Review
Year 2020,
Ağız Kanserleri Özel Sayısı, 271 - 274, 28.09.2020
Abstract
Bu derlemedeki amacımız, çocuklarda löseminin erken teşhis edilmesi, klinik özellikleri, komplikasyonları ve ağız içi tedavi yaklaşımları hakkında bilgi vermektir.PUBMED, RESEARCH GATE ve GOOGLE SCHOLAR arama motorlarında ‘leukemia in children’; ‘oral manifestations for leukemia’ ; ‘leukemia oral symptoms’ kelimeleri aratıldı. Literatürlerin başlık ve özetleri değerlendirildi, uygun literatürler seçilerek analiz edildi.Lösemi hematopoetik hücrelerin normalden fazla çoğalmasıyla seyreden malign bir hastalıktır. Etiyolojisi kesin değildir. İlerleme şekline göre akut ve kronik olabilir. Bunun dışında hücrelerin tipine göre ana olarak lenfositik ve myolositik olarak da sınıflandırılır. Tedavisi remisyon indüksiyonu, konsolidasyon ve idame tedavisi olmak üzere üç aşamada yapılır. Yüksek risk grubu lösemi hastalarında kemik iliği nakli yapılması tercih edilebilir. Löseminin tipleri ve tercih edilen tedavi şekline göre ağız içi bulgular farklılık arz edebilir. Semptomlar daha çok pansitopeni (anemi, nötropeni ve trombositopeni) nedeniyle oluşur. Mukozal solgunluk, dişeti kanaması, ekimoz, ülserasyon, trismus, gingival hiperplazi ve mukozal enfeksiyonlar en fazla gözlenen bulgulardır. Tedavi sırasında ve sonrasında ise yapılan işlemlere bağlı olarak mukozitis, kserostomi, deskuamasyon, kandidiazis görülmektedir.Lösemi çocukluk döneminde en fazla görülen malign hastalıktır. Vücudun diğer bölgelerinde olduğu gibi ağız içinde de bulgu verir ve henüz tanı konmamış kişilerde hastalık açısından yönlendirici olabilir. Hastalığın tanısında diş hekimlerine büyük sorumluluk düşmektedir.
Keywords
References
- Seth R, Singh A. Leukemias in children. The Indian Journal of Pediatrics. 2015;82(9):817-24.
- Apak H. Çocukluk çağı lösemileri Derleme. Türk Pediatri Arşivi. 2006;41(4):189-96.
- Madhusoodhan PP, Carroll WL, Bhatla T. Progress and prospects in pediatric leukemia. Current problems in pediatric and adolescent health care. 2016;46(7):229-41.
- Bennett JH. Case of hypertrophy of the spleen and liver inwhich death took place from suppuration of the blood. . EdinburghMedical and Surgical Journal. 1845;64:413-23.
- Virchow R. Zur pathologischen physiologie des blutes. II. Weisses blut. Archives of Pathology, Anatomy and Physiology, I. 1847:563-72.
- Neumann E. Ein neuer fall von Leukamie mit erkrankung des knochenmarks. Archives Heilkunde. 1872;13:502-8.
- Jin M, Xu S, An Q, Wang P. A review of risk factors for childhood leukemia. Eur Rev Med Pharmacol Sci. 2016;20(18):3760-4.
- Belson M, Kingsley B, Holmes A. Risk factors for acute leukemia in children: a review. Environmental health perspectives. 2007;115(1):138-45.
- McReynolds LJ, Savage SA. Pediatric leukemia susceptibility disorders: manifestations and management. ASH Education Program Book. 2017;2017(1):242-50.
- Anak S, Uysalol E. Akut Miyeloid Lösemi (AML). Çocuk Dergisi. 2012;12(4):153-8.
- Colby-Graham MF, Chordas C. The childhood leukemias. Journal of pediatric nursing. 2003;18(2):87-95.
- Uzunhan TA, Karakaş Z. Çocukluk Çağı Akut Lenfoblastik Lösemisi. Çocuk Dergisi. 2012;12(1):6-15.
- Pui C-H, Evans WE. Treatment of acute lymphoblastic leukemia. New England Journal of Medicine. 2006;354(2):166-78.
- Yeşilipek MA. Çocuklarda hematopoetik kök hücre nakli. Türk Pediatri Arşivi. 2014;49(2):91-8.
- Francisconi CF, Caldas RJ, Oliveira Martins LJ, Fischer Rubira CM, da Silva Santos PS. Leukemic oral manifestations and their management. Asian Pacific Journal of Cancer Prevention. 2016;17(3):911-5.
- Demirer S, Özdemir H, Şencanc M, Marakoğlud I. Gingival hyperplasia as an early diagnostic oral manifestation in acute monocytic leukemia: a case report. European journal of dentistry. 2007;1(02):111-4.
- Guan G, Firth N. Oral manifestations as an early clinical sign of acute myeloid leukaemia: a case report. Australian dental journal. 2015;60(1):123-7.
- Xavier AM, Hegde AM. Preventive protocols and oral management in childhood leukemia-the pediatric specialist’s role. Asian Pac J Cancer Prev. 2010;11(1):39-43.
- Özmekik Ö, Ulukapı I. Kemoterapi alan çocuklarda diş hekimliği yaklaşımı. Acta Odontologica Turcica. 2014;31(3):154-9.
- Hong CH. Considerations in the pediatric population with cancer. Dental Clinics of North America. 2008;52(1):155-81.
- Dentistry AAoP. Dental management of pediatric patients receiving immunosuppressive therapy and/or radiation therapy. The reference manual of pediatric dentistry. 2018;40:422-30.
