., Rasić, Z., Smiljanić, A., & Turcić, I. (2008). Acute rhabdomyolysis: a case report and literature review. Acta Medica Croatica: Casopis Hravatske Akademije Medicinskih Znanosti, 62(3), 317–322. Peringat, J., Manappallil, R. G., & Karadan, U. (2018). Rhabdomyolysis: a rare complication of Hashimoto’s thyroiditis precipitated by statin therapy. BMJ Case Reports, bcr-2017-223229. https://doi.org/10.1136/bcr-2017-223229
  • Porter, R. S. (2011). The Merck Manuel of Patient Symptoms (2nd ed.). Merck and Co.,Inc.
  • Rodríguez-Capote, K., Balion, C. M., Hill, S. A., Cleve, R., Yang, L., & El Sharif, A. (2009). Utility of Urine Myoglobin for the Prediction of Acute Renal Failure in Patients with Suspected Rhabdomyolysis: A Systematic Review. Clinical Chemistry, 55(12), 2190–2197. https://doi.org/10.1373/clinchem.2009.128546
  • Thompson, P. D., Panza, G., Zaleski, A., & Taylor, B. (2016). Statin-Associated Side Effects. Journal of the American College of Cardiology, 67(20), 2395–2410. https://doi.org/10.1016/j.jacc.2016.02.071
  • Torres, P., Helmstetter, J., & Journal, A. K. (2015). Rhabdomyolysis: pathogenesis, diagnosis, and treatment. Ochsner Journal, 15(1), 58–69.
  • Vanholder, R., Sever, M. S., Erek, E., & Lameire, N. (2000). Rhabdomyolysis. Journal of the American Society of Nephrology, 11(8), 1553–1561. https://doi.org/10.1681/ASN.V1181553
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makalesi
Yazarlar

Alpaslan Mert Bu kişi benim

Ömer Faruk Tekin

Yayımlanma Tarihi 1 Ocak 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 8 Sayı: 1

Kaynak Göster

APA Mert, A., & Tekin, Ö. F. (2022). Atorvastatin induced rhabdomyolysis: A case report. International Journal of Health Administration and Education Congress (Sanitas Magisterium), 8(1), 46-53.
AMA Mert A, Tekin ÖF. Atorvastatin induced rhabdomyolysis: A case report. Sanitas magisterium. Ocak 2022;8(1):46-53.
Chicago Mert, Alpaslan, ve Ömer Faruk Tekin. “Atorvastatin Induced Rhabdomyolysis: A Case Report”. International Journal of Health Administration and Education Congress (Sanitas Magisterium) 8, sy. 1 (Ocak 2022): 46-53.
EndNote Mert A, Tekin ÖF (01 Ocak 2022) Atorvastatin induced rhabdomyolysis: A case report. International Journal of Health Administration and Education Congress (Sanitas Magisterium) 8 1 46–53.
IEEE A. Mert ve Ö. F. Tekin, “Atorvastatin induced rhabdomyolysis: A case report”, Sanitas magisterium, c. 8, sy. 1, ss. 46–53, 2022.
ISNAD Mert, Alpaslan - Tekin, Ömer Faruk. “Atorvastatin Induced Rhabdomyolysis: A Case Report”. International Journal of Health Administration and Education Congress (Sanitas Magisterium) 8/1 (Ocak 2022), 46-53.
JAMA Mert A, Tekin ÖF. Atorvastatin induced rhabdomyolysis: A case report. Sanitas magisterium. 2022;8:46–53.
MLA Mert, Alpaslan ve Ömer Faruk Tekin. “Atorvastatin Induced Rhabdomyolysis: A Case Report”. International Journal of Health Administration and Education Congress (Sanitas Magisterium), c. 8, sy. 1, 2022, ss. 46-53.
Vancouver Mert A, Tekin ÖF. Atorvastatin induced rhabdomyolysis: A case report. Sanitas magisterium. 2022;8(1):46-53.

https://dergipark.org.tr/tr/download/journal-file/2143321433