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Evaluating the Predictability and Regenerative Capacity of Novel Platelet Concentrate (PC)-Titanium Platelet Rich Fibrin (T-PRF) in the field of Dentistry- A Narrative Review

Year 2023, , 332 - 339, 29.09.2023

Shiva Shankar Gummalurı , Kaarthikeyan Gurumoorthy , Anil Kumar Kancharla , Ramanarayana Boyapati

https://doi.org/10.7126/cumudj.1252781

Abstract

Periodontal disease treatment is always a challenging task. Various treatment modalities have been applied for treating this painless chronic condition. With advancement in the field of research in dentistry researchers shifted towards the autologous products hence came the usage of platelet concentrates in various branches of dentistry. Initially fibrin glue, platelet rich plasma (PRP) have been tried but because of their drawbacks platelet rich fibrin (PRF) came into play. Due to possible contamination of silica particles in silica tubes or silica coated plastic tubes and shorter resorption time, titanium attracted the researchers. This lead to introduction of titanium platelet rich fibrin (T-PRF) a second generation platelet concentrate. This had a thicker fibrin meshwork, better cellular entrapment, greater resorption rate and titanium tubes are inert, better haemocompatible and non-corrosive. It also eliminates the possible contamination of silica test tubes and silica coated plastic tubes. Present article is a review on T-PRF and its usage in the field of dentistry.

