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Dental kök hücre kaynakları ve kemik doku mühendisliğinde kullanılma potansiyelleri

Year 2015, Volume: 49 Issue: 2, 51 - 56, 18.05.2015

Fatih Asutay Ahmet Acar Ümit Yolcu Mustafa Kırtay Hilal Alan

https://doi.org/10.17096/jiufd.42908

Abstract

Doku mühendisliği yaklaşımları, kemik
iyileşmesi ile ilgilenen her tıp alanında heyecan
uyandırmaktadır. İyileşme sürelerinin kısalması, daha
kaliteli ve fonksiyonel doku elde edilmesi ve ikincil
bir cerrahi sahaya gereksinimi ortadan kaldırması bu
yaklaşımların nihai hedeflerindendir. Mezenşimal kök
hücreler bu alandaki çalışmalarda giderek artarak
kullanılmakta ve sonuçlar umut vermektedir. Dental
kök hücreler de hem kolay temin edilebilmesi hem de
üstün özellikleri sebebiyle ön plana çıkmaktadırlar.
Bu çalışmada dental kök hücrelerin kemik doku
mühendisliği yaklaşımları için önemi ve rejenerasyon
potansiyelleri incelenmiştir.

Keywords

Dental kök hücreler kemik dokusu mühendisliği oral ve maksillofasiyal cerrahi

References

  • Guskuma MH, Hochuli-Vieira E, Pereira FP, Rangel-Garcia Junior I, Okamoto R, Okamoto T, Magro Filho O. Bone regeneration in surgically created defects filled with autogenous bone: an epifluorescence microscopy analysis in rats. J Appl Oral Sci 2010;18(4):346-353.
  • Goh BT, Lee S, Tideman H, Stoelinga PJ. Mandibular reconstruction in adults: a review. Int J Oral Maxillofac Surg 2008;37(7):597-605.
  • Kinoshita Y, Maeda H. Recent developments of functional scaffolds for craniomaxillofacial bone tissue engineering applications. ScientificWorldJournal 2013; 2013:863157.
  • Riccio M, Maraldi T, Pisciotta A, La Sala GB, Ferrari A, Bruzzesi G, Motta A, Migliaresi C, De Pol A. Fibroin scaffold repairs critical-size bone defects in vivo supported by human amniotic fluid and dental pulp stem cells. Tissue Eng Part A. 2012;18(9-10):1006-1013.
  • van der Kooy D, Weiss S. Why stem cells? Science 2000; 287(5457):1439-1441.
  • Giordano G, La Monaca G, Annibali S, Cicconetti A, Ottolenghi L. Stem cells from oral niches: a review. Ann Stomatol 2011;2(1-2):3-8.
  • Yamanaka S. Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 2007;1(1):39-49.
  • Takahashi K, Okita K, Nakagawa M, Yamanaka S. Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc 2007;2(12):3081-3089.
  • Ding DC, Shyu WC, Lin SZ. Mesenchymal stem cells. Cell Transplant 2011;20(1):5-14.
  • İnan S, Özbilgin K. Kök Hücre Biyolojisi. Sağlıkta Birikim Derg 2009; 1(5):11-23.
  • Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 2000;97(25):13625-13630.
  • Stevens A, Zuliani T, Olejnik C, LeRoy H, Obriot H, Kerr-Conte J, Formstecher P, Bailliez Y, Polakowska RR. Human dental pulp stem cells differentiate into neural crest-derived melanocytes and have label-retaining and sphere-forming abilities. Stem Cells Dev 2008;17(6):1175-1184.
  • Yan X, Qin H, Qu C, Tuan RS, Shi S, Huang GT. iPS cells reprogrammed from human mesenchymal-like stem/progenitor cells of dental tissue origin. Stem Cells Dev 2010;19(4):469-480.
  • Otaki S, Ueshima S, Shiraishi K, Sugiyama K, Hamada S, Yorimoto M, Matsuo O. Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into immunocompromised mice. Cell Biol Int 2007;31(10):1191-1197.
  • d'Aquino R, De Rosa A, Lanza V, Tirino V, Laino L, Graziano A, Desiderio V, Laino G, Papaccio G. Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur Cell Mater 2009;18:75-83.
  • Huang GT, Gronthos S, Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res 2009;88(9):792-806.
  • Li JH, Liu DY, Zhang FM, Wang F, Zhang WK, Zhang ZT. Human dental pulp stem cell is a promising autologous seed cell for bone tissue engineering. Chin Med J 2011;124(23):4022-4028.
