Research Article
Evaluation of the effect of various therapeutic agents on osseointegration of dental implants: Complications in a rabbit tibia model
Abstract
Objective: The aim of our study is to evaluate the complications that occurred on rabbit tibia bones after implant placement.
Material and Method: In our study, 10 adult male white healthy New Zealand rabbits (average weight: 3,000 to 3,500 g) were used. Different numbers of dental implants were placed in the experimental animals. Complications in rabbit tibias were observed and radiological results were reported.
Results: Of the 10 rabbits included in the postoperative study, one (10%) died immediately after the operation, eight (80%) within the first 24 hours, and the last one (10%) died within the next 48 hours of the operation.
Conclusion: Based on the complications experienced during this study and the data we obtained, we conclude that the rabbit tibia is not suitable for such studies. More comprehensive and multi-center studies are needed to draw more firm conclusions on this subject.
Supporting Institution
Van Yuzuncu Yıl University Scientific Research Project
Project Number
TSA-2019-8658
References
- Appukuttan DP. (2016). Strategies to manage patients with dental anxiety and dental phobia: literature review. Clinical, Cosmetic and Investigational Dentistry, 35-50.
- Branemark PI. (1977). Osseointegrated implants in the treatment of the edentulous jaw: experience from a 10-year period. Journal of Plastic, Reconstructive & Aesthetic Surgery, 16, 1-132.
- Del Fabbro M, Testori T, Francetti L, Taschieri S, Weinstein R. (2006). Systematic review of survival rates for immediately loaded dental implants. International Journal of Periodontics & Restorative Dentistry, 26(3).
- Esposito M, Hirsch JM, Lekholm U, Thomsen P. (1998). Biological factors contributing to failures of osseointegrated oral implants,(I). Success criteria and epidemiology. European Journal of Oral Sciences, 106(1), 527-551.
- Francetti L, Cavalli N, TaschieriS, Corbella S. (2019). Ten years follow‐up retrospective study on implant survival rates and prevalence of peri‐implantitis in implant‐supported full‐arch rehabilitations. Clinical Oral Implants Research, 30(3), 252-260.
- Gilsanz V, Roe TF, Gibbens DT, Schulz EE, Carlson ME, Gonzalez O, et al.(1988). Effect of sex steroids on peak bone density of growing rabbits. American Journal of Physiology-Endocrinology and Metabolism, 255(4), E416-E421.
- Hoffmann O, Angelov N, Zafiropoulos GG, Andreana S. (2012). Osseointegration of zirconia implants with different surface characteristics: an evaluation in rabbits. International Journal of Oral & Maxillofacial Implants, 27(2).
- Lang NP, Berglundh T, HeitzMayfield LJ, Pjetursson BE, Salvi GE, Sanz M. (2004). Consensus statements and recommended clinical procedures regarding implant survival and complications. International Journal of Oral and Maxillofacial Implants, 19,150-154.
- Mapara M, Thomas BS, Bhat KM. (2012). Rabbit as an animal model for experimental research. Dental Research Journal, 9(1), 111.
- Marco F, Milena F, Gianluca G, Vittoria O. (2005). Peri-implant osteogenesis in health and osteoporosis. Micron, 36(7-8), 630-644.
- Martiniakova M, Omelka R, Chrenek P, Ryban L, Parkányi V, Grosskopf B, et al. (2005). Changes of femoral bone tissue microstructure in transgenic rabbits. Folia Biologica-Praha, 51(5), 140.
- Misch CE. (2007). Bone Density: A Key Determinant for Treatment Planning. Contemporary Implant Dentistry. 3rd ed. St Louis: Mosby, 130-146.
- Neyt JG, Buckwalter JA, Carroll N. (1998). Use of animal models in musculoskeletal research. The Iowa Orthopaedic Journal, 18, 118.
- Pearce AI, Richards RG, Milz S, Schneider E, Pearce SG. (2007). Animal models for implant biomaterial research in bone: A review. Europan Cells and Materials, 13(1), 1-10.
