Effects of T-PRF and A-PRF on the Osteogenic Biomarkers in Intrabony Defects of Periodontitis Patients

Siddika Selva Süme Keşir; Meltem Hendek; Üçler Kısa; Ebru Olgun

doi:10.7126/cumudj.1253515

EN

Effects of T-PRF and A-PRF on the Osteogenic Biomarkers in Intrabony Defects of Periodontitis Patients

Abstract

Background: Different derivatives of platelet-rich fibrin (PRF) have been developed but the efficacy of these derivatives in tissue healing and regeneration is still unclear. The aim of this study was to evaluate the effects of titanium-prepared PRF (T-PRF) and advanced PRF (A-PRF) on osteogenic biomarkers in gingival crevicular fluid (GCF) and clinical parameters. Methods: Seventeen systemically healthy participants with 30 bilateral infrabony defects were recruited. Following phase I periodontal therapy, intrabony defects were treated either with A-PRF+open flap debridement (OFD) or T-PRF+OFD. Plaque index (PI), gingival index (GI), pocket depth (PD), clinical attachment loss (CAL) was recorded at the baseline and 6th month after treatment. GCF samples were collected at the baseline and 3rd, 6th months after surgery. Nuclear factor receptor activator (RANK), receptor activator nuclear kappa-B ligand (RANKL), osteoprotegerin (OPG) and tumor necrosis factor alpha converting enzyme (TACE) in GCF samples were analyzed by human enzyme-linked immunosorbent assay (ELISA). Results: In both groups, statistically significant changes were observed in clinical parameters, however, there was no difference between the groups. In terms of osteogenic biomarkers in GCF, there were no statistically significant differences between and within the groups. Conclusion: Different derivatives of PRF can be used to enhance the clinical outcomes of intrabony defects in periodontitis.

Keywords

Supporting Institution

This research was supported by the Scientific Research Project Fund of Kırıkkale University

Project Number

2015/074

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Siddika Selva Süme Keşir
0000-0003-0817-2803
Türkiye

Meltem Hendek ^*
0000-0003-1518-4159
Türkiye

Üçler Kısa
0000-0002-8131-6810
Türkiye

Ebru Olgun
0000-0001-5001-8151
Türkiye

Publication Date

September 29, 2023

Submission Date

February 21, 2023

Acceptance Date

June 14, 2023

Published in Issue

Year 1970 Volume: 26 Number: 3

DOI

https://doi.org/10.7126/cumudj.1253515

IZ

https://izlik.org/JA95MG94BR

Cite

RIS / Bibtex

EndNote

Süme Keşir SS, Hendek M, Kısa Ü, Olgun E (September 1, 2023) Effects of T-PRF and A-PRF on the Osteogenic Biomarkers in Intrabony Defects of Periodontitis Patients. Cumhuriyet Dental Journal 26 3 248–254.

Cited By

Efficacy of Titanium-Reinforced Platelet-Rich Fibrin in Treating Intrabony Defects: A Systematic Review and Meta-Analysis

Medical Journal of Dr. D.Y. Patil Vidyapeeth

https://doi.org/10.4103/mjdrdypu.mjdrdypu_411_25

Structural and Mechanical Characterization of Titanium-Reinforced PlateletRich Fibrin (T- PRF) in Healthy and Periodontitis affected Patients

Cumhuriyet Dental Journal

https://doi.org/10.7126/cumudj.1666750

Öz

Effects of T-PRF and A-PRF on the Osteogenic Biomarkers in Intrabony Defects of Periodontitis Patients

Abstract

Keywords

Supporting Institution

Project Number

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Efficacy of Titanium-Reinforced Platelet-Rich Fibrin in Treating Intrabony Defects: A Systematic Review and Meta-Analysis

Structural and Mechanical Characterization of Titanium-Reinforced PlateletRich Fibrin (T- PRF) in Healthy and Periodontitis affected Patients