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Distraksiyon osteogenezinde düşük yoğunlukta ultrason stimülasyonunun kemik mineral yoğunluğuna etkisinin DEXA ile incelemesi

Year 2012, , 201 - 211, 30.07.2012

Fatih Coşkunses , Funda Tuğcu

https://doi.org/10.7126/cdj.2012.1228

Abstract

Objectives: Distraction osteogenesis (DO) is a surgical method which provides new bone formation by gradually increasing the distance between bone segment surfaces created by osteotomy. In the present study assessing the effect of low intensity pulsed ultrasound stimulation (LIPUS) on bone mineral density (BMD) of the bone formed in distraction osteogenesis (DO) with dual energy X-ray absorptiometry (DEXA) and making a comparison between postoperative 30th and 60th days was aimed.
Materials and Methods: A total of 8 New Zealand rabbits were used in the study While DO was applied to 4 rabbits, 4 were applied 30mW/cm2 (1Mhz) LIPUS on DO site for 20 min a day during distraction period in addition to DO application
Results: In LIPUS group, mean BMD values were seen to be above the initial values on 30th day while on 60th day the increase ratio was greater when compared. BMD values were seen to be below initial values both on 30 and 60 days postoperatively in control group.
Conclusion: By the effect of LIPUS, majority of bone maturation is completed within the first 30 days and gained bone may resist to functional forces.

ÖZET
Amaç: Distraksiyon osteogenezi (DO), osteotomi ile oluşturulmuş kemik segmentlerinin apareyler yardımı ile kademeli olarak birbirinden ayrılmasıyla birlikte yeni kemik oluşumunun sağlandığı cerrahi bir yöntemdir. Bu çalışmada Düşük Yoğunlukta Ultrason Stimülasyonu’nun (DYUS) DO’ inde oluşan kemiğin mineral yoğunluğu üzerine etkinliğinin, cerrahi öncesi ve cerrahi sonrası otuzuncu ve altmışıncı günlerde Dual Enerji X Işını Absorbsiyormetrisi (DEXA) yöntemi ile fotodensitometrik olarak değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem: Çalışmada 8 Yeni Zelanda tavşanı dahil edilmiştir. Tavşanların mandibulalarına DO uygulaması yapılmıştır. 4 tavşana DO uygulamasına ek olarak distraksiyon periyodunda DYUS uygulaması yapılırken 4 tavşana sadece DO uygulaması yapılarak kontrol grubunu oluşturmaları sağlanmıştır.
Bulgular: DYUS uygulaması yapılan grupta kemik mineral yoğunluğunun otuzunca günde başlangıç seviyesinin üzerinde bir değere ulaştığı gözlenmiştir. Aynı grupta altmışıncı günde kemik mineral yoğunluğu değerleri bir miktar daha artmıştır. Kontrol grubunda otuzuncu günde kemik mineral yoğunluğu azalırken altmışıncı günde başlangıç seviyesine yakın değerlere ulaşılmıştır.
Sonuç: DYUS’ un etkisiyle DO’inde kemik olgunlaşmasının büyük bir bölümünün ilk 30 günde tamamlandığı ve kazanılan kemiğin fonksiyonel kuvvetlere direnç gösterebileceği düşünülebilir.
Anahtar Kelimeler: Distraksiyon Osteogenezi, düşük yoğunlukta ultrason stimülasyonu, kemik mineral yoğunluğu.