  • Gandia C, Arminan A, Garcia-Verdugo JM, Lledo E, Ruiz A, Minana MD, Sanchez-Torrijos J, Paya R, Mirabet V, Carbonell-Uberos F, Llop M, Montero JA, Sepúlveda P. Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction. Stem Cells 2008;26(3):638-645.
  • Kerkis I, Ambrosio CE, Kerkis A, Martins DS, Zucconi E, Fonseca SA, Cabral RM, Maranduba CM, Gaiad TP, Morini AC, Vieira NM, Brolio MP, Sant'Anna OA, Miglino MA, Zatz M. Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or systemic? J Transl Med 2008;6:35.
  • Nakashima M, Iohara K, Sugiyama M. Human dental pulp stem cells with highly angiogenic and neurogenic potential for possible use in pulp regeneration. Cytokine Growth Factor Rev 2009;20(5-6):435-440.
  • Gomes JA, Geraldes Monteiro B, Melo GB, Smith RL, Cavenaghi Pereira da Silva M, Lizier NF, Kerkis A, Cerruti H, Kerkis I. Corneal reconstruction with tissue-engineered cell sheets composed of human immature dental pulp stem cells. Invest Ophthalmol Vis Sci 2010;51(3):1408-1414.
  • Yao S, Pan F, Prpic V, Wise GE. Differentiation of stem cells in the dental follicle. J Dent Res 2008;87(8):767-771.
  • Mori G, Ballini A, Carbone C, Oranger A, Brunetti G, Di Benedetto A, Rapone B, Cantore S, Di Comite M, Colucci S, Grano M, Grassi FR. Osteogenic differentiation of dental follicle stem cells. Int J Med Sci 2012;9(6):480-487.
  • Honda MJ, Imaizumi M, Suzuki H, Ohshima S, Tsuchiya S, Satomura K. Stem cells isolated from human dental follicles have osteogenic potential. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111(6):700-708.
  • Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, Zhang C, Liu H, Gronthos S, Wang CY, Wang S, Shi S. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PloS One 2006;1:e79.
  • Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S, Shi S, Huang GT. Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. J Endod 2008;34(2):166-171.
  • Chueh LH, Huang GT. Immature teeth with periradicular periodontitis or abscess undergoing apexogenesis: a paradigm shift. J Endod 2006;32(12):1205-1213.
  • Estrela C, Alencar AH, Kitten GT, Vencio EF, Gava E. Mesenchymal stem cells in the dental tissues: perspectives for tissue regeneration. Braz Dent J 2011;22(2):91-98.
  • Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A 2003;100(10):5807-5812.
  • Shi S, Bartold PM, Miura M, Seo BM, Robey PG, Gronthos S. The efficacy of mesenchymal stem cells to regenerate and repair dental structures. Orthod Craniofac Res 2005;8(3):191-199.
  • Atalayın Ç, Ergücü Z, Tezel H. Diş hekimliğinde kök hücre ve dental pulpa kök hücreleri. GÜ Diş Hekim Fak Derg 2012;29(2):115-120.
  • Yamankoç G, Aren G. İnsan dişlerinin doku mühendisliğindeki önemi. İstanbul Üniv Diş Hekim Fak Derg 2010;44(1):33-38.
  • Seo BM, Sonoyama W, Yamaza T, Coppe C, Kikuiri T, Akiyama K, Lee JS, Shi S. SHED repair critical-size calvarial defects in mice. Oral Dis 2008;14(5):428-434.
  • Govindasamy V, Abdullah AN, Ronald VS, Musa S, Ab Aziz ZA, Zain RB, Totey S, Bhonde RR, Abu Kasim NH. Inherent differential propensity of dental pulp stem cells derived from human deciduous and permanent teeth. J Endod 2010;36(9):1504-1515.
  • Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY, Shi S. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004;364(9429):149-155.
  • Trubiani O, Orsini G, Zini N, Di Iorio D, Piccirilli M, Piattelli A, Caputi S. Regenerative potential of human periodontal ligament derived stem cells on three-dimensional biomaterials: a morphological report. J Biomed Mater Res A 2008;87(4):986-993.
  • O'Keefe RJ, Mao J. Bone tissue engineering and regeneration: from discovery to the clinic-an overview. Tissue Eng Part B Rev 2011;17(6):389-392.
  • Amini AR, Laurencin CT, Nukavarapu SP. Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng 2012;40(5):363-408.