Keywords

Periodontitis Platelet Rich Fibrin Platelets

Supporting Institution

Article is self funded

Project Number

Not applicable

Thanks

Nil

References

  • 1. Könönen E, Gursoy M, Gursoy UK. Periodontitis: a multifaceted disease of tooth-supporting tissues. J Clin Med. 2019;8:1135-1147.
  • 2. Siaili M, Chatzopoulou D, Gillam D. An overview of periodontal regenerative procedures for the general dental practitioner. Saudi Dent J 2018;30:26-37.
  • 3. Barbato L, Selvaggi F, Kalemaj Z, Buti J, Bendinelli E, Marca ML, et al. Clinical efficacy of minimally invasive surgical (MIS) and non-surgical (MINST) treatments of periodontal intra-bony defect. A systematic review and network meta-analysis of RCTs. Clin Oral Investig. 2020;24:1125-1135.
  • 4. Woo HN, Cho YJ, Tarafder S, Lee CH. The recent advances in scaffolds for integrated periodontal regeneration. Bioact Mater. 2021;6:3328-3342.
  • 5. Agrawal AA. Evolution, current status, and advances in the application of platelet concentrate in periodontics and implantology. World J Clin Cases. 2017;5:159-171.
  • 6. Dhillon RS, Schwarz EM, Maloney MD. Platelet-rich plasma therapy-future or trend? Arthritis Res Ther. 2012;14:1-10.
  • 7. Bhumika Vaswani PB. Titanium-Platelet Rich Fibrin. J Res Med Dent Sci. 2022;10:220-223.
  • 8. Fujioka-Kobayashi M, Schaller B, Mourão CFDAB, Zhang Y, Sculean A, Miron RJ. Biological characterization of an injectable platelet-rich fibrin mixture consisting of autologous albumin gel and liquid platelet-rich fibrin (Alb-PRF). Platelets. 2021;32:74-81.
  • 9. Miron RJ, Chai J, Zheng S, Feng M, Sculean A, Zhang Y. A novel method for evaluating and quantifying cell types in platelet-rich fibrin and an introduction to horizontal centrifugation. J Biomed Mater Res A. 2019;107:2257-2271.
  • 10. Serafini G, Lopreiato M, Lollobrigida M, Lamazza L, Mazzucchi G, Fortunato L, et al. Platelet-rich fibrin (PRF) and its related products: biomolecular characterization of the liquid fibrinogen. J Clin Med. 2020;9:1099-1108.
  • 11. Choukroun J, Diss A, Simonpieri A, Girard M-O, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e56-e60.
  • 12. O'Connell SM. Safety issues associated with platelet-rich fibrin method. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:587-593.
  • 13. Tunalı M, Özdemir H, Küçükodacı Z, Akman S, Yaprak E, Toker H, et al. A novel platelet concentrate: titanium-prepared platelet-rich fibrin. BioMed Res Int. 2014;2014:1-8.
  • 14. Tunalı M, Özdemir H, Küçükodacı Z, Akman S, Fıratlı E. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate. British J Oral Maxillofacial Surg. 2013;51:438-443.
  • 15. Chatterjee A, Debnath K, Ali MM, Babu C, Gowda PL. Comparative histologic evaluation of titanium platelet-rich fibrin and platelet-rich fibrin in hypertensive and smoker participants: A cell cytology study. J Indian Soc Periodontol. 2017;21:195-200.
  • 16. Bhattacharya HS, Gummaluri SS, Astekar M, Gummaluri RK. Novel method of determining the periodontal regenerative capacity of T‑PRF and L‑PRF: An immunohistochemical study. Dent Med Probl. 2020;57:137-144.
  • 17. Gummaluri SS, Bhattacharya HS, Astekar M, Cheruvu S. Evaluation of titanium-prepared platelet-rich fibrin and leucocyte platelet-rich fibrin in the treatment of intra-bony defects: A randomized clinical trial. J Dent Res Dent Clin Dent Prospects. 2020;14:83-91.
  • 18. Pachito DV, Bagattini ÂM, de Almeida AM, Mendrone-Júnior A, Riera R. Technical Procedures for Preparation and Administration of Platelet-Rich Plasma and Related Products: A Scoping Review. Front Cell Dev Biol. 2020;8:1556-1567.
  • 19. Pradeep A, Rao NS, Agarwal E, Bajaj P, Kumari M, Naik SB. Comparative evaluation of autologous platelet‐rich fibrin and platelet‐rich plasma in the treatment of 3‐wall intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2012;83:1499-1507.
  • 20. Ghanaati S, Booms P, Orlowska A, Kubesch A, Lorenz J, Rutkowski J, et al. Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. J Oral Implantol. 2014;40:679-689.
  • 21. Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig. 2017;21:2619-2627.
  • 22. Dai Y, Han X-H, Hu L-H, Wu H-W, Huang S-Y, Lü Y-P. Efficacy of concentrated growth factors combined with mineralized collagen on quality of life and bone reconstruction of guided bone regeneration. Regen Biomater. 2020;7:313-320.
  • 23. Fujioka-Kobayashi M, Kono M, Katagiri H, Schaller B, Zhang Y, Sculean A, et al. Histological comparison of Platelet-rich fibrin clots prepared by fixed-angle versus horizontal centrifugation. Platelets. 2021;32:413-419.
  • 24. Mitra DK, Potdar PN, Prithyani SS, Rodrigues SV, Shetty GP, Talati MA. Comparative study using autologous platelet-rich fibrin and titanium prepared platelet-rich fibrin in the treatment of infrabony defects: An in vitro and in vivo study. J Indian Soc Periodontol. 2019;23:554-561.
