Review
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Year 2023, Volume: 26 Issue: 2, 194 - 203, 23.06.2023

Sweta Pradhan , Neetha Shetty

https://doi.org/10.7126/cumudj.1128860

Abstract

References

  • Reference 1. Suchetha A, Lakshmi P, Bhat D, Mundinamane DB, Soorya KV, Bharwani GA. Platelet concentration in platelet concentrates and periodontal regeneration-unscrambling the ambiguity. Contemp Clin Dent 2015; 6:510-6
  • Reference2. ZhuW, Ma X, GouM, Mei D, Zhang K, Chen S. 3D printing of functional biomaterials for tissue engineering. Current opinion in biotechnology.; 40:103–12 (2016).
  • Reference 3. BarbeckM, Najman S, Stojanovic S, Mitic Z, Zivkovic JM, Choukroun J, et al. Addition of blood to a phycogenic bone substitute leads to increase in vivo vascularization. Biomedical materials (Bristol, England).; 10(5):055007 (2015)
  • Reference 4. Agarwal AA. Evolution current status and evidence in application of platelet Concentrates in periodontology and implantology. World J Clin Cases; 5 :159-71 (2017)
  • Reference 5. Harrison P. Platelet function analysis. Blood Rev 2005; 19:111-23. 4.
  • Reference6. Marx, RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004; 62:489–496.
  • Reference7. Agrawal AA. Evolution, current status and advances in application of platelet concentrate in periodontics and implantology. World J Clin Cases 2017; 5(5): 159-171 Available from: URL: http://www. wjgnet.com/2307-8960/full/v5/i5/159.htm DOI: http://dx.doi. org/10.12998/wjcc. v5.i5.159
  • Reference8. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J et al (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101: e37–e44
  • Reference9. Dhurat R, Sukesh M. Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author’s Perspective. J Cutan Aesthetic Surg.; 7: 189-97 (2014).
  • Reference10. Sunitha Raja V, Munirathnam Naidu E (2008) Platelet rich fibrin: evolution of a second-generation platelet concentrate. Indian J Dent Res 19:42–46
  • Reference11. Dhurat R, Sukesh M. Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author’s Perspective. J Cutan Aesthetic Surg.; 7: 189-97 (2014).
  • Reference 12. Chandran P, Sivadas A. Platelet-rich fibrin: Its role in periodontal regeneration. J Dent Res; 5: 117–22 (2014)
  • Reference 13. Ghanatti S, BoomsP,Orlowska A, Kubesch A, Lorenz J, Rutkowski J et al. Advanced platelet rich fibrin a new concept of cell based tissue engineering by means of inflammatory cells. J Oral Implantol; 6: 679-89 (2014).
  • Reference 14. Kobayashi E, Fluckiger L, Fujioka-Kobayashi M, Sawada K, Sculean A,Schaller B, et al. Comparative release of growth factors from PRP, PRF,and advanced-PRF+. Clin Oral Investig; 2:23-30 (2016).
  • Reference 15. Mourao CF, Valiense H, Melo ER, Mourão NB, Maia MD. Obtention of injectable platelets richfibrin (i-PRF) and its polymerization with bone graft: technical note. Rev Col Bras Cir; 42: 421-3 (2015)
  • Reference 16. Shah R. An Update on the Protocols and Biologic Actions of Platelet Rich Fibrin in Dentistry. European J Prosthodont Restorative Dent; 25: 64–72 (2017)
  • Reference 17. Tunalý M, Ozdemir H, Kucukodacý Z, Akman S, Fýratlý E. In vivo evaluation of titaniumprepared platelet-rich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg; 51:438-43 (2013)
  • Reference 18. Jing Qiao, Na An & Xiangying Ouyang (2017) Quantification of growth factors in different platelet concentrates, Platelets, 28:8, 774-778, DOI: 10.1080/09537104.2016.1267338
  • Reference 19. Fujioka et al., Schaller B, Mourão CF, Zhang Y, Sculean A, Miron RJ. (2020): Biological characterization of an injectable platelet-rich fibrin mixture consisting of autologous albumin gel and liquid platelet-rich fibrin (Alb-PRF). Platelets. 23:1-8
