B 12 VİTAMİN DÜZEYİ EKSİKLİĞİ OLAN HASTALARLA NORMAL OLAN HASTALARIN KARDİYOVASKÜLER RİSK FAKTÖRLERİ AÇISINDAN RETROSPEKTİF OLARAK DEĞERLENDİRMESİ

HAMDİ Küçük; GÜNTER Dilsiz; NEJAT Demircan; EROL Aktunç; Ayşe Demir Akça; Fürüzan Köktürk

Year 2015, Volume: 2 Issue: 1, 1 - 11, 27.11.2015

HAMDİ Küçük GÜNTER Dilsiz NEJAT Demircan EROL Aktunç Ayşe Demir Akça Fürüzan Köktürk

Abstract

References

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Ulusal Kalp Sağlığı Politikası, Türk Kardiyoloji Derneği web sayfası http://www.tkd.org.tr/pages.asp.pg=276
Minnet C. Çocukluk Çağında B 12 Vitamini Eksikliğinin Oksidan-Antioksidan Sistem ve DNA Hasarı İle İlişkisi (tez). Şanlıurfa: Harran Üniversitesi Tıp Fakültesi; 2006.
Türkiye kalp ve damar hastalıklarını önleme ve kontrol etme programı 2008
Yesilbursa D., Serdar O.A., Gemici K.,Kaya K.,Güllüsü S.,Aydınlar A. Ve ark. Koroner arter hastalığında risk faktörlerinin ve anjiografik bulguların cinsiyetlere göre karsılaştırılması. Türkiye Tıp Dergisi.1998;5(1):17-20.
Coldiz G.A., Willet V.C., Stamgfer M.J. Menopause and the risk of coronary heart disease in women. N. Engl J. Med. 1987; 316: 1105-1111.
Djanmohammedi R.A., Sansoy V., Yigit Z., Gürmen T.,Gülbaran M., Öztürk S. Ve ark. Koroner arter hastalarında sekonder korumanın etkinliğinin değerlendirilmesi. Türk Kardiyoloji Derneği Arşivi. 2000; 28 (4): 216-223.
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Vasan RS, Larson MG, Leip EG, Evans JC, O’Donnell Cj, Kannel WB, Levy D: Impact of high –normal blood pressure on the risk of cardiovascular disease.N Eng J Med 2001 ;345:1291-1297
Türk Kardiyoloji Derneği Ulusal Hipertansiyon Tedavi ve Takip Kılavuzu. Türk Kardiyoloji Derneği Arş. 2000;28: 335-97
Karpuz H, Gizli Düşman Artik daha mı tehlikeli. Sanovizon, 4: 10-14, 2004
Expert panel on detection, evaluation and treatment high blood cholesterol in adults. Executive summary of the third report of the national cholesterol education program (NCEP). (adult tratment panel III). JAMA 2001; 285:2486
Diabetes Mellitus Ve Komplikasyonlarının Tanı, Tedavi Ve İzlem Kılavuzu-2011
The Diabetes Control and Complications Trial Research Group.The efect of intensive treatement of diabetes on the developement and progression of long term complications in insulin dependent diabetes mellitus. N Engl J Med 1993;329: 997-86
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Calle EE, Thun MJ, Petrilli JM, et al. Body- mass index and mortality in a prospective cohort of U.S. adults. N Eng J Med 1999; 341: 1097
Onat A, Şenocak M. Obesity in Turkish adults: prevalence, validity as a coronary risk factors and interrelation with other risk factors. Int J Ang 1995; 4: 94-8.
Joint National Committee on Prevention, Evaluation and Treatment of High Blood Pressure. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC 7 Report). National Institutes of Health; National Heart, Lung and Blood Institute. JAMA 2003; 289: 2560-2572
Van den Hoogen PCW, Feskens EJM, Jaglekerke NJD. The relation betveen blood pressure and mortality due to coronary heart disease among men in different parts of the Word. N Eng J Med 2000; 342: 1
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B 12 VİTAMİN DÜZEYİ EKSİKLİĞİ OLAN HASTALARLA NORMAL OLAN HASTALARIN KARDİYOVASKÜLER RİSK FAKTÖRLERİ AÇISINDAN RETROSPEKTİF OLARAK DEĞERLENDİRMESİ

Year 2015, Volume: 2 Issue: 1, 1 - 11, 27.11.2015

HAMDİ Küçük GÜNTER Dilsiz NEJAT Demircan EROL Aktunç Ayşe Demir Akça Fürüzan Köktürk