- Pjetursson BE, Heimisdottir K. (2018). Dental implants are they better than natural teeth? European Journal of Oral Sciences, 126, 81-7. Sanchez-Perez A, Cachazo-Jiménez C, Sánchez-Matás C, Martín-de-Llano JJ, Davis S, Carda-Batalla C. (2020). Effects of ultraviolet photoactivation on osseointegration of commercial pure titanium dental implant after 8 weeks in a rabbit model. Journal of Oral Implantology, 46(2), 101-107.
- Scarano A, Crocetta E, Quaranta A, Lorusso F. (2018). Influence of the thermal treatment to address a better osseointegration of Ti6Al4V dental implants: Histological and histomorphometrical study in a rabbit model. BioMed Research International, 2018.
- Sennerby L, Thomsen P, Ericson LE. (1992). A morphometric and biomechanic comparison of titanium implants inserted in rabbit cortical and cancellous bone. International Journal of Oral & Maxillofacial Implants, 7(1).
- Shi X, Xu L, Violin KB, Lu S. (2016). Improved osseointegration of long-term stored SLA implant by hydrothermal sterilization. Journal of The Mechanical Behavior of Biomedical Materials, 53, 312-319.
- Sykaras N, Iacopino AM, Marker VA, Triplett RG, Woody RD. (2000). Implant materials, designs, and surface topographies: their effect on osseointegration: A literature review. International Journal of Oral & Maxillofacial Implants, 15(5).
Çeşitli terapötik ajanların dental implantların osseointegrasyonu üzerine olan etkisinin incelenmesi: Tavşan tibia modelinde görülen komplikasyonlar
Abstract
Amaç: Çalışmamızın amacı, yerleştirilen implantlar sonrası tavşan tibia kemikleri üzerinde meydana gelen komplikasyonları değerlendirmektir.
Materyal ve Metot: Çalışmamızda sağlıklı (ortalama ağırlığı 3000–3500 g), 10 adet yetişkin erkek, beyaz Yeni Zelanda tavşanı kullanılmıştır. Deney hayvanlarına farklı sayılarda (1-3) dental implant yerleştirilmiştir. Tavşan tibialarındaki komplikasyonlar gözlenmiştir ve radyolojik sonuçları bildirilmiştir.
Bulgular: Operasyon sonrası çalışmaya dahil edilen 10 tavşandan biri (%10) operasyondan hemen sonra, sekizi (%80) operasyon sonrası ilk 24 saat içerisinde ve kalan biri (%10) sonraki 48 saat içerisinde kaybedilmiştir.
Sonuç: Çalışmamız süresince yaşanan komplikasyonlar ve elde etiğimiz verilere göre bu tür çalışmalar için tavşan tibiasının uygun olmadığı sonucuna varılmıştır. Kesin sonuçlar için daha kapsamlı ve çok merkezli çalışmalara gereksinim vardır.
Keywords
Project Number
TSA-2019-8658
References
- Appukuttan DP. (2016). Strategies to manage patients with dental anxiety and dental phobia: literature review. Clinical, Cosmetic and Investigational Dentistry, 35-50.
- Branemark PI. (1977). Osseointegrated implants in the treatment of the edentulous jaw: experience from a 10-year period. Journal of Plastic, Reconstructive & Aesthetic Surgery, 16, 1-132.
- Del Fabbro M, Testori T, Francetti L, Taschieri S, Weinstein R. (2006). Systematic review of survival rates for immediately loaded dental implants. International Journal of Periodontics & Restorative Dentistry, 26(3).
- Esposito M, Hirsch JM, Lekholm U, Thomsen P. (1998). Biological factors contributing to failures of osseointegrated oral implants,(I). Success criteria and epidemiology. European Journal of Oral Sciences, 106(1), 527-551.
- Francetti L, Cavalli N, TaschieriS, Corbella S. (2019). Ten years follow‐up retrospective study on implant survival rates and prevalence of peri‐implantitis in implant‐supported full‐arch rehabilitations. Clinical Oral Implants Research, 30(3), 252-260.
