Case Report
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Year 2022, Volume: 49 Issue: 2, 92 - 95, 31.08.2022
https://doi.org/10.52037/eads.2022.0033

Abstract

References

  • 1. McMenamin ME. Myopericytoma. World Health Organization Classification of Tumours.In: Fletcher CDM, Unni KK, Mertens F, editors. Pathology and genetics of tumors of soft tissue and bone. Lyon: IARC Press; 2002. pp. 139–139.
  • 2. Porat Ben Amy D, Yaffe V, Kawar R, Akrish S, Abu El-Naaj I. Oral myopericytoma: a rare pediatric case report and a review of the literature. BMC Oral Health. 2021 Apr 7;21(1):176. DOI: 10.1186/s12903-021-01534-y.
  • 3. Datta V, Rawal YB, Mincer HH, Anderson MK. Myopericytoma of the oral cavity. Head Neck. 2007 Jun;29(6):605-8.
  • 4. Vasenwala SM, Afroz N, Ansari HA, Khan AH, Basari R, Rehman S. Myopericytoma of lip: a rare lesion in an unusual location. Indian J Pathol Microbiol. 2015 Apr-Jun;58(2):211-3.
  • 5. Ju WT, Zhao TC, Liu Y, Dong MJ, Wang LZ, Li J, Tan YR, Zhong LP. Clinical and pathologic analysis of myopericytoma in the oral and maxillofacial region. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Oct;128(4):393-399. DOI: 10.1016/j.oooo.2019.06.004. Epub 2019 Jun 14.
  • 6. Aung PP, Goldberg LJ, Mahalingam M, Bhawan J. Cutaneous miyopericy toma: a report of 3 cases and review of the literature. Dermatopathology (Basel). 2015;2(1):9–14.
  • 7. Akbulut S, Berk D, Demir MG, Kayahan S. Myopericytoma of the tongue: a case report. Acta Medica (Hradec Kralove). 2013;56(3):124-5.
  • 8. Lau PP, Wong O-K, Lui PC, et al. Myopericytoma in patients with AIDS: a new class of Epstein-Barr virus-associated tumor. Am J Surg Pathol. 2009;33(11):1666–72.
  • 9. Terada T. Myopericytoma of low-grade malignancy in the oral cavity. Rare Tumors. 2012 Jan 2;4(1):e9. DOI: 10.4081/rt.2012.e9. Epub 2012 Jan 20.
  • 10. Ide F, Obara K, Yamada H, Mishima K, Saito I. Intravascular myopericytoma of the oral mucosa: a rare histologic variant in an uncommon location. Virchows Arch. 2007;450(4):475–7.
  • 11. Sapelli S, Ribas M, Martins WD, de Noronha L, Gomes AP. Myopericytoma of the lip: report of case. Head Neck. 2009;31(4):561–4.
  • 12. Laga AC, Tajirian AL, Islam MN, Bhattacharyya I, Cohen DM, Plamondon CJ, Robinson-Bostom L. Myopericytoma: report of two cases associated with trauma. J Cutan Pathol. 2008 Sep;35(9):866-70. DOI: 10.1111/j.1600-0560.2007.00910.x. Epub 2008 May 20.
  • 13. Uchida Y, Kuriyama M, Yoshida Y, Yano A, Orihashi K. Diagnosis and surgical management of the arterial myopericytoma. J Plast Reconstr Aesthet Surg. 2012;65(7):e200-201.
  • 14. Mathew NK, Zhang KY, Batstone MD. Myopericytoma of the coronoid process: a case report and review of the literature. Oral Maxillofac Surg Cases. 2015;1(2):25–8.
  • 15. McMenamin ME, Fletcher CDM. Malignant myopericytoma: expanding the spectrum of tumors with miyopericytic differentiation. Histopathology 2002;41:450– 460.
  • 16. Granter SR, Badizadegan K, Fletcher CDM. Miyofibromatosis in adults, glomangiopericytoma, and myopericytoma: A spectrum of tumors showing perivascular myoid differentiation. Am J Surg Pathol 1998; 22: 513–25.
  • 17. Almeida LKY, Jabur RO, Silveira HA, Polanco XBJ, da Silva RAB, Ribeiro-Silva A, León JE. Gingival ossifying myopericytoma in a pediatric patient: Immunohistochemical analysis and literature review. Oral Oncol. 2020 Aug;107:104826. doi: 10.1016/j.oraloncology.2020.104826. Epub 2020 Jun 4. PMID: 32505552.
  • 18. Sadahira C, Yoneda K, Tetsuya M, et al. Periungual myopericytoma. J Am Acad Dermatol 2006; 54: 1107.
  • 19. Stoeltzing O, McCarty MF, Wey JS, et al. Role of hypoxiainducible factor 1a in gastric cancer cell growth, angiogenesis, and vessel maturation. J Natl Cancer Inst 2004; 96: 946.
  • 20. S. Hartmann, C. Döring, C. Agostinelli, et al.miRNA expression profiling divides follicular dendritic cell sarcomas into two groups, related to fibroblasts and myopericytomas or Castleman disease Eur J Cancer, 64 ( 2016 ), s. 159 – 166.
  • 21. Deyrup AT, Lee VK, Hill CE, Cheuk W, Toh HC, Kesavan S, et al. Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: A clinicopathologic and molecular analysis of 29 tumors from 19 patients. Am J Surg Pathol 2006;30:75-82.

