Research Article
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Year 2019, Volume: 53 Issue: 1, 38 - 43, 31.01.2019

Abstract

References

  • Socransky SS, Haffajee AD. Nature of periodontal diseases. Ann Periodontol 1997;2:3-10. [CrossRef ]
  • Dikbas I, Tanalp J, Tomruk CO, Koksal T. Evaluation of reasons for extraction of crowned teeth: a prospective study at a university clinic. ActaOdontol Scand. 2013;71:848-856. [CrossRef ]
  • Zander HA, Polson AM, Heijl LC. Goals of periodontal therapy. J Periodontol. 1976 May;47(5):261-6. [CrossRef ]
  • Caton J, Nyman S, Zander H. Histometric Evaluation of Periodontal Surgery. II Connective tissue attachment levels after four regenerative procedures. J Clin Periodontol 1980;7:224-31. [CrossRef ]
  • Melcher AH. On the repair potential of periodontal tissues. J Periodontol. 1976;47:256-260. [CrossRef ]
  • Nyman S, Lindhe J, Karring T, Rylander H. New Attachment following surgical treatment of human periodontal disease. J ClinPeriodontol. 1982;9:290-6. [CrossRef ]
  • Mayubala I, Shivkumar M, Sureshkumar RV, Sastry TP. Bioactivity and Osseointegration Study of Calcium Phosphate Ceramic of different chemical composition. J Biomed Mater Res. 2002;63:2:200-8. [CrossRef ]
  • Wilson J, Low SB. Bioactive ceramics for periodontal treatment: comparative studies in the Patus Monkey. J Appl Biomater 1992;3:123-9. [CrossRef ]
  • Gosain AK, Song L, Riordan P, Amarante MT, Nagy PG, Wilson CR, et al.A 1-year study of osteoinduction in hydroxyapatite-derived biomaterials in an adult sheep model: part I. Plast Reconstr Surg. 2002;109:619-30. [CrossRef ]
  • Koepp HE, Schorlemmer S, Kessler S, Brenner RE, Claes L, Günther KP, Ignatius AA. Biocompatibility and osseointegration of beta-TCP: histomorphological and biomechanical studies in a weight-bearing sheep model. J Biomed Mater Res B Appl Biomater. 2004 Aug 15;70:209-17. [CrossRef ]
  • Busschop J, De Boever J. Clinical and histological characteristics of lyophilized allogenicduramater in periodontal bony defects in humans. J Clin Periodontol. 1983;10:399-411. [CrossRef ]
  • Pitaru S, Tal H, Soldinger M. Partial regeneration of periodontal tissues using collagen barriers. Initial observations in the canine. J Periodontol. 1988;59:380-6. [CrossRef ]
  • Sandhya G, Bal Reddy P, Jeevan Kumar A, Sridhar Reddy B, Prasad N, and Kiran G. Surgical Management of Oro-Antral Communications Using Resorbable GTR Membrane and FDMB Sandwich Technique: A Clinical Study. J Maxillofac Oral Surg. 2013 Sep;12:254-9. [CrossRef ]
  • Anila S.Nandkumar K. To evaluate the efficacy of a Collagen barrier membrane of Fish origin for GTR with or without autologous PRP in the treatment of periodontal intrabony defects. Trends Biomater Artif Organs. 2006;20:78-83.
  • The American Academy of Periodontology. Position paper- The potential role of growth and differentiation factors in periodontal regeneration. J Periodontol. 1996;67:545-53.
  • Howell TH, Fiorellini J, Paquette D, Offenbacher S, Antoniades H, Linch S. Evaluation of platelet derived growth factor – BB / Purified Insulin- Like Growth Factor –I in patients with periodontal disease. J Dent Res. 1995;74:253-7.
  • Arlson NE, Roach RB Jr. Platelet rich plasma; Clinical Applications in Dentistry. J Am Dent Assoc. 2002 Oct;133:1383-6. [CrossRef ]
  • Marx RE, Carlson ER, Eichstaedt RM Schimmele SR, Strauss JE, Georgeff KR. Platelet rich plasma-Growth Factor enhancement for one Grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Jun;85:638-46. [CrossRef ]
  • Silness J, Loe H. Periodontal disease in pregnancy II. Corelation between oral hygiene and periodontal conditions. Acta Odont Scand. 1964;24:747-59. [CrossRef ]
