NEKROTİZAN PERİODONTAL HASTALIKLARDA SERUM İSKEMİK MODİFİYE ALBÜMİN SEVİYELERİNİN DEĞERLENDİRİLMESİ: ÖN ÇALIŞMA
Öz
Amaç:
Albümin, primer olarak karaciğerden sentezlenen majör bir plazma proteinidir.
İskemi, hipoksi, asidozis, süperoksid-radikal yaralanmaları gibi birçok durum,
albüminin metal iyon bağlama kapasitesinde azalmaya ve metabolik olarak farklı
protein üretimine neden olmakta- dır. Bu değişim, ölçülebilir bir değişim olup,
iskemik modi- fiye albümin (IMA) olarak bilinir. Serumdaki artmış iske- mik
modifiye albümin seviyeleri, C-reaktif protein (CRP) ve interlökin-6 (IL-6)
seviyeleri ile anlamlı derecede ilişkili bulunmuştur. Bu ön çalışmanın amacı,
nekrotizan ülseratif periodontal hastalıklarda IMA seviyelerini, bu seviyelerin
CRP ve IL-6 seviyeleri ile ilişkisini ve bu değerlerin periodontal tedaviden
sonra nasıl değiştiğini incelemektir.
Gereç ve Yöntem: Bu
çalışmada, nekrotizan ülseratif gingivitis (NUG) (1 vaka) ve nekrotizan
ülseratif perio- dontitisin (NUP) akut ve subakut fazlarında olan hastaların (2
vaka) başlangıçtaki ve cerrahi olmayan periodontal tedavi sonrası 1. aydaki ve
sistemik ve periodontal olarak sağlıklı kontrol bireylerinin (3 vaka)
başlangıçtaki serum IMA, CRP ve IL-6 seviyeleri değerlendirilmiştir.
Bulgular: Başlangıçtaki
CRP ve IL-6 seviyeleri NUP’un akut fazında olan hastada NUP’un subakut fazında
olan hastaya ve NUG hastasına göre daha yüksek bulunmuş- tur. CRP ve IL-6
seviyeleri nekrotizan hastalıklarda kontrol bireylerine göre daha yüksek
bulunmuştur. Başlangıçtaki IMA seviyelerinin NUP hastalarında, NUG hastasına
göre daha yüksek olduğu gözlenirken; en düşük değerler kont- rol bireylerinde
bulunmuştur. IMA, CRP ve IL-6 değerleri- nin her üçü de tedavi ile birlikte
kontrol seviyelerine düşüş göstermiştir.
Sonuç: Bu
çalışmanın sonuçları göz önüne alınırsa, nek- rotizan periodontal hastalıklarda
artan IMA seviyelerinin,
hastalık aktivite kriteri olarak kullanılabileceğini söyleye- biliriz.
Anahtar kelimeler:
Nekrotizan ülseratif gingivitis, nekrotizan ülseratif periodontitis, iskemik
modifiye albümin
EVALUATION OF ISCHEMIA MODIFIED ALBUMIN LEVELS IN
NECROTIZING ULCERATIVE PERIODONTAL DISEASES: PRELIMINARY STUDY
ABSTRACT
Aim: Albumin is a major plasma protein synthesized primarily in the liver.
Various conditions; such as ischemia, hypoxia, acidosis, superoxide-radical
injury cause reduction of the binding capacity of albumin for metals and cause
metabolic production of different proteins. This variation is measurable and
it’s known as ischemia modified albumin (IMA). Increased serum levels of IMA
were significantly associated with serum levels of C-reactive protein (CRP) and
interleukin-6 (IL-6). The aim of this preliminary study is to investigate the
IMA levels, and the relationship between the levels of IMA and CRP and also
IL-6 in patients with necrotizing ulcerative periodontal diseases.
Case Reports: In this study, serum IMA, CRP and IL-6 levels were
determined by ELISA method in patients with NUG, with acute and sub acute
phases of NUP, and in systemically and periodontally healthy control subjects,
before and after 1 month of non-surgical periodontal treatment.
Results: Baseline CRP and IL-6 levels
were higher in-patient with acute phase of NUP than the
patients with sub acute phase of NUP, and NUG. At the same time, CRP and IL-6
levels were higher in necrotizing diseases than in control subjects. Baseline
IMA levels were higher in patients with acute and sub acute phases of NUP than the patient with NUG. And baseline
IMA levels were higher in both NUP and NUG patients than in control subjects.
