Öz
Oral lesions like ulceration, vesicle, bullae are seen as some of the autoimmune diseases that may be first found to guide the diagnosis when they occur at an early stage of the diseases. These lesions may appear with the skin lesions of the diseases that can be found anywhere in the body. Therefore, directing the patients with lesions in the mouth to the dermatologist for a skin examination and follow-up. This study is informed about etiology, clinical features, and treatment of autoimmune diseases such as lichen planus and pemphigus vulgaris which are caused symptoms in the oral mucosa.
Anahtar Kelimeler
Autoimmune diseases Mucocutaneous Aphthous stomatitis Lichen planus
Kaynakça
- Tüzün Y, Tüzün B, Enver Ö. Dudak ve Ağız Boşluğu Hastalıkları, Dermatoloji, Ed. Tüzün Y, Kotoğan A, Aydemir EH, Baransü O. 2. Baskı, İstanbul, Nobel Tıp Kitapevleri, 1994;537-554.
- Rogers RS, Mehregan DA. Disorders of Oral Cavity, Dermatology, Ed. Moschella SL, Hurley HJ, 3. Baskı. Philadelphia; WB Sounders Company, 1992;2087-2122.
- Çevikbaş U (editör), Güllüoğlu M, Özgür M. Robbins temel patoloji (basic pathology), 8. Basım, İstanbul: Nobel Tıp Kitabevi 2008; 108-118.
- Yücetaş Ş. Ağız ve çevre dokusu hastalıkları A, Güneş Tıp Kitabevi, 2005, s.352-355, 365-377.
- Regezi JA, Sciubba JJ, Jordan RJK. Oral pathology clinical pathologic correlations, fifth edition 2008, Elsevier science, 92-98.
- Krupaa RJ, Sankari SL, Rajeshb E. Oral lichen planus: An overview, J Pharm Bioallied Sci. 2015; 7(Suppl 1): S158–S161
- Carrozzo M, Thorpe R. Oral lichen planus: a review, Minerva Stomatol. 2009; 58(10):519-37.
- Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology, Third edition, Elsevier, 2008; 782-792
- Rajendran R, Sivapadasundaram B. Shafer's Textbook of Oral Pathology; 7th ed. New Delhi, India: Elsevier; 2012. pp. 808–12.
- Langais RP, Miller CS, Nield-Gehrig JS. Color atlas of common oral diseases, Lippincott Williams & Wilkins, fourth edition, 2009. pp.128-150.
- Xiao G, Zuo X. Epigenetics in systemic lupus erythematosus (Review), Biomedical reports 2016; 4:135-139.
- Borchers AT, Leibushor N, Naguwa SM, Cheema GS, Shoenfeld Y, Gershwin ME. Lupus nephritis: a critical review. Autoimmun Rev. 2012 Dec;12(2):174-94.
- Baican A, Chiorean R, Leucuta DC, Baican C, Danescu S, Ciuce D, Sitaru C. Prediction of survival for patients with pemphigus vulgaris and pemphigus foliaceus: a retrospective cohort study. Orphanet Journal of Rare Diseases. 2015; 10:48
- Stanley JR. Pemphigus. In: Freedberg IM EA, Wolff K, Austen KF, Goldsmith LA, Katz SI, Eds. Fitz¬patrick’s Dermatology in General Medicine. 6th Ed, New York: McGraw-Hill Company 2003:558-67.
- Brenner S, Sason A, Sharon O. Pemphigus and Infections. Clin Dermatol. 2002; 20(1):114-8.
- Nguyen ET, Lin SK, Wu JJ. Pemphigus Vulgaris with Tense Bullae. Perm J. 2015; 19(1):77-78.
- Metin SM, Kızılyel O, Elmas ÖF, Bilen H, Akdeniz N, Çalık M, Atasoy M. 102 Pemfigus hastasının retrospektif değerlendirilmesi. Türkderm. 2015; 49: 125-8.
- Kanjanabuch P, Arporniem S, Thamrat S, Thumasombut P. Mucous membrane pemphigoid in a patient with hypertension treated with atenolol: a case report Journal of Medical Case Reports. 2012;6:373.