Keywords

Distraction osteogenesis; low intensity pulsed ultrasound stimulation; bone mineral density

References

  • Ilizarov GA. The tension–stress effect on the genesis and growth of the tissues Part 1; The influence of stability of fixation and soft tissue preservation. 1989;238:249-281. Orthop
  • Lynch SE, Genco RJ, Marx RE. Tissue Engineering Apllications in Maxillofacial Periodontics. Publisihing 1999;131–146. and Quintessence Co Inc, Chicago,
  • Codivilla A. On the means of lengthening, in the lower limb the muscles and tissues which are shortened through deformity. Am J Orthop Surg 1905;2:353–369.
  • Snyder CC, Levine GA, Swanson HM. Mandibular lengthening by gradual distraction. Preliminary report. Plast Reconstr Surg 1973;51:505–514.
  • Mccarthy JG, Schreiber J, Karp N, Thorne CH, Grayson BH. Lengthening the human mandible by gradual distraction. Plast Reconstr Surg 1992;89(1):1–8.[CrossRef]
  • Ryaby JT. Clinical effects of electromagnetic and electric fields on fracture 1998;355:205–215.[CrossRef] Clin Orthop
  • Hadjiargyrou M, Mcleod K, Ryaby JP, Rubin C. Enhancement of fracture healing by low intensity ultrasound. Clin [CrossRef]
  • Ganey TM, Klotch DW, Sasse J. Basement membrane of blood vessels during distraction osteogenesis. Clin Orthop 1994;301:132-139.[CrossRef]
  • Klotch DW, Ganey TM, Slater-Haase A. Assessment of bone formation during osteoneogenesis: A canine model. Otolaryngol Head Neck Surg 1995;112:291-302.[CrossRef] 10. Cope JB, Samchukov ML. Mineralization dynamics of regenerate bone osteodistraction. Int J Oral Maxillofac Surg 2001;30:234-242.[CrossRef]
  • Karaharju-Suvanto T, Karaharju EO, Ranta R. Mandibular distraction. An experimental study on sheep. J Craniomaxillofac Surg 1990;18:280- 283.
  • Tavakoli K, Walsh WW, Bonar F. The role of latency in mandibular osteodistraction. J Craniomaxillofac Surg 1998;26:209-219. [CrossRef]
  • Ayoub AF, Richardson W, Koppel D. Segmental mandibular reconstruction by distraction osteogenesis: An animal study. Br J Oral Maxillofac Surg 2001;39:356-364. automatic
  • Troulis MJ, Glowacki J, Perrott DH. Effects of latency and rate on bone formation in a porcine mandibular distraction model. J Oral Maxillofac Surg 2000;58:507-513.[CrossRef]
  • Wiltfang J, Kessler P, Merten HA. Continuous and intermittent bone distraction using a microhydraulic cylinder: An experimental study in minipigs. Br J Oral Maxillofac Surg 2001; 39:2-7.[CrossRef]
  • Califano L, Cortese A, Zupi A. Mandibular lengthening by external distraction: An experimental study in the rabbit. J Oral Maxillofac Surg 1994;52:1179-1183.[CrossRef]
  • Al Ruhaimi KA. Comparison of different distraction rates in the mandible: investigation. Int J Oral Maxillofac Surg 2001;30:220-227.[CrossRef]
  • Rowe NM, Mehrara BJ, Dudziak ME. mandibular Rat osteogenesis: Part I. Histologic and radiographic analysis. Plast Reconstr Surg 1998;102:2022-2032.[CrossRef]
  • Warren SM, Mehrara BJ, Steinbrech DS. Rat mandibular distraction osteogenesis: distraction versus acute lengthening. Plast Reconstr Surg 2001;107:441- 453.[CrossRef] III. Gradual
  • Aida T, Yoshıoka I, Tomınaga K, Fukuda J. Effects of latency period in a osteogenesis. Int J Oral Maxillofac Surg 2003;32(1):54–63.[CrossRef]
  • Tüz HH, Kişnişci RŞ, Günhan Ö. Histomorphometric short-term changes in masseter muscle after lengthening the rabbit mandible by distraction osteogenesis. J Oral Maxillofac Surg 2003;61:615–620. [CrossRef] evaluation of
  • Tüz HH, Dolanmaz A,bPampu AA, Kişnişci Histomorphometric delayed changes in masseter muscle after lengthening the rabbit mandible by distraction osteogenesis. Oral Diseases 2009;15:142–147. Ö. of
  • Fischgrund J, Paley D, Suter C. Variables affecting time to bone healing during limb lengthening. Clin Orthop 1994;301:31–38.[CrossRef]
  • Aldegheri R. Femoral callotasis. J Pediatr Orthop: Part B 1997;6:42–49. [CrossRef]
