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Diş Hekimliğinde Kök Hücrelerin Kullanım Alanları ve Dental Kök Hücrelere İlişkin Farkındalık

Year 2022, Volume: 11 Issue: 1, 65 - 70, 17.01.2022
https://doi.org/10.54617/adoklinikbilimler.944594

Abstract

Kök hücreler devamlı olarak yenilenebilen ve belirli hücre çeşitlerine farklılaşabilen, vücudumuzdaki doku ve organların kaynağını oluşturan ana hücrelerdir. Temel olarak embriyojenik kök hücreler ve yetişkin kök hücreler olarak ikiye ayrılırlar. Embriyojenik kök hücreler pluripotent özelliktedir. Ancak elde edilmelerinde etik problemler söz konusudur. Yetişkin kök hücreler ise sınırlı multipotent özelliktedir. Dental kök hücreler yetişkin kök hücrelerdir. Dolayısıyla elde edilmesi ve saklanmasında embriyojenik kök hücrelerdeki etik sorunlar yaşanmamaktadır. Diş hekimliğinde kök hücre çalışmaları özellikle dental kök hücre kaynaklarının kolay şekilde elde edilip, saklanabilmesi sayesinde umut veren bir alandır. Dental kök hücreler yalnızca Diş Hekimliği alanında değil, bir çok tıbbi hastalıkların tedavisi için de potansiyel teşkil etmektedir. Dental kök hücreler kullanılarak tedavi sağlama süreci, dişini bağışlayacak veya saklayacak donör ve hastadan dental kök hücreleri toplayacak ve kök hücreler kullanılarak tedaviyi sağlayacak sağlayıcı, yani diş hekimi ile başlar. Diş hekimlerinin ve diş hekimliği öğrencilerinin kök hücreler ve dental kök hücrelerle ilgili belirli bilgiye sahip olmaları ve gelişmeleri takip etmeleri beklenmektedir. Bu çalışmada diş hekimliğinde kullanılan kök hücreler ve diş hekimleri ile diş hekimliği öğrencilerinin kök hücreler ve dental kök hücreler hakkında bilgi düzeylerini araştıran mevcut literatür özetlenmiştir. Bu sayede diş hekimlerinin kök hücrelere ve dental kök hücrelere dair bilgilerinin tazelenmesi ve farkındalıklarının artırılması amaçlanmaktadır.

References

  • Casagrande L, Mattuella LG, de Araujo FB, Eduardo J. Stem cells in dental practice: per- spectives in conservative pulp therapies. J Clin Pediatr Dent 2006 Fall;31(1):25-7.
  • Avcu F. [The Biology of stem cell]. Turkiye Klinikleri J Surg Med Sci 2006;2(43):1-4.
  • Sedgley C, Botero T. Dental stem cells and their sources. Dent Clin North Am. 2012;56:549–61. [PubMed: 22835537].
  • Pandey D, Kaur S, Kamath A. 2016. Banking umbilical cord blood (UCB) stem cells: awareness, attitude and expectations of potential donors from one of the largest potential repository (India). PLOS ONE 11:e0155782
  • Rai S, Kaur M, Kaur S. Applications of stem cells in interdisciplinary dentistry and beyond: An overview. Ann Med Health Sci Res 2013;3:245-54.