A Rare Tumor of The Oral Mucosa, Myopericytoma: Case Report

Year 2022, Volume: 49 Issue: 2, 92 - 95, 31.08.2022
https://doi.org/10.52037/eads.2022.0033

Abstract

Myopericytoma (MPC) is defined as a benign mesenchymal neoplasm consisting mostly of oval spindle-shaped myoid-like cells with perivascular growth. Apart from being a rare lesion in all anatomical regions of the body, it is extremely rare in the oral and maxillofacial region and only a limited number of cases have been reported in the literature. We present here the case of MPC in a 42-year-old female patient who had a painless, enlarging lesion in the anterior mandible. Intraoral examination of the lesion revealed a smooth, nonwhite, pedunculated, fibrotic, painless, and nonbleeding lesion in the lingual aspect of the anterior mandible. Histopathologic examination revealed a tumor consisting of spherical/nodular structures composed of spindle cells and hemangioperistomatous vascular structures in the form of staghorn. These tumor cells showed no signs of malignancy. On immunohistochemical examination, the tumor cells were positive for CD34 and SMA. SMA Protein was also focally positive in nodular structures formed by spindle cells and tumor stroma. S-100 protein was negative in the lesion. To our knowledge, this is the second case of MPC that occurred in the mandibular gingiva.