  • El-Bialy TH, Royston TJ, Magin RL. The effect of pulsed ultrasound on mandibular distraction. Ann Biomed Eng 2002;30:1251–1261.[CrossRef]
  • Duarte LR. The stimulation of bone growth by ultrasound. Arch Orthop Trauma [CrossRef]
  • Rubin C, Bolander M, Ryaby JP. The use of low-intensity ultrasound to 209 accelerate the healing of fractures. J Bone Joint Surg Am 2001;83.259–265
  • Warden SJ, Favaloro JM, Bennell KL. Low-intensity stimulates a bone-forming response in UMR-106 cells. Biochem Biophys Res [CrossRef] ultrasound Comm 2001;286:443–450.
  • Fëdotov SN, Minin EA, Borisov IN. Effect of local cooling and ultrasound on the reparative processes following mandibular fracture. Stomatologiia (Mosk);1986;65:4–6. 30. Harris M. The management of osteoradionecrosis of the mandible with ultrasound therapy. Br J Oral Maxillofac Surg 1992;30: 313–318.[CrossRef] conservative
  • Chang WH, Sun JS, Chang SP, Lin JC. Study of thermal effects of ultrasound stimulation on fracture healing. 2002;23(4):256–263.[CrossRef]
  • Welgus HG, Jeffrey JJ, Eisen, AA, Roswit WT, Stricklin GP. Human skin fibroblast collagenase: interaction with substrate and inhibitor. Coll Relat Res 1985;5(2):167–179.
  • Fyfe MC, Chahl LA. The effect of ultrasound on experimental oedema in rats. 1980;6(2):107–111.[CrossRef] Med Biol
  • Maxwell L, Collecutt T, Gledhill M, Sharma S, Edgar S, Gavin JB. The augmentation of leucocyte adhesion to endothelium ultrasound. Ultrasound Med Biol 1994;20:383–390.[CrossRef]
  • Doan N, Reher P, Meghji S, Harris M. In vitro effects of therapeutic ultrasound on cell proliferation, protein synthesis, and cytokine production by human fibroblasts, osteoblasts, and monocytes. J Oral Maxillofac Surg 1999;57:409–419. [CrossRef]
  • Reher P, Doan N, Bradnock B, Meghji S, Harris M. Effect of ultrasound on the production of IL-8, basic FGF and VEGF. Cytokine 1999;11:416–423.
  • Sun JS, Tsuang YH, Lin FH. Bone defect healing enhanced by ultrasound stimulation: an in vitro tissue culture model. 1999;46:253–261.[CrossRef] Res
  • Sun JS, Hong RC, Chang WH. In vitro effects of low-intensity ultrasound stimulation on the bone cells. J Biomed Mater Res 2001;57:449–456. [CrossRef]
  • Dyson M, Brookes M. Stimulation of bone repair by ultrasound. Ultrasound Med Biol Suppl 1983;2:61–67.
  • Ding Y, Li G, Zhang X, Jianhua AO, Liu W, Qin MA, Liu Y, Liu B. Effect of low-ıntensity pulsed ultrasound on bone formation during mandible distraction osteogenesis in a canine model. a preliminary study. J Oral Maxillofac Surg 2009;67:2431–2439.
  • Wiltink A, Nijweide PJ, Oosterbaan WA, Hekkenberg RT, Helders PJM. Effect of therapeutic ultrasound on endochondral ossification. Ultrasound Med [CrossRef] 1995;21:121–127.
  • Wu CC, Lewallen DG, Bolander ME, Bronk J, Kinnick R, Greenleaf JF. Exposure to low intensity ultrasound stimulates aggrecan gene expression by cultured chondrocytes. Trans Orthop Res Soc 1996;21:622–634.
  • Parvizi J, Parpura V, Kinnick RR, Greenleaf JF, Bolander ME. Low intensity intracellular concentrations of calcium in chondrocytes. Trans Orthop Res Soc 1997;22:465–470. increases
  • Yang KH, Parvizi J, Wang SJ, Lewallen DG, Kinnick RR, Greenleaf JF, Bolander ME. Exposure to low- intensity aggrecan gene expression in a rat femur fracture model. Journal of Orthopaedic 1996;14(5):802–809.[CrossRef]
  • Harle J, Salih V, Knowles JC, Mayia F, Olsen I. Effects of therapeutic ultrasound expression. J Mater Sci 12(10- 12):1001–1004. osteoblast gene
  • Tis JE, Meffert CR, Inoue N, Mccarthy EF, Machen MS, Mchale KA, Chao EYS. The effect of low intensity pulsed ultrasound applied to rabbit tibiae during the consolidation phase of distraction osteogenesis. J Orthop Res 2006;20:793–800.
  • Eyres KS, Bell MJ, Kanis JA. Methods of assessing new bone formation during limb lengthening. Ultrasonography, dual energy x-ray absorptiometry compared. J Bone Joint Surg 1993;75B:358-364. radiography

