Öz
The primary surface structure of the oral cavity mucous membrane is lined with squamous epithelium.86-95% of
malignant tumors of the head and neck region develop from this structure. In order to determine the risk of malignant
transformation of the precancerous lesion, the degree of dysplasia observed in the epithelium as a result of
histopathological evaluation should be evaluated. High-grade epithelial dysplasia and carcinoma in-situ undergo
irreversible change if left untreated, and ultimately result in the development of invasive carcinoma through the
accumulation of genetic abnormalities caused by persistent exposure. It is most common in male over the age of 40.
Tobacco, alcohol use, poor oral hygiene and chronic irritation are the most important etiological factors. Clinically,
the first sign is the presence of painless ulcers. The most affected areas are; although these include the tongue, lower
lip, and floor of the mouth, these types of carcinomas can occur anywhere in the mouth. In this case report; the
clinical, radiological and pathological findings of a 55-year-old female patient who was diagnosed with in-situ
carcinoma that started as a painless swelling in the gingiva in the maxillary anterior and right premolar region and
showed extensive involvement are presented.
Anahtar Kelimeler
Oral cancer Carcinoma In-Situ Oral Cavity Cone-Beam Computed Tomography
Kaynakça
- 1. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2009;45(4-5):309-16.
- 2. Werning JW. Oral cancer: diagnosis, management, and rehabilitation: Thieme Medical Pub; 2007.
- 3. Huang SH. Oral cancer: Current role of radiotherapy and chemotherapy. Med Oral Patol Oral Cir Bucal 2013;18(2):e233.
- 4. Izumo T, Kirita T, Ariji E, Ozeki S, Okada N, Okabe S, et al. General rules for clinical and pathological studies on oral cancer: a synopsis. Jpn J Clin Oncol2012;42(11):1099-109.
- 5. Vijayakumar V, Reghunathan D, Edacheriyan B, Mukundan A. Role of toluidine blue staining in suspicious lesions of oral cavity and oropharynx. Indian J Otolaryngol Head Neck Surg 2019;71(1):142-6.
- 6. Pereira NDS, Pinheiro TN. Histomorphometric comparative analysis between oral dysplastic potentially malignant disorders and oral squamous cell carcinoma. EurJ Dent 2019;13(01):001-4.
- 7. Poh CF, Ng S, Berean KW, Williams PM, Rosin MP, Zhang L. Biopsy and histopathologic diagnosis of oral premalignant and malignant lesions. J Can Dent Assoc 2008;74(3).
- 8. Speight PM. Update on oral epithelial dysplasia and progression to cancer. Head Neck Pathol 2007;1(1):61-6.
- 9. El-Naggar AK, Chan JK, Grandis JR, Takata T, Slootweg P. WHO classification of head and neck tumours. WHO/IARC Classification of Tumours. World Heal Organ 2017.
- 10. Soares AB, de Araújo VC, Passador-Santos F, Thomaz LA, de Freitas ALS, Mautoni MC, et al. Uncommon Pigmented Carcinoma In Situ: Case Report and Brief Review. J ClinPathol 2021;14:2632010X211009819.
- 11. Müller S. Melanin‐associated pigmented lesions of the oral mucosa: presentation, differential diagnosis, and treatment. Dermatol Ther 2010;23(3):220-9.
- 12. Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA, editors. Environmental and chemical carcinogenesis. Seminars in cancer biology; 2004: Elsevier.
- 13. Haksever M. Oral kavite kanserlerinde evreleme, prognostik faktörler ve evreleme sistemi üzerine değerlendirmeler. Kocatepe Tıp Dergisi 2013;14(2):109-17.
- 14. Gillison ML. Current topics in the epidemiology of oral cavity and oropharyngeal cancers. J Sci Special Head and Neck2007;29(8):779-92.
- 15. Peláez C, LA ML. Effects of the consumption of alcohol in the oral cavity: relationship with oral cancer. Medicina oral: organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal. 2004;9(1):14-23.
- 16. Akmansoy Bp, Şakir Md, Alatli C. Oral skuamöz hücreli karsinom: 3 olgu sunumu ve literatür derlemesi. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 2018;28(2):239-44.
- 17. Rivera C, Oliveira AK, Costa RAP, De Rossi T, Leme AFP. Prognostic biomarkers in oral squamous cell carcinoma: a systematic review. Oral Oncol 2017;72:38-47.
- 18. Öztürk B, Coşkun U, Yaman E, Kaya A, Yıldız R, Benekli M, et al. Oral kavite kanserlerinde risk faktörleri, premalign lezyonlar ve kemoprevensiyon. UHOD 2009;19(2):118.
- 19. Noguchi M, Tsuno H, Ishizaka R, Fujiwara K, Imaue S, Tomihara K, et al. Primary peri-implant oral intra-epithelial neoplasia/carcinoma in situ: a case report considering risk factors for carcinogenesis. Int J İmplant Dent 2017;3(1):1-5.