  • Saxer UP and MuhlemannHtR. Motivaion and Education. SSO Schweiz Monatsschr Zahnheilkd. 1975 Sep;85(9):905-19.
  • Camargo PM, Lekovic V, Weinlander M, Vasilic N, Madzarevic M, Kenney EB. Platelet rich plasma and bovine porous bone mineral combined with guided tissue regeneration in the treatment of intrabony defects in humans. J Periodont Res. 2002;37:300-6. [CrossRef ]
  • Wang HL, Pappert TD, Castelli WA, Chiego Jr. DJ, Shyr Y and Smith BA. The effect of platelet derived growth factor on the cellular response of the periodontium: An auto-radiographic study on dogs. J Periodontol. 1994;65:429-36. [CrossRef ]
  • Rutherford RB, Niekrash CE, Kennedy JE,Charette MF. Platelet derived and insulin like growth factors stimulate regeneration of periodontal attachment in monkeys. J Periodont Res. 2002;27:285-90. [CrossRef ]
  • Christgau M, Moder D, Wagner J, Glässl M, Hiller KA, Wenzel A, Schmalz G. Influence of autologous platelet concentrate on healing on intrabony defects following guided tissue regeneration therapy: A randomized Prospective Clinical Split- Mouth Study. J Clin Periodontol. 2006;33(12):908-21. [CrossRef ]
  • Yassibag-Berkman Z, Tuncer O, Subasioglu T, Kantarci A. Combined use of platelet rich plasma and bone grafting with and without guided tissue regeneration in the treatment of anterior interproximal defects. J Periodontol. 2007;78:801-9. [CrossRef ]
  • Massague J. The TGF-beta family of growth and differentiation factors. Cell 1987;49:437-8. [CrossRef ]
  • Appel TR, Pötzsch B, Müller J, von Lindern JJ, Bergé SJ, Reich RH. Comparison of three different preparations of platelet concentrates for growth factor enrichment. Clin Oral Impl Res 2002;13:522-8. [CrossRef ]
  • Ross R. Platelet-derived growth factor. Lancet. 1989 May 27;1(8648):1179-82. [CrossRef ]
  • Christgau M, Bader N, Felden A, Gradl J, Wenzel A,Schmalz G. Guided tissue regeneration in intrabony defects using an experimental bioresorbablepolydioxanon (PDS) membrane. A 24-month split-mouth study. J Clin Periodontol. 2002;29:710-23. [CrossRef ]
  • King GN, King N, Hughes F. Effect of two delivery systems for rhBMP-2 on periodontal regeneration in vivo. J Periodont Res. 1998;33:226-34. [CrossRef ]
  • Lekovic V,Camargo PM, Weinlander M, Vasilic N, Alesiz, Canney EG. Effectiveness of a combination of platelet rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II furcation in humans. J Clin Periodontol. 2003;30:746-51. [CrossRef ]
  • Lioubavina-Hack N, Carmagnola D, Lynch SE, Karring T. Effect of bio-oss with or without platelet derived growth factor on bone formation by guided tissue regeneration: A pilot study in rats. J Clin Periodontol. 2005;32:1254-60. [CrossRef ]
  • Brägger U, Hämmerle CF, Mombelli A, Bürgin W. and Lang NP. Remodelling of periodontal tissues adjacent to sites treated according to the principles of guided tissue regeneration (GTR). J Clin Periodontol. 1992;19:615-24. [CrossRef ]
  • Christgau M, Bader N, Felden A, Gradl J, Wenzel A, Schmalz G. Guided tissue regeneration in intrabony defects using an experimental bioresorbablepolydioxanon (PDS) membrane. A 24-month split-mouth study. J Clin Periodontol. 2002;29:710-23. [CrossRef ]
  • Sarment DP, Cooke JW, Miller SE, Jin Q, McGuire MK, Kao RT, et al. Effect of rhPDGF-BB on bone turnover during periodontal repair. J Clin Periodontol. 2006;33:135-40. [CrossRef ]
  • Giannobile, WV, Whitson SW. Lynch SE. Non-coordinate control of bone formation displayed by growth factor combinations with IGF-I. J Dent Res. 1997;76:1569-78. [CrossRef ]