Year 2012, , 201 - 211, 30.07.2012

Fatih Coşkunses , Funda Tuğcu

https://doi.org/10.7126/cdj.2012.1228

Abstract

References

  • Ilizarov GA. The tension–stress effect on the genesis and growth of the tissues Part 1; The influence of stability of fixation and soft tissue preservation. 1989;238:249-281. Orthop
  • Lynch SE, Genco RJ, Marx RE. Tissue Engineering Apllications in Maxillofacial Periodontics. Publisihing 1999;131–146. and Quintessence Co Inc, Chicago,
  • Codivilla A. On the means of lengthening, in the lower limb the muscles and tissues which are shortened through deformity. Am J Orthop Surg 1905;2:353–369.
  • Snyder CC, Levine GA, Swanson HM. Mandibular lengthening by gradual distraction. Preliminary report. Plast Reconstr Surg 1973;51:505–514.
  • Mccarthy JG, Schreiber J, Karp N, Thorne CH, Grayson BH. Lengthening the human mandible by gradual distraction. Plast Reconstr Surg 1992;89(1):1–8.[CrossRef]
  • Ryaby JT. Clinical effects of electromagnetic and electric fields on fracture 1998;355:205–215.[CrossRef] Clin Orthop
  • Hadjiargyrou M, Mcleod K, Ryaby JP, Rubin C. Enhancement of fracture healing by low intensity ultrasound. Clin [CrossRef]
  • Ganey TM, Klotch DW, Sasse J. Basement membrane of blood vessels during distraction osteogenesis. Clin Orthop 1994;301:132-139.[CrossRef]
  • Klotch DW, Ganey TM, Slater-Haase A. Assessment of bone formation during osteoneogenesis: A canine model. Otolaryngol Head Neck Surg 1995;112:291-302.[CrossRef] 10. Cope JB, Samchukov ML. Mineralization dynamics of regenerate bone osteodistraction. Int J Oral Maxillofac Surg 2001;30:234-242.[CrossRef]
  • Karaharju-Suvanto T, Karaharju EO, Ranta R. Mandibular distraction. An experimental study on sheep. J Craniomaxillofac Surg 1990;18:280- 283.
  • Tavakoli K, Walsh WW, Bonar F. The role of latency in mandibular osteodistraction. J Craniomaxillofac Surg 1998;26:209-219. [CrossRef]
  • Ayoub AF, Richardson W, Koppel D. Segmental mandibular reconstruction by distraction osteogenesis: An animal study. Br J Oral Maxillofac Surg 2001;39:356-364. automatic
  • Troulis MJ, Glowacki J, Perrott DH. Effects of latency and rate on bone formation in a porcine mandibular distraction model. J Oral Maxillofac Surg 2000;58:507-513.[CrossRef]
  • Wiltfang J, Kessler P, Merten HA. Continuous and intermittent bone distraction using a microhydraulic cylinder: An experimental study in minipigs. Br J Oral Maxillofac Surg 2001; 39:2-7.[CrossRef]
  • Califano L, Cortese A, Zupi A. Mandibular lengthening by external distraction: An experimental study in the rabbit. J Oral Maxillofac Surg 1994;52:1179-1183.[CrossRef]
  • Al Ruhaimi KA. Comparison of different distraction rates in the mandible: investigation. Int J Oral Maxillofac Surg 2001;30:220-227.[CrossRef]
