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Predictive Value of the Intestinal Free Fatty Acid Binding Protein in Celiac Disease

Yıl 2022, Cilt: 13 Sayı: 1, 30 - 35, 01.01.2022
https://doi.org/10.31067/acusaglik.979140

Öz

Purpose: Non-invasive tests used in the screening and follow-up of celiac disease (CD) are currently below expectations because they show false negatives/positives and are not always correlated with duodenal histology. We aimed to investigate the predictive value of intestinal free fatty acid binding protein (FABP-I) which can easily be released into the circulation in the presence of enterocyte damage in a short time in CD.
Methods: This study included 59 patients with CD who were not on gluten free diet (GFD)(n=24) and who were on GFD(n=35) and 52 healthy controls. Demographic variables, complete blood count, ferritin, vitamin D, calcium, phosphorus, vitamin B12, prothrombin time, INR, and serum FABP-I levels were recorded for all groups.
Results: There was no difference between the groups in terms of complete blood count, ferritin, calcium, phosphorus, vitamin B12, prothrombin time and INR (all p>0.05). Mean serum FABP-I was determined as 499.2±33.3 ng/L for patients with CD who were not on GFD and as 487.7±48.0 ng/L for who were on GFD, and these values were significantly higher when compared to the healthy controls 432.2±63.8 ng/L(p<0.001). The sensitivity, specificity, positive predictive value, and negative predictive value of FABP-I for a cut-off value of 456.8 ng/L were 84.7%, 69.2%, 10.2% and 61.5%, respectively(AUC=0.785).

Conclusion: This study has shown that FABP-I can serve as a non-invasive predictive marker for CD diagnosis. Overlooked diagnosis in serology-negative patients and false serology positivity for reasons other than CD will be prevented with its use in clinical practice since FABP-I directly reflects intestinal damage.

Destekleyen Kurum

This work is supported by the Scientific Research Project Fund of Cumhuriyet University

Proje Numarası

T-762.