Conclusion: Based on our
results, we can say the increased levels of IMA in necrotizing periodontal
disease; can be used as a criterion of disease activity.
Keywords: Acute
necrotizing ulcerative gingivitis, necrotizing ulcerative periodontitis,
ischemia modified albumin
Anahtar Kelimeler
Nekrotizan ülseratif gingivitis nekrotizan ülseratif periodontitis
Kaynakça
- 1. Barnes GP, Bowles WF, Carter HG. Acute necrotizing ulcerative gingivitis: A survey of 218 cases. J Periodontol 1973; 44:35-42.
- 2. Kara C, Demir T, Tezel A. Kronik Periodontitisin Ağız Kokusuyla İlişkisi. Atatürk Üniv Diş Hek Fak Derg 2007; 17: 6-11.
- 3. Horning GM, Cohen ME. Necrotizing ulcerative gingivitis, periodontitis, and stomatitis: Clinical staging and predisposing factors. J Periodontol 1995; 66:990-8.
- 4. Grupe HE, Wilder LS. Observations of necrotizing gingivitis in 870 military trainees. J Periodontol 1956; 27:255-61.
- 5. Shields WD. Acute necrotizing ulcerative gingivitis. A study of some of the contributing factors and their validity in an Army population. J Periodontol 1977; 48:346-9.
- 6. Stevens AW Jr., Cogen RB, Cohen-Cole S, Freeman A. Demographic and clinical data associated with acute necrotizing ulcerative gingivitis in a dental school population. (ANUG-demographic and clinical data). J Clin Periodontol 1984; 11:487-93.
- 7. Falkler WA Jr., Martin SA, Vincent JW, Tall BD, Nauman RK, Suzuki JB. A clinical, demographic and microbiologic study of ANUG patients in an urban dental school. J Clin Periodontol 1987; 14:307-14.
- 8. Cogen RB, Stevens AW Jr., Cohen-Cole S, Kirk K, Freeman A. Leukocyte function in the etiology of acute necrotizing ulcerative gingivitis. J Periodontol 1983; 54:402-7.
- 9. Enwonwu CO. Epidemiological and biochemical studies of necrotizing ulcerative gingivitis and noma (cancrum oris) in Nigerian children. Arch Oral Biol 1972; 17:1357-71.
- 10. Osuji OO. Necrotizing ulcerative gingivitis and cancrum oris (noma) in Ibadans, Nigeria. J Periodontol 1990;61: 769-72.
- 21. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes review and clinical implications. Clin Chem Lab Med 2011;49:177–84.
- 22. Borderie D, Allanore Y, Meune C, Devaux JY, Ekindjian OG, Kahan A. High ischemia modified albumin concentration reflects oxidative stress but not myocardial involvement in systemic sclerosis. Clin Chem 2004;50:2190–3.
- 23. Kaplan M, Yuksel M, Ates I, Kilic ZM, Kilic H, Kuzu UB, Kayacetin E. Is ischemia modified albumin a disease activity marker for inflammatory bowel diseases? J Gastroenterol Hepatol 2015; 8. [Epub ahead of print]
- 24. Leitemperguer MR, Tatsch E, Kober H, De Carvalho JA, Moresco RN, Da Silva JE. Assessment of ischemia-modified albumin levels in patients with rheumatoid arthritis. Clinical laboratory 2014; 60: 1065-70.
- 25. Ozdemir M, Kiyici A, Balevi A, Mevlitoglu I, Peru C. Assessment of ischaemia-modified albumin level in patients with psoriasis. Clinical and experimental dermatology 2012; 37: 610-4.
- 26. Marshall JC, Vincent JL, Fink MP, Cook DJ, Rubenfeld G, Foster D, et.al. Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000. Crit Care Med 2003; 31:1560-7.
- 27. Gunduz A, Turkmen S, Turedi S, Mentese A, Yulug E, Ulusoy H, et.al. Time-dependent variations in ischemia-modified albumin levels in mesenteric ischemia. Acad Emerg Med 2009;16:539-43.
- 28. Stephensen CB. Burden of infection on growth failure. J Nutr. 1999;129(2S Suppl):534S-8S.