- Xu HH, Werth VP, Parisi E, Sollecito TP. Mucous membrane pemphigoid. Dent Clin N Am. 2013; 57:611–30.
- Lee HY, Blazek C, Beltraminelli H, Borradori L. Oral mucous membrane pemphigoid: complete response to topical tacrolimus. Acta Derm Venereol. 2011;91(5):604-5.
- Neff AG, Turner M, Mutasim DF. Treatment strategies in mucous membrane pemphigoid. Ther Clin Risk Manag. 2008;4(3):617-26
- Schmidt E, della Torre R, Borradori L. Clinical features and practical diagnosis of bullous pemphigoid. Immunol Allergy Clin North Am. 2012;32(2):217-32.
- Bilic M, Mutasim D. Bullous pemphigoid. In: Enna SJ, David BB, editors. xPharm: The Comprehensive Pharmacology Reference. New York, NY: Elsevier Science Inc. 2007. p.1-9.
- Mihályi L, Kiss M, Dobozy A, Kemény L, Husz S. Clinical relevance of autoantibodies in patients with autoimmune bullous dermatosis. Clin Dev Immunol. 2012;2012:369546
- Patel LM, Lambert PJ, Gagna CE, Maghari A, Lambert WC. Cutaneous signs of systemic disease. Clin Dermatol. 2011;29(5):511-22.
- Ergüven M, Tekin E, Yılmaz Ö, Yıldı N. Sistemik Lupus Eritematozus Vakalarında Klinik Prezantasyon ve Laboratuvar Bulgularının Değerlendirilmesi. Çocuk Dergisi. 2007; 7(4):240-246.
- Trayes KP, Love G, Studdiford JS. Erythema Multiforme: Recognition and Management. Am Fam Physician. 2019;100(2):82-88.
- Mizuki N, Meguro A, Tohnai I, Gul A, Ohno S, Mizuki N. Association of histocompatibility complex class I chain-related gene A and HLA-B alleles with Behçet’s disease in Turkey, Jpn J Ophthalmol, 2007;51(6):431-6.
- Boyvat A. Behçet Hastalığında Deri ve Mukoza Belirtileri. Turkderm. 2009; 43 Özel Sayı 2: 42-7.
- Scherrer MAR, Rocha VB, Garcia LC. Behçet's disease: review with emphasis on dermatological aspects. An Bras Dermatol. 2017; 92(4):452-464.
- Melikoglu M, Uysal S, Krueger JG. Characterization of the divergent wound-healing responses occurring in the pathergy reaction and normal healthy volunteers. J Immunol. 2006; 177: 6415-6421.
- Yazıcı A. Behçet Hastalığı'nın Etiopatogenezi. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 2013;39(2) 131-136.
- Chen LY, Tsaı M, Tsaı LT, Lu HM, Jan CI. Primary Sjögren's syndrome initially presenting as submandibular mucosa associated lymphoid tissue lymphoma. A case report. Oncology Letters. 2016;11: 921-924.
- Foster H, Walker D, Charles P. Association of DR3 with susceptibility to and severity of primary Sjögren’s syndrome in a family study. Br J Rheumatol. 1992; 31:309.
- Hamburger J. Sjögren’s syndrome-managing oral and systemic symptoms via a multidisciplinary approach. Oral Diseases. 2004; 10:306-9.
- Nakagawa Y. Management of drymouth in Sj€ogren’s syndrome. Jpn Dent Sci Rev. 2011;47: 115–23.
Öz
Otoimmun hastalıkların bazılarında ülserasyon, vezikül ve bül gibi ağız lezyonları, hastalığın erken döneminde ortaya çıktığında tanı koymada yol gösterici ilk bulgu olabilir. Bu lezyonlar vücudun herhangi bir yerinde bulunabilen deri lezyonlarıyla birlikte görülebilir. Bu nedenle ağzında lezyon olan hastada derinin tamamının muayenesi için hastanın dermatoloğa yönlendirilmesi ve takibi önemlidir. Bu derlemede oral mukozada bulgu veren liken planus, pemfigus vulgaris gibi otoimmun hastalıkların etiyolojisi, klinik özellikleri ve tedavisi hakkında bilgi verilmiştir.
