Araştırma Makalesi
Yıl 2018,
Cilt: 52 Sayı: 3, 143 - 149, 01.09.2018
Öz
Kaynakça
- healing in diabetes. Diabet Med 2006; 23: 594-608. 2. Linde K. St. John’s wort - an overview. Forsch Komplementmed 2009; 16: 146-55. 3. Zorzetto C, Sánchez-Mateo CC, Rabanal RM, Lupidi G, Petrelli D, Vitali LA, Bramucci M, Quassinti L, Caprioli G, Papa F, Ricciutelli M, Sagratini G, Vittori S, Maggi F.Phytochemical analysis and in vitro biological activity of three Hypericum species from the Canary Islands (Hypericum reflexum, Hypericum canariense and Hypericum grandifolium). Fitoterapia 2015; 100: 95-109. 4. Damlar I, Arpag OF, Tatli U, Altan A. Effects of Hypericum perforatum on the healing of xenografts: a histomorphometric study in rabbits. BJOMS 2017; 55: 383-7. 5. Süntar IP, Akkol EK, Yilmazer D, Baykal T, Kirmizibekmez H, Alper M, Yeşilada E. Investigations on the in vivo wound healing potential of Hypericum perforatum L. J Ethnopharmacol 2010; 127: 468-77. 6. Wolfle U, Seelinger G, Schempp CM. Topical application of St. John’s wort (Hypericum perforatum). Planta Med 2014; 80: 109-20. 7. Nahrstedt A, Butterweck V. Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry 1997; 30: 129-34. 8. Woessner JF Jr. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 1961; 93: 440-7. 9. Castro FC, Magre A, Cherpinski R, Zelante PM, Neves LM, Esquisatto MA, Mendonça FA, Santos GM. Effects of microcurrent application alone or in combination with topical Hypericum perforatum L. and Arnica montana L. on surgically induced wound healing in Wistar rats. Homeopathy 2012; 101: 147-53. 10. Lavagna SM, Secci D, Chimenti P, Bonsignore L, Ottaviani A, Bizzarri B. Efficacy of Hypericum and Calendula oils in the epithelial reconstruction of surgical wounds in childbirth with caesarean section. Farmaco 2001; 56: 451-3. 11. Yeşilada E, Honda G, Sezik E, Tabata M, Fujita T, Tanaka T, Takeda Y, Takaishi Y. Traditional medicine in Turkey. V. Folk medicine in the inner Taurus Mountains. J Ethnopharmacol 1995; 46: 133-52. 12. Yadollah-Damavandi S, Chavoshi-Nejad M, Jangholi E, Nekouyian N, Hosseini S, Seifaee A, Rafiee S, Karimi H, Ashkani-Esfahani S, Parsa Y, Mohsenikia M. Topical Hypericum perforatum Improves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model. Evid Based Complement Alternat med 2015; 2015: doi: 10.1155/2015/245328. 13. Farsak M, Özdağli G, Özmüş D, Çömelekoğlu Ü, Yalın S, Bozdoğan Arpacı R, Gen R, Kanık A, Ümit Talas D. Effects of Hypericum perforatum on an Experimentally Induced Diabetic Wound in a Rat Model. Wounds 2017; 29: E10-7. 14. Rao SG, Udupa AL, Rao G, Rao PGM, Kulkarni DR. Wound healing activity of Calendula officinalis and Hypericum: two homeopathic drugs promoting wound healing in rats. Fitoterapia 1991; 62: 508-10. 15. Menegazzi M, Di Paola R, Mazzon E, Muià C, Genovese T, Crisafulli C, Suzuki H, Cuzzocrea S. Hypericum perforatum attenuates the development of carrageenan-induced lung injury in mice. Free Radic Biol Med 2006; 40: 740-53. 16. Hammer KD, Hillwig ML, Solco AK, Dixon PM, Delate K, Murphy PA, Wurtele ES, Birt DF. Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells. J Agric Food Chem 2007; 55: 7323-31. 17. Cecchini C, Cresci A, Coman MM, Ricciutelli M, Sagratini G, Vittori S, Lucarini D, Maggi F. Antimicrobial activity of seven hypericum entities from central Italy. Planta Med 2007; 73: 564-6. 18. Getie M, Gebre-Mariam T, Rietz R, Neubert RH. Evaluation of the release profiles of flavonoids from topical formulations of the crude extract of the leaves of Dodonea viscosa (Sapindaceae). Pharmazie 2002; 57: 320-2. 19. Bystrov NS, Dobrynin VN, Kolosov MN, Chernov BK, Chervin, II. Structure of the chromophoric part of hyperforin. Dokl Akad Nauk SSSR 1975; 225: 1327-8. 20. Teixeira AS, Andrade SP. Glucose-induced inhibition of angiogenesis in the rat sponge granuloma is prevented by aminoguanidine. Life Sci 1999; 64: 655-62. 21. Schempp CM, Kiss J, Kirkin V, Averbeck M, Simon-Haarhaus B, Kremer B, Termeer CC, Sleeman J, Simon JC. Hyperforin acts as an angiogenesis inhibitor. Planta Med 2005; 71: 999-1004. 22. Bitar MS, Farook T, Wahid S, Francis IM. Glucocorticoid-dependent impairment of wound healing in experimental diabetes: amelioration by adrenalectomy and RU 486. J Surg Res 1999; 82: 234-43. 