- Cheng K, Molassiotis A, Chang A, Wai W, Cheung S. Evaluation of an oral care protocol intervention in the prevention of chemotherapy-induced oral mucositis in paediatric cancer patients. European journal of cancer. 2001;37(16):2056-63.
Year 2020,
Ağız Kanserleri Özel Sayısı, 271 - 274, 28.09.2020
Abstract
Aim of present review is to provide information about the early diagnosis of leukemia, clinical features, complications, and oral treatment approaches in children.The words ‘leukemia in children’; ‘oral manifestations for leukemia’; ‘leukemia oral symptoms’ were searched in PUBMED, RESEARCH GATE and GOOGLE SCHOLAR search engines. The titles and summaries of the literatures were evaluated, and appropriate literature was selected and analyzed.Leukemia is a malignant disease with hematopoietic cells multiplying more than normal. Its etiology is uncertain. The disease can be acute and chronic, depending on how it progresses. It is classified as lymphocytic and myolocytic depend on the histological type of cells. The treatment is carried out in three stages: remission induction, consolidation and maintenance therapy. Bone marrow transplantation can be preferred in patients with high risk leukemia. Intraoral symptoms and treatment may differ depending on the types of leukemia. Symptoms are mostly caused by pancytopenia (anemia, neutropenia and thrombocytopenia). Mucosal paleness, gingival bleeding, ecchymosis, ulceration, trismus, gingival hyperplasia and mucosal infections are the most common symptoms. Because of the procedures performed, during and after treatment mucositis, xerostomy, desquamation can be observed. Leukemia is the most common malignant disease in childhood. Like the other parts of the body, it gives symptoms in the mouth and can be a guide for diagnosis of disease. Dentists have a great responsibility in the diagnosis of the disease.
Keywords
References
- Seth R, Singh A. Leukemias in children. The Indian Journal of Pediatrics. 2015;82(9):817-24.
- Apak H. Çocukluk çağı lösemileri Derleme. Türk Pediatri Arşivi. 2006;41(4):189-96.
- Madhusoodhan PP, Carroll WL, Bhatla T. Progress and prospects in pediatric leukemia. Current problems in pediatric and adolescent health care. 2016;46(7):229-41.
- Bennett JH. Case of hypertrophy of the spleen and liver inwhich death took place from suppuration of the blood. . EdinburghMedical and Surgical Journal. 1845;64:413-23.
- Virchow R. Zur pathologischen physiologie des blutes. II. Weisses blut. Archives of Pathology, Anatomy and Physiology, I. 1847:563-72.
- Neumann E. Ein neuer fall von Leukamie mit erkrankung des knochenmarks. Archives Heilkunde. 1872;13:502-8.
- Jin M, Xu S, An Q, Wang P. A review of risk factors for childhood leukemia. Eur Rev Med Pharmacol Sci. 2016;20(18):3760-4.
- Belson M, Kingsley B, Holmes A. Risk factors for acute leukemia in children: a review. Environmental health perspectives. 2007;115(1):138-45.
- McReynolds LJ, Savage SA. Pediatric leukemia susceptibility disorders: manifestations and management. ASH Education Program Book. 2017;2017(1):242-50.
- Anak S, Uysalol E. Akut Miyeloid Lösemi (AML). Çocuk Dergisi. 2012;12(4):153-8.
- Colby-Graham MF, Chordas C. The childhood leukemias. Journal of pediatric nursing. 2003;18(2):87-95.
- Uzunhan TA, Karakaş Z. Çocukluk Çağı Akut Lenfoblastik Lösemisi. Çocuk Dergisi. 2012;12(1):6-15.
- Pui C-H, Evans WE. Treatment of acute lymphoblastic leukemia. New England Journal of Medicine. 2006;354(2):166-78.
- Yeşilipek MA. Çocuklarda hematopoetik kök hücre nakli. Türk Pediatri Arşivi. 2014;49(2):91-8.
- Francisconi CF, Caldas RJ, Oliveira Martins LJ, Fischer Rubira CM, da Silva Santos PS. Leukemic oral manifestations and their management. Asian Pacific Journal of Cancer Prevention. 2016;17(3):911-5.
- Demirer S, Özdemir H, Şencanc M, Marakoğlud I. Gingival hyperplasia as an early diagnostic oral manifestation in acute monocytic leukemia: a case report. European journal of dentistry. 2007;1(02):111-4.
- Guan G, Firth N. Oral manifestations as an early clinical sign of acute myeloid leukaemia: a case report. Australian dental journal. 2015;60(1):123-7.
- Xavier AM, Hegde AM. Preventive protocols and oral management in childhood leukemia-the pediatric specialist’s role. Asian Pac J Cancer Prev. 2010;11(1):39-43.
- Özmekik Ö, Ulukapı I. Kemoterapi alan çocuklarda diş hekimliği yaklaşımı. Acta Odontologica Turcica. 2014;31(3):154-9.
- Hong CH. Considerations in the pediatric population with cancer. Dental Clinics of North America. 2008;52(1):155-81.
- Dentistry AAoP. Dental management of pediatric patients receiving immunosuppressive therapy and/or radiation therapy. The reference manual of pediatric dentistry. 2018;40:422-30.
- Cheng K, Molassiotis A, Chang A, Wai W, Cheung S. Evaluation of an oral care protocol intervention in the prevention of chemotherapy-induced oral mucositis in paediatric cancer patients. European journal of cancer. 2001;37(16):2056-63.
There are 22 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | DERLEME |
| Authors | |
| Publication Date | September 28, 2020 |
| Published in Issue | Year 2020 Ağız Kanserleri Özel Sayısı |