  • Gopal KS, Lankupalli AM. Stem cell therapy: A new hope for dentist. J Clin Diagn Res 2012;6:142-4.
  • Derubeis AR, Cancedda R. Bone marrow stromal cells (BMSCs) in bone engineering: limitations and recent advances. Ann Biomed Eng. 2004;32:160–5.
  • Han J, Okada H, Takai H, Nakayama Y, Maeda T, Ogata Y. Collection and culture of alveolar bone marrow multipotent mesenchymal stromal cells from older individuals. J Cell Bio- chem. 2009;107:1198–204.
  • Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A. 2000;97:13625–30.
  • Salkın H, Gönen ZB, Ergen E, Bahar D, Çetin M. Effects of TGF-β1 Overexpression on Biological Characteristics of Human Dental Pulp-derived Mesenchymal Stromal Cells. Int J Stem Cells. 2019 Mar 30;12(1):170-182. doi: 10.15283/ijsc18051. PMID: 30595006; PMCID: PMC6457704.
  • Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA 2003;100:5807–12.
  • Shi S, Bartold PM, Miura M, Seo BM, Robey PG, Gronthos S. The efficacyof mesenchymal stem cells to regenerate and repair dental structures. OrthodCraniofac Res 2005;8(3):191–9.
  • Rai B. Stem Cells from human exfoliated deciduous teeth and SHED Bank: A Mini View. Internet J Bioeng 2007;2:2.
  • Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG,et al. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A. 2003;100:5807–12.
  • Shi S, Robey PG, Gronthos S. Comparison of human dental pulp and bone marrow stromal stem cells by cDNA microarray analysis. Bone. 2001;29:532–9.
  • Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, C, Zhang et al. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS One. 2006;1:e79.
  • Park BW, Kang EJ, Byun JH, Son MG, Kim HJ, Hah YS, et al. In vitro and in vivo osteogenesis of human mesenchymal stem cells derived from skin, bone marrow and dental follicle tissues. Differentiation. 2012;83:249–59.
  • Morsczeck C, Go ̈ tz W, Schierholz J, Zeilhofer F, Ku ̈ hn U, Mo ̈ hl C, et al. Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol. 2005;24:155–65.
  • Trubiani O, Orsini G, Zini N, Di Iorio D, Piccirilli M, Piattelli A, et al. Re- generative potential of human periodontal ligament derived stem cells on three-dimensional biomaterials: a morphological report. J Biomed Mater Res A 2008;87:986-93.
  • Park JC, Kim JM, Jung IH, Kim JC, Choi SH, Cho KS, et al. Isolation and characterization of human periodontal ligament (PDL) stem cells (PDLSCs) from the inflamed pdl tissue: In vitro and in vivo evaluations. J Clin Periodontol 2011;38:721-31.
  • Gronthos S, Mrozik K, Shi S, Bartold P. Ovine periodontal ligament stem cells: isolation, characterization, and differentiation potential. Calcified tissue international. 2006;79(5):310-7.
  • Agata H, Asahina I, Yamazaki Y, Uchida M, Shinohara Y, Honda MJ, et al. Effective bone engineering with periosteum- derived cells. J Dent Res. 2007;86:79–83.
  • Sonoyama W, Liu Y, Fang D, Yamaza T, Seo B-M, Zhang C, et al. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PloS one. 2006;1(1):e79.
  • Nagata M, Hoshina H, Li M, Arasawa M, Uematsu K, Ogawa S, et al. A clinical study of alveolar bone tissue engineering with cultured autogenous periosteal cells: coordinated activation of bone formation and resorption. Bone. 2012;50:1123–9.
  • Schmelzeisen R, Schimming R, Sittinger M. Making bone: implant insertion into tissue-engineered bone for maxillary sinus floor augmentation-a preliminary report. J Craniomaxillofac Surg. 2003;31:34–9.