  • Reference 20. Miron et al., Chai J, Zheng S, Feng M, Sculean A, Zhang Y. (2019): A novel method for evaluating and quantifying cell types in platelet rich fibrin and an introduction to horizontal centrifugation. Journal of Biomedical Materials Research Part A., 107(10):2257-71.
  • Reference 21. Soffer E, Ouhayoun JP, Anagnostou F (2003) Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:521–528
  • Reference 22. Arora NS, Ramanayke T et al (2009) Platelet-rich plasma: a literature review. Implant Dent 18(4):303–308
  • Reference 23. Suaid FF, Carvalho MD, Santamaria MP, Casati MZ, Nociti FH Jr, Sallum AW, Sallum EA. Platelet-rich plasma and connective tissue grafts in the treatment of gingival recessions: a histometric study in dogs. J Periodontol. 2008; 79:888-95. Ann Dent UM. 2020
  • Reference 24. Wiltfang J, Schlegel KA, Schultze-Mosgau S, et al. Sinus floor augmentation with beta-tricalciumphosphate: does platelet-rich plasma promote its osseous integration and degradation? Clin Oral Impl Res. 2003; 14:213–8.
  • Reference25. Carvalho MD, Suaid FF, Santamaria MP, et al. Platelet-rich plasma plus bioactive glass in the treatment of intra-bony defects: a study in dogs. J Appl Oral Sci. 2011; 19:82-89.
  • Reference26. Anitua E. Plasma rich in growth factors: Preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 1999; 14:529 35.
  • Reference27. Lekovic V, Camargo PM, Weinlaender M, Vasilic N, Kenney EB. Comparison of platelet rich plasma, bovine porous bone mineral, and guided tissue regeneration versus platelet rich plasma and bovine porous bone mineral in the treatment of intrabony defects: A re-entry study. J Periodontol 2002; 73:198 205.
  • Reference28. Eskan MA, Greenwell H, Hill M, et al. Platelet-rich plasma-assisted guided bone regeneration for ridge augmentation: a randomized, controlled clinical trial. J Periodontol. 2014; 85:661–8. 33.
  • Reference29. Panda S, Doraiswamy J, Malaiappan S, Varghese SS, Del Fabbro M. Additive effect of autologous platelet concentrates in treatment of intrabony defects: a systematic review and meta-analysis. J Investig Clin Dent. 2016; 7:13-26
  • Reference30. Shivashankar VY, Johns DA, Vidyanath S, Kumar MR. Platelet rich fibrin in the revitalization of tooth with necrotic pulp and open apex. J Conserv Dent 2012; 15:395 8.
  • Reference31. Dohan Ehrenfest DM, de Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin1 in Choukroun’s plateletrich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors 2009; 27: 63-69
  • Reference32. Naik B, Karunakar P, Jayadev M, Marshal VR. Role of Platelet rich fibrin in wound healing: A critical review. J Conserv Dent 2013; 16:284 93.
  • Reference33. Duan X, Lin Z, Lin X, et al. Study of platelet-rich fibrin combined with rat periodontal ligament stem cells in periodontal tissue regeneration. J Cell Mol Med. 2018; 22:1047-1055.
  • Reference34. Wang Z, Han L, Sun T, et al. Preparation and effect of lyophilized platelet-rich fibrin on the osteogenic potential of bone marrow mesenchymal stem cells in vitro and in vivo. Heliyon. 2019;5: e02739.
  • Reference35. Deepa D, Jain N. Gingival fenestration defect in the maxillary anterior region treated with coronally positioned flap using platelet rich fibrin membrane. J Interdiscipl Dent 2015; 5:140 4.
  • Reference36. Pradeep AR, Rao NS, Agarwal E, Bajaj P, Kumari M, Naik SB. Comparative evaluation of autologous platelet rich fibrin and platelet rich plasma in the treatment of 3 wall intrabony defects in chronic periodontitis: A randomized controlled clinical trial. J Periodontol 2012; 83:1499 507.
  • Reference37. Agarwal A, Gupta ND, Jain A. Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: A randomized split mouth clinical trial. Acta Odontol Scand. 2016; 74:36–43.