Anahtar Kelimeler
Otoimmun hastalıklar Mukokutanöz Aftöz Stomatit Liken planus
Kaynakça
- Tüzün Y, Tüzün B, Enver Ö. Dudak ve Ağız Boşluğu Hastalıkları, Dermatoloji, Ed. Tüzün Y, Kotoğan A, Aydemir EH, Baransü O. 2. Baskı, İstanbul, Nobel Tıp Kitapevleri, 1994;537-554.
- Rogers RS, Mehregan DA. Disorders of Oral Cavity, Dermatology, Ed. Moschella SL, Hurley HJ, 3. Baskı. Philadelphia; WB Sounders Company, 1992;2087-2122.
- Çevikbaş U (editör), Güllüoğlu M, Özgür M. Robbins temel patoloji (basic pathology), 8. Basım, İstanbul: Nobel Tıp Kitabevi 2008; 108-118.
- Yücetaş Ş. Ağız ve çevre dokusu hastalıkları A, Güneş Tıp Kitabevi, 2005, s.352-355, 365-377.
- Regezi JA, Sciubba JJ, Jordan RJK. Oral pathology clinical pathologic correlations, fifth edition 2008, Elsevier science, 92-98.
- Krupaa RJ, Sankari SL, Rajeshb E. Oral lichen planus: An overview, J Pharm Bioallied Sci. 2015; 7(Suppl 1): S158–S161
- Carrozzo M, Thorpe R. Oral lichen planus: a review, Minerva Stomatol. 2009; 58(10):519-37.
- Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology, Third edition, Elsevier, 2008; 782-792
- Rajendran R, Sivapadasundaram B. Shafer's Textbook of Oral Pathology; 7th ed. New Delhi, India: Elsevier; 2012. pp. 808–12.
- Langais RP, Miller CS, Nield-Gehrig JS. Color atlas of common oral diseases, Lippincott Williams & Wilkins, fourth edition, 2009. pp.128-150.
- Xiao G, Zuo X. Epigenetics in systemic lupus erythematosus (Review), Biomedical reports 2016; 4:135-139.
- Borchers AT, Leibushor N, Naguwa SM, Cheema GS, Shoenfeld Y, Gershwin ME. Lupus nephritis: a critical review. Autoimmun Rev. 2012 Dec;12(2):174-94.
- Baican A, Chiorean R, Leucuta DC, Baican C, Danescu S, Ciuce D, Sitaru C. Prediction of survival for patients with pemphigus vulgaris and pemphigus foliaceus: a retrospective cohort study. Orphanet Journal of Rare Diseases. 2015; 10:48
- Stanley JR. Pemphigus. In: Freedberg IM EA, Wolff K, Austen KF, Goldsmith LA, Katz SI, Eds. Fitz¬patrick’s Dermatology in General Medicine. 6th Ed, New York: McGraw-Hill Company 2003:558-67.
- Brenner S, Sason A, Sharon O. Pemphigus and Infections. Clin Dermatol. 2002; 20(1):114-8.
- Nguyen ET, Lin SK, Wu JJ. Pemphigus Vulgaris with Tense Bullae. Perm J. 2015; 19(1):77-78.
- Metin SM, Kızılyel O, Elmas ÖF, Bilen H, Akdeniz N, Çalık M, Atasoy M. 102 Pemfigus hastasının retrospektif değerlendirilmesi. Türkderm. 2015; 49: 125-8.
- Kanjanabuch P, Arporniem S, Thamrat S, Thumasombut P. Mucous membrane pemphigoid in a patient with hypertension treated with atenolol: a case report Journal of Medical Case Reports. 2012;6:373.
- Xu HH, Werth VP, Parisi E, Sollecito TP. Mucous membrane pemphigoid. Dent Clin N Am. 2013; 57:611–30.