  • 25. Yajamanya SR, Chatterjee A, Babu CN, Karunanithi D. Fibrin network pattern changes of platelet-rich fibrin in young versus old age group of individuals: A cell block cytology study. J Indian Soc Periodontol. 2016;20:151-156.
  • 26. Bhattacharya HS, Gummaluri SS, Astekar M, Sapra G and, Manjunath RGS. Comparative histological evaluation of L-PRF with T-PRF: A scanning electron microscopic study. J Exp Ther Oncol. 2022;13:207-213 (article in press).
  • 27. Ravi S, Santhanakrishnan M. Mechanical, chemical, structural analysis and comparative release of PDGF-AA from L-PRF, A-PRF and T-PRF-an in vitro study. Biomater Res. 2020;24:1-10.
  • 28. Arabaci T, Albayrak M. Titanium‐prepared platelet‐rich fibrin provides advantages on periodontal healing: A randomized split‐mouth clinical study. J Periodontol. 2018;89:255-264.
  • 29. Pirebas H, Hendek M, Kisa U, Yalim M, Erdemir E. Effect of titanium-prepared platelet-rich fibrin treatment on the angiogenic biomarkers in gingival crevicular fluid in infrabony defects of patients with chronic periodontitis: A randomized controlled clinical trial. Niger J Clin Pract. 2018;21:69-75.
  • 30. Chatterjee A, Pradeep AR, Garg V, Yajamanya S, Ali MM, Priya VS. Treatment of periodontal intrabony defects using autologous platelet‐rich fibrin and titanium platelet‐rich fibrin: a randomized, clinical, comparative study. J Invest Clin Dent. 2017;8:e12231-e12236.
  • 31. Ustaoğlu G, Aydin ZU, Özelçi F. Comparison of GTR, T-PRF and open-flap debridement in the treatment of intrabony defects with endo-period lesions: a randomized controlled trial. Med Oral Patol Oral Cir Bucal. 2020;25:e117-e123.
  • 32. Razi MA, Mahajan A, Qamar S, Mehra S, Roy TR, Kumari P. A Comparative Study of Platelet-rich Fibrin (PRF) and Titanium-prepared Platelet-rich Fibrin (T-PRF) in Management of Endo-period Lesions. The Journal of Contemporary Dental Practice. 2020;21:998-1001.
  • 33. Ustaoğlu G, Ercan E, Tunali M. The role of titanium-prepared platelet-rich fibrin in palatal mucosal wound healing and histoconduction. Acta Odontol Scand. 2016;74:558-564.
  • 34. Mahale SA, Katkurwar A, Bhandare JV, Mahale A. The use of titanium platelet-rich fibrin to enhance the treatment outcome of intrabony defect in the chronic periodontitis patients–A systematic review and meta-analysis. J Dent Res Rev. 2022;9:1-8.
  • 35. Reshma AP, Varghese SS, Pampadykandathil LP. Comparison between the regenerative potential of different types of platelet concentrates in periodontal intrabony defect management: A systematic review. J Indian Soc Periodontol. 2022;26:425-433.
  • 36. Gummaluri SS, Bhattacharya HS, Kumar G, Chaudhary B, Karthikeyan SS. Predictable treatment of gingival recession using titanium prepared platelet-rich fibrin in combination with coronally advanced flap. Contemp Clin Dent. 2021;12:174-178.
  • 37. Ahmed S, Yadav S, Kaushik M. Promenade to enhanced aesthetics: Gingival recession coverage in combination of modified coronally advanced tunnel technique with T-PRF, A case report. J Positive School Psychol. 2022;6:3352-3357.
  • 38. Agarwal MC, Rathore P, Gummaluri SS, Agarwal P, Kumari S. Vestibular incision subperiosteal tunnel access with titanium-prepared platelet-rich fibrin–A golden approach for treating multiple recession defects in esthetic zone. Contemp Clin Dent. 2019;10:682-685.
  • 39. Agarwal MC, Kumar G, Manjunath RS, Karthikeyan SS, Gummaluri SS. Pinhole surgical technique–A novel minimally invasive approach for treatment of multiple gingival recession defects: A case series. Contemp Clin Dent. 2020;11:97-100.
  • 40. Koyuncuoglu CZ, Ercan E, Bilge U, Tunali M, Firatli E. Management of Deep Gingival Recessions by Modified Coronally Advanced Tunnel Technique with Titanium Platelet Rich Fibrin Membrane or Connective Tissue Graft: 36 Months Follow-up Clinical Study. Clin Exp Health Sci. 2020;10:297-303.
  • 41. Bhattacharya HS, Gummaluri SS, Rani A, Verma S, Bhattacharya P, Rayashettypura Gurushanth SM. Additional benefits of titanium platelet-rich fibrin (T-PRF) with a coronally advanced flap (CAF) for recession coverage: A case series. Dent Med Probl. 2023;60(2):279-285.
  • 42. Olgun E, Ozkan SY, Atmaca HT, Yalim M, Hendek MK. Comparison of the clinical, radiographic, and histological effects of titanium‐prepared platelet-rich fibrin to allograft materials in sinus‐lifting procedures. J Invest Clin Dent. 2018;9:e12347-e12354.
  • 43. Ustaoğlu G, Paksoy T, Gümüş KÇ. Titanium-prepared platelet-rich fibrin versus connective tissue graft on peri-implant soft tissue thickening and keratinized mucosa width: a randomized, controlled trial. J Oral Maxillofac Surg. 2020;78:1112-1123.
  • 44. Ercan E, Suner SS, Silan C, Yilmaz S, Siddikoglu D, Sahiner N, et al. Titanium platelet–rich fibrin (T-PRF) as a high-capacity doxycycline delivery system. Clin Oral Investig. 2022:1-10.
  • 45. Şentürk F, Bahadır O, Aktaş O, Bıyık AF, Ercan E. Effects of titanium prepared platelet-rich fibrin on facial nerve regeneration: an experimental study. Braz J Otorhinolaryngol. 2022;88:867-874.