  • Reference38. Strauss FJ, Stähli A, Gruber R. The use of platelet-rich fibrin to enhance the outcomes of implant therapy: A systematic review. Clin Oral Implants Res. 2018;29 Suppl 18(Suppl Suppl 18):6-19.
  • Reference39. Li F, Jiang P, Pan J, Liu C, Zheng L. Synergistic Application of Platelet-Rich Fibrin and 1% Alendronate in Periodontal Bone Regeneration: A Meta-Analysis. Biomed Research International. 2019: 9148183.
  • Reference40. Dohan Ehrenfest DM, Pinto NR, Pereda A, Jiménez P, Corso MD, Kang BS, Nally M, Lanata N, Wang HL, Quirynen M. The impact of the centrifuge characteristics and centrifugation protocols on the cells, growth factors, and fibrin architecture of a leukocyte- and platelet-rich fibrin (L-PRF) clot and membrane. Platelets. 2018; 29:171-184.
  • Reference41. Temmerman A, Cleeren GJ, Castro AB, Teughels W, Quirynen M. L-PRF for increasing the width of keratinized mucosa around implants: A split-mouth, randomized, controlled pilot clinical trial. J Periodontal Res. 2018; 53:793- 800.
  • Reference42. Eppley BL, Pietrzak WS, Blanton M. Platelet-rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg. 2006; 118: 147e–159e.
  • Reference43. Pitzurra L, Jansen IDC, de Vries TJ, Hoogenkamp MA, Loos BG. Effects of L-PRF and A-PRF+ on periodontal fibroblasts in in vitro wound healing experiments. J Periodontal Res. 2020; 55:287-295.
  • Reference44. Ozsagir ZB, Saglam E, Sen Yilmaz B, Choukroun J, Tunali M. Injectable platelet-rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: A randomized controlled clinical trial. Journal of Clinical Periodontology. 2020; 47:489-499.
  • Reference45. Chatterjee, A.; Pradeep, A.R.; Garg, V.; Yajamanya, S.; Ali, M.M.; Priya, V.S. Treatment of periodontal intrabony defects using autologous platelet-rich fibrin and titanium platelet-rich fibrin: A randomized, clinical, comparative study. J. Investig. Clin. Dent. 2017, 8.
  • Reference46. Arabaci T, Albayrak M. Titanium-prepared platelet-rich fibrin provides advantages on periodontal healing: A randomized split-mouth clinical study. J Periodontol. 2018;89:255-264.
  • Reference47. Bozkurt Doğan Ş, Öngöz Dede F, Ballı U, Atalay EN, Durmuşlar MC. Concentrated growth factor in the treatment of adjacent multiple gingival recessions: a split-mouth randomized clinical trial. J Clin Periodontol. 2015; 42:868-875.
  • Reference48. . Gökmenoğlu C, Yavuz MC, Sadik E, Çanakçi V, Kara C. Treatment of Different Types of Bone Defects with Concentrated Growth Factor: Four Case Reports. Int J Oral Dent Health. 2016; 2:029(2):2.
  • Reference49. Sohn DS, Huang B, Kim J, Park WE, Park CC. Utilization of autologous concentrated growth factors (CGF) enriched bone graft matrix (Sticky bone) and CGF-enriched fibrin membrane in Implant Dentistry. J. Implant Adv. Clin. Dent 2015; 7:11-29.
  • Reference50. . Mustafa Özay Uslu, Mehmet Kızıltoprak, Ömer Alperen Kırmızıgül. Autologous Fibrin Glue as a Novel Platelet Concentration in Palatal Wound Healing. Dent Res and Oral Health. 2019; 2:40-46.
  • Reference51. Wang S, Li Z, Xu R. Human Cancer and Platelet Interaction, a Potential Therapeutic Target. Int J Mol Sci. 2018; 19:1246.
  • Reference52. DovizioM, BrunoA, ContursiA, GrandeR, PatrignaniP. Platelets and extracellular vesicles in cancer: diagnostic and therapeutic implications. Cancer Metastasis Rev 2018; 37:455–467.
  • Reference53. Son SR, Sarkar SK, Nguyen-Thuy BL, Padalhin AR, Kim BR, Jung HI, Lee BT. Platelet-rich plasma encapsulation in hyaluronic acid/gelatin-BCP hydrogel for growth factor delivery in BCP sponge scaffold for bone regeneration. J Biomater Appl. 2015;29:988-1002.