- Gilsanz V, Roe TF, Gibbens DT, Schulz EE, Carlson ME, Gonzalez O, et al.(1988). Effect of sex steroids on peak bone density of growing rabbits. American Journal of Physiology-Endocrinology and Metabolism, 255(4), E416-E421.
- Hoffmann O, Angelov N, Zafiropoulos GG, Andreana S. (2012). Osseointegration of zirconia implants with different surface characteristics: an evaluation in rabbits. International Journal of Oral & Maxillofacial Implants, 27(2).
- Lang NP, Berglundh T, HeitzMayfield LJ, Pjetursson BE, Salvi GE, Sanz M. (2004). Consensus statements and recommended clinical procedures regarding implant survival and complications. International Journal of Oral and Maxillofacial Implants, 19,150-154.
- Mapara M, Thomas BS, Bhat KM. (2012). Rabbit as an animal model for experimental research. Dental Research Journal, 9(1), 111.
- Marco F, Milena F, Gianluca G, Vittoria O. (2005). Peri-implant osteogenesis in health and osteoporosis. Micron, 36(7-8), 630-644.
- Martiniakova M, Omelka R, Chrenek P, Ryban L, Parkányi V, Grosskopf B, et al. (2005). Changes of femoral bone tissue microstructure in transgenic rabbits. Folia Biologica-Praha, 51(5), 140.
- Misch CE. (2007). Bone Density: A Key Determinant for Treatment Planning. Contemporary Implant Dentistry. 3rd ed. St Louis: Mosby, 130-146.
- Neyt JG, Buckwalter JA, Carroll N. (1998). Use of animal models in musculoskeletal research. The Iowa Orthopaedic Journal, 18, 118.
- Pearce AI, Richards RG, Milz S, Schneider E, Pearce SG. (2007). Animal models for implant biomaterial research in bone: A review. Europan Cells and Materials, 13(1), 1-10.
- Pjetursson BE, Heimisdottir K. (2018). Dental implants are they better than natural teeth? European Journal of Oral Sciences, 126, 81-7. Sanchez-Perez A, Cachazo-Jiménez C, Sánchez-Matás C, Martín-de-Llano JJ, Davis S, Carda-Batalla C. (2020). Effects of ultraviolet photoactivation on osseointegration of commercial pure titanium dental implant after 8 weeks in a rabbit model. Journal of Oral Implantology, 46(2), 101-107.
- Scarano A, Crocetta E, Quaranta A, Lorusso F. (2018). Influence of the thermal treatment to address a better osseointegration of Ti6Al4V dental implants: Histological and histomorphometrical study in a rabbit model. BioMed Research International, 2018.
- Sennerby L, Thomsen P, Ericson LE. (1992). A morphometric and biomechanic comparison of titanium implants inserted in rabbit cortical and cancellous bone. International Journal of Oral & Maxillofacial Implants, 7(1).
- Shi X, Xu L, Violin KB, Lu S. (2016). Improved osseointegration of long-term stored SLA implant by hydrothermal sterilization. Journal of The Mechanical Behavior of Biomedical Materials, 53, 312-319.
- Sykaras N, Iacopino AM, Marker VA, Triplett RG, Woody RD. (2000). Implant materials, designs, and surface topographies: their effect on osseointegration: A literature review. International Journal of Oral & Maxillofacial Implants, 15(5).
There are 19 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Periodontics |
| Journal Section | Original Research Articles |
| Authors | |
| Project Number | TSA-2019-8658 |
| Publication Date | August 30, 2023 |
| Submission Date | June 16, 2023 |
| Published in Issue | Year 2023 Volume: 16 Issue: 2 |
Van Health Sciences Journal (Van Sağlık Bilimleri Dergisi) başlıklı eser bu Creative Commons Atıf-Gayri Ticari 4.0 Uluslararası Lisansı ile lisanslanmıştır.