The effects of autologous platelet concentrate on the healing of intra-bony defects: a randomized clinical trial

Year 2019, Volume: 53 Issue: 1, 38 - 43, 31.01.2019

Abstract

Purpose
The present study aimed to evaluate the clinical and radiographic effects of
autologous platelet concentrate (APC) on the healing of intra-bony defects filled
with β-tricalcium phosphate (β-TCP) and covered with collagen membranes.
Subjects and methods
This study included 30 defects of 14 systemically healthy subjects. All of them had,
at least, two deep intra-bony, inter-proximal periodontal defects. Minimum probing
pocket depth (PPD) was 6 mm. Clinical and imaging examination was performed
both at baseline and at 3, 6, and 9 months after surgery.
Results
Both the test and control group revealed a significant reduction in all variables
when compared with the base line. Mean reduction of the PPD in two groups at
each follow-up time point showed no significant difference. Means of the clinical
attachment gain of the same groups were significantly different (p<0.05). Mean
gingival recession at 3 month was not significant. However, the means of gingival
recession coverage of two groups were significantly different at 6 and 9 months
(p<0.05 for both).
Conclusion
Sites treated with APC are more likely to demonstrate more clinical attachment gain
and recession coverage at the end of 9 month compared to those without APC.

References

  • Socransky SS, Haffajee AD. Nature of periodontal diseases. Ann Periodontol 1997;2:3-10. [CrossRef ]
  • Dikbas I, Tanalp J, Tomruk CO, Koksal T. Evaluation of reasons for extraction of crowned teeth: a prospective study at a university clinic. ActaOdontol Scand. 2013;71:848-856. [CrossRef ]
  • Zander HA, Polson AM, Heijl LC. Goals of periodontal therapy. J Periodontol. 1976 May;47(5):261-6. [CrossRef ]
  • Caton J, Nyman S, Zander H. Histometric Evaluation of Periodontal Surgery. II Connective tissue attachment levels after four regenerative procedures. J Clin Periodontol 1980;7:224-31. [CrossRef ]
  • Melcher AH. On the repair potential of periodontal tissues. J Periodontol. 1976;47:256-260. [CrossRef ]
  • Nyman S, Lindhe J, Karring T, Rylander H. New Attachment following surgical treatment of human periodontal disease. J ClinPeriodontol. 1982;9:290-6. [CrossRef ]
  • Mayubala I, Shivkumar M, Sureshkumar RV, Sastry TP. Bioactivity and Osseointegration Study of Calcium Phosphate Ceramic of different chemical composition. J Biomed Mater Res. 2002;63:2:200-8. [CrossRef ]
  • Wilson J, Low SB. Bioactive ceramics for periodontal treatment: comparative studies in the Patus Monkey. J Appl Biomater 1992;3:123-9. [CrossRef ]
  • Gosain AK, Song L, Riordan P, Amarante MT, Nagy PG, Wilson CR, et al.A 1-year study of osteoinduction in hydroxyapatite-derived biomaterials in an adult sheep model: part I. Plast Reconstr Surg. 2002;109:619-30. [CrossRef ]
  • Koepp HE, Schorlemmer S, Kessler S, Brenner RE, Claes L, Günther KP, Ignatius AA. Biocompatibility and osseointegration of beta-TCP: histomorphological and biomechanical studies in a weight-bearing sheep model. J Biomed Mater Res B Appl Biomater. 2004 Aug 15;70:209-17. [CrossRef ]
  • Busschop J, De Boever J. Clinical and histological characteristics of lyophilized allogenicduramater in periodontal bony defects in humans. J Clin Periodontol. 1983;10:399-411. [CrossRef ]
  • Pitaru S, Tal H, Soldinger M. Partial regeneration of periodontal tissues using collagen barriers. Initial observations in the canine. J Periodontol. 1988;59:380-6. [CrossRef ]
  • Sandhya G, Bal Reddy P, Jeevan Kumar A, Sridhar Reddy B, Prasad N, and Kiran G. Surgical Management of Oro-Antral Communications Using Resorbable GTR Membrane and FDMB Sandwich Technique: A Clinical Study. J Maxillofac Oral Surg. 2013 Sep;12:254-9. [CrossRef ]
  • Anila S.Nandkumar K. To evaluate the efficacy of a Collagen barrier membrane of Fish origin for GTR with or without autologous PRP in the treatment of periodontal intrabony defects. Trends Biomater Artif Organs. 2006;20:78-83.
  • The American Academy of Periodontology. Position paper- The potential role of growth and differentiation factors in periodontal regeneration. J Periodontol. 1996;67:545-53.
  • Howell TH, Fiorellini J, Paquette D, Offenbacher S, Antoniades H, Linch S. Evaluation of platelet derived growth factor – BB / Purified Insulin- Like Growth Factor –I in patients with periodontal disease. J Dent Res. 1995;74:253-7.
  • Arlson NE, Roach RB Jr. Platelet rich plasma; Clinical Applications in Dentistry. J Am Dent Assoc. 2002 Oct;133:1383-6. [CrossRef ]
