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Ağız Mukozası Epitelinde Psödoepitelyomatöz Hiperplazi

Yıl 2019, Cilt: 21 Sayı: 3, 151 - 155, 30.12.2019

Ömer Günhan Devrim Kahraman

https://doi.org/10.18678/dtfd.662776

Öz

Ağız mukozasını örten çok katlı yassı epitel irritasyonlara açıktır ve anormal reaktif proliferasyonlar gösterebilir. Bu değişiklikler anormal bir klinik kitle yaratabilir ve histolojik olarak neoplastik lezyonları taklit edebilir. Bu reaksiyonlar psödoepitelyomatöz hiperplazi veya psödokarsinomatöz değişiklik olarak adlandırılmaktadır. Epitelin rejeneratif amaçla gösterdiği bu tür anormal proliferasyonlar oral patolojide deneyimsiz hekimlerin yanlışlıkla ağız kanseri tanısı koymalarına neden olabilir. Diğer yandan histolojik benzerliklerden dolayı oral kanserler de reaktif lezyon olarak yanlış tanı alabilirler ve bu da hastaların doğru tedavi almalarında gecikmelere neden olacaktır. Bu makalede ağız ve çevre dokularında psödoepitelyomatöz hiperplaziye yol açabilen nedenlere ve ilişkili olduğu spesifik hastalıklara değinilecektir. Aynı zamanda bu lezyonun morfolojik özellikleri ile histolojik benzerlik gösterebilen oral kanserlerle ayırıcı tanısı işlenecektir. Klinik özelliklerin iyi bilinmesi ve histolojik bulguların dikkatli değerlendirilmesi ileride gelişebilecek istenmeyen sorunları önleyecektir. Bu yazıda verilen bilgiler daha çok patologların kullanımına yönelik olmakla birlikte, klinisyenlerin de tanı sürecindeki sorunları ve güçlükleri bilmeleri doğru tanıyı koymada yol gösterici olacaktır.

Anahtar Kelimeler

psödoepitelyomatöz hiperplazi psödokarsinomatöz değişiklik ağız mukozası

Kaynakça

  • Nayak VN, Uma K, Girish HC, Murgod S, Shyamala K, Naik RB. Pseudoepitheliomatous hyperplasia in oral lesions: A review. J Int Oral Health. 2015;7(9):148-52.
  • El-Khoury J, Kibbi AG, Abbas O. Mucocutaneous pseudoepitheliomatous hyperplasia: A review. Am J Dermatopathol. 2012;34(2):165-75.
  • Zayour M, Lazova R. Pseudoepitheliomatous hyperplasia: A review. Am J Dermatopathol. 2011;33(2):112-26.
  • Zarovnaya E, Black C. Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck. Arch Pathol Lab Med. 2005;129(8):1032-6.
  • Speight PM, Khurram SA, Kujan O. Oral potentially malignant disorders: Risk of progression to malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125(6):612-27.
  • Warter A, Walter P, Meyer C, Barrière P, Galatir L, Wilk A. Mandibula pseusocarcinomatous hyperplasia. Histopathology. 2000;37(2):115-7.
  • Fusch A, Hartmann S, Ernestus K, Mutzbauer G, Linz C, Brands RC, et al. Mandibular intraosseous pseudocarcinomatous hyperplasia: a case report. J Med Case Rep. 2016;10(1):268.
  • Sali AP, Sahay A. Chromoblastomycosis of the leg. Pol J Pathol. 2017;68(2):182-4.
  • Wu A. Pseudocarcinomatous hyperplasia of the urinary bladder. Arch Pathol Lab Med. 2014;138(10):1268-71.
  • Lane Z, Epstein JI. Pseudocarcinomatous epithelial hyperplasia in the bladder unassociated with prior irradiation or chemotherapy. Am J Surg Pathol. 2008;32(1):92-7.
  • Chan TY, Epstein JI. Radiation or chemotherapy cystitis with “pseudocarcinomatous” features. Am J Surg Pathol. 2004;28(7):909-13.
  • Aydintug YS, Bayar GR, Ozkan A, Gunhan O, Musabak U. Thymoma with immunodeficiency with multiple recurrent oral herpetic infections. J Dent Sci. 2016;11(1):103-6.
  • Levandoski KA, Nazarian RM, Asgari MM. Hypertrophic lichen planus mimicking squamous cell carcinoma: The importance of clinicopathologic correlation. JAAD Case Rep. 2017;3(2):151-4.
  • Wipf A, Wipf H, Miller D. Sweet syndrome with pseudocarcinomatous hyperplasia: A case report and review of the literature. J Cutan Pathol. 2019;46(7):520-7.
  • Günhan Ö, Avci A, Dereci Ö, Akgün S, Celasun B. Extensive fibrin accumulation and accompanying epithelial changes in the pathogenesis of ligneous mucosal disease (ligneous periodontitis). Am J Dermatopathol. 2012;34(1):35-40.
  • Simunovic C, Shinohara MM. Complications of decorative tattoos: recognition and management. Am J Clin Dermatol. 2014;15(6):525-36.
  • Price A, Miller JH, Junkins-Hopkins JM. Pseudocarcinomatous hyperplasia in anaplastic large cell lymphoma, a mimicker of poorly differentiated squamous cell carcinoma: Report of a case and review of the literature. J Cutan Pathol. 2015;42(11):863-9.
  • Bellafiore S, Grenzi L, Simonetti V, Piana S. Pseudocarcinomatous hyperplasia hiding lymphomatoid papulosis: A low-power view pitfall. Int J Surg Pathol. 2016;24(3):232-6.
  • Ra SH, Su A, Li X, Binder S. Molecularly enriched pathways and differentially expressed genes distinguishing cutaneous squamous cell carcinoma from pseudoepitheliomatous hyperplasia. Diagn Mol Pathol. 2013;22(1):41-7.

