The Effect of Peri-Implant Disease on Oxidative Stress Markers Levels in Peri-Implant Sulcus Fluid: A Cross-Sectional, Pilot Study
Öz
Background: Peri-implant diseases are inflammatory diseases as periodontal disease. An array of oxidative stress markers has been examined in the disease and health of the periodontal tissues. The purpose of the study was to test whether peri-implant conditions have an impact on the peri-implant sulcus fluid oxidative stress markers.
Materials and Methods: A total of 44 participants were included in the study. Collected samples divided 3 groups, 14 samples for healthy implants; 15 samples for peri-implant mucositis; and 15 samples for peri-implantitis. In clinical periodontal examination, plaque index (PI), modified bleeding index (mSBI), probing bleeding (BOP), probing pocket depth (PPD), gingival index (GI), modified plaque index (MPI) were measured. Peri-implant sulcus fluid (PISF) samples were collected for evaluating and measuring biochemical analysis of total oxidant status (TOS) and total antioxidant capacity (TAOC) and oxidative stress index (OSI).
Results: The TOS level in PISF was statistically significantly higher in the peri-implantitis when compared to the healthy group (p=0.041). There was no statistically significant difference (p>0.05) between groups in terms of TAOC and OSI parameters.
Conclusions: As a result of the current study, it can be said that, due to its inflammatory character, peri-implantitis can increase total oxidant status (TOS) in peri-implant sulcus fluid (PISF). Multicentered research is needed to explain which immunological mechanism triggers the oxidative system in peri-implantitis in order to understand the potential role of oxidative stress markers in peri-implant inflammation.
Anahtar Kelimeler
Oxidative Stress Peri-Implant Disease Peri-Implant Sulcus Fluid Peri-Implantitis Peri-Implant Mucositis Oxidative Stress, Peri-Implant Disease, Peri-Implant Sulcus Fluid, Peri-Implantitis, Peri-Implant Mucositis
Kaynakça
- REFERENCES 1. Belser UC, Mericske-Stern R, Bernard JP, Taylor TD Prosthetic management of the partially dentate patient with fixed implant restorations. In: Clinical oral implants research. Clin Oral Implants Res, 2000;S126–145
- 2. Schwarz F, Derks J, Monje A, Wang H-L Peri-implantitis. J Periodontol 2018 ;89:S267–S290.
- 3. Caton JG, Armitage G, Berglundh T, et al A new classification scheme for periodontal and peri-implant diseases and conditions - Introduction and key changes from the 1999 classification. J. Periodontol. 2018; 45:1–8
- 4. Araujo MG, Lindhe J Peri-implant health. J Periodontol2018; 89:S249–S256.
- 5. Heitz-Mayfield LJA, Salvi GE Peri-implant mucositis. J Periodontol 2018;89:S257–S266.
- 6. Renvert S, Persson GR, Pirih FQ, Camargo PM Peri-implant health, peri-implant mucositis, and peri-implantitis: Case definitions and diagnostic considerations. J Periodontol 2018;89:S304–S312.
- 7. Candel-Martí M-E, Flichy-Fernández A-J, Alegre-Domingo T, et al Interleukins IL-6, IL-8, IL-10, IL-12 and periimplant disease. An update. Med Oral Patol Oral Cir Bucal 2011;16:518-21
- 8. Phaniendra A, Jestadi DB, Periyasamy L Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases. Indian J. Clin. Biochem. 2015; 30:11–26
- 9. Vascotto C, Tiribelli C Oxidative Stress, Antioxidant Defenses, and the Liver. 2015; pp 41–64
- 10. Chapple ILC, Matthews JB The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol. 2000 2007; 43:160–232
- 11. Papapanou PN, Sanz M, Buduneli N, et al Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol 2018;89:S313–S318.
- 12. Loe H, Silness J, Löe H, et al Periodontal Disease in Pregnancy I. Prevalence and Severity. Acta Odontol Scand1963; 21:533–551.
- 13. Silness J, Loe H Periodontal Disease in Pregnancy 11. Correlation Between Oral Hygiene and Periodontal Condition. Acta odontal scand 1963;22:121–135.
- 14. Acipinar S, Karsiyaka Hendek M, Olgun E, Kisa U Evaluation of FGF-23 and 25(OH)D3 levels in peri-implant sulcus fluid in peri-implant health and diseases. Clin Implant Dent Relat Res 2019;21:1106–1112.
- 15. Erel O A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 2004;37:277–85.
- 16. Uzunkaya M, Gundogar H Evaluation of periostin levels in gingival crevicular fluid and peri-implant sulcus fluid in patients with periodontal and peri-implanter disease: A cross-sectional study. Ann Med Res2019; 26:2093.
- 17. Gundogar H, Ozsoy B, Uzunkaya M, Senyurt SZ EK Effect of peri-implant disease on adropin levels: A cross-sectional pilot study. Eur J Ther 2020;26:61–5
- 18. Akman AC, Askin SB, Guncu GN, Nohutcu RM Evaluation of Gingival Crevicular Fluid and Peri-Implant Sulcus Fluid Levels of Periostin: A Preliminary Report. J Periodontol2017; 1–11.
