Çocukluk Çağı Kanser Tedavisinin Oral ve Dental Dokular Üzerine Erken ve Geç Dönem Etkileri

Solmaz Mobaraki; Aysun Avşar

Review

Adverse Effects Of Childhood Cancer On The Oral And Dental Tissues Of Children

Year 2019, Volume: 5 Issue: 3, 76 - 82, 29.12.2019

Solmaz Mobaraki Aysun Avşar

Abstract

Increasing survival rates in childhood cancers is causing both short term and long term side effects. Intense chemothearpy and radiothearpy treatments that are given before hemopoetic stem cell transplantion in early ages are especially resulting most serious complications. In addition to direct sitotoxic effect on oral mucose membrane, the complications from cancer type and the suppression of the immune system by the applied treatment are causing serious changes in oral and dental tissue. Viral and fungal infections in oral cavity, reduction in saliva buffering capacity and flow rate and increased caries prevalence resulting the patient to feel pain thus disrupting quality of life. Dental agenezis, root malformation, developmental enamel defects, tooth development, caries are diagnosed as late term side effects. The rule of thumb in preventing oral and dental side effects that might appear during antineoplastic treatment is to protect the patient from getting an infection before the treatment begins. To eliminate both odontogenic and non-odontojenic infection sources, a comprehensive oral and dental evaluation must be done .In this review together with current studies, it is intended to share knowledge and essential prevention techniques about the early and late term side effects of childhood cancers on oral and dental tissue while increasing the quality of life of the patient and their treatment.

Keywords

Childhood cancer, oral-dental tissue, early-late adverse effects

References

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Çocukluk Çağı Kanser Tedavisinin Oral ve Dental Dokular Üzerine Erken ve Geç Dönem Etkileri

Year 2019, Volume: 5 Issue: 3, 76 - 82, 29.12.2019

Solmaz Mobaraki Aysun Avşar

Abstract

Çocukluk çağı kanserlerinde sağ kalım oranının artması, kısa ve uzun dönemde görülen yan etkilerin artışına neden olmaktadır. Özellikle erken yaşlarda hemopoetik kök hücre naklinden önce yapılan yoğun kemoterapi ve radyoterapi uygulamaları en ciddi komplikasyonları ortaya çıkarmaktadır. Oral mukoz membrana direk sitotoksik etkisinin yanı sıra, hastalıktan kaynaklı komplikasyonlar ve uygulanan tedavinin bağışıklık sistemini baskılayıcı etkisi, oral ve dental dokularda ciddi değişiklikler meydana getirmektedir. Oral kavitede görülen viral ve fungal enfeksiyonlar, tükürük tamponlama kapasitesinde ve akış hızındaki azalma, artmış çürük riski tedavi protokolünün aksamasına yol açabildiği gibi, çocuğun ağrı duymasına sebep olduğu için yaşam kalitesini de bozmaktadır. Diş agenezisi, gelişimsel mine defektleri, diş gelişim bozuklukları, kök amomalileri, diş çürüğü geç dönemde ortaya çıkan yan etkiler olarak tanımlanmaktadır. Antineoplastik tedavi süresince ortaya çıkacak oral ve dental yan etkilerin önlenmesinde ilk kural, tedavi öncesinde çocuğun enfeksiyondan korunmasıdır. Bu amaçla hem odontojenik hem non-odontojenik enfeksiyon kaynaklarını elimine etmek için kapsamlı bir oral ve dental değerlendirme yapılmalıdır. Tüm bu değerlendirme sırasında medikal ve dental ekip yakın iletişimde olmalıdır. Bu derleme ile güncel çalışmalar eşliğinde çocukluk çağı kanserlerinin oral ve dental dokular üzerine erken ve geç dönem yan etkilerinin tanımlanması ve bu yan etkilerin çocuğun tedavisini ve yaşam kalitesini azaltmasını önlemek için alınacak temel önlemler hakkında bilgi paylaşımımız amaçlanmıştır.