Pseudoepitheliomatous Hyperplasia in Oral Mucosa Epithelium

Yıl 2019, Cilt: 21 Sayı: 3, 151 - 155, 30.12.2019

Ömer Günhan Devrim Kahraman

https://doi.org/10.18678/dtfd.662776

Öz

Squamous epithelium covering the oral mucosa is open to a variety of irritations and may show aberrant reactive proliferations. These changes may create an abnormal clinical mass and histologically mimic neoplastic lesions. These reactions are called pseudoepitheliomatous hyperplasia or pseudocarcinomatous change. Exaggerated abnormal reactive changes may cause misdiagnosis of oral cancer in the mouth by inexperienced persons in oral pathology. On the other hand, due to histological similarities, also oral cancers may underdiagnosed wrongly as reactive lesions and lead to delays in cancer diagnosis and treatment. In this article, the causes of pseudoepitheliomatous hyperplasia and related specific diseases will be discussed. Additionally, the differential diagnosis of oral cancers from reactive lesions will be covered. The well knowing of the clinical features and a careful histological evaluation will prevent undesirable problems in the future. The information of the article is more useful for the pathologists; however, it will be helpful for the clinicians to know the problems and difficulties in the accurate diagnostic process.

Anahtar Kelimeler

pseudoepitheliomatous hyperplasia pseudocarcinomatous change oral mucosa

Kaynakça

  • Nayak VN, Uma K, Girish HC, Murgod S, Shyamala K, Naik RB. Pseudoepitheliomatous hyperplasia in oral lesions: A review. J Int Oral Health. 2015;7(9):148-52.
  • El-Khoury J, Kibbi AG, Abbas O. Mucocutaneous pseudoepitheliomatous hyperplasia: A review. Am J Dermatopathol. 2012;34(2):165-75.
  • Zayour M, Lazova R. Pseudoepitheliomatous hyperplasia: A review. Am J Dermatopathol. 2011;33(2):112-26.
  • Zarovnaya E, Black C. Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck. Arch Pathol Lab Med. 2005;129(8):1032-6.
  • Speight PM, Khurram SA, Kujan O. Oral potentially malignant disorders: Risk of progression to malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125(6):612-27.
  • Warter A, Walter P, Meyer C, Barrière P, Galatir L, Wilk A. Mandibula pseusocarcinomatous hyperplasia. Histopathology. 2000;37(2):115-7.
  • Fusch A, Hartmann S, Ernestus K, Mutzbauer G, Linz C, Brands RC, et al. Mandibular intraosseous pseudocarcinomatous hyperplasia: a case report. J Med Case Rep. 2016;10(1):268.
  • Sali AP, Sahay A. Chromoblastomycosis of the leg. Pol J Pathol. 2017;68(2):182-4.
  • Wu A. Pseudocarcinomatous hyperplasia of the urinary bladder. Arch Pathol Lab Med. 2014;138(10):1268-71.
  • Lane Z, Epstein JI. Pseudocarcinomatous epithelial hyperplasia in the bladder unassociated with prior irradiation or chemotherapy. Am J Surg Pathol. 2008;32(1):92-7.
  • Chan TY, Epstein JI. Radiation or chemotherapy cystitis with “pseudocarcinomatous” features. Am J Surg Pathol. 2004;28(7):909-13.
  • Aydintug YS, Bayar GR, Ozkan A, Gunhan O, Musabak U. Thymoma with immunodeficiency with multiple recurrent oral herpetic infections. J Dent Sci. 2016;11(1):103-6.