- 19. Mousavi Jazi M, Sadeghi Pour Rodsari HR, Mirmiran F Level of Oxidative Stress Markers in Peri-Implant Crevicular Fluid and Their Correlation with Clinical Parameters. J Dent (Tehran) 2015; 12:340–6
- 20. Liskmann S, Vihalemm T, Salum O, et al Characterization of the antioxidant profile of human saliva in peri-implant health and disease. Clin Oral Implants Res 2007;18:27–33.
- 21. Toczewska J, Maciejczyk M, Konopka T, Zalewska A Total oxidant and antioxidant capacity of gingival crevicular fluid and saliva in patients with periodontitis: Review and clinical study. Antioxidants2020; 9:(5):450
- 22. Baltacıoğlu E, Yuva P, Aydın G, et al Lipid Peroxidation Levels and Total Oxidant/Antioxidant Status in Serum and Saliva From Patients With Chronic and Aggressive Periodontitis. Oxidative Stress Index: A New Biomarker for Periodontal Disease? J Periodontol 2014; 85:1432–1441.
- 23. Zhang T, Andrukhov O, Haririan H, et al Total antioxidant capacity and total oxidant status in saliva of periodontitis patients in relation to bacterial load. Frontiers Cell Infection Microbiology 2016;5: article97 :1-10
- 24. Wei D, Zhang XL, Wang YZ, et al Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy. Aust Dent J 2010;55:70–78.
- 25. Salvi GE, Cosgarea R, Sculean A Prevalence and Mechanisms of Peri-implant Diseases. J Dent Res 2017;96:31–37.
- 26. Javed F, Al-Hezaimi K, Salameh Z, et al Proinflammatory cytokines in the crevicular fluid of patients with peri-implantitis. Cytokine2011; 53:8–12
- 27. Kaklamanos EG, Tsalikis L A review on peri-implant crevicular fluid assays potential in monitoring and predicting peri-implant tissue responses. J. Int. Acad. Periodontol. 2002; 4:49–59
Peri-İmplant Hastalığın Peri-İmplanter Sulkus Sıvısında Oksidatif Stres Belir-teçleri Seviyeleri Üzerindeki Etkisi: Kesitsel, Pilot Çalışma
Öz
Günümüzde dental implantların diş eksikliklerinde sıklıkla kullanılmasıyla peri-implanter hastalıklarında görülme sayısında artış olmuştur. Peri-implanter hastalıklar da periodontal hastalıklar gibi inflamatuar hastalıklardır. Oksidatif stres periodontal hastalıklarda etken olarak görülmüş ve birçok oksidatif stres belirleçleri hastalık ile sağlıkta incelenmiştir. Çalışmamızın amacı, peri-implanter hastalıkların peri-implanter oluk sıvısı oksidatif stres belirteçlerine etkisinin incelenmesidir. Çalışmaya klinik ve radyolojik olarak peri-implant sağlıklı tanısı konmuş 14 örnek, peri-implant mukozitis tanısı konmuş 15 örnek, peri-implantitis tanısı konmuş 15 örnek dahil edildi. Hastalardan periodontal klinik ölçümler (plak indeksi (PI), sondalama cep derinliği (SCD), gingival indeks (GI), sondalamada kanama indeksi (BOP), modifiye plak indeksi (mPI), modifiye kanama indeksi (mKI)) ve peri-implant oluğu sıvısı (PİOS) örnekleri alındı. Örneklerin istatistiksel olarak analizinde Shaphiro Wilk testi, Mann Whitney U testi ve Ki kare testi kullanıldı. Çalışmamızda total oksidan seviye (TOS) parametresi, peri-implantitis grubunda peri-implant sağlıklı grubuna göre istatistiksel olarak anlamlı düzeyde yüksek bulunmuştur. Total antioksidan seviye (TAS) ve oksidatif stres indeksi (OSİ) parametrelerine baktığımızda gruplar arasında istatistiksel olarak anlamlı bir farklılık bulunamamıştır. Peri-implantitisin inflamatuar karakterinden dolayı TOS’ u arttıracağı çalışmamızın sonuçlarına göre söylenebilir. Oksidatif stres belirteçlerinin peri-implant inflamasyonda ki potansiyel rolünü anlamak için peri-implant sağlıklı, peri-implant mukozitis ve peri-implantitis bölgelerinden alınan örneklerin değerlendirildiği çok merkezli, daha detaylı ileri çalışmalara ihtiyaç vardır.
Anahtar Kelimeler
oksidatif stres peri-implant hastalık peri-implant oluk sıvısı
Kaynakça
- REFERENCES 1. Belser UC, Mericske-Stern R, Bernard JP, Taylor TD Prosthetic management of the partially dentate patient with fixed implant restorations. In: Clinical oral implants research. Clin Oral Implants Res, 2000;S126–145
- 2. Schwarz F, Derks J, Monje A, Wang H-L Peri-implantitis. J Periodontol 2018 ;89:S267–S290.