Platelet concentrates – A panacea for periodontal regeneration.

Year 2023, Volume: 26 Issue: 2, 194 - 203, 23.06.2023

Sweta Pradhan , Neetha Shetty

https://doi.org/10.7126/cumudj.1128860

Abstract

Periodontitis is an inflammatory condition of the periodontium leading to loss of supporting structures of the tooth. The regeneration of periodontium refers to the restoration of the lost tissues to their original form and function by reiterating the fundamental wound healing processes involved in their development. Research has led to the development of “Autologous biomaterials” provide signals for healing, repair, and regeneration. These autologous substances also fosters neo-angiogenesis and new bone formation and therefore have yielded encouraging results in the field of regenerative dentistry.
Platelet concentrates have higher concentration of growth factors which enhance periodontal regeneration. Blood derivatives have several advantages such as being autogenous, cost effective, less time consuming, simple to perform and prolonged release of growth factors. Since inception, many approaches have evolved also in-depth research has been done regarding its biological and clinical applications. Several modifications have been advocated in the conventional protocol like the advanced PRF, injectable PRF, PRF lysate and Titanium-prepared PRF.
This review paper addresses the evolution, applications of platelet concentrates for tissue engineering, recent advances, and novel protocols. Furthermore, several future perspectives of platelet concentrates, such as platelet concentrates as drug delivery agents, platelet dust and liposomes encapsulating platelet concentrates are also discussed.

Keywords

Autologous biomaterials Periodontal Regeneration Platelet concentrates Platelet rich Fibrin.