Year 2023, , 332 - 339, 29.09.2023

Shiva Shankar Gummalurı , Kaarthikeyan Gurumoorthy , Anil Kumar Kancharla , Ramanarayana Boyapati

https://doi.org/10.7126/cumudj.1252781

Abstract

Keywords

Periodontitis Platelet Rich Fibrin Platelets

Project Number

Not applicable

References

  • 1. Könönen E, Gursoy M, Gursoy UK. Periodontitis: a multifaceted disease of tooth-supporting tissues. J Clin Med. 2019;8:1135-1147.
  • 2. Siaili M, Chatzopoulou D, Gillam D. An overview of periodontal regenerative procedures for the general dental practitioner. Saudi Dent J 2018;30:26-37.
  • 3. Barbato L, Selvaggi F, Kalemaj Z, Buti J, Bendinelli E, Marca ML, et al. Clinical efficacy of minimally invasive surgical (MIS) and non-surgical (MINST) treatments of periodontal intra-bony defect. A systematic review and network meta-analysis of RCTs. Clin Oral Investig. 2020;24:1125-1135.
  • 4. Woo HN, Cho YJ, Tarafder S, Lee CH. The recent advances in scaffolds for integrated periodontal regeneration. Bioact Mater. 2021;6:3328-3342.
  • 5. Agrawal AA. Evolution, current status, and advances in the application of platelet concentrate in periodontics and implantology. World J Clin Cases. 2017;5:159-171.
  • 6. Dhillon RS, Schwarz EM, Maloney MD. Platelet-rich plasma therapy-future or trend? Arthritis Res Ther. 2012;14:1-10.
  • 7. Bhumika Vaswani PB. Titanium-Platelet Rich Fibrin. J Res Med Dent Sci. 2022;10:220-223.
  • 8. Fujioka-Kobayashi M, Schaller B, Mourão CFDAB, Zhang Y, Sculean A, Miron RJ. Biological characterization of an injectable platelet-rich fibrin mixture consisting of autologous albumin gel and liquid platelet-rich fibrin (Alb-PRF). Platelets. 2021;32:74-81.
  • 9. Miron RJ, Chai J, Zheng S, Feng M, Sculean A, Zhang Y. A novel method for evaluating and quantifying cell types in platelet-rich fibrin and an introduction to horizontal centrifugation. J Biomed Mater Res A. 2019;107:2257-2271.
  • 10. Serafini G, Lopreiato M, Lollobrigida M, Lamazza L, Mazzucchi G, Fortunato L, et al. Platelet-rich fibrin (PRF) and its related products: biomolecular characterization of the liquid fibrinogen. J Clin Med. 2020;9:1099-1108.
  • 11. Choukroun J, Diss A, Simonpieri A, Girard M-O, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e56-e60.
  • 12. O'Connell SM. Safety issues associated with platelet-rich fibrin method. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:587-593.
  • 13. Tunalı M, Özdemir H, Küçükodacı Z, Akman S, Yaprak E, Toker H, et al. A novel platelet concentrate: titanium-prepared platelet-rich fibrin. BioMed Res Int. 2014;2014:1-8.
  • 14. Tunalı M, Özdemir H, Küçükodacı Z, Akman S, Fıratlı E. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate. British J Oral Maxillofacial Surg. 2013;51:438-443.
  • 15. Chatterjee A, Debnath K, Ali MM, Babu C, Gowda PL. Comparative histologic evaluation of titanium platelet-rich fibrin and platelet-rich fibrin in hypertensive and smoker participants: A cell cytology study. J Indian Soc Periodontol. 2017;21:195-200.
  • 16. Bhattacharya HS, Gummaluri SS, Astekar M, Gummaluri RK. Novel method of determining the periodontal regenerative capacity of T‑PRF and L‑PRF: An immunohistochemical study. Dent Med Probl. 2020;57:137-144.
  • 17. Gummaluri SS, Bhattacharya HS, Astekar M, Cheruvu S. Evaluation of titanium-prepared platelet-rich fibrin and leucocyte platelet-rich fibrin in the treatment of intra-bony defects: A randomized clinical trial. J Dent Res Dent Clin Dent Prospects. 2020;14:83-91.
  • 18. Pachito DV, Bagattini ÂM, de Almeida AM, Mendrone-Júnior A, Riera R. Technical Procedures for Preparation and Administration of Platelet-Rich Plasma and Related Products: A Scoping Review. Front Cell Dev Biol. 2020;8:1556-1567.