  • Rowe NM, Mehrara BJ, Dudziak ME. mandibular Rat osteogenesis: Part I. Histologic and radiographic analysis. Plast Reconstr Surg 1998;102:2022-2032.[CrossRef]
  • Warren SM, Mehrara BJ, Steinbrech DS. Rat mandibular distraction osteogenesis: distraction versus acute lengthening. Plast Reconstr Surg 2001;107:441- 453.[CrossRef] III. Gradual
  • Aida T, Yoshıoka I, Tomınaga K, Fukuda J. Effects of latency period in a osteogenesis. Int J Oral Maxillofac Surg 2003;32(1):54–63.[CrossRef]
  • Tüz HH, Kişnişci RŞ, Günhan Ö. Histomorphometric short-term changes in masseter muscle after lengthening the rabbit mandible by distraction osteogenesis. J Oral Maxillofac Surg 2003;61:615–620. [CrossRef] evaluation of
  • Tüz HH, Dolanmaz A,bPampu AA, Kişnişci Histomorphometric delayed changes in masseter muscle after lengthening the rabbit mandible by distraction osteogenesis. Oral Diseases 2009;15:142–147. Ö. of
  • Fischgrund J, Paley D, Suter C. Variables affecting time to bone healing during limb lengthening. Clin Orthop 1994;301:31–38.[CrossRef]
  • Aldegheri R. Femoral callotasis. J Pediatr Orthop: Part B 1997;6:42–49. [CrossRef]
  • El-Bialy TH, Royston TJ, Magin RL. The effect of pulsed ultrasound on mandibular distraction. Ann Biomed Eng 2002;30:1251–1261.[CrossRef]
  • Duarte LR. The stimulation of bone growth by ultrasound. Arch Orthop Trauma [CrossRef]
  • Rubin C, Bolander M, Ryaby JP. The use of low-intensity ultrasound to 209 accelerate the healing of fractures. J Bone Joint Surg Am 2001;83.259–265
  • Warden SJ, Favaloro JM, Bennell KL. Low-intensity stimulates a bone-forming response in UMR-106 cells. Biochem Biophys Res [CrossRef] ultrasound Comm 2001;286:443–450.
  • Fëdotov SN, Minin EA, Borisov IN. Effect of local cooling and ultrasound on the reparative processes following mandibular fracture. Stomatologiia (Mosk);1986;65:4–6. 30. Harris M. The management of osteoradionecrosis of the mandible with ultrasound therapy. Br J Oral Maxillofac Surg 1992;30: 313–318.[CrossRef] conservative
  • Chang WH, Sun JS, Chang SP, Lin JC. Study of thermal effects of ultrasound stimulation on fracture healing. 2002;23(4):256–263.[CrossRef]
  • Welgus HG, Jeffrey JJ, Eisen, AA, Roswit WT, Stricklin GP. Human skin fibroblast collagenase: interaction with substrate and inhibitor. Coll Relat Res 1985;5(2):167–179.
  • Fyfe MC, Chahl LA. The effect of ultrasound on experimental oedema in rats. 1980;6(2):107–111.[CrossRef] Med Biol
  • Maxwell L, Collecutt T, Gledhill M, Sharma S, Edgar S, Gavin JB. The augmentation of leucocyte adhesion to endothelium ultrasound. Ultrasound Med Biol 1994;20:383–390.[CrossRef]
  • Doan N, Reher P, Meghji S, Harris M. In vitro effects of therapeutic ultrasound on cell proliferation, protein synthesis, and cytokine production by human fibroblasts, osteoblasts, and monocytes. J Oral Maxillofac Surg 1999;57:409–419. [CrossRef]