- 29. Horning GM. Necotizing gingivostomatitis: NUG to noma. Compend Contin Educ Dent. 1996;17:951-4.
Öz
Kaynakça
- 1. Barnes GP, Bowles WF, Carter HG. Acute necrotizing ulcerative gingivitis: A survey of 218 cases. J Periodontol 1973; 44:35-42.
- 2. Kara C, Demir T, Tezel A. Kronik Periodontitisin Ağız Kokusuyla İlişkisi. Atatürk Üniv Diş Hek Fak Derg 2007; 17: 6-11.
- 3. Horning GM, Cohen ME. Necrotizing ulcerative gingivitis, periodontitis, and stomatitis: Clinical staging and predisposing factors. J Periodontol 1995; 66:990-8.
- 4. Grupe HE, Wilder LS. Observations of necrotizing gingivitis in 870 military trainees. J Periodontol 1956; 27:255-61.
- 5. Shields WD. Acute necrotizing ulcerative gingivitis. A study of some of the contributing factors and their validity in an Army population. J Periodontol 1977; 48:346-9.
- 6. Stevens AW Jr., Cogen RB, Cohen-Cole S, Freeman A. Demographic and clinical data associated with acute necrotizing ulcerative gingivitis in a dental school population. (ANUG-demographic and clinical data). J Clin Periodontol 1984; 11:487-93.
- 7. Falkler WA Jr., Martin SA, Vincent JW, Tall BD, Nauman RK, Suzuki JB. A clinical, demographic and microbiologic study of ANUG patients in an urban dental school. J Clin Periodontol 1987; 14:307-14.
- 8. Cogen RB, Stevens AW Jr., Cohen-Cole S, Kirk K, Freeman A. Leukocyte function in the etiology of acute necrotizing ulcerative gingivitis. J Periodontol 1983; 54:402-7.
- 9. Enwonwu CO. Epidemiological and biochemical studies of necrotizing ulcerative gingivitis and noma (cancrum oris) in Nigerian children. Arch Oral Biol 1972; 17:1357-71.
- 10. Osuji OO. Necrotizing ulcerative gingivitis and cancrum oris (noma) in Ibadans, Nigeria. J Periodontol 1990;61: 769-72.
- 21. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes review and clinical implications. Clin Chem Lab Med 2011;49:177–84.
- 22. Borderie D, Allanore Y, Meune C, Devaux JY, Ekindjian OG, Kahan A. High ischemia modified albumin concentration reflects oxidative stress but not myocardial involvement in systemic sclerosis. Clin Chem 2004;50:2190–3.
- 23. Kaplan M, Yuksel M, Ates I, Kilic ZM, Kilic H, Kuzu UB, Kayacetin E. Is ischemia modified albumin a disease activity marker for inflammatory bowel diseases? J Gastroenterol Hepatol 2015; 8. [Epub ahead of print]
- 24. Leitemperguer MR, Tatsch E, Kober H, De Carvalho JA, Moresco RN, Da Silva JE. Assessment of ischemia-modified albumin levels in patients with rheumatoid arthritis. Clinical laboratory 2014; 60: 1065-70.
- 25. Ozdemir M, Kiyici A, Balevi A, Mevlitoglu I, Peru C. Assessment of ischaemia-modified albumin level in patients with psoriasis. Clinical and experimental dermatology 2012; 37: 610-4.
- 26. Marshall JC, Vincent JL, Fink MP, Cook DJ, Rubenfeld G, Foster D, et.al. Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000. Crit Care Med 2003; 31:1560-7.
- 27. Gunduz A, Turkmen S, Turedi S, Mentese A, Yulug E, Ulusoy H, et.al. Time-dependent variations in ischemia-modified albumin levels in mesenteric ischemia. Acad Emerg Med 2009;16:539-43.
- 28. Stephensen CB. Burden of infection on growth failure. J Nutr. 1999;129(2S Suppl):534S-8S.
- 29. Horning GM. Necotizing gingivostomatitis: NUG to noma. Compend Contin Educ Dent. 1996;17:951-4.
Ayrıntılar
| Konular | Sağlık Kurumları Yönetimi |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Aralık 2016 |
| Yayımlandığı Sayı | Yıl 2016 Cilt: 26 Sayı: 3 |
Kaynak Göster
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