- 20. Andre K, Schraub S, Mercier M, Bontemps P. Role of alcohol and tobacco in the aetiology of head and neck cancer: a case-control study in the Doubs region of France. European Journal of Cancer Part B: Oral Oncol 1995;31(5):301-9.
- 21. Lissowska J, Pilarska A, Pilarski P, Samolczyk-Wanyura D, Piekarczyk J, Bardin-Mikolajczak A, et al. Smoking, alcohol, diet, dentition and sexual practices in the epidemiology of oral cancer in Poland. Eur J Cancer Prev 2003:25-33
Öz
Kaynakça
- 1. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2009;45(4-5):309-16.
- 2. Werning JW. Oral cancer: diagnosis, management, and rehabilitation: Thieme Medical Pub; 2007.
- 3. Huang SH. Oral cancer: Current role of radiotherapy and chemotherapy. Med Oral Patol Oral Cir Bucal 2013;18(2):e233.
- 4. Izumo T, Kirita T, Ariji E, Ozeki S, Okada N, Okabe S, et al. General rules for clinical and pathological studies on oral cancer: a synopsis. Jpn J Clin Oncol2012;42(11):1099-109.
- 5. Vijayakumar V, Reghunathan D, Edacheriyan B, Mukundan A. Role of toluidine blue staining in suspicious lesions of oral cavity and oropharynx. Indian J Otolaryngol Head Neck Surg 2019;71(1):142-6.
- 6. Pereira NDS, Pinheiro TN. Histomorphometric comparative analysis between oral dysplastic potentially malignant disorders and oral squamous cell carcinoma. EurJ Dent 2019;13(01):001-4.
- 7. Poh CF, Ng S, Berean KW, Williams PM, Rosin MP, Zhang L. Biopsy and histopathologic diagnosis of oral premalignant and malignant lesions. J Can Dent Assoc 2008;74(3).
- 8. Speight PM. Update on oral epithelial dysplasia and progression to cancer. Head Neck Pathol 2007;1(1):61-6.
- 9. El-Naggar AK, Chan JK, Grandis JR, Takata T, Slootweg P. WHO classification of head and neck tumours. WHO/IARC Classification of Tumours. World Heal Organ 2017.
- 10. Soares AB, de Araújo VC, Passador-Santos F, Thomaz LA, de Freitas ALS, Mautoni MC, et al. Uncommon Pigmented Carcinoma In Situ: Case Report and Brief Review. J ClinPathol 2021;14:2632010X211009819.
- 11. Müller S. Melanin‐associated pigmented lesions of the oral mucosa: presentation, differential diagnosis, and treatment. Dermatol Ther 2010;23(3):220-9.
- 12. Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA, editors. Environmental and chemical carcinogenesis. Seminars in cancer biology; 2004: Elsevier.
- 13. Haksever M. Oral kavite kanserlerinde evreleme, prognostik faktörler ve evreleme sistemi üzerine değerlendirmeler. Kocatepe Tıp Dergisi 2013;14(2):109-17.
- 14. Gillison ML. Current topics in the epidemiology of oral cavity and oropharyngeal cancers. J Sci Special Head and Neck2007;29(8):779-92.
- 15. Peláez C, LA ML. Effects of the consumption of alcohol in the oral cavity: relationship with oral cancer. Medicina oral: organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal. 2004;9(1):14-23.
- 16. Akmansoy Bp, Şakir Md, Alatli C. Oral skuamöz hücreli karsinom: 3 olgu sunumu ve literatür derlemesi. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 2018;28(2):239-44.
- 17. Rivera C, Oliveira AK, Costa RAP, De Rossi T, Leme AFP. Prognostic biomarkers in oral squamous cell carcinoma: a systematic review. Oral Oncol 2017;72:38-47.
- 18. Öztürk B, Coşkun U, Yaman E, Kaya A, Yıldız R, Benekli M, et al. Oral kavite kanserlerinde risk faktörleri, premalign lezyonlar ve kemoprevensiyon. UHOD 2009;19(2):118.
- 19. Noguchi M, Tsuno H, Ishizaka R, Fujiwara K, Imaue S, Tomihara K, et al. Primary peri-implant oral intra-epithelial neoplasia/carcinoma in situ: a case report considering risk factors for carcinogenesis. Int J İmplant Dent 2017;3(1):1-5.
- 20. Andre K, Schraub S, Mercier M, Bontemps P. Role of alcohol and tobacco in the aetiology of head and neck cancer: a case-control study in the Doubs region of France. European Journal of Cancer Part B: Oral Oncol 1995;31(5):301-9.
- 21. Lissowska J, Pilarska A, Pilarski P, Samolczyk-Wanyura D, Piekarczyk J, Bardin-Mikolajczak A, et al. Smoking, alcohol, diet, dentition and sexual practices in the epidemiology of oral cancer in Poland. Eur J Cancer Prev 2003:25-33
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Diş Hekimliği |
| Bölüm | Olgu Sunumları |
| Yazarlar | |
| Yayımlanma Tarihi | 25 Mart 2022 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 1 Sayı: 3 |