References

  • Reference 1. Suchetha A, Lakshmi P, Bhat D, Mundinamane DB, Soorya KV, Bharwani GA. Platelet concentration in platelet concentrates and periodontal regeneration-unscrambling the ambiguity. Contemp Clin Dent 2015; 6:510-6
  • Reference2. ZhuW, Ma X, GouM, Mei D, Zhang K, Chen S. 3D printing of functional biomaterials for tissue engineering. Current opinion in biotechnology.; 40:103–12 (2016).
  • Reference 3. BarbeckM, Najman S, Stojanovic S, Mitic Z, Zivkovic JM, Choukroun J, et al. Addition of blood to a phycogenic bone substitute leads to increase in vivo vascularization. Biomedical materials (Bristol, England).; 10(5):055007 (2015)
  • Reference 4. Agarwal AA. Evolution current status and evidence in application of platelet Concentrates in periodontology and implantology. World J Clin Cases; 5 :159-71 (2017)
  • Reference 5. Harrison P. Platelet function analysis. Blood Rev 2005; 19:111-23. 4.
  • Reference6. Marx, RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004; 62:489–496.
  • Reference7. Agrawal AA. Evolution, current status and advances in application of platelet concentrate in periodontics and implantology. World J Clin Cases 2017; 5(5): 159-171 Available from: URL: http://www. wjgnet.com/2307-8960/full/v5/i5/159.htm DOI: http://dx.doi. org/10.12998/wjcc. v5.i5.159
  • Reference8. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J et al (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101: e37–e44
  • Reference9. Dhurat R, Sukesh M. Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author’s Perspective. J Cutan Aesthetic Surg.; 7: 189-97 (2014).
  • Reference10. Sunitha Raja V, Munirathnam Naidu E (2008) Platelet rich fibrin: evolution of a second-generation platelet concentrate. Indian J Dent Res 19:42–46
  • Reference11. Dhurat R, Sukesh M. Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author’s Perspective. J Cutan Aesthetic Surg.; 7: 189-97 (2014).
  • Reference 12. Chandran P, Sivadas A. Platelet-rich fibrin: Its role in periodontal regeneration. J Dent Res; 5: 117–22 (2014)
  • Reference 13. Ghanatti S, BoomsP,Orlowska A, Kubesch A, Lorenz J, Rutkowski J et al. Advanced platelet rich fibrin a new concept of cell based tissue engineering by means of inflammatory cells. J Oral Implantol; 6: 679-89 (2014).
  • Reference 14. Kobayashi E, Fluckiger L, Fujioka-Kobayashi M, Sawada K, Sculean A,Schaller B, et al. Comparative release of growth factors from PRP, PRF,and advanced-PRF+. Clin Oral Investig; 2:23-30 (2016).
  • Reference 15. Mourao CF, Valiense H, Melo ER, Mourão NB, Maia MD. Obtention of injectable platelets richfibrin (i-PRF) and its polymerization with bone graft: technical note. Rev Col Bras Cir; 42: 421-3 (2015)
  • Reference 16. Shah R. An Update on the Protocols and Biologic Actions of Platelet Rich Fibrin in Dentistry. European J Prosthodont Restorative Dent; 25: 64–72 (2017)
  • Reference 17. Tunalý M, Ozdemir H, Kucukodacý Z, Akman S, Fýratlý E. In vivo evaluation of titaniumprepared platelet-rich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg; 51:438-43 (2013)
  • Reference 18. Jing Qiao, Na An & Xiangying Ouyang (2017) Quantification of growth factors in different platelet concentrates, Platelets, 28:8, 774-778, DOI: 10.1080/09537104.2016.1267338
  • Reference 19. Fujioka et al., Schaller B, Mourão CF, Zhang Y, Sculean A, Miron RJ. (2020): Biological characterization of an injectable platelet-rich fibrin mixture consisting of autologous albumin gel and liquid platelet-rich fibrin (Alb-PRF). Platelets. 23:1-8
  • Reference 20. Miron et al., Chai J, Zheng S, Feng M, Sculean A, Zhang Y. (2019): A novel method for evaluating and quantifying cell types in platelet rich fibrin and an introduction to horizontal centrifugation. Journal of Biomedical Materials Research Part A., 107(10):2257-71.