23. Ozturk N, Korkmaz S, Ozturk Y. Wound-healing activity of St. John’s Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts. J Ethnopharmacol 2007; 111: 33-9. 24. Arokiyaraj S, Balamurugan R, Augustian P. Antihyperglycemic effect of Hypericum perforatum ethyl acetate extract on streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed 2011; 1: 386-90. 25. Husain GM, Singh PN, Kumar V. Beneficial effects of a standardized Hypericum perforatum extract in rats with experimentally induced hyperglycemia. Drug Discov Ther 2009; 3: 215-20. 26. Can ÖD, Öztürk Y, Öztürk N, Sagratini G, Ricciutelli M, Vittori S, Maggi F. Effects of treatment with St. John’s Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats. Fitoterapia 2011; 82: 576-84. 27. Kamalakkannan N, Prince PS. Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats. Basic Clin Pharmacol Toxicol 2006; 98: 97-103. 28. Sidhu GS, Mani H, Gaddipati JP, Singh AK, Seth P, Banaudha KK, Patnaik GK, Maheshwari RK. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen 1999; 7: 362-37.
Yıl 2018,
Cilt: 52 Sayı: 3, 143 - 149, 01.09.2018
Öz
DOI: 10.26650/eor.2018.505
Purpose
This study aims to investigate the
histopathological and biochemical effects of the topical application of
Hypericum perforatum on the healing of surgical wounds created in the oral
mucosa of rats with experimentally induced diabetes mellitus.
Materials and methods
The study was carried out on 48 adult male
Wistar albino rats. The animals were divided into two main groups as control
and study groups. Two main groups were divided into three subgroups according
to the sacrification days. All rats were given streptozotocin 60 mg/kg, after
72 hours, and those having blood glucose levels above 200 mg/dL were included
in the study. Mucosal defects were created in the palatal area of the rats. H.
perforatum oil was applied topically twice a day to the wounds of the rats in
the study group. Animal were sacrificed on the 3rd, 7th and 10th days and
samples taken from the palatal wounds were examined histologically and
biochemically.
Results
On the 7th day, ulceration, necrosis,
epithelialization, polymorphonuclear leucocytes and hydroxyproline variables
showed statistically significant differences (p<0.05). Ulceration, necrosis
and polymorphonuclear leukocytes values were higher in the control group,
whereas epithelialization and hydroxyproline values were found to be higher in
the H. perforatum group. Among 10th-day groups, there was only a statistically
significant difference between the values of hydroxyproline, whereas H.
perforatum-treated group showed high hydroxyproline levels (p<0.05).
Conclusion
Topically applied H. perforatum did not
create any difference on the 3rd day, but it has positively affected the wound
healing on the 7th and 10th days in diabetic rats.
Kaynakça
- healing in diabetes. Diabet Med 2006; 23: 594-608. 2. Linde K. St. John’s wort - an overview. Forsch Komplementmed 2009; 16: 146-55. 3. Zorzetto C, Sánchez-Mateo CC, Rabanal RM, Lupidi G, Petrelli D, Vitali LA, Bramucci M, Quassinti L, Caprioli G, Papa F, Ricciutelli M, Sagratini G, Vittori S, Maggi F.Phytochemical analysis and in vitro biological activity of three Hypericum species from the Canary Islands (Hypericum reflexum, Hypericum canariense and Hypericum grandifolium). Fitoterapia 2015; 100: 95-109. 4. Damlar I, Arpag OF, Tatli U, Altan A. Effects of Hypericum perforatum on the healing of xenografts: a histomorphometric study in rabbits. BJOMS 2017; 55: 383-7. 5. Süntar IP, Akkol EK, Yilmazer D, Baykal T, Kirmizibekmez H, Alper M, Yeşilada E. Investigations on the in vivo wound healing potential of Hypericum perforatum L. J Ethnopharmacol 2010; 127: 468-77. 6. Wolfle U, Seelinger G, Schempp CM. Topical application of St. John’s wort (Hypericum perforatum). Planta Med 2014; 80: 109-20. 7. Nahrstedt A, Butterweck V. Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry 1997; 30: 129-34. 8. Woessner JF Jr. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 1961; 93: 440-7. 