  • Levandoski KA, Nazarian RM, Asgari MM. Hypertrophic lichen planus mimicking squamous cell carcinoma: The importance of clinicopathologic correlation. JAAD Case Rep. 2017;3(2):151-4.
  • Wipf A, Wipf H, Miller D. Sweet syndrome with pseudocarcinomatous hyperplasia: A case report and review of the literature. J Cutan Pathol. 2019;46(7):520-7.
  • Günhan Ö, Avci A, Dereci Ö, Akgün S, Celasun B. Extensive fibrin accumulation and accompanying epithelial changes in the pathogenesis of ligneous mucosal disease (ligneous periodontitis). Am J Dermatopathol. 2012;34(1):35-40.
  • Simunovic C, Shinohara MM. Complications of decorative tattoos: recognition and management. Am J Clin Dermatol. 2014;15(6):525-36.
  • Price A, Miller JH, Junkins-Hopkins JM. Pseudocarcinomatous hyperplasia in anaplastic large cell lymphoma, a mimicker of poorly differentiated squamous cell carcinoma: Report of a case and review of the literature. J Cutan Pathol. 2015;42(11):863-9.
  • Bellafiore S, Grenzi L, Simonetti V, Piana S. Pseudocarcinomatous hyperplasia hiding lymphomatoid papulosis: A low-power view pitfall. Int J Surg Pathol. 2016;24(3):232-6.
  • Ra SH, Su A, Li X, Binder S. Molecularly enriched pathways and differentially expressed genes distinguishing cutaneous squamous cell carcinoma from pseudoepitheliomatous hyperplasia. Diagn Mol Pathol. 2013;22(1):41-7.
Toplam 19 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Davetli Derleme
Yazarlar

Ömer Günhan 0000-0002-3712-1469

Devrim Kahraman Bu kişi benim 0000-0001-9858-9252

Yayımlanma Tarihi 30 Aralık 2019
Gönderilme Tarihi 6 Kasım 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 21 Sayı: 3

Kaynak Göster

APA Günhan, Ö., & Kahraman, D. (2019). Ağız Mukozası Epitelinde Psödoepitelyomatöz Hiperplazi. Duzce Medical Journal, 21(3), 151-155. https://doi.org/10.18678/dtfd.662776
AMA Günhan Ö, Kahraman D. Ağız Mukozası Epitelinde Psödoepitelyomatöz Hiperplazi. Duzce Med J. Aralık 2019;21(3):151-155. doi:10.18678/dtfd.662776
Chicago Günhan, Ömer, ve Devrim Kahraman. “Ağız Mukozası Epitelinde Psödoepitelyomatöz Hiperplazi”. Duzce Medical Journal 21, sy. 3 (Aralık 2019): 151-55. https://doi.org/10.18678/dtfd.662776.
EndNote Günhan Ö, Kahraman D (01 Aralık 2019) Ağız Mukozası Epitelinde Psödoepitelyomatöz Hiperplazi. Duzce Medical Journal 21 3 151–155.
IEEE Ö. Günhan ve D. Kahraman, “Ağız Mukozası Epitelinde Psödoepitelyomatöz Hiperplazi”, Duzce Med J, c. 21, sy. 3, ss. 151–155, 2019, doi: 10.18678/dtfd.662776.
ISNAD Günhan, Ömer - Kahraman, Devrim. “Ağız Mukozası Epitelinde Psödoepitelyomatöz Hiperplazi”. Duzce Medical Journal 21/3 (Aralık 2019), 151-155. https://doi.org/10.18678/dtfd.662776.
JAMA Günhan Ö, Kahraman D. Ağız Mukozası Epitelinde Psödoepitelyomatöz Hiperplazi. Duzce Med J. 2019;21:151–155.
MLA Günhan, Ömer ve Devrim Kahraman. “Ağız Mukozası Epitelinde Psödoepitelyomatöz Hiperplazi”. Duzce Medical Journal, c. 21, sy. 3, 2019, ss. 151-5, doi:10.18678/dtfd.662776.
Vancouver Günhan Ö, Kahraman D. Ağız Mukozası Epitelinde Psödoepitelyomatöz Hiperplazi. Duzce Med J. 2019;21(3):151-5.
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