  • Reference 21. Soffer E, Ouhayoun JP, Anagnostou F (2003) Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:521–528
  • Reference 22. Arora NS, Ramanayke T et al (2009) Platelet-rich plasma: a literature review. Implant Dent 18(4):303–308
  • Reference 23. Suaid FF, Carvalho MD, Santamaria MP, Casati MZ, Nociti FH Jr, Sallum AW, Sallum EA. Platelet-rich plasma and connective tissue grafts in the treatment of gingival recessions: a histometric study in dogs. J Periodontol. 2008; 79:888-95. Ann Dent UM. 2020
  • Reference 24. Wiltfang J, Schlegel KA, Schultze-Mosgau S, et al. Sinus floor augmentation with beta-tricalciumphosphate: does platelet-rich plasma promote its osseous integration and degradation? Clin Oral Impl Res. 2003; 14:213–8.
  • Reference25. Carvalho MD, Suaid FF, Santamaria MP, et al. Platelet-rich plasma plus bioactive glass in the treatment of intra-bony defects: a study in dogs. J Appl Oral Sci. 2011; 19:82-89.
  • Reference26. Anitua E. Plasma rich in growth factors: Preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 1999; 14:529 35.
  • Reference27. Lekovic V, Camargo PM, Weinlaender M, Vasilic N, Kenney EB. Comparison of platelet rich plasma, bovine porous bone mineral, and guided tissue regeneration versus platelet rich plasma and bovine porous bone mineral in the treatment of intrabony defects: A re-entry study. J Periodontol 2002; 73:198 205.
  • Reference28. Eskan MA, Greenwell H, Hill M, et al. Platelet-rich plasma-assisted guided bone regeneration for ridge augmentation: a randomized, controlled clinical trial. J Periodontol. 2014; 85:661–8. 33.
  • Reference29. Panda S, Doraiswamy J, Malaiappan S, Varghese SS, Del Fabbro M. Additive effect of autologous platelet concentrates in treatment of intrabony defects: a systematic review and meta-analysis. J Investig Clin Dent. 2016; 7:13-26
  • Reference30. Shivashankar VY, Johns DA, Vidyanath S, Kumar MR. Platelet rich fibrin in the revitalization of tooth with necrotic pulp and open apex. J Conserv Dent 2012; 15:395 8.
  • Reference31. Dohan Ehrenfest DM, de Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin1 in Choukroun’s plateletrich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors 2009; 27: 63-69
  • Reference32. Naik B, Karunakar P, Jayadev M, Marshal VR. Role of Platelet rich fibrin in wound healing: A critical review. J Conserv Dent 2013; 16:284 93.
  • Reference33. Duan X, Lin Z, Lin X, et al. Study of platelet-rich fibrin combined with rat periodontal ligament stem cells in periodontal tissue regeneration. J Cell Mol Med. 2018; 22:1047-1055.
  • Reference34. Wang Z, Han L, Sun T, et al. Preparation and effect of lyophilized platelet-rich fibrin on the osteogenic potential of bone marrow mesenchymal stem cells in vitro and in vivo. Heliyon. 2019;5: e02739.
  • Reference35. Deepa D, Jain N. Gingival fenestration defect in the maxillary anterior region treated with coronally positioned flap using platelet rich fibrin membrane. J Interdiscipl Dent 2015; 5:140 4.
  • Reference36. Pradeep AR, Rao NS, Agarwal E, Bajaj P, Kumari M, Naik SB. Comparative evaluation of autologous platelet rich fibrin and platelet rich plasma in the treatment of 3 wall intrabony defects in chronic periodontitis: A randomized controlled clinical trial. J Periodontol 2012; 83:1499 507.
  • Reference37. Agarwal A, Gupta ND, Jain A. Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: A randomized split mouth clinical trial. Acta Odontol Scand. 2016; 74:36–43.
  • Reference38. Strauss FJ, Stähli A, Gruber R. The use of platelet-rich fibrin to enhance the outcomes of implant therapy: A systematic review. Clin Oral Implants Res. 2018;29 Suppl 18(Suppl Suppl 18):6-19.