Keywords

Çocukluk çağı kanserleri, oral-dental dokular, erken-geç dönem etki

References

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2. Johnston WT, Erdmann F, Newton R, Steliarova-Foucher E, Schüz J, Roman ,Childhood cancer: Estimating regional and global incidence. E. Cancer Epidemiol. 2020 Jan 7:101662. 3. Childhood cancer: the need to invest in the future.The Lancet Haematology.Lancet Haematol. 2020;7: e82.
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5. Oral and dental considerations in pediatric cancers.Ritwik P, Chrisentery-Singleton TE. Cancer Metastasis Rev. 2020 Jan 27.
6. Parra JJ, Alvarado MC, Monsalve P, Costa ALF, Montesinos GA, Parra PA. Oral health in children with acute lymphoblastic leukaemia: before and after chemotherapy treatment. Eur Arch Paediatr Dent. 2020; 21:129-136.
7. Gupta R, Musallam KM, Taher AT, Rivella S.Ineffective Erythropoiesis: Anemia and Iron Overload. Hematol Oncol Clin North Am. 2018 ;32:213-221.
8. Soares TC, Correa ME, Cintra GF, Miranda EC, Cintra ML. The impact of morphological and immunohistological changes in minor salivary glands on the health of the oral cavity in HSCT patients. Bone Marrow Transplant. 2013; 48:1525-1529.
9. Outcomes of allogenic hematopoietic cell transplantation for childhood chronic myeloid leukemia: Single-center experience. Pediatr Transplant. 2020 ;11: e13664.
10. Hafez HA, Abdallah A, Hammad M, Hamdy N, Yassin D, Salem S, Hassanain O, Elhalaby L, Elhaddad A. Management of fever and neutropenia in children with cancer: A survey of Australian and New Zealand practice. J Paediatr Child Health. 2018; 54:761-769.
11. A.M. Glenny, F. Gibson, E. Auld et al. The development of evidence-based guidelines on mouth care for children, teenagers and young adults treated for cancer. European journal of cancer 2010; 46: 1399–1412.
12. Kapoor G, Goswami M, Sharma S, Mehta A, Dhillon JK. Assessment of oral health status of children with Leukemia: A cross-sectional study. Spec Care Dentist. 2019; 39:564-571.
13. Yavuz B, Bal Yılmaz .Investigation of the effects of planned mouth care education on the degree of oral mucositis in pediatric oncology patients. H.J Pediatr Oncol Nurs. 2015; 32:47-56.
14. Tecco S, Sciara S, Pantaleo G, Nota A, Visone A, Germani S, Polizzi E, Gherlone .The association between minor recurrent aphthous stomatitis (RAS), children's poor oral condition, and underlying negative psychosocial habits and attitudes towards oral hygiene. EF.BMC Pediatr. 2018; 13; 18:136.
15. Sonis ST. The pathobiology of mucositis. Nat Rev Cancer. 2004 Apr;4(4):277-84.
16. Lalla RV, Saunders DP, Peterson DE.Chemotherapy or radiation-induced oral mucositis. Dent Clin North Am. 2014 ;58:341-349.
17. Oosterom N, Berrevoets M, den Hoed MAH, Zolk O, Hoerning S, Pluijm SMF, Pieters R, de Jonge R, Tissing WJE, van den Heuvel-Eibrink MM, Heil SG.The role of genetic polymorphisms in the thymidylate synthase (TYMS) gene in methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia. Pharmacogenet Genomics. 2018.
18. Bennett M. Pain management for chemotherapy-induced oral mucositis. Nurs Child Young People. 2016;8;28: 25-29.
19. Allen G, Logan R, Revesz T, Keefe D, Gue S.J .The Prevalence and Investigation of Risk Factors of Oral Mucositis in a Pediatric Oncology Inpatient Population; a Prospective Study. Pediatr Hematol Oncol. 2018; 40:15-21.
20. McGuire DB, Fulton JS, Park J, Brown CG, Correa ME, Eilers J, Elad S, Gibson F, Oberle-Edwards LK, Bowen J, Lalla RV .Systematic review of basic oral care for the management of oral mucositis in cancer patients. Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO).Support Care Cancer. 2013; 21:3165-3177.
21. Mazhari F, Shirazi AS, Shabzendehdar M. Management of oral mucositis in pediatric patients receiving cancer therapy: A systematic review and meta-analysis. Pediatr Blood Cancer. 2019 ;66: e27403.
22. He M, Zhang B, Shen N, Wu N, Sun J. A systematic review and meta-analysis of the effect of low-level laser therapy (LLLT) on chemotherapy-induced oral mucositis in pediatric and young patients. Eur J Pediatr. 2018; 177:7-17.
23. Aghamohamamdi A, Hosseinimehr SJ. Natural Products for Management of Oral Mucositis Induced by Radiotherapy and Chemotherapy. Integr Cancer Ther. 2016 Mar;15(1):60-8.