  • 19. Pradeep A, Rao NS, Agarwal E, Bajaj P, Kumari M, Naik SB. Comparative evaluation of autologous platelet‐rich fibrin and platelet‐rich plasma in the treatment of 3‐wall intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2012;83:1499-1507.
  • 20. Ghanaati S, Booms P, Orlowska A, Kubesch A, Lorenz J, Rutkowski J, et al. Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. J Oral Implantol. 2014;40:679-689.
  • 21. Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig. 2017;21:2619-2627.
  • 22. Dai Y, Han X-H, Hu L-H, Wu H-W, Huang S-Y, Lü Y-P. Efficacy of concentrated growth factors combined with mineralized collagen on quality of life and bone reconstruction of guided bone regeneration. Regen Biomater. 2020;7:313-320.
  • 23. Fujioka-Kobayashi M, Kono M, Katagiri H, Schaller B, Zhang Y, Sculean A, et al. Histological comparison of Platelet-rich fibrin clots prepared by fixed-angle versus horizontal centrifugation. Platelets. 2021;32:413-419.
  • 24. Mitra DK, Potdar PN, Prithyani SS, Rodrigues SV, Shetty GP, Talati MA. Comparative study using autologous platelet-rich fibrin and titanium prepared platelet-rich fibrin in the treatment of infrabony defects: An in vitro and in vivo study. J Indian Soc Periodontol. 2019;23:554-561.
  • 25. Yajamanya SR, Chatterjee A, Babu CN, Karunanithi D. Fibrin network pattern changes of platelet-rich fibrin in young versus old age group of individuals: A cell block cytology study. J Indian Soc Periodontol. 2016;20:151-156.
  • 26. Bhattacharya HS, Gummaluri SS, Astekar M, Sapra G and, Manjunath RGS. Comparative histological evaluation of L-PRF with T-PRF: A scanning electron microscopic study. J Exp Ther Oncol. 2022;13:207-213 (article in press).
  • 27. Ravi S, Santhanakrishnan M. Mechanical, chemical, structural analysis and comparative release of PDGF-AA from L-PRF, A-PRF and T-PRF-an in vitro study. Biomater Res. 2020;24:1-10.
  • 28. Arabaci T, Albayrak M. Titanium‐prepared platelet‐rich fibrin provides advantages on periodontal healing: A randomized split‐mouth clinical study. J Periodontol. 2018;89:255-264.
  • 29. Pirebas H, Hendek M, Kisa U, Yalim M, Erdemir E. Effect of titanium-prepared platelet-rich fibrin treatment on the angiogenic biomarkers in gingival crevicular fluid in infrabony defects of patients with chronic periodontitis: A randomized controlled clinical trial. Niger J Clin Pract. 2018;21:69-75.
  • 30. Chatterjee A, Pradeep AR, Garg V, Yajamanya S, Ali MM, Priya VS. Treatment of periodontal intrabony defects using autologous platelet‐rich fibrin and titanium platelet‐rich fibrin: a randomized, clinical, comparative study. J Invest Clin Dent. 2017;8:e12231-e12236.
  • 31. Ustaoğlu G, Aydin ZU, Özelçi F. Comparison of GTR, T-PRF and open-flap debridement in the treatment of intrabony defects with endo-period lesions: a randomized controlled trial. Med Oral Patol Oral Cir Bucal. 2020;25:e117-e123.
  • 32. Razi MA, Mahajan A, Qamar S, Mehra S, Roy TR, Kumari P. A Comparative Study of Platelet-rich Fibrin (PRF) and Titanium-prepared Platelet-rich Fibrin (T-PRF) in Management of Endo-period Lesions. The Journal of Contemporary Dental Practice. 2020;21:998-1001.
  • 33. Ustaoğlu G, Ercan E, Tunali M. The role of titanium-prepared platelet-rich fibrin in palatal mucosal wound healing and histoconduction. Acta Odontol Scand. 2016;74:558-564.
  • 34. Mahale SA, Katkurwar A, Bhandare JV, Mahale A. The use of titanium platelet-rich fibrin to enhance the treatment outcome of intrabony defect in the chronic periodontitis patients–A systematic review and meta-analysis. J Dent Res Rev. 2022;9:1-8.