  • Reference39. Li F, Jiang P, Pan J, Liu C, Zheng L. Synergistic Application of Platelet-Rich Fibrin and 1% Alendronate in Periodontal Bone Regeneration: A Meta-Analysis. Biomed Research International. 2019: 9148183.
  • Reference40. Dohan Ehrenfest DM, Pinto NR, Pereda A, Jiménez P, Corso MD, Kang BS, Nally M, Lanata N, Wang HL, Quirynen M. The impact of the centrifuge characteristics and centrifugation protocols on the cells, growth factors, and fibrin architecture of a leukocyte- and platelet-rich fibrin (L-PRF) clot and membrane. Platelets. 2018; 29:171-184.
  • Reference41. Temmerman A, Cleeren GJ, Castro AB, Teughels W, Quirynen M. L-PRF for increasing the width of keratinized mucosa around implants: A split-mouth, randomized, controlled pilot clinical trial. J Periodontal Res. 2018; 53:793- 800.
  • Reference42. Eppley BL, Pietrzak WS, Blanton M. Platelet-rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg. 2006; 118: 147e–159e.
  • Reference43. Pitzurra L, Jansen IDC, de Vries TJ, Hoogenkamp MA, Loos BG. Effects of L-PRF and A-PRF+ on periodontal fibroblasts in in vitro wound healing experiments. J Periodontal Res. 2020; 55:287-295.
  • Reference44. Ozsagir ZB, Saglam E, Sen Yilmaz B, Choukroun J, Tunali M. Injectable platelet-rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: A randomized controlled clinical trial. Journal of Clinical Periodontology. 2020; 47:489-499.
  • Reference45. Chatterjee, A.; Pradeep, A.R.; Garg, V.; Yajamanya, S.; Ali, M.M.; Priya, V.S. Treatment of periodontal intrabony defects using autologous platelet-rich fibrin and titanium platelet-rich fibrin: A randomized, clinical, comparative study. J. Investig. Clin. Dent. 2017, 8.
  • Reference46. Arabaci T, Albayrak M. Titanium-prepared platelet-rich fibrin provides advantages on periodontal healing: A randomized split-mouth clinical study. J Periodontol. 2018;89:255-264.
  • Reference47. Bozkurt Doğan Ş, Öngöz Dede F, Ballı U, Atalay EN, Durmuşlar MC. Concentrated growth factor in the treatment of adjacent multiple gingival recessions: a split-mouth randomized clinical trial. J Clin Periodontol. 2015; 42:868-875.
  • Reference48. . Gökmenoğlu C, Yavuz MC, Sadik E, Çanakçi V, Kara C. Treatment of Different Types of Bone Defects with Concentrated Growth Factor: Four Case Reports. Int J Oral Dent Health. 2016; 2:029(2):2.
  • Reference49. Sohn DS, Huang B, Kim J, Park WE, Park CC. Utilization of autologous concentrated growth factors (CGF) enriched bone graft matrix (Sticky bone) and CGF-enriched fibrin membrane in Implant Dentistry. J. Implant Adv. Clin. Dent 2015; 7:11-29.
  • Reference50. . Mustafa Özay Uslu, Mehmet Kızıltoprak, Ömer Alperen Kırmızıgül. Autologous Fibrin Glue as a Novel Platelet Concentration in Palatal Wound Healing. Dent Res and Oral Health. 2019; 2:40-46.
  • Reference51. Wang S, Li Z, Xu R. Human Cancer and Platelet Interaction, a Potential Therapeutic Target. Int J Mol Sci. 2018; 19:1246.
  • Reference52. DovizioM, BrunoA, ContursiA, GrandeR, PatrignaniP. Platelets and extracellular vesicles in cancer: diagnostic and therapeutic implications. Cancer Metastasis Rev 2018; 37:455–467.
  • Reference53. Son SR, Sarkar SK, Nguyen-Thuy BL, Padalhin AR, Kim BR, Jung HI, Lee BT. Platelet-rich plasma encapsulation in hyaluronic acid/gelatin-BCP hydrogel for growth factor delivery in BCP sponge scaffold for bone regeneration. J Biomater Appl. 2015;29:988-1002.
There are 53 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Review
Authors

Sweta Pradhan 0000-0002-3604-9901

Neetha Shetty 0000-0001-8841-6235

Publication Date June 23, 2023
Submission Date June 10, 2022
Published in Issue Year 2023Volume: 26 Issue: 2

Cite

EndNote Pradhan S, Shetty N (June 1, 2023) Platelet concentrates – A panacea for periodontal regeneration. Cumhuriyet Dental Journal 26 2 194–203.
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