24. Münstedt K, Männle H.Using Bee Products for the Prevention and Treatment of Oral Mucositis Induced by Cancer Treatment. Molecules. 2019 ;24.
25. Cardona A, Balouch A, Abdul MM, Sedghizadeh PP, Enciso R.J .Efficacy of chlorhexidine for the prevention and treatment of oral mucositis in cancer patients: a systematic review with meta-analyses. Oral Pathol Med. 2017;46:680-688.
26. Gammelsrud KW, Sandven P, Høiby EA, Sandvik L, Brandtzaeg P, Gaustad P. Colonization by Candida in children with cancer, children with cystic fibrosis, and healthy controls. Clin Microbiol Infect. 2011; 17:1875-1881.
27. González Gravina H, González de Morán E, Zambrano O, Lozano Chourio M, Rodríguez de Valero S, Robertis S, Mesa L. Oral Candidiasis in children and adolescents with cancer. Identification of Candida spp. Med Oral Patol Oral Cir Bucal. 2007;12: E419-423.
28. Alberth M, Majoros L, Kovalecz G, Borbás E, Szegedi I, J Márton I, Kiss C. Significance of oral Candida infections in children with cancer. Pathol Oncol Res. 2006;12:237-241.
29. Hamzavi SS1, Amanati A2,3, Badiee P1, Kadivar MR1, Jafarian H1, Ghasemi F1, Haghpanah S4, Dehghani M5, Norouzian Baghani A6 .Changing face of Candida colonization pattern in pediatric patients with hematological malignancy during repeated hospitalizations, results of a prospective observational study (2016-2017) in shiraz, Iran. BMC Infect Dis. 2019; 19:759.
30. de Mendonça RM, de Araújo M, Levy CE, Morari J, Silva RA, Yunes JA, Brandalise SR.Dan Med J. 2013 ;60: B4698.Candida and candidaemia. Susceptibility and epidemiology.Arendrup MCProspective evaluation of HSV, Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia. Support Care Cancer. 2012; 20:1101-7.
31. Sepúlveda E, Brethauer U, Rojas J, Fernández E, Le Fort P. Oral ulcers in children under chemotherapy: clinical characteristics and their relationwith Herpes Simplex Virus type 1 and Candida albicans. Med Oral Patol Oral Cir Bucal. 2005;10 Suppl 1: E1-8.
32. Morgan JE, Hassan H, Cockle JV, Lethaby C, James B, Phillips RS.Critical review of current clinical practice guidelines for antifungal therapy in paediatric haematology and oncology. Support Care Cancer. 2017; 25:221-228.
33. Groll AH, Just-Nuebling G, Kurz M, Mueller C, Nowak-Goettl U, Schwabe D, Shah PM, Kornhuber B.J .Fluconazole versus nystatin in the prevention of candida infections in children and adolescents undergoing remission induction or consolidation chemotherapy for cancer. Antimicrob Chemother. 1997; 40:855-862.
34. Döring M1, Eikemeier M, Cabanillas Stanchi KM, Hartmann U, Ebinger M, Schwarze CP, Schulz A, Handgretinger R, Müller I. Antifungal prophylaxis with posaconazole vs. fluconazole or itraconazole in pediatric patients with neutropenia. Eur J Clin Microbiol Infect Dis. 2015; 34:1189-1200.
35. Wass EN, Hernandez EA, Sierra CM.Comparison of the Efficacy of Posaconazole Delayed Release Tablets and Suspension in Pediatric Hematology/Oncology Patients. J Pediatr Pharmacol Ther. 2020 ;25:47-52.
36. Ramphal R, Grant RM, Dzolganovski B, Constantin J, Tellier R, Allen U, Weitzman S, Matlow A, Petric M, Sung L.Herpes simplex virus in febrile neutropenic children undergoing chemotherapy for cancer: a prospective cohort study. Pediatr Infect Dis J. 2007 ;26:700-7004.
37. Righini-Grunder F, Hurni M, Warschkow R, Rischewski J.Frequency of Oral Mucositis and Local Virus Reactivation in Herpes Simplex Virus Seropositive Children with Myelosuppressive Therapy. Klin Padiatr. 2015; 227:335-338.
38. Glenny AM, Gibson F, Auld E, Coulson S, Clarkson JE, Craig JV, Eden OB, Khalid T, Worthington HV, Pizer B. The development of evidence-based guidelines on mouth care for children, teenagers and young adults treated for cancer. Children's Cancer and Leukaemia Group (CCLG)/Paediatric Oncology Nurses Forum's (CCLG-PONF) Mouth Care Group.Eur J Cancer. 2010; 46:1399-412.
39. Busenhart DM, Erb J, Rigakos G, Eliades T, Papageorgiou SN.Adverse effects of chemotherapy on the teeth and surrounding tissues of children with cancer: A systematic review with meta-analysis. Oral Oncol. 2018; 83:64-72.
40. Nemeth O, Kivovics M, Pinke I, Marton K, Kivovics P, Garami M. .Late effects of multiagent chemotherapy on salivary secretion in children cancer survivors. J Am Coll Nutr. 2014;33 :186-191.
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There are 58 citations in total.