DENTAL STEM CELL SOURCES AND THEIR POTENTIALS FOR BONE TISSUE ENGINEERING

Year 2015, Volume: 49 Issue: 2, 51 - 56, 18.05.2015

Fatih Asutay Ahmet Acar Ümit Yolcu Mustafa Kırtay Hilal Alan

https://doi.org/10.17096/jiufd.42908

Abstract

Tissue engineering arouses excitement in all medical fields that deal with bone healing. The iyileşmesi ile ilgilenen her tıp alanında heyecan ultimate aim of these approaches are to shorten uyandırmaktadır. İyileşme sürelerinin kısalması, daha the healing process, obtain highly differentiated kaliteli ve fonksiyonel doku elde edilmesi ve ikincil functional tissues and eliminate the need for a second bir cerrahi sahaya gereksinimi ortadan kaldırması bu surgical site required for autogenous bone grafts. Mesenchymal stem cells have been increasingly hücreler bu alandaki çalışmalarda giderek artarak used in the experiments which were conducted in kullanılmakta ve sonuçlar umut vermektedir. Dental these fields and the results are promising. Dental stem cells have come to the forefront both because of their relative ease of access and also their Bu çalışmada dental kök hücrelerin kemik doku superior characteristics. This article investigates mühendisliği yaklaşımları için önemi ve rejenerasyon the importance of dental stem cells for bone tissue engineering and their regeneration potentials