- 3. Caton JG, Armitage G, Berglundh T, et al A new classification scheme for periodontal and peri-implant diseases and conditions - Introduction and key changes from the 1999 classification. J. Periodontol. 2018; 45:1–8
- 4. Araujo MG, Lindhe J Peri-implant health. J Periodontol2018; 89:S249–S256.
- 5. Heitz-Mayfield LJA, Salvi GE Peri-implant mucositis. J Periodontol 2018;89:S257–S266.
- 6. Renvert S, Persson GR, Pirih FQ, Camargo PM Peri-implant health, peri-implant mucositis, and peri-implantitis: Case definitions and diagnostic considerations. J Periodontol 2018;89:S304–S312.
- 7. Candel-Martí M-E, Flichy-Fernández A-J, Alegre-Domingo T, et al Interleukins IL-6, IL-8, IL-10, IL-12 and periimplant disease. An update. Med Oral Patol Oral Cir Bucal 2011;16:518-21
- 8. Phaniendra A, Jestadi DB, Periyasamy L Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases. Indian J. Clin. Biochem. 2015; 30:11–26
- 9. Vascotto C, Tiribelli C Oxidative Stress, Antioxidant Defenses, and the Liver. 2015; pp 41–64
- 10. Chapple ILC, Matthews JB The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol. 2000 2007; 43:160–232
- 11. Papapanou PN, Sanz M, Buduneli N, et al Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol 2018;89:S313–S318.
- 12. Loe H, Silness J, Löe H, et al Periodontal Disease in Pregnancy I. Prevalence and Severity. Acta Odontol Scand1963; 21:533–551.
- 13. Silness J, Loe H Periodontal Disease in Pregnancy 11. Correlation Between Oral Hygiene and Periodontal Condition. Acta odontal scand 1963;22:121–135.
- 14. Acipinar S, Karsiyaka Hendek M, Olgun E, Kisa U Evaluation of FGF-23 and 25(OH)D3 levels in peri-implant sulcus fluid in peri-implant health and diseases. Clin Implant Dent Relat Res 2019;21:1106–1112.
- 15. Erel O A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 2004;37:277–85.
- 16. Uzunkaya M, Gundogar H Evaluation of periostin levels in gingival crevicular fluid and peri-implant sulcus fluid in patients with periodontal and peri-implanter disease: A cross-sectional study. Ann Med Res2019; 26:2093.
- 17. Gundogar H, Ozsoy B, Uzunkaya M, Senyurt SZ EK Effect of peri-implant disease on adropin levels: A cross-sectional pilot study. Eur J Ther 2020;26:61–5
- 18. Akman AC, Askin SB, Guncu GN, Nohutcu RM Evaluation of Gingival Crevicular Fluid and Peri-Implant Sulcus Fluid Levels of Periostin: A Preliminary Report. J Periodontol2017; 1–11.
- 19. Mousavi Jazi M, Sadeghi Pour Rodsari HR, Mirmiran F Level of Oxidative Stress Markers in Peri-Implant Crevicular Fluid and Their Correlation with Clinical Parameters. J Dent (Tehran) 2015; 12:340–6
- 20. Liskmann S, Vihalemm T, Salum O, et al Characterization of the antioxidant profile of human saliva in peri-implant health and disease. Clin Oral Implants Res 2007;18:27–33.
- 21. Toczewska J, Maciejczyk M, Konopka T, Zalewska A Total oxidant and antioxidant capacity of gingival crevicular fluid and saliva in patients with periodontitis: Review and clinical study. Antioxidants2020; 9:(5):450
- 22. Baltacıoğlu E, Yuva P, Aydın G, et al Lipid Peroxidation Levels and Total Oxidant/Antioxidant Status in Serum and Saliva From Patients With Chronic and Aggressive Periodontitis. Oxidative Stress Index: A New Biomarker for Periodontal Disease? J Periodontol 2014; 85:1432–1441.
- 23. Zhang T, Andrukhov O, Haririan H, et al Total antioxidant capacity and total oxidant status in saliva of periodontitis patients in relation to bacterial load. Frontiers Cell Infection Microbiology 2016;5: article97 :1-10
- 24. Wei D, Zhang XL, Wang YZ, et al Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy. Aust Dent J 2010;55:70–78.
- 25. Salvi GE, Cosgarea R, Sculean A Prevalence and Mechanisms of Peri-implant Diseases. J Dent Res 2017;96:31–37.
- 26. Javed F, Al-Hezaimi K, Salameh Z, et al Proinflammatory cytokines in the crevicular fluid of patients with peri-implantitis. Cytokine2011; 53:8–12
- 27. Kaklamanos EG, Tsalikis L A review on peri-implant crevicular fluid assays potential in monitoring and predicting peri-implant tissue responses. J. Int. Acad. Periodontol. 2002; 4:49–59
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 29 Aralık 2021 |
| Gönderilme Tarihi | 8 Mart 2021 |
| Kabul Tarihi | 8 Kasım 2021 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 18 Sayı: 3 |
Harran Üniversitesi Tıp Fakültesi Dergisi / Journal of Harran University Medical Faculty