Kaynakça

  • 1. Vreugdenhil AC, Wolters VM, Adriaanse MP, et al. Additional value of serum I-FABP levels for evaluating celiac disease activity inchildren. Scand J Gastroenterol. 2011;46:1435-41. DOI:10.3109/00365521.2011.627447
  • 2. Adriaanse MP, Tack GJ, Passos VL, et al. Serum I-FABP as marker for enterocyte damage in coeliac disease and its relation to villous atrophy and circulating autoantibodies. Aliment Pharmacol Ther. 2013;37:482-90. DOI:10.1111/apt.12194
  • 3. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol. 1999;11:1185-94. DOI: 10.1097/00042737-199910000-00019
  • 4. Rubio TA, Hill ID, Kelly CP, et al. ACG clinical guidelines: Diagnosis and management of celiac disease. Am J Gastroenterol. 2013;108:656-76. DOI: 10.1038/ajg.2013.79
  • 5. Volta U, Fabbri A, Parisi C, et al. Old and new serological test for celiac disease screening. Expert Rev Gastroenterol Hepatol. 2010;4:31-5. DOI: 10.1586/egh.09.66
  • 6. Lewis NR, Scott BB. Meta-analysis: deamidated gliadin peptide antibody and tissue transglutaminase antibody compared as screening tests for coeliac disease. Aliment Pharmacol Ther. 2010;31:73-81. DOI: 10.1111/j.1365-2036.2009.04110.x
  • 7. Adriaanse MPM, Mubarak A, Riedl RG, et al. Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP. Sci Rep. 2017;7:8671. DOI: 10.1038/s41598-017-07242-4
  • 8. Ho SSC, Keenan JI, Day AS. The Role of Gastrointestinal-Related Fatty Acid-Binding Proteins as Biomarkers in Gastrointestinal Diseases. Dig Dis Sci. 2020;65:376-90. DOI: 10.1007/s10620-019-05841-x
  • 9. Not T, Ziberna F, Vatta S, et al. Cryptic genetic gluten intolerance revealed by intestinal antitransglutaminase antibodies and response to gluten-free diet. Gut. 2011;6011:1487-93. DOI: 10.1136/gut.2010.232900
  • 10. Salardi S, Volta U, Zucchini S, et al. Prevalence of celiac disease in children with type 1 diabetes mellitus increased in the mid-1990s: an 18-year longitudinal study based on anti-endomysial antibodies. J Pediatr Gastroenterol Nutr. 2008;46:612-4. DOI: 10.1097/MPG.0b013e31815d697e
  • 11. Shamaly H, Hartman C, Pollack S, et al. Tissue transglutaminase antibodies are a useful serological marker for the diagnosis of celiac disease in patients with Down syndrome. J Pediatr Gastroenterol Nutr. 2007;44:583-6. DOI: 10.1097/MPG.0b013e3180320679
  • 12. Sardy M, Csikos M, Geisen C, et al. Tissue transglutaminase ELISA positivity in autoimmune disease independent of gluten-sensitive disease. Clin Chim Acta. 2007;376:126-35. DOI: 10.1016/j.cca.2006.08.006
  • 13. Sood A, Khurana MS, Mahajan R, et al. Prevalence and clinical significance of IgA anti-tissue transglutaminase antibodies in patients with chronic liver disease. J Gastroenterol Hepatol. 2017;32:446-50. DOI: 10.1111/jgh.13474
  • 14. Oldenburger IB, Wolters VM, Kardol-Hoefnagel T, et al. Serum intestinal fatty acid-binding protein in the noninvasive diagnosis of celiac disease. APMIS. 2018;126:186-90. DOI: 10.1111/apm.12800
  • 15. Dipper CR, Maitra S, Thomas R, et al. Anti-tissue transglutaminase antibodies in the follow-up of adult coeliac disease. Aliment Parmacol Ther. 2009;30:236-244. DOI: 10.1111/j.1365-2036.2009.04039.x
  • 16. Gidrewicz D, Trevenen CL, Lyon M, et al. Normalization time of celiac serology in children on a gluten-free diet. J Pediatr Gastroenterol Nutr. 2017;64:362-7. DOI: 10.1097/MPG.0000000000001270
  • 17. Al-Toma A, Volta U, Auricchio R, et al. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterol J. 2019;7:583-613. DOI: 10.1177/2050640619844125
Yıl 2022, Cilt: 13 Sayı: 1, 30 - 35, 01.01.2022
https://doi.org/10.31067/acusaglik.979140

Öz

Proje Numarası

T-762.