  • Izumi K, Tobita T, Feinberg SE. Isolation of human oral ker- atinocyte progenitor/stem cells. J Dent Res. 2007;86:341–6.
  • Jones KB, Klein OD. Oral epithelial stem cells in tissue main- tenance and disease: the first steps in a long journey. Int J Oral Sci. 2013;5:121–9.
  • Izumi K, Feinberg SE, Iida A, Yoshizawa M. Intraoral grafting of an ex vivo produced oral mucosa equivalent: a preliminary report. Int J Oral Maxillofac Surg. 2003;32:188–97.
  • Du L, Yang P, Ge S. Culturing and characterization of human gingival mesenchymal stem cells and their chemotactic responses to stromal cell-derived factor-1. Hua Xi Kou Qiang Yi Xue Za Zhi. 2015;33:238–43.
  • Niada S, Ferreira LM, Arrigoni E, Addis A, Campagnol M, Broccaioli E, et al. Porcine adipose-derived stem cells from buccal fat pad and subcutaneous adipose tissue for future pre- clinical studies in oral surgery. Stem Cell Res Ther. 2013;4:148.
  • Hung CN, Mar K, Chang HC, Chiang YL, Hu HY, Lai CC, et al. A comparison between adipose tissue and dental pulp as sources of MSCs for tooth regeneration. Biomaterials. 2011;32:6995– 7005.
  • Kulakov AA, Goldshtein DV, Grigoryan AS, Rzhaninova AA, Alekseeva IS, Arutyunyan IV, et al. Clinical study of the effi- ciency of combined cell transplant on the basis of multipotent mesenchymal stromal adipose tissue cells in patients with pro- nounced deficit of the maxillary and mandibulary bone tissue. Bull Exp Biol Med. 2008;146:522–5.
  • Guo J, Weng J, Rong Q, Zhang X, Zhu S, Huang D, et al. Investigation of multipotent postnatal stem cells from human maxillary sinus membrane. Sci Rep. 2015;5:11660.
  • Kim SW, Lee IK, Yun KI, Kim CH, Park JU. Adult stem cells derived from human maxillary sinus membrane and their osteogenic differentiation. Int J Oral Maxillofac Implants. 2009;24:991–8.
  • Alhadlaq A, Al-Maflehi N, Alzahrani S, AlAssiri A. Assessment of knowledge and attitude toward stem cells and their implications in dentistry among recent graduates of dental schools in Saudi Arabia. Saudi Dent J. 2019 Jan;31(1):66-75.
  • Alomar RK, Aladhyani SM, Aldossary MN, Almohaimel SA, Salam M, Almutairi AF. A prospective Saudi dental stem-cell bank from the perspective of the public and dental practitioners: A cross sectional survey. J Family Med Prim Care. 2020 Feb 28;9(2):864-870.
  • Sede et al., 2016 M.A. Sede, O. Audu, C.C. Azodo Nigerian dental students' permissive tendency to the proposed organized incorporation of stem cells application into dental curriculum: a cross-sectional study J. Oral Res. Rev., 8 (2) (2016), p. 72
  • Frati P, Gulino M, Pacchiarotti A, D'Errico S, Sicuro L, Fineschi V. A survey of Italian physicians' opinion about stem cells research: what doctors prefer and what the law requires. Biomed Res Int. 2014;2014:480304.
  • Katge F, Shetty AJ, Rusawat B, Vamsi K C. Knowledge and attitude of Indian dentists regarding dental stem cells: A cross-sectional descriptive survey. Indian J Dent Res 2017;28:367-74.
  • Krasner P, Verlander P. Stem cells in dentistry and medicine: the dentist's role. Dent Today. 2011 Jan;30(1):128, 130-4; quiz 135. PMID: 21306072.
Year 2022, Volume: 11 Issue: 1, 65 - 70, 17.01.2022
https://doi.org/10.54617/adoklinikbilimler.944594