  • Reher P, Doan N, Bradnock B, Meghji S, Harris M. Effect of ultrasound on the production of IL-8, basic FGF and VEGF. Cytokine 1999;11:416–423.
  • Sun JS, Tsuang YH, Lin FH. Bone defect healing enhanced by ultrasound stimulation: an in vitro tissue culture model. 1999;46:253–261.[CrossRef] Res
  • Sun JS, Hong RC, Chang WH. In vitro effects of low-intensity ultrasound stimulation on the bone cells. J Biomed Mater Res 2001;57:449–456. [CrossRef]
  • Dyson M, Brookes M. Stimulation of bone repair by ultrasound. Ultrasound Med Biol Suppl 1983;2:61–67.
  • Ding Y, Li G, Zhang X, Jianhua AO, Liu W, Qin MA, Liu Y, Liu B. Effect of low-ıntensity pulsed ultrasound on bone formation during mandible distraction osteogenesis in a canine model. a preliminary study. J Oral Maxillofac Surg 2009;67:2431–2439.
  • Wiltink A, Nijweide PJ, Oosterbaan WA, Hekkenberg RT, Helders PJM. Effect of therapeutic ultrasound on endochondral ossification. Ultrasound Med [CrossRef] 1995;21:121–127.
  • Wu CC, Lewallen DG, Bolander ME, Bronk J, Kinnick R, Greenleaf JF. Exposure to low intensity ultrasound stimulates aggrecan gene expression by cultured chondrocytes. Trans Orthop Res Soc 1996;21:622–634.
  • Parvizi J, Parpura V, Kinnick RR, Greenleaf JF, Bolander ME. Low intensity intracellular concentrations of calcium in chondrocytes. Trans Orthop Res Soc 1997;22:465–470. increases
  • Yang KH, Parvizi J, Wang SJ, Lewallen DG, Kinnick RR, Greenleaf JF, Bolander ME. Exposure to low- intensity aggrecan gene expression in a rat femur fracture model. Journal of Orthopaedic 1996;14(5):802–809.[CrossRef]
  • Harle J, Salih V, Knowles JC, Mayia F, Olsen I. Effects of therapeutic ultrasound expression. J Mater Sci 12(10- 12):1001–1004. osteoblast gene
  • Tis JE, Meffert CR, Inoue N, Mccarthy EF, Machen MS, Mchale KA, Chao EYS. The effect of low intensity pulsed ultrasound applied to rabbit tibiae during the consolidation phase of distraction osteogenesis. J Orthop Res 2006;20:793–800.
  • Eyres KS, Bell MJ, Kanis JA. Methods of assessing new bone formation during limb lengthening. Ultrasonography, dual energy x-ray absorptiometry compared. J Bone Joint Surg 1993;75B:358-364. radiography
There are 45 citations in total.

Details

Primary Language Turkish
Journal Section Original Research Articles
Authors

Fatih Coşkunses

Funda Tuğcu

Publication Date July 30, 2012
Submission Date December 6, 2011
Published in Issue Year 2012

Cite

EndNote Coşkunses F, Tuğcu F (July 1, 2012) Distraksiyon osteogenezinde düşük yoğunlukta ultrason stimülasyonunun kemik mineral yoğunluğuna etkisinin DEXA ile incelemesi. Cumhuriyet Dental Journal 15 3 201–211.

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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