Kaynakça

  • 1. Vreugdenhil AC, Wolters VM, Adriaanse MP, et al. Additional value of serum I-FABP levels for evaluating celiac disease activity inchildren. Scand J Gastroenterol. 2011;46:1435-41. DOI:10.3109/00365521.2011.627447
  • 2. Adriaanse MP, Tack GJ, Passos VL, et al. Serum I-FABP as marker for enterocyte damage in coeliac disease and its relation to villous atrophy and circulating autoantibodies. Aliment Pharmacol Ther. 2013;37:482-90. DOI:10.1111/apt.12194
  • 3. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol. 1999;11:1185-94. DOI: 10.1097/00042737-199910000-00019
  • 4. Rubio TA, Hill ID, Kelly CP, et al. ACG clinical guidelines: Diagnosis and management of celiac disease. Am J Gastroenterol. 2013;108:656-76. DOI: 10.1038/ajg.2013.79
  • 5. Volta U, Fabbri A, Parisi C, et al. Old and new serological test for celiac disease screening. Expert Rev Gastroenterol Hepatol. 2010;4:31-5. DOI: 10.1586/egh.09.66
  • 6. Lewis NR, Scott BB. Meta-analysis: deamidated gliadin peptide antibody and tissue transglutaminase antibody compared as screening tests for coeliac disease. Aliment Pharmacol Ther. 2010;31:73-81. DOI: 10.1111/j.1365-2036.2009.04110.x
  • 7. Adriaanse MPM, Mubarak A, Riedl RG, et al. Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP. Sci Rep. 2017;7:8671. DOI: 10.1038/s41598-017-07242-4
  • 8. Ho SSC, Keenan JI, Day AS. The Role of Gastrointestinal-Related Fatty Acid-Binding Proteins as Biomarkers in Gastrointestinal Diseases. Dig Dis Sci. 2020;65:376-90. DOI: 10.1007/s10620-019-05841-x
  • 9. Not T, Ziberna F, Vatta S, et al. Cryptic genetic gluten intolerance revealed by intestinal antitransglutaminase antibodies and response to gluten-free diet. Gut. 2011;6011:1487-93. DOI: 10.1136/gut.2010.232900
  • 10. Salardi S, Volta U, Zucchini S, et al. Prevalence of celiac disease in children with type 1 diabetes mellitus increased in the mid-1990s: an 18-year longitudinal study based on anti-endomysial antibodies. J Pediatr Gastroenterol Nutr. 2008;46:612-4. DOI: 10.1097/MPG.0b013e31815d697e
  • 11. Shamaly H, Hartman C, Pollack S, et al. Tissue transglutaminase antibodies are a useful serological marker for the diagnosis of celiac disease in patients with Down syndrome. J Pediatr Gastroenterol Nutr. 2007;44:583-6. DOI: 10.1097/MPG.0b013e3180320679
  • 12. Sardy M, Csikos M, Geisen C, et al. Tissue transglutaminase ELISA positivity in autoimmune disease independent of gluten-sensitive disease. Clin Chim Acta. 2007;376:126-35. DOI: 10.1016/j.cca.2006.08.006
  • 13. Sood A, Khurana MS, Mahajan R, et al. Prevalence and clinical significance of IgA anti-tissue transglutaminase antibodies in patients with chronic liver disease. J Gastroenterol Hepatol. 2017;32:446-50. DOI: 10.1111/jgh.13474
  • 14. Oldenburger IB, Wolters VM, Kardol-Hoefnagel T, et al. Serum intestinal fatty acid-binding protein in the noninvasive diagnosis of celiac disease. APMIS. 2018;126:186-90. DOI: 10.1111/apm.12800
  • 15. Dipper CR, Maitra S, Thomas R, et al. Anti-tissue transglutaminase antibodies in the follow-up of adult coeliac disease. Aliment Parmacol Ther. 2009;30:236-244. DOI: 10.1111/j.1365-2036.2009.04039.x
  • 16. Gidrewicz D, Trevenen CL, Lyon M, et al. Normalization time of celiac serology in children on a gluten-free diet. J Pediatr Gastroenterol Nutr. 2017;64:362-7. DOI: 10.1097/MPG.0000000000001270
  • 17. Al-Toma A, Volta U, Auricchio R, et al. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterol J. 2019;7:583-613. DOI: 10.1177/2050640619844125
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Gastroenteroloji ve Hepatoloji
Bölüm Research Article
Yazarlar

Pınar Gökçen

Erol Çakmak 0000-0002-6468-3483

Gupse Adalı 0000-0002-6468-3483

Halef Dogan 0000-0001-8738-0760

Hatice Özer 0000-0001-6479-3626

Oguzhan Ozturk 0000-0002-7718-8684

Hamdi Levent Doğanay 0000-0002-2263-6689

Kamil Ozdil 0000-0003-2556-3064

Proje Numarası T-762.
Erken Görünüm Tarihi 14 Ekim 2021
Yayımlanma Tarihi 1 Ocak 2022
Gönderilme Tarihi 6 Ağustos 2021
Yayımlandığı Sayı Yıl 2022Cilt: 13 Sayı: 1

Kaynak Göster

EndNote Gökçen P, Çakmak E, Adalı G, Dogan H, Özer H, Ozturk O, Doğanay HL, Ozdil K (01 Ocak 2022) Predictive Value of the Intestinal Free Fatty Acid Binding Protein in Celiac Disease. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 13 1 30–35.