Abstract

References

  • Casagrande L, Mattuella LG, de Araujo FB, Eduardo J. Stem cells in dental practice: per- spectives in conservative pulp therapies. J Clin Pediatr Dent 2006 Fall;31(1):25-7.
  • Avcu F. [The Biology of stem cell]. Turkiye Klinikleri J Surg Med Sci 2006;2(43):1-4.
  • Sedgley C, Botero T. Dental stem cells and their sources. Dent Clin North Am. 2012;56:549–61. [PubMed: 22835537].
  • Pandey D, Kaur S, Kamath A. 2016. Banking umbilical cord blood (UCB) stem cells: awareness, attitude and expectations of potential donors from one of the largest potential repository (India). PLOS ONE 11:e0155782
  • Rai S, Kaur M, Kaur S. Applications of stem cells in interdisciplinary dentistry and beyond: An overview. Ann Med Health Sci Res 2013;3:245-54.

  • Gopal KS, Lankupalli AM. Stem cell therapy: A new hope for dentist. J Clin Diagn Res 2012;6:142-4.
  • Derubeis AR, Cancedda R. Bone marrow stromal cells (BMSCs) in bone engineering: limitations and recent advances. Ann Biomed Eng. 2004;32:160–5.
  • Han J, Okada H, Takai H, Nakayama Y, Maeda T, Ogata Y. Collection and culture of alveolar bone marrow multipotent mesenchymal stromal cells from older individuals. J Cell Bio- chem. 2009;107:1198–204.
  • Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A. 2000;97:13625–30.
  • Salkın H, Gönen ZB, Ergen E, Bahar D, Çetin M. Effects of TGF-β1 Overexpression on Biological Characteristics of Human Dental Pulp-derived Mesenchymal Stromal Cells. Int J Stem Cells. 2019 Mar 30;12(1):170-182. doi: 10.15283/ijsc18051. PMID: 30595006; PMCID: PMC6457704.
  • Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA 2003;100:5807–12.
  • Shi S, Bartold PM, Miura M, Seo BM, Robey PG, Gronthos S. The efficacyof mesenchymal stem cells to regenerate and repair dental structures. OrthodCraniofac Res 2005;8(3):191–9.
  • Rai B. Stem Cells from human exfoliated deciduous teeth and SHED Bank: A Mini View. Internet J Bioeng 2007;2:2.
  • Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG,et al. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A. 2003;100:5807–12.
  • Shi S, Robey PG, Gronthos S. Comparison of human dental pulp and bone marrow stromal stem cells by cDNA microarray analysis. Bone. 2001;29:532–9.
  • Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, C, Zhang et al. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS One. 2006;1:e79.
  • Park BW, Kang EJ, Byun JH, Son MG, Kim HJ, Hah YS, et al. In vitro and in vivo osteogenesis of human mesenchymal stem cells derived from skin, bone marrow and dental follicle tissues. Differentiation. 2012;83:249–59.
  • Morsczeck C, Go ̈ tz W, Schierholz J, Zeilhofer F, Ku ̈ hn U, Mo ̈ hl C, et al. Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol. 2005;24:155–65.
  • Trubiani O, Orsini G, Zini N, Di Iorio D, Piccirilli M, Piattelli A, et al. Re- generative potential of human periodontal ligament derived stem cells on three-dimensional biomaterials: a morphological report. J Biomed Mater Res A 2008;87:986-93.
  • Park JC, Kim JM, Jung IH, Kim JC, Choi SH, Cho KS, et al. Isolation and characterization of human periodontal ligament (PDL) stem cells (PDLSCs) from the inflamed pdl tissue: In vitro and in vivo evaluations. J Clin Periodontol 2011;38:721-31.
  • Gronthos S, Mrozik K, Shi S, Bartold P. Ovine periodontal ligament stem cells: isolation, characterization, and differentiation potential. Calcified tissue international. 2006;79(5):310-7.
  • Agata H, Asahina I, Yamazaki Y, Uchida M, Shinohara Y, Honda MJ, et al. Effective bone engineering with periosteum- derived cells. J Dent Res. 2007;86:79–83.
  • Sonoyama W, Liu Y, Fang D, Yamaza T, Seo B-M, Zhang C, et al. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PloS one. 2006;1(1):e79.
  • Nagata M, Hoshina H, Li M, Arasawa M, Uematsu K, Ogawa S, et al. A clinical study of alveolar bone tissue engineering with cultured autogenous periosteal cells: coordinated activation of bone formation and resorption. Bone. 2012;50:1123–9.