Abstract

Kardiyovasküler hastalık açısından bilinen risk faktörleri olan obezite, ileri yaş, hipertansiyon,
dislipidemi, diyabet, sigara gibi faktörlerin yanı sıra yapılan çalışmalar B 12 vitamin eksikliğininde
homosistein düzeyini artırarak koroner hastalıklar için bağımsız bir risk faktörü oluşturduğu
gösterilmiştir. Bu çalışmada polikliniğimize başvurmuş ve B 12 vitamin eksikliği görülmüş hastaları, B 12
düzeyi normal olan hastalara göre diğer kardiyovasküler risk faktörleri açısından değerlendirdik ve bu
hastalarda olası koroner hastalıklar için var olan risk faktörlerini göstermeye çalıştık. Bülent Ecevit
Üniversitesi Uygulama ve Araştırma Hastanesi Aile Hekimliği Polikliniği’ne son 1 (bir) yıl içinde
başvurmuş ve B 12 vitamin eksikliği gözlemlenmiş hastaların dosyalarından sağlık bilgileri, ilaç kullanım
öyküleri, sigara, kronik hastalık, aile öykülerini kullanarak, fizik muayene bulgularından kan basıncı ve
VKI’lerıne bakarak, istenilen laboratuvar sonuçlarından B 12 düzeyi, HDL, LDL, total kolesterol, CRP,
trigliserid düzeylerine bakarak var olan kardiyovasküler riskleri belirlemeyi amaçladık. Var olan risk
faktörleri bakımından her iki cinsiyet ve B 12 vitamin eksikliği olan ve olmayan hastalar ayrı ayrı
değerlendirilmiş ve framingham risk skorlaması ile gelecek on yılda ki olası riskleri hesaplanmıştır.
Hastaların framingham skorlamasına göre beklenen on yıllık risk faktörleri açısından aralarında anlamlı
bir fark bulunmamıştır.