Details

Primary Language	Turkish
Subjects	Dentistry
Journal Section	Collection
Authors	Solmaz Mobaraki 0000-0001-8740-0792 Aysun Avşar This is me 0000-0003-3911-4526
Publication Date	December 29, 2019
Published in Issue	Year 2019 Volume: 5 Issue: 3

Cite

APA	Mobaraki, S., & Avşar, A. (2019). Çocukluk Çağı Kanser Tedavisinin Oral ve Dental Dokular Üzerine Erken ve Geç Dönem Etkileri. Journal of International Dental Sciences (Uluslararası Diş Hekimliği Bilimleri Dergisi), 5(3), 76-82.
AMA	Mobaraki S, Avşar A. Çocukluk Çağı Kanser Tedavisinin Oral ve Dental Dokular Üzerine Erken ve Geç Dönem Etkileri. J Int Dent Sci. December 2019;5(3):76-82.
Chicago	Mobaraki, Solmaz, and Aysun Avşar. “Çocukluk Çağı Kanser Tedavisinin Oral Ve Dental Dokular Üzerine Erken Ve Geç Dönem Etkileri”. Journal of International Dental Sciences (Uluslararası Diş Hekimliği Bilimleri Dergisi) 5, no. 3 (December 2019): 76-82.
EndNote	Mobaraki S, Avşar A (December 1, 2019) Çocukluk Çağı Kanser Tedavisinin Oral ve Dental Dokular Üzerine Erken ve Geç Dönem Etkileri. Journal of International Dental Sciences (Uluslararası Diş Hekimliği Bilimleri Dergisi) 5 3 76–82.
IEEE	S. Mobaraki and A. Avşar, “Çocukluk Çağı Kanser Tedavisinin Oral ve Dental Dokular Üzerine Erken ve Geç Dönem Etkileri”, J Int Dent Sci, vol. 5, no. 3, pp. 76–82, 2019.
ISNAD	Mobaraki, Solmaz - Avşar, Aysun. “Çocukluk Çağı Kanser Tedavisinin Oral Ve Dental Dokular Üzerine Erken Ve Geç Dönem Etkileri”. Journal of International Dental Sciences (Uluslararası Diş Hekimliği Bilimleri Dergisi) 5/3 (December 2019), 76-82.
JAMA	Mobaraki S, Avşar A. Çocukluk Çağı Kanser Tedavisinin Oral ve Dental Dokular Üzerine Erken ve Geç Dönem Etkileri. J Int Dent Sci. 2019;5:76–82.
MLA	Mobaraki, Solmaz and Aysun Avşar. “Çocukluk Çağı Kanser Tedavisinin Oral Ve Dental Dokular Üzerine Erken Ve Geç Dönem Etkileri”. Journal of International Dental Sciences (Uluslararası Diş Hekimliği Bilimleri Dergisi), vol. 5, no. 3, 2019, pp. 76-82.
Vancouver	Mobaraki S, Avşar A. Çocukluk Çağı Kanser Tedavisinin Oral ve Dental Dokular Üzerine Erken ve Geç Dönem Etkileri. J Int Dent Sci. 2019;5(3):76-82.

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It is aimed that the Journal of International Dentistry Sciences be included in the Ulakbim TR Dizin. Necessary preparations are continuing for the issues to be published in 2020 in the TR Dizin.