  • Schmelzeisen R, Schimming R, Sittinger M. Making bone: implant insertion into tissue-engineered bone for maxillary sinus floor augmentation-a preliminary report. J Craniomaxillofac Surg. 2003;31:34–9.
  • Izumi K, Tobita T, Feinberg SE. Isolation of human oral ker- atinocyte progenitor/stem cells. J Dent Res. 2007;86:341–6.
  • Jones KB, Klein OD. Oral epithelial stem cells in tissue main- tenance and disease: the first steps in a long journey. Int J Oral Sci. 2013;5:121–9.
  • Izumi K, Feinberg SE, Iida A, Yoshizawa M. Intraoral grafting of an ex vivo produced oral mucosa equivalent: a preliminary report. Int J Oral Maxillofac Surg. 2003;32:188–97.
  • Du L, Yang P, Ge S. Culturing and characterization of human gingival mesenchymal stem cells and their chemotactic responses to stromal cell-derived factor-1. Hua Xi Kou Qiang Yi Xue Za Zhi. 2015;33:238–43.
  • Niada S, Ferreira LM, Arrigoni E, Addis A, Campagnol M, Broccaioli E, et al. Porcine adipose-derived stem cells from buccal fat pad and subcutaneous adipose tissue for future pre- clinical studies in oral surgery. Stem Cell Res Ther. 2013;4:148.
  • Hung CN, Mar K, Chang HC, Chiang YL, Hu HY, Lai CC, et al. A comparison between adipose tissue and dental pulp as sources of MSCs for tooth regeneration. Biomaterials. 2011;32:6995– 7005.
  • Kulakov AA, Goldshtein DV, Grigoryan AS, Rzhaninova AA, Alekseeva IS, Arutyunyan IV, et al. Clinical study of the effi- ciency of combined cell transplant on the basis of multipotent mesenchymal stromal adipose tissue cells in patients with pro- nounced deficit of the maxillary and mandibulary bone tissue. Bull Exp Biol Med. 2008;146:522–5.
  • Guo J, Weng J, Rong Q, Zhang X, Zhu S, Huang D, et al. Investigation of multipotent postnatal stem cells from human maxillary sinus membrane. Sci Rep. 2015;5:11660.
  • Kim SW, Lee IK, Yun KI, Kim CH, Park JU. Adult stem cells derived from human maxillary sinus membrane and their osteogenic differentiation. Int J Oral Maxillofac Implants. 2009;24:991–8.
  • Alhadlaq A, Al-Maflehi N, Alzahrani S, AlAssiri A. Assessment of knowledge and attitude toward stem cells and their implications in dentistry among recent graduates of dental schools in Saudi Arabia. Saudi Dent J. 2019 Jan;31(1):66-75.
  • Alomar RK, Aladhyani SM, Aldossary MN, Almohaimel SA, Salam M, Almutairi AF. A prospective Saudi dental stem-cell bank from the perspective of the public and dental practitioners: A cross sectional survey. J Family Med Prim Care. 2020 Feb 28;9(2):864-870.
  • Sede et al., 2016 M.A. Sede, O. Audu, C.C. Azodo Nigerian dental students' permissive tendency to the proposed organized incorporation of stem cells application into dental curriculum: a cross-sectional study J. Oral Res. Rev., 8 (2) (2016), p. 72
  • Frati P, Gulino M, Pacchiarotti A, D'Errico S, Sicuro L, Fineschi V. A survey of Italian physicians' opinion about stem cells research: what doctors prefer and what the law requires. Biomed Res Int. 2014;2014:480304.
  • Katge F, Shetty AJ, Rusawat B, Vamsi K C. Knowledge and attitude of Indian dentists regarding dental stem cells: A cross-sectional descriptive survey. Indian J Dent Res 2017;28:367-74.
  • Krasner P, Verlander P. Stem cells in dentistry and medicine: the dentist's role. Dent Today. 2011 Jan;30(1):128, 130-4; quiz 135. PMID: 21306072.
There are 40 citations in total.

Details

Primary Language Turkish
Subjects Dentistry
Journal Section Derleme
Authors

Şule Kahraman 0000-0001-9454-7733

Ertan Delilbaşı 0000-0002-7241-4152

Publication Date January 17, 2022
Submission Date June 3, 2021
Published in Issue Year 2022 Volume: 11 Issue: 1

Cite

Vancouver Kahraman Ş, Delilbaşı E. Diş Hekimliğinde Kök Hücrelerin Kullanım Alanları ve Dental Kök Hücrelere İlişkin Farkındalık. ADO Klinik Bilimler Dergisi. 2022;11(1):65-70.