Keywords

Koroner arter hastalığı, B 12, Framingham risk skorlaması

References

Koylan N. Ateroskleroz ve hiperlipidemi ilişkisine epidemiyolojik yaklaşım. Hipokrat Kardiyoloji.1998;1(7):22-26.
Kıvanç M.M, Bozkurt G, Bayram S, Özer Y, Kardiyak yoğun bakim ünitelerinde rehabilitasyon uygulamalarının incelenmesi. İçinde: Onat A. (ed.) Türk Kardiyoloji Derneği Arşivi XVI. Ulusal Kardiyoloji Kongresi Bildiri Özetleri. İstanbul: 2000: SB 149.
Ulusal Kalp Sağlığı Politikası, Türk Kardiyoloji Derneği web sayfası http://www.tkd.org.tr/pages.asp.pg=276
Minnet C. Çocukluk Çağında B 12 Vitamini Eksikliğinin Oksidan-Antioksidan Sistem ve DNA Hasarı İle İlişkisi (tez). Şanlıurfa: Harran Üniversitesi Tıp Fakültesi; 2006.
Türkiye kalp ve damar hastalıklarını önleme ve kontrol etme programı 2008
Yesilbursa D., Serdar O.A., Gemici K.,Kaya K.,Güllüsü S.,Aydınlar A. Ve ark. Koroner arter hastalığında risk faktörlerinin ve anjiografik bulguların cinsiyetlere göre karsılaştırılması. Türkiye Tıp Dergisi.1998;5(1):17-20.
Coldiz G.A., Willet V.C., Stamgfer M.J. Menopause and the risk of coronary heart disease in women. N. Engl J. Med. 1987; 316: 1105-1111.
Djanmohammedi R.A., Sansoy V., Yigit Z., Gürmen T.,Gülbaran M., Öztürk S. Ve ark. Koroner arter hastalarında sekonder korumanın etkinliğinin değerlendirilmesi. Türk Kardiyoloji Derneği Arşivi. 2000; 28 (4): 216-223.
Onat A, Büyük öztürk K, Sansoy V, Surdum Avci G, Çam N, Akgün G, Tokgözoglu L, Çağlar N, San M, Nişancı Y, Oto A, Ergene O,Türk Kardiyoloji Derneği, Koroner Kalp hastalığı, Korunma ve Tedavi Kılavuzu, İstanbul. Yenilik Basımevi, 2002
Wood J. Koroner risk faktörleri ve modifikasyonu. Keles I(ed), Kardiyolojinin Sırları, İstanbul, Nobel Matbaacılık 118-123, 2002
The 7th Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure http://www.nhlbi.nih.gov/ guidelines/ hypertension/index.htm 2003
Wong ND, Cupples LA, Ostfeld AM, Levy D, Kannel WB: Risk factors for long-term coronary prognosis after initial myocardial infarction: the Framigham Study. AM J Epidemiol,1989; 130: 469-480
Vasan RS, Larson MG, Leip EG, Evans JC, O’Donnell Cj, Kannel WB, Levy D: Impact of high –normal blood pressure on the risk of cardiovascular disease.N Eng J Med 2001 ;345:1291-1297
Türk Kardiyoloji Derneği Ulusal Hipertansiyon Tedavi ve Takip Kılavuzu. Türk Kardiyoloji Derneği Arş. 2000;28: 335-97
Karpuz H, Gizli Düşman Artik daha mı tehlikeli. Sanovizon, 4: 10-14, 2004
Expert panel on detection, evaluation and treatment high blood cholesterol in adults. Executive summary of the third report of the national cholesterol education program (NCEP). (adult tratment panel III). JAMA 2001; 285:2486
Diabetes Mellitus Ve Komplikasyonlarının Tanı, Tedavi Ve İzlem Kılavuzu-2011
The Diabetes Control and Complications Trial Research Group.The efect of intensive treatement of diabetes on the developement and progression of long term complications in insulin dependent diabetes mellitus. N Engl J Med 1993;329: 997-86
Wilhemsson C, Elmfeldt D et al:Smoking and myocardial infarction. Lancet 1975;1:415-
US Department of Health and Human Services. The Health Consequences of Smoking: Cardiovascular Disease_ A Report of the Surgeon General. Washington, DC: Office of Smoking and Health, US Gover nment Printing Office; 1983.
Eckel RH, Krauss RM. American Heart Association call to action: Obesity as a majör risk factors. Circulation 1998; 97: 2099
National Task Force on the Prevention and Treatment of Obesity. Dieting and the development of eating disorders in overweight and obese adults. Arch Int Med 2000;
: 2581-9.
Calle EE, Thun MJ, Petrilli JM, et al. Body- mass index and mortality in a prospective cohort of U.S. adults. N Eng J Med 1999; 341: 1097
Onat A, Şenocak M. Obesity in Turkish adults: prevalence, validity as a coronary risk factors and interrelation with other risk factors. Int J Ang 1995; 4: 94-8.
Joint National Committee on Prevention, Evaluation and Treatment of High Blood Pressure. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC 7 Report). National Institutes of Health; National Heart, Lung and Blood Institute. JAMA 2003; 289: 2560-2572
Van den Hoogen PCW, Feskens EJM, Jaglekerke NJD. The relation betveen blood pressure and mortality due to coronary heart disease among men in different parts of the Word. N Eng J Med 2000; 342: 1
Hurt’s The Heart. Valentin Fuster, R. Wayne Alexander, Robert O’Rourke. 10. Baskısının Türkçe çevirisi. And Danışmanlık Eğitim Yayıncılık ve Organizasyon Ltd. Şti. 1. Basım. 2002 Sayfa, 1065-1109
Clinical Obesity / Edited by Peter G. Kopelman and Michael Stock, 1998. Birinci baskısının Türkçesi. Klinik Obezite 2000. And Danışmanlık, Eğitim, Yayıncılık ve Organizasyon Ltd. Şti. Sayfa 1,2,3.
Hubert HB, Feinleib M, MacNamara PM, et al. Obesity as an independent risk factors for cardiovascular disease: A 26 year follow-up of participants in the Framingham Heart Study. Circulation 1983; 67: 968
Jousilahti P, Tuomilehto J, Vartiainene E, et al. Body weight, cardiovascular risk factors, and coronary mortality. Circulation 1996; 93: 1372-9
Prof. Dr. Altan Onat, Prof. Dr. Vedat Sansoy, Prof. Dr. İnan Soydan, Prof. Dr. Lale Tokgözoğlu, Prof. Dr. Kamil Adalet., TEKHARF; On iki Yıllık İzleme Deneyimine Göre Türk Erişkinlerinde Kalp Sağlığı. Argos İletişim Hizmetleri Reklamcılık ve Ticaret Anonim Şirketi. Temmuz 2003, İstanbul.
Fuster V, Alexander RW, O’Rourke RA: Hurst’sThe Heart1.baski ;3:1131-1160,2002
Basic Pathology, Kumar, Cotran, Robbins Türkçesi, Nobel Tıp Kitabevleri Ltd. Şti. Temmuz 2000. Sayfa 283-289
İç Hastalıkları. İliçin, Biberoğlu, Süleymanlar, Ünal. Güneş Kitabevi 2. baskı, 2003. Sayfa, 449-474
Hopkins PN, Williams RR. Human genetics and coronary heart disease: A public heart perspective. Annu Rev Nutr 1989; 9:303
Hurt’s The Heart. Valentin Fuster, R. Wayne Alexander, Robert O’Rourke. 10. Baskısının Türkçe çevirisi. And Danışmanlık Eğitim Yayıncılık ve Organizasyon Ltd. Şti. 1. Basım. 2002 Sayfa, 1065-1109
Fletcher GF, Balady G, Blair SN, et al. Statement on exercise: Benefits and recommendations for physical activity. Circulation 1996; 94:857
Haskell WL. Sedentary lifestyle as a risk factors for coronary heart disease. In: Pearson TA, ed. Primer in Preventive Cardiology. Dallas: American Heart Association; 1994:173
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Primary Language	TR, EN
Journal Section	Makaleler
Authors	HAMDİ Küçük This is me GÜNTER Dilsiz This is me NEJAT Demircan EROL Aktunç This is me Ayşe Demir Akça Fürüzan Köktürk
Publication Date	November 27, 2015
Published in Issue	Year 2015 Volume: 2 Issue: 1