  • 35. Reshma AP, Varghese SS, Pampadykandathil LP. Comparison between the regenerative potential of different types of platelet concentrates in periodontal intrabony defect management: A systematic review. J Indian Soc Periodontol. 2022;26:425-433.
  • 36. Gummaluri SS, Bhattacharya HS, Kumar G, Chaudhary B, Karthikeyan SS. Predictable treatment of gingival recession using titanium prepared platelet-rich fibrin in combination with coronally advanced flap. Contemp Clin Dent. 2021;12:174-178.
  • 37. Ahmed S, Yadav S, Kaushik M. Promenade to enhanced aesthetics: Gingival recession coverage in combination of modified coronally advanced tunnel technique with T-PRF, A case report. J Positive School Psychol. 2022;6:3352-3357.
  • 38. Agarwal MC, Rathore P, Gummaluri SS, Agarwal P, Kumari S. Vestibular incision subperiosteal tunnel access with titanium-prepared platelet-rich fibrin–A golden approach for treating multiple recession defects in esthetic zone. Contemp Clin Dent. 2019;10:682-685.
  • 39. Agarwal MC, Kumar G, Manjunath RS, Karthikeyan SS, Gummaluri SS. Pinhole surgical technique–A novel minimally invasive approach for treatment of multiple gingival recession defects: A case series. Contemp Clin Dent. 2020;11:97-100.
  • 40. Koyuncuoglu CZ, Ercan E, Bilge U, Tunali M, Firatli E. Management of Deep Gingival Recessions by Modified Coronally Advanced Tunnel Technique with Titanium Platelet Rich Fibrin Membrane or Connective Tissue Graft: 36 Months Follow-up Clinical Study. Clin Exp Health Sci. 2020;10:297-303.
  • 41. Bhattacharya HS, Gummaluri SS, Rani A, Verma S, Bhattacharya P, Rayashettypura Gurushanth SM. Additional benefits of titanium platelet-rich fibrin (T-PRF) with a coronally advanced flap (CAF) for recession coverage: A case series. Dent Med Probl. 2023;60(2):279-285.
  • 42. Olgun E, Ozkan SY, Atmaca HT, Yalim M, Hendek MK. Comparison of the clinical, radiographic, and histological effects of titanium‐prepared platelet-rich fibrin to allograft materials in sinus‐lifting procedures. J Invest Clin Dent. 2018;9:e12347-e12354.
  • 43. Ustaoğlu G, Paksoy T, Gümüş KÇ. Titanium-prepared platelet-rich fibrin versus connective tissue graft on peri-implant soft tissue thickening and keratinized mucosa width: a randomized, controlled trial. J Oral Maxillofac Surg. 2020;78:1112-1123.
  • 44. Ercan E, Suner SS, Silan C, Yilmaz S, Siddikoglu D, Sahiner N, et al. Titanium platelet–rich fibrin (T-PRF) as a high-capacity doxycycline delivery system. Clin Oral Investig. 2022:1-10.
  • 45. Şentürk F, Bahadır O, Aktaş O, Bıyık AF, Ercan E. Effects of titanium prepared platelet-rich fibrin on facial nerve regeneration: an experimental study. Braz J Otorhinolaryngol. 2022;88:867-874.
There are 45 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Review
Authors

Shiva Shankar Gummalurı 0000-0003-3892-7322

Kaarthikeyan Gurumoorthy 0000-0002-5521-7157

Anil Kumar Kancharla 0000-0003-2161-0687

Ramanarayana Boyapati 0000-0002-9196-0183

Project Number Not applicable
Publication Date September 29, 2023
Submission Date February 21, 2023
Published in Issue Year 2023

Cite

EndNote Gummalurı SS, Gurumoorthy K, Kancharla AK, Boyapati R (September 1, 2023) Evaluating the Predictability and Regenerative Capacity of Novel Platelet Concentrate (PC)-Titanium Platelet Rich Fibrin (T-PRF) in the field of Dentistry- A Narrative Review. Cumhuriyet Dental Journal 26 3 332–339.

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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