- Lee HY, Blazek C, Beltraminelli H, Borradori L. Oral mucous membrane pemphigoid: complete response to topical tacrolimus. Acta Derm Venereol. 2011;91(5):604-5.
- Neff AG, Turner M, Mutasim DF. Treatment strategies in mucous membrane pemphigoid. Ther Clin Risk Manag. 2008;4(3):617-26
- Schmidt E, della Torre R, Borradori L. Clinical features and practical diagnosis of bullous pemphigoid. Immunol Allergy Clin North Am. 2012;32(2):217-32.
- Bilic M, Mutasim D. Bullous pemphigoid. In: Enna SJ, David BB, editors. xPharm: The Comprehensive Pharmacology Reference. New York, NY: Elsevier Science Inc. 2007. p.1-9.
- Mihályi L, Kiss M, Dobozy A, Kemény L, Husz S. Clinical relevance of autoantibodies in patients with autoimmune bullous dermatosis. Clin Dev Immunol. 2012;2012:369546
- Patel LM, Lambert PJ, Gagna CE, Maghari A, Lambert WC. Cutaneous signs of systemic disease. Clin Dermatol. 2011;29(5):511-22.
- Ergüven M, Tekin E, Yılmaz Ö, Yıldı N. Sistemik Lupus Eritematozus Vakalarında Klinik Prezantasyon ve Laboratuvar Bulgularının Değerlendirilmesi. Çocuk Dergisi. 2007; 7(4):240-246.
- Trayes KP, Love G, Studdiford JS. Erythema Multiforme: Recognition and Management. Am Fam Physician. 2019;100(2):82-88.
- Mizuki N, Meguro A, Tohnai I, Gul A, Ohno S, Mizuki N. Association of histocompatibility complex class I chain-related gene A and HLA-B alleles with Behçet’s disease in Turkey, Jpn J Ophthalmol, 2007;51(6):431-6.
- Boyvat A. Behçet Hastalığında Deri ve Mukoza Belirtileri. Turkderm. 2009; 43 Özel Sayı 2: 42-7.
- Scherrer MAR, Rocha VB, Garcia LC. Behçet's disease: review with emphasis on dermatological aspects. An Bras Dermatol. 2017; 92(4):452-464.
- Melikoglu M, Uysal S, Krueger JG. Characterization of the divergent wound-healing responses occurring in the pathergy reaction and normal healthy volunteers. J Immunol. 2006; 177: 6415-6421.
- Yazıcı A. Behçet Hastalığı'nın Etiopatogenezi. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 2013;39(2) 131-136.
- Chen LY, Tsaı M, Tsaı LT, Lu HM, Jan CI. Primary Sjögren's syndrome initially presenting as submandibular mucosa associated lymphoid tissue lymphoma. A case report. Oncology Letters. 2016;11: 921-924.
- Foster H, Walker D, Charles P. Association of DR3 with susceptibility to and severity of primary Sjögren’s syndrome in a family study. Br J Rheumatol. 1992; 31:309.
- Hamburger J. Sjögren’s syndrome-managing oral and systemic symptoms via a multidisciplinary approach. Oral Diseases. 2004; 10:306-9.
- Nakagawa Y. Management of drymouth in Sj€ogren’s syndrome. Jpn Dent Sci Rev. 2011;47: 115–23.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Diş Hekimliği |
| Bölüm | Oral Diagnosis and Dentomaxillofacial Radiology |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Haziran 2022 |
| Gönderilme Tarihi | 11 Ocak 2022 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 4 Sayı: 2 |
"Dünyada herşey için, medeniyet için, hayat için, başarı için en gerçek yol gösterici ilimdir, fendir. İlim ve fennin dışında yol gösterici aramak gaflettir, cahilliktir, doğru yoldan sapmaktır. Yalnız ilmin ve fenin yaşadığımız her dakikadaki safhalarının gelişimini anlamak ve ilerlemeleri zamanında takip etmek şarttır. Bin, iki bin, binlerce yıl önceki ilim ve fen lisanının koyduğu kuralları, şu kadar bin yıl sonra bugün aynen uygulamaya kalkışmak elbette ilim ve fennin içinde bulunmak değildir."