Cite

APA	Küçük, H., Dilsiz, G., Demircan, N., Aktunç, E., et al. (2015). B 12 VİTAMİN DÜZEYİ EKSİKLİĞİ OLAN HASTALARLA NORMAL OLAN HASTALARIN KARDİYOVASKÜLER RİSK FAKTÖRLERİ AÇISINDAN RETROSPEKTİF OLARAK DEĞERLENDİRMESİ. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM, 2(1), 1-11.
AMA	Küçük H, Dilsiz G, Demircan N, Aktunç E, Demir Akça A, Köktürk F. B 12 VİTAMİN DÜZEYİ EKSİKLİĞİ OLAN HASTALARLA NORMAL OLAN HASTALARIN KARDİYOVASKÜLER RİSK FAKTÖRLERİ AÇISINDAN RETROSPEKTİF OLARAK DEĞERLENDİRMESİ. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM. November 2015;2(1):1-11.
Chicago	Küçük, HAMDİ, GÜNTER Dilsiz, NEJAT Demircan, EROL Aktunç, Ayşe Demir Akça, and Fürüzan Köktürk. “B 12 VİTAMİN DÜZEYİ EKSİKLİĞİ OLAN HASTALARLA NORMAL OLAN HASTALARIN KARDİYOVASKÜLER RİSK FAKTÖRLERİ AÇISINDAN RETROSPEKTİF OLARAK DEĞERLENDİRMESİ”. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM 2, no. 1 (November 2015): 1-11.
EndNote	Küçük H, Dilsiz G, Demircan N, Aktunç E, Demir Akça A, Köktürk F (November 1, 2015) B 12 VİTAMİN DÜZEYİ EKSİKLİĞİ OLAN HASTALARLA NORMAL OLAN HASTALARIN KARDİYOVASKÜLER RİSK FAKTÖRLERİ AÇISINDAN RETROSPEKTİF OLARAK DEĞERLENDİRMESİ. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM 2 1 1–11.
IEEE	H. Küçük, G. Dilsiz, N. Demircan, E. Aktunç, A. Demir Akça, and F. Köktürk, “B 12 VİTAMİN DÜZEYİ EKSİKLİĞİ OLAN HASTALARLA NORMAL OLAN HASTALARIN KARDİYOVASKÜLER RİSK FAKTÖRLERİ AÇISINDAN RETROSPEKTİF OLARAK DEĞERLENDİRMESİ”, Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM, vol. 2, no. 1, pp. 1–11, 2015.
ISNAD	Küçük, HAMDİ et al. “B 12 VİTAMİN DÜZEYİ EKSİKLİĞİ OLAN HASTALARLA NORMAL OLAN HASTALARIN KARDİYOVASKÜLER RİSK FAKTÖRLERİ AÇISINDAN RETROSPEKTİF OLARAK DEĞERLENDİRMESİ”. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM 2/1 (November 2015), 1-11.
JAMA	Küçük H, Dilsiz G, Demircan N, Aktunç E, Demir Akça A, Köktürk F. B 12 VİTAMİN DÜZEYİ EKSİKLİĞİ OLAN HASTALARLA NORMAL OLAN HASTALARIN KARDİYOVASKÜLER RİSK FAKTÖRLERİ AÇISINDAN RETROSPEKTİF OLARAK DEĞERLENDİRMESİ. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM. 2015;2:1–11.
MLA	Küçük, HAMDİ et al. “B 12 VİTAMİN DÜZEYİ EKSİKLİĞİ OLAN HASTALARLA NORMAL OLAN HASTALARIN KARDİYOVASKÜLER RİSK FAKTÖRLERİ AÇISINDAN RETROSPEKTİF OLARAK DEĞERLENDİRMESİ”. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM, vol. 2, no. 1, 2015, pp. 1-11.
Vancouver	Küçük H, Dilsiz G, Demircan N, Aktunç E, Demir Akça A, Köktürk F. B 12 VİTAMİN DÜZEYİ EKSİKLİĞİ OLAN HASTALARLA NORMAL OLAN HASTALARIN KARDİYOVASKÜLER RİSK FAKTÖRLERİ AÇISINDAN RETROSPEKTİF OLARAK DEĞERLENDİRMESİ. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM. 2015;2(1):1-11.

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