  • Marx RE, Carlson ER, Eichstaedt RM Schimmele SR, Strauss JE, Georgeff KR. Platelet rich plasma-Growth Factor enhancement for one Grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Jun;85:638-46. [CrossRef ]
  • Silness J, Loe H. Periodontal disease in pregnancy II. Corelation between oral hygiene and periodontal conditions. Acta Odont Scand. 1964;24:747-59. [CrossRef ]
  • Saxer UP and MuhlemannHtR. Motivaion and Education. SSO Schweiz Monatsschr Zahnheilkd. 1975 Sep;85(9):905-19.
  • Camargo PM, Lekovic V, Weinlander M, Vasilic N, Madzarevic M, Kenney EB. Platelet rich plasma and bovine porous bone mineral combined with guided tissue regeneration in the treatment of intrabony defects in humans. J Periodont Res. 2002;37:300-6. [CrossRef ]
  • Wang HL, Pappert TD, Castelli WA, Chiego Jr. DJ, Shyr Y and Smith BA. The effect of platelet derived growth factor on the cellular response of the periodontium: An auto-radiographic study on dogs. J Periodontol. 1994;65:429-36. [CrossRef ]
  • Rutherford RB, Niekrash CE, Kennedy JE,Charette MF. Platelet derived and insulin like growth factors stimulate regeneration of periodontal attachment in monkeys. J Periodont Res. 2002;27:285-90. [CrossRef ]
  • Christgau M, Moder D, Wagner J, Glässl M, Hiller KA, Wenzel A, Schmalz G. Influence of autologous platelet concentrate on healing on intrabony defects following guided tissue regeneration therapy: A randomized Prospective Clinical Split- Mouth Study. J Clin Periodontol. 2006;33(12):908-21. [CrossRef ]
  • Yassibag-Berkman Z, Tuncer O, Subasioglu T, Kantarci A. Combined use of platelet rich plasma and bone grafting with and without guided tissue regeneration in the treatment of anterior interproximal defects. J Periodontol. 2007;78:801-9. [CrossRef ]
  • Massague J. The TGF-beta family of growth and differentiation factors. Cell 1987;49:437-8. [CrossRef ]
  • Appel TR, Pötzsch B, Müller J, von Lindern JJ, Bergé SJ, Reich RH. Comparison of three different preparations of platelet concentrates for growth factor enrichment. Clin Oral Impl Res 2002;13:522-8. [CrossRef ]
  • Ross R. Platelet-derived growth factor. Lancet. 1989 May 27;1(8648):1179-82. [CrossRef ]
  • Christgau M, Bader N, Felden A, Gradl J, Wenzel A,Schmalz G. Guided tissue regeneration in intrabony defects using an experimental bioresorbablepolydioxanon (PDS) membrane. A 24-month split-mouth study. J Clin Periodontol. 2002;29:710-23. [CrossRef ]
  • King GN, King N, Hughes F. Effect of two delivery systems for rhBMP-2 on periodontal regeneration in vivo. J Periodont Res. 1998;33:226-34. [CrossRef ]
  • Lekovic V,Camargo PM, Weinlander M, Vasilic N, Alesiz, Canney EG. Effectiveness of a combination of platelet rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II furcation in humans. J Clin Periodontol. 2003;30:746-51. [CrossRef ]
  • Lioubavina-Hack N, Carmagnola D, Lynch SE, Karring T. Effect of bio-oss with or without platelet derived growth factor on bone formation by guided tissue regeneration: A pilot study in rats. J Clin Periodontol. 2005;32:1254-60. [CrossRef ]
  • Brägger U, Hämmerle CF, Mombelli A, Bürgin W. and Lang NP. Remodelling of periodontal tissues adjacent to sites treated according to the principles of guided tissue regeneration (GTR). J Clin Periodontol. 1992;19:615-24. [CrossRef ]
  • Christgau M, Bader N, Felden A, Gradl J, Wenzel A, Schmalz G. Guided tissue regeneration in intrabony defects using an experimental bioresorbablepolydioxanon (PDS) membrane. A 24-month split-mouth study. J Clin Periodontol. 2002;29:710-23. [CrossRef ]
  • Sarment DP, Cooke JW, Miller SE, Jin Q, McGuire MK, Kao RT, et al. Effect of rhPDGF-BB on bone turnover during periodontal repair. J Clin Periodontol. 2006;33:135-40. [CrossRef ]
  • Giannobile, WV, Whitson SW. Lynch SE. Non-coordinate control of bone formation displayed by growth factor combinations with IGF-I. J Dent Res. 1997;76:1569-78. [CrossRef ]
There are 36 citations in total.

Details

Primary Language English
Journal Section Original Research Articles
Authors

Nitin Kudyar This is me 0000-0003-4882-6795

Nitin Dani This is me 0000-0002-4254-6920

Shahab Saquib Abullais 0000-0002-5223-2167

Nabeeh A. Alqahtani This is me 0000-0001-5064-7556

Aashima Gupta This is me 0000-0002-4367-4844

Nilofar Attar This is me 0000-0001-6279-3534

Publication Date January 31, 2019
Submission Date January 18, 2018
Published in Issue Year 2019 Volume: 53 Issue: 1

Cite

EndNote Kudyar N, Dani N, Abullais SS, Alqahtani NA, Gupta A, Attar N (January 1, 2019) The effects of autologous platelet concentrate on the healing of intra-bony defects: a randomized clinical trial. European Oral Research 53 1 38–43.