9. Castro FC, Magre A, Cherpinski R, Zelante PM, Neves LM, Esquisatto MA, Mendonça FA, Santos GM. Effects of microcurrent application alone or in combination with topical Hypericum perforatum L. and Arnica montana L. on surgically induced wound healing in Wistar rats. Homeopathy 2012; 101: 147-53. 10. Lavagna SM, Secci D, Chimenti P, Bonsignore L, Ottaviani A, Bizzarri B. Efficacy of Hypericum and Calendula oils in the epithelial reconstruction of surgical wounds in childbirth with caesarean section. Farmaco 2001; 56: 451-3. 11. Yeşilada E, Honda G, Sezik E, Tabata M, Fujita T, Tanaka T, Takeda Y, Takaishi Y. Traditional medicine in Turkey. V. Folk medicine in the inner Taurus Mountains. J Ethnopharmacol 1995; 46: 133-52. 12. Yadollah-Damavandi S, Chavoshi-Nejad M, Jangholi E, Nekouyian N, Hosseini S, Seifaee A, Rafiee S, Karimi H, Ashkani-Esfahani S, Parsa Y, Mohsenikia M. Topical Hypericum perforatum Improves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model. Evid Based Complement Alternat med 2015; 2015: doi: 10.1155/2015/245328. 13. Farsak M, Özdağli G, Özmüş D, Çömelekoğlu Ü, Yalın S, Bozdoğan Arpacı R, Gen R, Kanık A, Ümit Talas D. Effects of Hypericum perforatum on an Experimentally Induced Diabetic Wound in a Rat Model. Wounds 2017; 29: E10-7. 14. Rao SG, Udupa AL, Rao G, Rao PGM, Kulkarni DR. Wound healing activity of Calendula officinalis and Hypericum: two homeopathic drugs promoting wound healing in rats. Fitoterapia 1991; 62: 508-10. 15. Menegazzi M, Di Paola R, Mazzon E, Muià C, Genovese T, Crisafulli C, Suzuki H, Cuzzocrea S. Hypericum perforatum attenuates the development of carrageenan-induced lung injury in mice. Free Radic Biol Med 2006; 40: 740-53. 16. Hammer KD, Hillwig ML, Solco AK, Dixon PM, Delate K, Murphy PA, Wurtele ES, Birt DF. Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells. J Agric Food Chem 2007; 55: 7323-31. 17. Cecchini C, Cresci A, Coman MM, Ricciutelli M, Sagratini G, Vittori S, Lucarini D, Maggi F. Antimicrobial activity of seven hypericum entities from central Italy. Planta Med 2007; 73: 564-6. 18. Getie M, Gebre-Mariam T, Rietz R, Neubert RH. Evaluation of the release profiles of flavonoids from topical formulations of the crude extract of the leaves of Dodonea viscosa (Sapindaceae). Pharmazie 2002; 57: 320-2. 19. Bystrov NS, Dobrynin VN, Kolosov MN, Chernov BK, Chervin, II. Structure of the chromophoric part of hyperforin. Dokl Akad Nauk SSSR 1975; 225: 1327-8. 20. Teixeira AS, Andrade SP. Glucose-induced inhibition of angiogenesis in the rat sponge granuloma is prevented by aminoguanidine. Life Sci 1999; 64: 655-62. 21. Schempp CM, Kiss J, Kirkin V, Averbeck M, Simon-Haarhaus B, Kremer B, Termeer CC, Sleeman J, Simon JC. Hyperforin acts as an angiogenesis inhibitor. Planta Med 2005; 71: 999-1004. 22. Bitar MS, Farook T, Wahid S, Francis IM. Glucocorticoid-dependent impairment of wound healing in experimental diabetes: amelioration by adrenalectomy and RU 486. J Surg Res 1999; 82: 234-43. 23. Ozturk N, Korkmaz S, Ozturk Y. Wound-healing activity of St. John’s Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts. J Ethnopharmacol 2007; 111: 33-9. 24. Arokiyaraj S, Balamurugan R, Augustian P. Antihyperglycemic effect of Hypericum perforatum ethyl acetate extract on streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed 2011; 1: 386-90. 25. Husain GM, Singh PN, Kumar V. Beneficial effects of a standardized Hypericum perforatum extract in rats with experimentally induced hyperglycemia. Drug Discov Ther 2009; 3: 215-20. 26. Can ÖD, Öztürk Y, Öztürk N, Sagratini G, Ricciutelli M, Vittori S, Maggi F. Effects of treatment with St. John’s Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats. Fitoterapia 2011; 82: 576-84. 27. Kamalakkannan N, Prince PS. Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats. Basic Clin Pharmacol Toxicol 2006; 98: 97-103. 28. Sidhu GS, Mani H, Gaddipati JP, Singh AK, Seth P, Banaudha KK, Patnaik GK, Maheshwari RK. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen 1999; 7: 362-37.
Toplam 1 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Araştırmalar |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Eylül 2018 |
| Gönderilme Tarihi | 9 Ekim 2017 |
| Yayımlandığı Sayı | Yıl 2018 Cilt: 52 Sayı: 3 |