Keywords

Dental stem cells bone tissue engineering oral and maxillofacial surgery

References

  • Guskuma MH, Hochuli-Vieira E, Pereira FP, Rangel-Garcia Junior I, Okamoto R, Okamoto T, Magro Filho O. Bone regeneration in surgically created defects filled with autogenous bone: an epifluorescence microscopy analysis in rats. J Appl Oral Sci 2010;18(4):346-353.
  • Goh BT, Lee S, Tideman H, Stoelinga PJ. Mandibular reconstruction in adults: a review. Int J Oral Maxillofac Surg 2008;37(7):597-605.
  • Kinoshita Y, Maeda H. Recent developments of functional scaffolds for craniomaxillofacial bone tissue engineering applications. ScientificWorldJournal 2013; 2013:863157.
  • Riccio M, Maraldi T, Pisciotta A, La Sala GB, Ferrari A, Bruzzesi G, Motta A, Migliaresi C, De Pol A. Fibroin scaffold repairs critical-size bone defects in vivo supported by human amniotic fluid and dental pulp stem cells. Tissue Eng Part A. 2012;18(9-10):1006-1013.
  • van der Kooy D, Weiss S. Why stem cells? Science 2000; 287(5457):1439-1441.
  • Giordano G, La Monaca G, Annibali S, Cicconetti A, Ottolenghi L. Stem cells from oral niches: a review. Ann Stomatol 2011;2(1-2):3-8.
  • Yamanaka S. Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 2007;1(1):39-49.
  • Takahashi K, Okita K, Nakagawa M, Yamanaka S. Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc 2007;2(12):3081-3089.
  • Ding DC, Shyu WC, Lin SZ. Mesenchymal stem cells. Cell Transplant 2011;20(1):5-14.
  • İnan S, Özbilgin K. Kök Hücre Biyolojisi. Sağlıkta Birikim Derg 2009; 1(5):11-23.
  • Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 2000;97(25):13625-13630.
  • Stevens A, Zuliani T, Olejnik C, LeRoy H, Obriot H, Kerr-Conte J, Formstecher P, Bailliez Y, Polakowska RR. Human dental pulp stem cells differentiate into neural crest-derived melanocytes and have label-retaining and sphere-forming abilities. Stem Cells Dev 2008;17(6):1175-1184.
  • Yan X, Qin H, Qu C, Tuan RS, Shi S, Huang GT. iPS cells reprogrammed from human mesenchymal-like stem/progenitor cells of dental tissue origin. Stem Cells Dev 2010;19(4):469-480.
  • Otaki S, Ueshima S, Shiraishi K, Sugiyama K, Hamada S, Yorimoto M, Matsuo O. Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into immunocompromised mice. Cell Biol Int 2007;31(10):1191-1197.
  • d'Aquino R, De Rosa A, Lanza V, Tirino V, Laino L, Graziano A, Desiderio V, Laino G, Papaccio G. Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur Cell Mater 2009;18:75-83.
  • Huang GT, Gronthos S, Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res 2009;88(9):792-806.
  • Li JH, Liu DY, Zhang FM, Wang F, Zhang WK, Zhang ZT. Human dental pulp stem cell is a promising autologous seed cell for bone tissue engineering. Chin Med J 2011;124(23):4022-4028.
  • Gandia C, Arminan A, Garcia-Verdugo JM, Lledo E, Ruiz A, Minana MD, Sanchez-Torrijos J, Paya R, Mirabet V, Carbonell-Uberos F, Llop M, Montero JA, Sepúlveda P. Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction. Stem Cells 2008;26(3):638-645.
  • Kerkis I, Ambrosio CE, Kerkis A, Martins DS, Zucconi E, Fonseca SA, Cabral RM, Maranduba CM, Gaiad TP, Morini AC, Vieira NM, Brolio MP, Sant'Anna OA, Miglino MA, Zatz M. Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or systemic? J Transl Med 2008;6:35.
  • Nakashima M, Iohara K, Sugiyama M. Human dental pulp stem cells with highly angiogenic and neurogenic potential for possible use in pulp regeneration. Cytokine Growth Factor Rev 2009;20(5-6):435-440.
  • Gomes JA, Geraldes Monteiro B, Melo GB, Smith RL, Cavenaghi Pereira da Silva M, Lizier NF, Kerkis A, Cerruti H, Kerkis I. Corneal reconstruction with tissue-engineered cell sheets composed of human immature dental pulp stem cells. Invest Ophthalmol Vis Sci 2010;51(3):1408-1414.
  • Yao S, Pan F, Prpic V, Wise GE. Differentiation of stem cells in the dental follicle. J Dent Res 2008;87(8):767-771.
  • Mori G, Ballini A, Carbone C, Oranger A, Brunetti G, Di Benedetto A, Rapone B, Cantore S, Di Comite M, Colucci S, Grano M, Grassi FR. Osteogenic differentiation of dental follicle stem cells. Int J Med Sci 2012;9(6):480-487.
  • Honda MJ, Imaizumi M, Suzuki H, Ohshima S, Tsuchiya S, Satomura K. Stem cells isolated from human dental follicles have osteogenic potential. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111(6):700-708.
  • Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, Zhang C, Liu H, Gronthos S, Wang CY, Wang S, Shi S. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PloS One 2006;1:e79.
  • Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S, Shi S, Huang GT. Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. J Endod 2008;34(2):166-171.
  • Chueh LH, Huang GT. Immature teeth with periradicular periodontitis or abscess undergoing apexogenesis: a paradigm shift. J Endod 2006;32(12):1205-1213.
  • Estrela C, Alencar AH, Kitten GT, Vencio EF, Gava E. Mesenchymal stem cells in the dental tissues: perspectives for tissue regeneration. Braz Dent J 2011;22(2):91-98.
  • Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A 2003;100(10):5807-5812.
  • Shi S, Bartold PM, Miura M, Seo BM, Robey PG, Gronthos S. The efficacy of mesenchymal stem cells to regenerate and repair dental structures. Orthod Craniofac Res 2005;8(3):191-199.
  • Atalayın Ç, Ergücü Z, Tezel H. Diş hekimliğinde kök hücre ve dental pulpa kök hücreleri. GÜ Diş Hekim Fak Derg 2012;29(2):115-120.
  • Yamankoç G, Aren G. İnsan dişlerinin doku mühendisliğindeki önemi. İstanbul Üniv Diş Hekim Fak Derg 2010;44(1):33-38.
  • Seo BM, Sonoyama W, Yamaza T, Coppe C, Kikuiri T, Akiyama K, Lee JS, Shi S. SHED repair critical-size calvarial defects in mice. Oral Dis 2008;14(5):428-434.
  • Govindasamy V, Abdullah AN, Ronald VS, Musa S, Ab Aziz ZA, Zain RB, Totey S, Bhonde RR, Abu Kasim NH. Inherent differential propensity of dental pulp stem cells derived from human deciduous and permanent teeth. J Endod 2010;36(9):1504-1515.
  • Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY, Shi S. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004;364(9429):149-155.
  • Trubiani O, Orsini G, Zini N, Di Iorio D, Piccirilli M, Piattelli A, Caputi S. Regenerative potential of human periodontal ligament derived stem cells on three-dimensional biomaterials: a morphological report. J Biomed Mater Res A 2008;87(4):986-993.
  • O'Keefe RJ, Mao J. Bone tissue engineering and regeneration: from discovery to the clinic-an overview. Tissue Eng Part B Rev 2011;17(6):389-392.
  • Amini AR, Laurencin CT, Nukavarapu SP. Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng 2012;40(5):363-408.
There are 38 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Review Articles
Authors