References

  • 1. McMenamin ME. Myopericytoma. World Health Organization Classification of Tumours.In: Fletcher CDM, Unni KK, Mertens F, editors. Pathology and genetics of tumors of soft tissue and bone. Lyon: IARC Press; 2002. pp. 139–139.
  • 2. Porat Ben Amy D, Yaffe V, Kawar R, Akrish S, Abu El-Naaj I. Oral myopericytoma: a rare pediatric case report and a review of the literature. BMC Oral Health. 2021 Apr 7;21(1):176. DOI: 10.1186/s12903-021-01534-y.
  • 3. Datta V, Rawal YB, Mincer HH, Anderson MK. Myopericytoma of the oral cavity. Head Neck. 2007 Jun;29(6):605-8.
  • 4. Vasenwala SM, Afroz N, Ansari HA, Khan AH, Basari R, Rehman S. Myopericytoma of lip: a rare lesion in an unusual location. Indian J Pathol Microbiol. 2015 Apr-Jun;58(2):211-3.
  • 5. Ju WT, Zhao TC, Liu Y, Dong MJ, Wang LZ, Li J, Tan YR, Zhong LP. Clinical and pathologic analysis of myopericytoma in the oral and maxillofacial region. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Oct;128(4):393-399. DOI: 10.1016/j.oooo.2019.06.004. Epub 2019 Jun 14.
  • 6. Aung PP, Goldberg LJ, Mahalingam M, Bhawan J. Cutaneous miyopericy toma: a report of 3 cases and review of the literature. Dermatopathology (Basel). 2015;2(1):9–14.
  • 7. Akbulut S, Berk D, Demir MG, Kayahan S. Myopericytoma of the tongue: a case report. Acta Medica (Hradec Kralove). 2013;56(3):124-5.
  • 8. Lau PP, Wong O-K, Lui PC, et al. Myopericytoma in patients with AIDS: a new class of Epstein-Barr virus-associated tumor. Am J Surg Pathol. 2009;33(11):1666–72.
  • 9. Terada T. Myopericytoma of low-grade malignancy in the oral cavity. Rare Tumors. 2012 Jan 2;4(1):e9. DOI: 10.4081/rt.2012.e9. Epub 2012 Jan 20.
  • 10. Ide F, Obara K, Yamada H, Mishima K, Saito I. Intravascular myopericytoma of the oral mucosa: a rare histologic variant in an uncommon location. Virchows Arch. 2007;450(4):475–7.
  • 11. Sapelli S, Ribas M, Martins WD, de Noronha L, Gomes AP. Myopericytoma of the lip: report of case. Head Neck. 2009;31(4):561–4.
  • 12. Laga AC, Tajirian AL, Islam MN, Bhattacharyya I, Cohen DM, Plamondon CJ, Robinson-Bostom L. Myopericytoma: report of two cases associated with trauma. J Cutan Pathol. 2008 Sep;35(9):866-70. DOI: 10.1111/j.1600-0560.2007.00910.x. Epub 2008 May 20.
  • 13. Uchida Y, Kuriyama M, Yoshida Y, Yano A, Orihashi K. Diagnosis and surgical management of the arterial myopericytoma. J Plast Reconstr Aesthet Surg. 2012;65(7):e200-201.
  • 14. Mathew NK, Zhang KY, Batstone MD. Myopericytoma of the coronoid process: a case report and review of the literature. Oral Maxillofac Surg Cases. 2015;1(2):25–8.
  • 15. McMenamin ME, Fletcher CDM. Malignant myopericytoma: expanding the spectrum of tumors with miyopericytic differentiation. Histopathology 2002;41:450– 460.
  • 16. Granter SR, Badizadegan K, Fletcher CDM. Miyofibromatosis in adults, glomangiopericytoma, and myopericytoma: A spectrum of tumors showing perivascular myoid differentiation. Am J Surg Pathol 1998; 22: 513–25.
  • 17. Almeida LKY, Jabur RO, Silveira HA, Polanco XBJ, da Silva RAB, Ribeiro-Silva A, León JE. Gingival ossifying myopericytoma in a pediatric patient: Immunohistochemical analysis and literature review. Oral Oncol. 2020 Aug;107:104826. doi: 10.1016/j.oraloncology.2020.104826. Epub 2020 Jun 4. PMID: 32505552.
  • 18. Sadahira C, Yoneda K, Tetsuya M, et al. Periungual myopericytoma. J Am Acad Dermatol 2006; 54: 1107.
  • 19. Stoeltzing O, McCarty MF, Wey JS, et al. Role of hypoxiainducible factor 1a in gastric cancer cell growth, angiogenesis, and vessel maturation. J Natl Cancer Inst 2004; 96: 946.
  • 20. S. Hartmann, C. Döring, C. Agostinelli, et al.miRNA expression profiling divides follicular dendritic cell sarcomas into two groups, related to fibroblasts and myopericytomas or Castleman disease Eur J Cancer, 64 ( 2016 ), s. 159 – 166.
  • 21. Deyrup AT, Lee VK, Hill CE, Cheuk W, Toh HC, Kesavan S, et al. Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: A clinicopathologic and molecular analysis of 29 tumors from 19 patients. Am J Surg Pathol 2006;30:75-82.
There are 21 citations in total.

Details

Primary Language English
Subjects Dentistry
Journal Section Case report articles
Authors

Elif Polat 0000-0001-9952-0548

İpek Atak 0000-0001-9663-5454

Mert Özlü 0000-0002-5923-9345

Candan Semra Paksoy This is me 0000-0002-6961-5172

Publication Date August 31, 2022
Submission Date May 25, 2022
Published in Issue Year 2022 Volume: 49 Issue: 2

Cite

Vancouver Polat E, Atak İ, Özlü M, Paksoy CS. A Rare Tumor of The Oral Mucosa, Myopericytoma: Case Report. EADS. 2022;49(2):92-5.