Fatih Asutay

Ahmet Acar

Ümit Yolcu

Mustafa Kırtay

Hilal Alan This is me

Publication Date May 18, 2015
Published in Issue Year 2015 Volume: 49 Issue: 2

Cite

APA Asutay, F., Acar, A., Yolcu, Ü., Kırtay, M., et al. (2015). DENTAL STEM CELL SOURCES AND THEIR POTENTIALS FOR BONE TISSUE ENGINEERING. Journal of Istanbul University Faculty of Dentistry, 49(2), 51-56. https://doi.org/10.17096/jiufd.42908
AMA Asutay F, Acar A, Yolcu Ü, Kırtay M, Alan H. DENTAL STEM CELL SOURCES AND THEIR POTENTIALS FOR BONE TISSUE ENGINEERING. J Istanbul Univ Fac Dent. May 2015;49(2):51-56. doi:10.17096/jiufd.42908
Chicago Asutay, Fatih, Ahmet Acar, Ümit Yolcu, Mustafa Kırtay, and Hilal Alan. “DENTAL STEM CELL SOURCES AND THEIR POTENTIALS FOR BONE TISSUE ENGINEERING”. Journal of Istanbul University Faculty of Dentistry 49, no. 2 (May 2015): 51-56. https://doi.org/10.17096/jiufd.42908.
EndNote Asutay F, Acar A, Yolcu Ü, Kırtay M, Alan H (May 1, 2015) DENTAL STEM CELL SOURCES AND THEIR POTENTIALS FOR BONE TISSUE ENGINEERING. Journal of Istanbul University Faculty of Dentistry 49 2 51–56.
IEEE F. Asutay, A. Acar, Ü. Yolcu, M. Kırtay, and H. Alan, “DENTAL STEM CELL SOURCES AND THEIR POTENTIALS FOR BONE TISSUE ENGINEERING”, J Istanbul Univ Fac Dent, vol. 49, no. 2, pp. 51–56, 2015, doi: 10.17096/jiufd.42908.
ISNAD Asutay, Fatih et al. “DENTAL STEM CELL SOURCES AND THEIR POTENTIALS FOR BONE TISSUE ENGINEERING”. Journal of Istanbul University Faculty of Dentistry 49/2 (May 2015), 51-56. https://doi.org/10.17096/jiufd.42908.
JAMA Asutay F, Acar A, Yolcu Ü, Kırtay M, Alan H. DENTAL STEM CELL SOURCES AND THEIR POTENTIALS FOR BONE TISSUE ENGINEERING. J Istanbul Univ Fac Dent. 2015;49:51–56.
MLA Asutay, Fatih et al. “DENTAL STEM CELL SOURCES AND THEIR POTENTIALS FOR BONE TISSUE ENGINEERING”. Journal of Istanbul University Faculty of Dentistry, vol. 49, no. 2, 2015, pp. 51-56, doi:10.17096/jiufd.42908.
Vancouver Asutay F, Acar A, Yolcu Ü, Kırtay M, Alan H. DENTAL STEM CELL SOURCES AND THEIR POTENTIALS FOR BONE TISSUE ENGINEERING. J Istanbul Univ Fac Dent. 2015;49(2):51-6.
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